Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity
Open accessAbstract
The subcutaneous adipose tissue (SAT) is the largest and best storage site for excess lipids. However, it has a limited ability to expand by recruiting and/or differentiating available precursor cells. When inadequate, this leads to a hypertrophic expansion of the cells with increased inflammation, insulin resistance, and a dysfunctional prolipolytic tissue. Epi-/genetic factors regulate SAT adipogenesis and genetic predisposition for type 2 diabetes is associated with markers of an impaired SAT adipogenesis and development of hypertrophic obesity also in nonobese individuals. We here review mechanisms for the adipose precursor cells to enter adipogenesis, emphasizing the role of bone morphogenetic protein-4 (BMP-4) and its endogenous antagonist gremlin-1, which is increased in hypertrophic SAT in humans. Gremlin-1 is a secreted and a likely important mechanism for the impaired SAT adipogenesis in hypertrophic obesity. Transiently increasing BMP-4 enhances adipogenic commitment of the precursor cells while maintained BMP-4 signaling during differentiation induces a beige/brown oxidative phenotype in both human and murine adipose cells. Adipose tissue growth and development also requires increased angiogenesis, and BMP-4, as a proangiogenic molecule, may also be an important feedback regulator of this. Hypertrophic obesity is also associated with increased lipolysis. Reduced lipid storage and increased release of FFA by hypertrophic SAT are important mechanisms for the accumulation of ectopic fat in the liver and other places promoting insulin resistance. Taken together, the limited expansion and storage capacity of SAT is a major driver of the obesity-associated metabolic complications.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
With overweight and obesity, adipocyte hypertrophy results in tissue hypoxia and mechanical stress which trigger immune cell invasion and activation.
“Whereas hyperplasia is regarded as metabolically protective, adipocyte hypertrophy results in tissue hypoxia and mechanical stress which trigger immune cell invasion and activation [18].”
From Obesity and MASLD: Is weight loss the (only) key to treat metabolic liver disease? (2024) · cites this paper as [18]
Figure 5 links hypertrophic expansion to excessive hypoxia, and section V describes how hypertrophic adipocytes promote macrophage recruitment and inflammation. The paper also links hypoxia to inflammatory pathways, but the passages do not identify mechanical stress as a trigger of immune-cell invasion or activation; Figure 5 says metabolic stress instead. Section V cautions that not all obese people develop chronic inflammation. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482 · see citing works
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189 · see citing works
Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention
Younossi, Z., Anstee, Q. M., Marietti, M., Hardy, T., Henry, L., Eslam, M., George, J., & Bugianesi, E. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.109 · Cited by 5,249 · see citing works
Weight-Reducing Effects of the Plasma Protein Encoded by the <i>obese</i> Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451 · see citing works
Identification and Importance of Brown Adipose Tissue in Adult Humans
Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399 · see citing works
Angiogenesis in health and disease
Carmeliet, P. (2003) · Nature Medicine · doi:10.1038/nm0603-653 · Cited by 4,258 · see citing works
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844 · see citing works
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works
Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., & Parks, E. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23621 · Cited by 3,604 · see citing works
Cold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452 · see citing works
Adipocytokines: mediators linking adipose tissue, inflammation and immunity
Tilg, H., & Moschen, A. R. (2006) · Nature reviews. Immunology · doi:10.1038/nri1937 · Cited by 3,196 · see citing works
Janssen, I., Heymsfield, S. B., & Ross, R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50216.x · Cited by 3,139 · see citing works
The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)
Buzzetti, E., Pinzani, M., & Tsochatzis, E. A. (2016) · Metabolism · doi:10.1016/j.metabol.2015.12.012 · Cited by 3,119 · see citing works
Functional Brown Adipose Tissue in Healthy Adults
Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808949 · Cited by 3,058 · see citing works
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
MAGIC, Speliotes, E. K., on behalf of Procardis Consortium, Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., Jackson, A. U., Allen, H. L., Lindgren, C. M., et al. (2010) · Nature Genetics · doi:10.1038/ng.686 · Cited by 2,912 · see citing works
Pathophysiology of human visceral obesity: an update
Tchernof, A., & Després, J.-P. (2013) · Physiological Reviews · doi:10.1152/physrev.00033.2011 · Cited by 2,583 · see citing works
What we talk about when we talk about fat
Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373 · see citing works
Dynamics of fat cell turnover in humans
Spalding, K. L., Arner, E., Westermark, P. O., Bernard, S., Buchholz, B. A., Bergmann, O., Blomqvist, L., Hoffstedt, J., Näslund, E., Britton, T., et al. (2008) · Nature · doi:10.1038/nature06902 · Cited by 2,357 · see citing works
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.
Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2391 · Cited by 2,292 · see citing works
Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation
Xue, J., Schmidt, S. V., Sander, J., Draffehn, A., Krebs, W., Quester, I., De Nardo, D., Gohel, T. D., Emde, M., Schmidleithner, L., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.01.006 · Cited by 2,210 · see citing works
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L., & Kahn, B. B. (2005) · Nature · doi:10.1038/nature03711 · Cited by 2,086 · see citing works
Fat and Beyond: The Diverse Biology of PPARγ
Tontonoz, P., & Spiegelman, B. M. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061307.091829 · Cited by 2,085 · see citing works
PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro
Rosen, E. D., Sarraf, P., Troy, A. E., Bradwin, G., Moore, K. J., Milstone, D. S., Spiegelman, B. M., & Mortensen, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80211-7 · Cited by 2,081 · see citing works
Triglyceride accumulation protects against fatty acid-induced lipotoxicity
Listenberger, L. L., Han, X., Lewis, S. E., Cases, S., Farese, R. V., Ory, D. S., & Schaffer, J. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630588100 · Cited by 2,075 · see citing works
PPARγ signaling and metabolism: the good, the bad and the future
Ahmadian, M., Suh, J. M., Hah, N., Liddle, C., Atkins, A. R., Downes, M., & Evans, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3159 · Cited by 2,016 · see citing works
PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development
Barak, Y., Nelson, M. C., Ong, E. S., Jones, Y., Ruiz‐Lozano, P., Chien, K. R., Koder, A., & Evans, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80209-9 · Cited by 1,960 · see citing works
Larsson, B., Svärdsudd, K., Welin, L., Wilhelmsen, L., Björntorp, P. A., & Tibblin, G. (1984) · BMJ · doi:10.1136/bmj.288.6428.1401 · Cited by 1,931 · see citing works
Relation of Body Fat Distribution to Metabolic Complications of Obesity*
KISSEBAH, A. H., VYDELINGUM, N., MURRAY, R., EVANS, D. J., KALKHOFF, R. K., & ADAMS, P. W. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-2-254 · Cited by 1,909 · see citing works
High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans
Saito, M., Okamatsu-Ogura, Y., Matsushita, M., Watanabe, K., Yoneshiro, T., Nio-Kobayashi, J., Iwanaga, T., Miyagawa, M., Kameya, T., Nakada, K., et al. (2009) · Diabetes · doi:10.2337/db09-0530 · Cited by 1,848 · see citing works
Transcriptional control of adipocyte formation
Farmer, S. R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.07.001 · Cited by 1,836 · see citing works
Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
Anstee, Q. M., Targher, G., & Day, C. P. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.41 · Cited by 1,747 · see citing works
Lapidus, L., Bengtsson, C., Larsson, B., Pennert, K. M., Rybo, E., & Sjöström, L. (1984) · BMJ · doi:10.1136/bmj.289.6454.1257 · Cited by 1,657 · see citing works
Wildman, R. P. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.15.1617 · Cited by 1,618 · see citing works
Adipose tissue as an endocrine organ
Galić, S., Oakhill, J. S., & Steinberg, G. R. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.018 · Cited by 1,597 · see citing works
New genetic loci link adipose and insulin biology to body fat distribution
The ADIPOGen Consortium, Shungin, D., The CARDIOGRAMplusC4D Consortium, The CKDGen Consortium, The GEFOS Consortium, The GENIE Consortium, The, G. L. G. C., The, I. C. B. P., The International Endogene Consortium, Study, T. L. C., et al. (2015) · Nature · doi:10.1038/nature14132 · Cited by 1,580 · see citing works
Adipose-derived circulating miRNAs regulate gene expression in other tissues
Thomou, T., Mori, M. A., Dreyfuss, J. M., Konishi, M., Sakaguchi, M., Wolfrum, C., Rao, T. N., Winnay, J. N., Garcia-Martin, R., Grinspoon, S. K., et al. (2017) · Nature · doi:10.1038/nature21365 · Cited by 1,539 · see citing works
Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes
Spranger, J., Kroke, A., Möhlig, M., Hoffmann, K., Bergmann, M. M., Ristow, M., Boeing, H., & Pfeiffer, A. F. H. (2003) · Diabetes · doi:10.2337/diabetes.52.3.812 · Cited by 1,493 · see citing works
Krotkiewski, M., Björntorp, P. A., Sjöström, L., & Smith, U. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111040 · Cited by 1,448 · see citing works
Self-citationThe Degree of Masculine Differentiation of Obesities
Vague, J. (1956) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/4.1.20 · Cited by 1,417 · see citing works
Regulation of bone mass by Wnt signaling
Krishnan, V. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28551 · Cited by 1,407 · see citing works
Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390 · see citing works
Barroso, I., Gurnell, M., Crowley, V. E. F., Agostini, M., Schwabe, J. W., Soos, M. A., Maslen, G. L., Williams, T. D. M., Lewis, H., Schafer, A. J., et al. (1999) · Nature · doi:10.1038/47254 · Cited by 1,368 · see citing works
Bouhlel, M. A., Derudas, B., Rigamonti, E., Dièvart, R., Brozek, J., Haulon, S., Zawadzki, C., Jude, B., Torpier, G., Marx, N., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.010 · Cited by 1,325 · see citing works
Obesity-associated improvements in metabolic profile through expansion of adipose tissue
Kim, J.-Y., van de Wall, E., Laplante, M., Azzara, A., Trujillo, M. E., Hofmann, S. M., Schraw, T., Durand, J. L., Li, H., Li, G., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31021 · Cited by 1,310 · see citing works
Relationship between Adipocyte Size and Adipokine Expression and Secretion
Skurk, T., Alberti-Huber, C., Herder, C., & Hauner, H. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1055 · Cited by 1,288 · see citing works
The Response to Long-Term Overfeeding in Identical Twins
Bouchard, C., Tremblay, A., Després, J.-P., Nadeau, A., Lupien, P. J., Thériault, G., Dussault, J., Moorjani, S., Pinault, S., & Fournier, G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005243222101 · Cited by 1,278 · see citing works
Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome
Yki‐Järvinen, H. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70032-4 · Cited by 1,260 · see citing works
Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation
Hosogai, N., Fukuhara, A., Oshima, K., Miyata, Y., Tanaka, S., Segawa, K., Furukawa, S., Tochino, Y., Komuro, R., Matsuda, M., et al. (2007) · Diabetes · doi:10.2337/db06-0911 · Cited by 1,257 · see citing works
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
Abel, E. D., Peroni, O. D., Kim, J. K., Kim, Y., Boss, O., Hadro, E., Minnemann, T., Shulman, G. I., & Kahn, B. B. (2001) · Nature · doi:10.1038/35055575 · Cited by 1,253 · see citing works
Skeletal muscle triglyceride levels are inversely related to insulin action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179 · see citing works
Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179 · see citing works
Cancello, R., Henegar, C., Viguerie, N., Taleb, S., Poitou, C., Rouault, C., Coupaye, M., Pelloux, V., Hugol, D., Bouillot, J.-L., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2277 · Cited by 1,164 · see citing works
Pajvani, U. B., Hawkins, M., Combs, T. P., Rajala, M. W., Doebber, T., Berger, J. P., Wagner, J. A., Wu, M., Knopps, A., Xiang, A. H., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311113200 · Cited by 1,163 · see citing works
The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
Perry, R. J., Samuel, V. T., Petersen, K. F., & Shulman, G. I. (2014) · Nature · doi:10.1038/nature13478 · Cited by 1,136 · see citing works
Regional adiposity and morbidity.
Kissebah, A. H., & Krakower, G. R. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.4.761 · Cited by 1,132 · see citing works
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099 · see citing works
Rotter, V., Nagaev, I., & Smith, U. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301977200 · Cited by 1,062 · see citing works
Self-citationLumeng, C. N., DeYoung, S. M., Bodzin, J. L., & Saltiel, A. R. (2007) · Diabetes · doi:10.2337/db06-1076 · Cited by 1,016 · see citing works
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
Martinon, F., Chen, X., Lee, A.-H., & Glimcher, L. H. (2010) · Nature Immunology · doi:10.1038/ni.1857 · Cited by 996 · see citing works
He, W., Barak, Y., Hevener, A. L., Olson, P., Liao, D., Le, J., Nelson, M. C., Ong, E. S., Olefsky, J. M., & Evans, R. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536828100 · Cited by 978 · see citing works
The role of macrophage phenotype in vascularization of tissue engineering scaffolds
Spiller, K. L., Anfang, R. R., Spiller, K. J., Ng, J., Nakazawa, K. R., Daulton, J. W., & Vunjak-Novakovic, G. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.02.012 · Cited by 948 · see citing works
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
Pal, D., Dasgupta, S., Kundu, R., Maitra, S., Das, G., Mukhopadhyay, S., Ray, S., Majumdar, S. S., & Bhattacharya, S. (2012) · Nature Medicine · doi:10.1038/nm.2851 · Cited by 922 · see citing works
Lumeng, C. N.-K., DelProposto, J. B., Westcott, D. J., & Saltiel, A. R. (2008) · Diabetes · doi:10.2337/db08-0872 · Cited by 919 · see citing works
The sexual dimorphism of obesity
Palmer, B. F., & Clegg, D. J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.11.029 · Cited by 919 · see citing works
Adipogenesis: From Stem Cell to Adipocyte
Tang, Q. Q., & Lane, M. D. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-052110-115718 · Cited by 897 · see citing works
Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue
Halberg, N., Khan, T., Trujillo, M. E., Wernstedt-Asterholm, I., Attie, A. D., Sherwani, S., Wang, Z. V., Landskroner-Eiger, S., Dineen, S., Magalang, U. J., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00192-09 · Cited by 896 · see citing works
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
Holland, W. L., Miller, R. A., Wang, Z. V., Sun, K., Barth, B. M., Bui, H. H., Davis, K. E., Bikman, B. T., Halberg, N., Rutkowski, J. M., et al. (2011) · Nature Medicine · doi:10.1038/nm.2277 · Cited by 892 · see citing works
Hypoxia and Adipose Tissue Function and Dysfunction in Obesity
Trayhurn, P. (2013) · Physiological Reviews · doi:10.1152/physrev.00017.2012 · Cited by 884 · see citing works
Klöting, N., Fasshauer, M., Dietrich, A., Kovacs, P., Schön, M. R., Kern, M., Stumvoll, M., & Blüher, M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00586.2009 · Cited by 856 · see citing works
Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects
Yore, M. M., Syed, I., Moraes‐Vieira, P. M., Zhang, T., Herman, M. A., Homan, E. A., Patel, R. T., Lee, J., Chen, S., Peroni, O. D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.035 · Cited by 845 · see citing works
Self-citationAdaptive thermogenesis in adipocytes: Is beige the new brown?
Wu, J., Cohen, P., & Spiegelman, B. M. (2013) · Genes & Development · doi:10.1101/gad.211649.112 · Cited by 828 · see citing works
Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBPδ gene
Tanaka, T., Yoshida, N., Kishimoto, T., & Akira, S. (1997) · The EMBO Journal · doi:10.1093/emboj/16.24.7432 · Cited by 804 · see citing works
Weyer, C., Foley, J. E., Bogardus, C., Tataranni, P. A., & Pratley, R. E. (2000) · Diabetologia · doi:10.1007/s001250051560 · Cited by 799 · see citing works
Bi-directional interconversion of brite and white adipocytes
Rosenwald, M., Perdikari, A., Rülicke, T., & Wolfrum, C. (2013) · Nature Cell Biology · doi:10.1038/ncb2740 · Cited by 792 · see citing works
Reduced Adipose Tissue Oxygenation in Human Obesity
Pasarica, M., Sereda, O. R., Redman, L. M., Albarado, D. C., Hymel, D. T., Roan, L. E., Rood, J. C., Burk, D. H., & Smith, S. R. (2009) · Diabetes · doi:10.2337/db08-1098 · Cited by 786 · see citing works
Yu, J. G., Javorschi, S., Hevener, A. L., Kruszynska, Y. T., Norman, R. A., Sinha, M. K., & Olefsky, J. M. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2968 · Cited by 724 · see citing works
Perry, R. J., Camporez, J.-P. G., Kursawe, R., Titchenell, P. M., Zhang, D., Perry, C. J., Jurczak, M. J., Abudukadier, A., Han, M. S., Zhang, X.-M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.012 · Cited by 719 · see citing works
Metabolic functions of FABPs—mechanisms and therapeutic implications
Hotamisligil, G. S., & Bernlohr, D. A. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.122 · Cited by 712 · see citing works
Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease
Softic, S., Cohen, D. E., & Kahn, C. R. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4054-0 · Cited by 709 · see citing works
Alternative Wnt Signaling Activates YAP/TAZ
Park, H. W., Kim, Y. C., Yu, B., Moroishi, T., Mo, J., Plouffe, S. W., Meng, Z., Lin, K. C., Yu, F., Alexander, C. M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.013 · Cited by 708 · see citing works
Jager, J., Grémeaux, T., Cormont, M., MARCHAND‐BRUSTEL, Y. L., & Tanti, J. (2006) · Endocrinology · doi:10.1210/en.2006-0692 · Cited by 697 · see citing works
Control of brown and beige fat development
Wang, W., & Seale, P. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.96 · Cited by 697 · see citing works
Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis
Sidossis, L. S., & Kajimura, S. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78362 · Cited by 689 · see citing works
Targeting adipose tissue in the treatment of obesity-associated diabetes
Kusminski, C. M., Bickel, P. E., & Scherer, P. E. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.75 · Cited by 678 · see citing works
Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans
Adams, J. M., Pratipanawatr, T., Berria, R., Wang, E. L., DeFronzo, R. A., Sullards, M. C., & Mandarino, L. J. (2004) · Diabetes · doi:10.2337/diabetes.53.1.25 · Cited by 670 · see citing works
Regulation of metabolism by the innate immune system
Lackey, D. E., & Olefsky, J. M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.189 · Cited by 667 · see citing works
Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology
Arner, E., Westermark, P. O., Spalding, K. L., Britton, T., Rydén, M., Frisén, J., Bernard, S., & Arner, P. (2010) · Diabetes · doi:10.2337/db09-0942 · Cited by 645 · see citing works
JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation
Han, M. S., Jung, D. Y., Morel, C., Lakhani, S. A., Kim, J. K., Flavell, R. A., & Davis, R. J. (2012) · Science · doi:10.1126/science.1227568 · Cited by 635 · see citing works
Distribution of macrophage polarization markers in human atherosclerosis
Stöger, J. L., Gijbels, M. J., van der Velden, S., Manca, M., van der Loos, C. M., Biessen, E. A. L., Daemen, M. J. A. P., Lutgens, E., & de Winther, M. P. J. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.09.013 · Cited by 622 · see citing works
De novo lipogenesis in health and disease
Ameer, F., Scandiuzzi, L., Hasnain, S., Kalbacher, H., & Zaidi, N. (2014) · Metabolism · doi:10.1016/j.metabol.2014.04.003 · Cited by 612 · see citing works
Wentworth, J. M., Naselli, G., Brown, W. A., Doyle, L., Phipson, B., Smyth, G. K., Wabitsch, M., O’Brien, P. E., & Harrison, L. C. (2010) · Diabetes · doi:10.2337/db09-0287 · Cited by 609 · see citing works
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
Herman, M. A., Peroni, O. D., Villoria, J., Schön, M. R., Abumrad, N. A., Blüher, M., Klein, S., & Kahn, B. B. (2012) · Nature · doi:10.1038/nature10986 · Cited by 599 · see citing works
Adipogenesis and WNT signalling
Christodoulides, C., Lagathu, C., Sethi, J. K., & Vidal‐Puig, A. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.09.002 · Cited by 596 · see citing works
Non-alcoholic fatty liver disease and obesity: Biochemical, metabolic and clinical presentations
Milić, S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i28.9330 · Cited by 594 · see citing works
Lemieux, I., Pascot, A., Prud’homme, D., Alméras, N., Bogaty, P. M., Nadeau, A., Bergeron, J., & Després, J. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.6.961 · Cited by 593 · see citing works
Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes
Himms-Hagen, J., Melnyk, A., Zingaretti, M. C., Ceresi, E., Barbatelli, G., & Cinti, S. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.3.c670 · Cited by 593 · see citing works
Lotta, L. A., Gulati, P., Day, F. R., Payne, F., Ongen, H., van de Bunt, M., Gaulton, K. J., Eicher, J. D., Sharp, S. J., Luan, J., et al. (2016) · Nature Genetics · doi:10.1038/ng.3714 · Cited by 587 · see citing works
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
Kumashiro, N., Erion, D. M., Zhang, D., Kahn, M., Beddow, S. A., Chu, X., Still, C. D., Gerhard, G. S., Han, X., Dziura, J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113359108 · Cited by 585 · see citing works
Zannettino, A. C. W., Paton, S., Arthur, A., Khor, F., Itescu, S., Gimble, J. M., & Gronthos, S. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21210 · Cited by 553 · see citing works
Characterization of the adipocyte cellular lineage in vivo
Berry, R., & Rodeheffer, M. S. (2013) · Nature Cell Biology · doi:10.1038/ncb2696 · Cited by 542 · see citing works
Transcriptional control of preadipocyte determination by Zfp423
Gupta, R. K., Arany, Z. P., Seale, P., Mepani, R. J., Li, Y., Conroe, H. M., Roby, Y. A., Kulaga, H. M., Reed, R. R., & Spiegelman, B. M. (2010) · Nature · doi:10.1038/nature08816 · Cited by 537 · see citing works
Bays, H. E., González-Campoy, J. M., Bray, G. A., Kitabchi, A. E., Bergman, D. A., Schorr, A. B., Rodbard, H. W., & Henry, R. R. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.3.343 · Cited by 531 · see citing works
Shepherd, P. R., Gnudi, L., Tozzo, E., Yang, H., Leach, F., & Kahn, B. B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41516-5 · Cited by 520 · see citing works
Vascular endothelial growth factor B controls endothelial fatty acid uptake
Hagberg, C. E., Falkevall, A., Wang, X., Larsson, E., Huusko, J., Nilsson, I., van Meeteren, L. A., Samén, E., Lu, L., Vanwildemeersch, M., et al. (2010) · Nature · doi:10.1038/nature08945 · Cited by 514 · see citing works
Smith, U., & Kahn, B. B. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12540 · Cited by 498 · see citing works
Self-citationSamuel, V. T., Liu, Z.-X., Wang, A., Beddow, S. A., Geisler, J. G., Kahn, M., Zhang, X.-M., Monia, B. P., Bhanot, S., & Shulman, G. I. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30400 · Cited by 497 · see citing works
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss
Gregor, M. F., Yang, L., Fabbrini, E., Mohammed, B. S., Eagon, J. C., Hotamisligil, G. S., & Klein, S. (2009) · Diabetes · doi:10.2337/db08-1220 · Cited by 488 · see citing works
CCAAT/enhancer-binding protein β is required for mitotic clonal expansion during adipogenesis
Tang, Q.-Q., Otto, T. C., & Lane, M. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337434100 · Cited by 485 · see citing works
Kupffer cells in non-alcoholic fatty liver disease: The emerging view
Baffy, G. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.03.008 · Cited by 475 · see citing works
Body fat distribution, insulin resistance, and metabolic diseases
Björntorp, P. (1997) · Nutrition · doi:10.1016/s0899-9007(97)00191-3 · Cited by 470 · see citing works
Boden, G., Duan, X., Homko, C., Molina, E. J., Song, W., Perez, O., Cheung, P., & Merali, S. (2008) · Diabetes · doi:10.2337/db08-0604 · Cited by 468 · see citing works
White Adipose Tissue as Endocrine Organ and Its Role in Obesity
Frigolet, M. E., Torres, N., & Tovar, A. R. (2008) · Archives of Medical Research · doi:10.1016/j.arcmed.2008.09.005 · Cited by 459 · see citing works
Nishimura, S., Manabe, I., Nagasaki, M., Hosoya, Y., Yamashita, H., Fujita, H., Ohsugi, M., Tobe, K., Kadowaki, T., Nagai, R., et al. (2007) · Diabetes · doi:10.2337/db06-1749 · Cited by 440 · see citing works
Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases
Cao, Y. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3055 · Cited by 437 · see citing works
Adipose tissue macrophages: going off track during obesity
Boutens, L., & Stienstra, R. (2016) · Diabetologia · doi:10.1007/s00125-016-3904-9 · Cited by 430 · see citing works
Kajimura, S., & Saito, M. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170252 · Cited by 428 · see citing works
Gupta, R. K., Mepani, R. J., Kleiner, S., Lo, J. C., Khandekar, M. J., Cohen, P., Frontini, A., Bhowmick, D. C., Ye, L., Cinti, S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.010 · Cited by 426 · see citing works
Adipose tissue angiogenesis1,2
Hausman, G., & Richardson, R. L. (2004) · Journal of Animal Science · doi:10.2527/2004.823925x · Cited by 421 · see citing works
Dichotomous effects of VEGF-A on adipose tissue dysfunction
Sun, K., Asterholm, I. W., Kusminski, C. M., Bueno, A. C., Wang, Z. V., Pollard, J. W., Brekken, R. A., & Scherer, P. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200447109 · Cited by 417 · see citing works
Regulation of Adipose Cell Number in Man
Prins, J. B., & O'rahilly, S. (1997) · Clinical Science · doi:10.1042/cs0920003 · Cited by 406 · see citing works
Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue
Kawasaki, N., Asada, R., Saito, A., Kanemoto, S., & Imaizumi, K. (2012) · Scientific Reports · doi:10.1038/srep00799 · Cited by 404 · see citing works
Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity
Jeffery, E., Church, C. D., Holtrup, B., Colman, L., & Rodeheffer, M. S. (2015) · Nature Cell Biology · doi:10.1038/ncb3122 · Cited by 404 · see citing works
Insulin resistance and impaired adipogenesis
Gustafson, B., Hedjazifar, S., Gogg, S., Hammarstedt, A., & Smith, U. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.01.006 · Cited by 398 · see citing works
Self-citationTemperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans
Lee, P., Smith, S., Linderman, J. D., Courville, A. B., Brychta, R. J., Dieckmann, W., Werner, C., Chen, K. Y., & Celi, F. S. (2014) · Diabetes · doi:10.2337/db14-0513 · Cited by 398 · see citing works
Defining stem and progenitor cells within adipose tissue
Lin, G., Garcia, M., Ning, H., Banie, L., Guo, Y.-L., Lue, T. F., & Lin, C.-S. (2008) · Stem Cells and Development · doi:10.1089/scd.2008.0117 · Cited by 398 · see citing works
Nonalcoholic Fatty Liver Disease: Cytokine-Adipokine Interplay and Regulation of Insulin Resistance
Tilg, H., & Hotamışlıgil, G. S. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.054 · Cited by 385 · see citing works
Production of Chemokines by Perivascular Adipose Tissue
Henrichot, E., Juge-Aubry, C. E., Pernin, A., Pache, J., Velebit, V., Dayer, J., Meda, P., Chizzolini, C., & Meier, C. A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000188508.40052.35 · Cited by 382 · see citing works
The Vascular Endothelium of the Adipose Tissue Gives Rise to Both White and Brown Fat Cells
Tran, K., Gealekman, O., Frontini, A., Zingaretti, M. C., Morroni, M., Giordano, A., Smorlesi, A., Perugini, J., Matteis, R. D., Sbarbati, A., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.008 · Cited by 381 · see citing works
Dubé, J. J., Amati, F., Stefanovic-Racic, M., Toledo, F. G. S., Sauers, S. E., & Goodpaster, B. H. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00769.2007 · Cited by 378 · see citing works
Emdin, C. A., Khera, A. V., Natarajan, P., Klarin, D., Zekavat, S. M., Hsiao, A. J., & Kathiresan, S. (2017) · JAMA · doi:10.1001/jama.2016.21042 · Cited by 378 · see citing works
Christy, R. J., Kaestner, K. H., Geiman, D. E., & Lane, M. D. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.6.2593 · Cited by 378 · see citing works
Regional differences in cellular mechanisms of adipose tissue gain with overfeeding
Tchoukalova, Y. D., Votruba, S. B., Tchkonia, T., Giorgadze, N., Kirkland, J. L., & Jensen, M. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005259107 · Cited by 377 · see citing works
Obesity Decreases Perioperative Tissue Oxygenation
Kabon, B., Nagele, A., Reddy, D., Eagon, C., Fleshman, J. W., Sessler, D. I., & Kurz, A. (2004) · Anesthesiology · doi:10.1097/00000542-200402000-00015 · Cited by 376 · see citing works
Gundra, U. M., Girgis, N. M., Ruckerl, D., Jenkins, S., Ward, L. N., Kurtz, Z. D., Wiens, K. E., Tang, M. S., Basu-Roy, U., Mansukhani, A., et al. (2014) · Blood · doi:10.1182/blood-2013-08-520619 · Cited by 371 · see citing works
Impaired Preadipocyte Differentiation in Human Abdominal Obesity
Isakson, P., Hammarstedt, A., Gustafson, B., & Smith, U. (2009) · Diabetes · doi:10.2337/db08-1770 · Cited by 369 · see citing works
Self-citationFructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease
ter Horst, K. W., & Serlie, M. J. M. (2017) · Nutrients · doi:10.3390/nu9090981 · Cited by 365 · see citing works
McLaughlin, T., Sherman, A., Tsao, P., Gonzalez, O., Yee, G., Lamendola, C., Reaven, G. M., & Cushman, S. W. (2007) · Diabetologia · doi:10.1007/s00125-007-0708-y · Cited by 364 · see citing works
Genetic Syndromes of Severe Insulin Resistance
Semple, R. K., Savage, D. B., Cochran, E. K., Görden, P., & O’Rahilly, S. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0020 · Cited by 363 · see citing works
Chao, L. C., Marcus‐Samuels, B., Mason, M. M., Moitra, J., Vinson, C., Arioǧlu, E., Gavrilova, O., & Reitman, M. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci11245 · Cited by 356 · see citing works
Stančáková, A., Javorský, M., Kuulasmaa, T., Haffner, S. M., Kuusisto, J., & Laakso, M. (2009) · Diabetes · doi:10.2337/db08-1607 · Cited by 348 · see citing works
Tang, Q.-Q., Grønborg, M., Huang, H., Kim, J. W., Otto, T. C., Pandey, A., & Lane, M. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503891102 · Cited by 333 · see citing works
C/EBPα is required for differentiation of white, but not brown, adipose tissue
Linhart, H., Ishimura‐Oka, K., DeMayo, F. J., Kibe, T., Repka, D., Poindexter, B. J., Bick, R. J., & Darlington, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211416898 · Cited by 333 · see citing works
Yamakawa, M., Liu, L. X., Date, T., Belanger, A. J., Vincent, K. A., Akita, G. Y., Kuriyama, T., Cheng, S. H., Gregory, R. J., & Jiang, C. (2003) · Circulation Research · doi:10.1161/01.res.0000093984.48643.d7 · Cited by 327 · see citing works
Scherag, A., Christian Dina, C., Hinney, A., Vatin, V., Scherag, S., Vogel, C. I. G., Müller, T. D., Grallert, H., Wichmann, H. ‐., Balkau, B., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000916 · Cited by 327 · see citing works
Goossens, G. H., Bizzarri, A., Venteclef, N., Essers, Y., Cleutjens, J. P., Konings, E., Jocken, J. W. E., Čajlaković, M., Ribitsch, V., Clément, K., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.027813 · Cited by 324 · see citing works
Pajvani, U. B., Trujillo, M. E., Combs, T. P., Iyengar, P., Jelicks, L., Roth, K. A., Kitsis, R. N., & Scherer, P. E. (2005) · Nature Medicine · doi:10.1038/nm1262 · Cited by 322 · see citing works
Cao, Y. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.008 · Cited by 321 · see citing works
Sacks, H. S., Fain, J. N., Holman, B., Cheema, P. S., Chary, A., Parks, F., Karas, J. G., Optican, R. J., Bahouth, S. W., Garrett, E., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0571 · Cited by 320 · see citing works
Elias, I., Franckhauser, S., Ferré, T., Vilà, L., Tafuro, S., MUÑOZ, S. A., Roca, C., Ramos, D., Pujol, A., Riu, E., et al. (2012) · Diabetes · doi:10.2337/db11-0832 · Cited by 320 · see citing works
Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue.
Yin, J., Gao, Z., He, Q., Zhou, D., Guo, Z., & Ye, J. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90760.2008 · Cited by 319 · see citing works
LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes
Li, P., Oh, D. Y., Bandyopadhyay, G. K., Lagakos, W., Talukdar, S., Osborn, O., Johnson, A., Chung, H., Mayoral, R., Maris, M., et al. (2015) · Nature Medicine · doi:10.1038/nm.3800 · Cited by 318 · see citing works
Metabolic Syndrome in Normal-Weight Americans
St‐Onge, M., Janssen, I., & Heymsfield, S. B. (2004) · Diabetes Care · doi:10.2337/diacare.27.9.2222 · Cited by 308 · see citing works
Role of ceramides in nonalcoholic fatty liver disease
Pagadala, M. R., Kasumov, T., McCullough, A. J., Zein, N. N., & Kirwan, J. P. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.04.005 · Cited by 306 · see citing works
The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis
Bala, S., Csák, T., Saha, B., Zatsiorsky, J., Kodys, K., Catalano, D. E., Satishchandran, A., & Szabó, G. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.01.035 · Cited by 305 · see citing works
Min, S. Y., Kady, J., Nam, M., Rojas-Rodriguez, R., Berkenwald, A., Kim, J. H., Noh, H. L., Kim, J. K., Cooper, M. P., Fitzgibbons, T. P., et al. (2016) · Nature Medicine · doi:10.1038/nm.4031 · Cited by 304 · see citing works
Link between obesity and type 2 diabetes
Golay, A., & Ybarra, J. (2005) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2005.07.010 · Cited by 301 · see citing works
Increased Brown Adipose Tissue Oxidative Capacity in Cold-Acclimated Humans
Blondin, D. P., Labbé, S. M., Tingelstad, H. C., Noll, C., Kunach, M., Phoenix, S., Guérin, B., Turcotte, É. E., Carpentier, A. C., Richard, D., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3901 · Cited by 300 · see citing works
Abdominal obesity: a marker of ectopic fat accumulation
Smith, U. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81507 · Cited by 299 · see citing works
Self-citationAdipose Vascular Endothelial Growth Factor Regulates Metabolic Homeostasis through Angiogenesis
Sung, H., Doh, K., Son, J. E., Park, J. G., Bae, Y., Choi, S., Nelson, S. M. L., Cowling, R. A., Nagy, K. V., Michael, I. P., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.010 · Cited by 299 · see citing works
Rondinone, C. M., Wang, L.-M., Lönnroth, P., Wesslau, C., Pierce, J. H., & Smith, U. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4171 · Cited by 297 · see citing works
Self-citationMutations in ligands and receptors of the leptin–melanocortin pathway that lead to obesity
Farooqi, I. S., & O’Rahilly, S. (2008) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0966 · Cited by 295 · see citing works
Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance
Jia, L., Vianna, C. R., Fukuda, M., Berglund, E. D., Liu, C., Tao, C., Sun, K., Liu, T., Harper, M. J., Lee, C. E., et al. (2014) · Nature Communications · doi:10.1038/ncomms4878 · Cited by 294 · see citing works
Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes
Cavelti‐Weder, C., Babians-Brunner, A., Keller, C., Stahel, M., Kurz-Levin, M. M., Zayed, H., Solinger, A. M., Mandrup-Poulsen, T. R., Dinarello, C. A., & Donath, M. Y. (2012) · Diabetes Care · doi:10.2337/dc11-2219 · Cited by 294 · see citing works
Trépo, E., Romeo, S., Zucman‐Rossi, J., & Nahon, P. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.03.011 · Cited by 293 · see citing works
Inflammation and impaired adipogenesis in hypertrophic obesity in man
Gustafson, B., Gogg, S., Hedjazifar, S., Jenndahl, L. E., Hammarstedt, A., & Smith, U. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00377.2009 · Cited by 289 · see citing works
Self-citationMartins, A. R., Nachbar, R. T., Gorjão, R., Vinolo, M. A. R., Festuccia, W. T., Lambertucci, R. H., Cury‐Boaventura, M. F., Silveira, L. R., Curi, R., & Hirabara, S. M. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-30 · Cited by 288 · see citing works
Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes
Hagberg, C. E., Mehlem, A., Falkevall, A., Muhl, L., Fam, B. C., Ortsäter, H., Scotney, P. D., Nyqvist, D., Samén, E., Li, L., et al. (2012) · Nature · doi:10.1038/nature11464 · Cited by 286 · see citing works
Bone Morphogenetic Protein-2 Stimulates Angiogenesis in Developing Tumors
Langenfeld, E. M., & Langenfeld, J. E. (2004) · Molecular Cancer Research · doi:10.1158/1541-7786.141.2.3 · Cited by 284 · see citing works
Zhang, J., Klemm, D. J., Vinson, C., & Lane, M. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311327200 · Cited by 283 · see citing works
Hypoxia decreases insulin signaling pathways in adipocytes.
Regazzetti, C., Peraldi, P., Grémeaux, T., Najem-Lendom, R., Ben-Sahra, I., Cormont, M., Bost, F., Le Marchand-Brustel, Y., Tanti, J.-F., & Giorgetti-Peraldi, S. (2009) · Diabetes · doi:10.2337/db08-0457 · Cited by 281 · see citing works
Kraakman, M. J., Murphy, A. J., Jandeleit-Dahm, K. A. M., & Kammoun, H. L. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00470 · Cited by 278 · see citing works
Fat cell enlargement is an independent marker of insulin resistance and ‘hyperleptinaemia’
Lundgren, M., Svensson, M. K. E., Lindmark, S., Renström, F., Ruge, T., & Eriksson, J. W. (2007) · Diabetologia · doi:10.1007/s00125-006-0572-1 · Cited by 278 · see citing works
Adipose tissue and its role in organ crosstalk
Romacho, T., Elsen, M., Röhrborn, D., & Eckel, J. (2014) · Acta Physiologica · doi:10.1111/apha.12246 · Cited by 278 · see citing works
Adipocyte Lipid Chaperone aP2 Is a Secreted Adipokine Regulating Hepatic Glucose Production
Cao, H., Sekiya, M., Ertunc, M. E., Burak, M. F., Mayers, J. R., White, A., Inouye, K., Rickey, L., Erçal, B., Furuhashi, M., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.012 · Cited by 276 · see citing works
Endoplasmic Reticulum Stress Markers Are Associated with Obesity in Nondiabetic Subjects
Sharma, N. K., Das, S. K., Mondal, A. K., Hackney, O. G., Chu, W. S., Kern, P. A., Rasouli, N., Spencer, H. J., Yao‐Borengasser, A., & Elbein, S. C. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1001 · Cited by 271 · see citing works
Jiang, C., Qu, A., Matsubara, T., Chanturiya, T., Jou, W., Gavrilova, O., Shah, Y. M., & Gonzalez, F. J. (2011) · Diabetes · doi:10.2337/db11-0174 · Cited by 269 · see citing works
Roberts, R., Hodson, L., Dennis, A., Neville, M. J., Humphreys, S. M., Harnden, K., Micklem, K., & Frayn, K. N. (2009) · Diabetologia · doi:10.1007/s00125-009-1300-4 · Cited by 263 · see citing works
Role of Insulin Resistance and Lipotoxicity in Non-Alcoholic Steatohepatitis
Cusi, K. J. (2009) · Clinics in Liver Disease · doi:10.1016/j.cld.2009.07.009 · Cited by 263 · see citing works
Mechanisms of obesity and related pathologies: The macro‐ and microcirculation of adipose tissue
Rutkowski, J. M., Davis, K. E., & Scherer, P. E. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07303.x · Cited by 254 · see citing works
Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity
Hoffstedt, J., Arner, E., Wahrenberg, H., Andersson, D. P., Qvisth, V., Löfgren, P., Rydén, M., Thörne, A., Wirén, M., Palmér, M., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1889-3 · Cited by 246 · see citing works
Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance
Arner, P., & Langin, D. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.03.002 · Cited by 245 · see citing works
Sopasakis, V. R., Sandqvist, M., Gustafson, B., Hammarstedt, A., Schmelz, M., Yang, X., Jansson, P., & Smith, U. (2004) · Obesity Research · doi:10.1038/oby.2004.51 · Cited by 243 · see citing works
Self-citationLocal proliferation of macrophages in adipose tissue during obesity-induced inflammation
Haase, J., Weyer, U., Immig, K., Klöting, N., Blüher, M., Eilers, J., Bechmann, I., & Gericke, M. T. (2013) · Diabetologia · doi:10.1007/s00125-013-3139-y · Cited by 237 · see citing works
Weighing in on Adipocyte Precursors
Berry, R., Jeffery, E. C., & Rodeheffer, M. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.003 · Cited by 235 · see citing works
Clarke, S. L., Robinson, C. E., & Gimble, J. M. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7627 · Cited by 235 · see citing works
Robciuc, M. R., Kivelä, R., Williams, I. M., de Boer, J. F., van Dijk, T. H., Elamaa, H. P., Tigistu‐Sahle, F., Molotkov, D. A., Leppänen, V., Käkelä, R., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.03.004 · Cited by 234 · see citing works
Abdominal Obesity and the Metabolic Syndrome
Björntorp, P. (1992) · Annals of Medicine · doi:10.3109/07853899209166997 · Cited by 233 · cited 1× · see citing works
“More than one-half a century ago, the importance of adipose tissue distribution for metabolic complications was recognized, and the so-called android obesity, with adipose tissue preferentially accumulated around the trunk, was identified as the form of obesity more strongly associated with metabolic disease (28, 29,…”
BackgroundAngiogenesis and development of adipose tissue
Christiaens, V., & LIJNEN, H. R. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.006 · Cited by 233 · see citing works
Shao, M., Ishibashi, J., Kusminski, C. M., Wang, Q. A., Hepler, C., Vishvanath, L., MacPherson, K. A., Spurgin, S. B., Sun, K., Holland, W. L., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.023 · Cited by 231 · see citing works
Adiponectin: Identification, physiology and clinical relevance in metabolic and vascular disease
Matsuzawa, Y. (2005) · Atherosclerosis Supplements · doi:10.1016/j.atherosclerosissup.2005.02.003 · Cited by 229 · see citing works
Bowers, R. R., Kim, J. W., Otto, T. C., & Lane, M. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605789103 · Cited by 228 · see citing works
Albuquerque, D., Stice, E. M., Rodríguez‐López, R., Manco, L., & Nóbrega, C. (2015) · Molecular Genetics and Genomics · doi:10.1007/s00438-015-1015-9 · Cited by 223 · see citing works
Human Brown Adipose Tissue: What We Have Learned So Far
Betz, M. J., & Enerbäck, S. (2015) · Diabetes · doi:10.2337/db15-0146 · Cited by 223 · see citing works
Girousse, A., Tavernier, G., Valle, C., Moro, C., Mejhert, N., Dinel, A., Houssier, M., Roussel, B., Besse‐Patin, A., Combes, M., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001485 · Cited by 221 · see citing works
Links Between Ectopic Fat and Vascular Disease in Humans
Lim, S. K., & Meigs, J. B. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303035 · Cited by 218 · see citing works
Critical Role for Ebf1 and Ebf2 in the Adipogenic Transcriptional Cascade
Jimenez, M. A., Åkerblad, P., Sigvardsson, M., & Rosen, E. D. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01557-06 · Cited by 218 · see citing works
Wang, C., Ou, H., Chen, M.-F., Chang, T., & Chang, C. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000297 · Cited by 215 · see citing works
BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis
Gustafson, B., Hammarstedt, A., Hedjazifar, S., Hoffmann, J. M., Svensson, P., Grimsby, J. S., Rondinone, C. M., & Smith, U. (2015) · Diabetes · doi:10.2337/db14-1127 · Cited by 215 · see citing works
Self-citationZhang, Y., Mei, H., Chang, X., Chen, F., Zhu, Y., & Han, X. (2016) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjw040 · Cited by 215 · see citing works
Adipocyte size as a determinant of metabolic disease and adipose tissue dysfunction
Laforest, S., Labrecque, J., Michaud, A., Cianflone, K., & Tchernof, A. (2015) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2015.1041582 · Cited by 214 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- 10.1093/ansci/82.3.925 · DOI
Cited by
Sorted by citations
NF-κB in biology and targeted therapy: new insights and translational implications
Guo, Q., Jin, Y., Chen, X., Ye, X., Shen, X., Lin, M., Zeng, C., Zhou, T., & Zhang, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01757-9 · Cited by 2,267 · see citing works
Adipose tissue dysfunction as determinant of obesity-associated metabolic complications
Longo, M., Zatterale, F., Naderi, J., Parrillo, L., Formisano, P., Raciti, G. A., Beguinot, F., & Miele, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092358 · Cited by 1,575 · see citing works
Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
Zatterale, F., Longo, M., Naderi, J., Raciti, G. A., Desiderio, A., Miele, C., & Beguinot, F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01607 · Cited by 1,180 · see citing works
The aetiology and molecular landscape of insulin resistance
James, D. E., Stöckli, J., & Birnbaum, M. J. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00390-6 · Cited by 701 · see citing works
Causes, consequences, and treatment of metabolically unhealthy fat distribution
Stefan, N. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30110-8 · Cited by 546 · see citing works
Lister, N. B., Baur, L. A., Felix, J. F., Hill, A. J., Marcus, C., Reinehr, T., Summerbell, C., & Wabitsch, M. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00435-4 · Cited by 547 · see citing works
Neeland, I. J., Lim, S., Tchernof, A., Gastaldelli, A., Rangaswami, J., Ndumele, C. E., Powell-Wiley, T. M., & Després, J.-P. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00563-5 · Cited by 463 · see citing works
Obesity and the risk of cardiometabolic diseases
Valenzuela, P. L., Carrera-Bastos, P., Castillo-García, A., Lieberman, D. E., Santos-Lozano, A., & Lucia, A. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00847-5 · Cited by 452 · see citing works
Borlaug, B. A., Jensen, M. D., Kitzman, D. W., Lam, C. S. P., Obokata, M., & Rider, O. J. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvac120 · Cited by 450 · see citing works
Reassessing human adipose tissue
Cypess, A. M. (2022) · New England Journal of Medicine · doi:10.1056/nejmra2032804 · Cited by 404 · see citing works
Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications
Ren, J. T., Wu, N. N., Wang, S., Sowers, J. R., & Zhang, Y. (2021) · Physiological Reviews · doi:10.1152/physrev.00030.2020 · Cited by 377 · see citing works
Cellular senescence: at the nexus between ageing and diabetes
Palmer, A. K., Gustafson, B., Kirkland, J. L., & Smith, U. (2019) · Diabetologia · doi:10.1007/s00125-019-4934-x · Cited by 337 · see citing works
Self-citationBeyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication
Funcke, J., & Scherer, P. E. (2019) · Journal of Lipid Research · doi:10.1194/jlr.r094060 · Cited by 337 · see citing works
Extracellular Matrix Remodeling of Adipose Tissue in Obesity and Metabolic Diseases
Ruiz‐Ojeda, F. J., Méndez-Gutiérrez, A., Aguilera, C. M., & Plaza‐Díaz, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194888 · Cited by 305 · see citing works
Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue
Saxton, S. N., Clark, B., Withers, S., Eringa, E. C., & Heagerty, A. M. (2019) · Physiological Reviews · doi:10.1152/physrev.00034.2018 · Cited by 277 · see citing works
Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
Zhao, Y., Xiong, W., Li, C., Zhao, R., Lu, H., Song, S., Zhou, Y., Hu, Y., Shi, B., & Ge, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01652-9 · Cited by 264 · see citing works
Gut microbiota in overweight and obesity: crosstalk with adipose tissue
Cani, P., & Hul, M. V. (2023) · Nature reviews: Gastroenterology & hepatology · doi:10.1038/s41575-023-00867-z · Cited by 177 · see citing works
Metabolically healthy obesity: from epidemiology and mechanisms to clinical implications
Schulze, M. B., & Stefan, N. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01008-5 · Cited by 184 · see citing works
Gustafson, B., Nerstedt, A., & Smith, U. (2019) · Nature Communications · doi:10.1038/s41467-019-10688-x · Cited by 182 · see citing works
Self-citationObesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce
Li, Q., Hagberg, C. E., Silva Cascales, H., Lang, S., Hyvönen, M. T., Salehzadeh, F., Chen, P., Alexandersson, I., Terezaki, E., Harms, M. J., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01501-8 · Cited by 178 · see citing works
Obesity and MASLD: Is weight loss the (only) key to treat metabolic liver disease?
Huttasch, M., Roden, M., & Kahl, S. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155937 · Cited by 169 · see citing works
Adipose tissue macrophages as potential targets for obesity and metabolic diseases
Li, X., Ren, Y., Chang, K.-W., Wu, W., Griffiths, H. R., Lu, S., & Gao, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1153915 · Cited by 165 · see citing works
Adipose tissue hyperplasia and hypertrophy in common and syndromic obesity-the case of BBS obesity
Horwitz, A., & Birk, R. (2023) · Nutrients · doi:10.3390/nu15153445 · Cited by 143 · see citing works
“Hypoplasia results from various factors, including genetic mutations, hormonal imbalances, ageing, or inadequate nutrient availability [39,40].”
BackgroundThe role of adipose tissue senescence in obesity- and ageing-related metabolic disorders
Liu, Z., Wu, K. K.-L., Jiang, X. X., Xu, A., & Cheng, K. K. Y. (2020) · Clinical Science · doi:10.1042/cs20190966 · Cited by 139 · see citing works
Angiogenic Abnormalities in Diabetes Mellitus: Mechanistic and Clinical Aspects
Fadini, G. P., Albiero, M., Bonora, B. M., & Avogaro, A. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00980 · Cited by 137 · see citing works
Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders
Morris, G., Puri, B. K., Walker, A. J., Maes, M. H. J., Carvalho, A. F., Bortolasci, C. C., Walder, K. R., & Berk, M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.025 · Cited by 112 · see citing works
Selenium and Selenoproteins in Adipose Tissue Physiology and Obesity
Tinkov, A. A., Ajsuvakova, O. P., Filippini, T., Zhou, J., Lei, X. G., Gatiatulina, E. R., Michalke, B., Геннадиевна, С. М., Vinceti, M., Aschner, M., et al. (2020) · Biomolecules · doi:10.3390/biom10040658 · Cited by 113 · see citing works
Increased cell senescence in human metabolic disorders
Spinelli, R., Baboota, R. K., Gogg, S., Bèguinot, F., Blüher, M., Nerstedt, A., & Smith, U. (2023) · Journal of Clinical Investigation · doi:10.1172/jci169922 · Cited by 117 · see citing works
Self-citationLiu, F., He, J., Wang, H., Zhu, D., & Bi, Y. (2020) · Obesity Surgery · doi:10.1007/s11695-020-04983-6 · Cited by 115 · see citing works
Lipedema: Insights into Morphology, Pathophysiology, and Challenges
Poojari, A., Dev, K., & Rabiee, A. (2022) · Biomedicines · doi:10.3390/biomedicines10123081 · Cited by 110 · see citing works
Adipocyte and steroidogenic cell cross-talk in polycystic ovary syndrome
de Medeiros, S. F., Rodgers, R. J., & Norman, R. J. (2021) · Human Reproduction Update · doi:10.1093/humupd/dmab004 · Cited by 107 · see citing works
Molecular basis of ageing in chronic metabolic diseases
Spinelli, R., Parrillo, L., Longo, M., Florese, P., Desiderio, A., Zatterale, F., Miele, C., Raciti, G. A., & Bèguinot, F. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01255-z · Cited by 100 · see citing works
The biology of human overfeeding: A systematic review
Bray, G. A., & Bouchard, C. (2020) · Obesity Reviews · doi:10.1111/obr.13040 · Cited by 93 · see citing works
Age-associated telomere attrition in adipocyte progenitors predisposes to metabolic disease
Gao, Z., Daquinag, A. C., Fussell, C., Zhao, Z., Dai, Y., Rivera, A., Snyder, B. E., Eckel-Mahan, K. L., & Kolonin, M. G. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00320-4 · Cited by 92 · see citing works
Alaaeldin, R., Abdel-Rahman, I. A. M., Hassan, H. A., Youssef, N., Allam, A. E., Abdelwahab, S. F., Zhao, Q.-L., & Fathy, M. (2021) · Molecules · doi:10.3390/molecules26247629 · Cited by 92 · see citing works
Adipose Tissue Macrophage Polarization in Healthy and Unhealthy Obesity
Ruggiero, A. D., Key, C.-C. C., & Kavanagh, K. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.625331 · Cited by 89 · see citing works
Multifactorial Basis and Therapeutic Strategies in Metabolism-Related Diseases
Guerra, J. V. D. S., Dias, M. M. G., Brilhante, A. J. V. C., Terra, M. F., García‐Arévalo, M., & Figueira, A. C. M. (2021) · Nutrients · doi:10.3390/nu13082830 · Cited by 87 · see citing works
Obesity and prostate cancer — microenvironmental roles of adipose tissue
Saha, A., Kolonin, M. G., & DiGiovanni, J. (2023) · Nature Reviews Urology · doi:10.1038/s41585-023-00764-9 · Cited by 86 · see citing works
The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health
Clemente‐Postigo, M., Tinahones, A., Bekay, R. E., Malagón, M. M., & Tinahones, F. J. (2020) · Metabolites · doi:10.3390/metabo10050179 · Cited by 77 · see citing works
Kruppa, P., Gohlke, S., Łapiński, K., García‐Carrizo, F., Soultoukis, G. A., Infanger, M., Schulz, T. J., & Ghods, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1223264 · Cited by 76 · see citing works
Schaffert, A., Karkossa, I., Ueberham, E., Schlichting, R., Walter, K., Arnold, J., Blüher, M., Heiker, J. T., Lehmann, J., Wabitsch, M., et al. (2022) · Environment International · doi:10.1016/j.envint.2022.107279 · Cited by 75 · see citing works
Matar, D. B., Zhra, M., Nassar, W. K., Altemyatt, H., Naureen, A., Abotouk, N., Elahi, M. A., & Aljada, A. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1592683 · Cited by 80 · see citing works
Role of TLR4 in the induction of inflammatory changes in adipocytes and macrophages
McKernan, K. E., Varghese, M., Patel, R. R., & Singer, K. (2020) · Adipocyte · doi:10.1080/21623945.2020.1760674 · Cited by 71 · see citing works
Exogenous FABP4 interferes with differentiation, promotes lipolysis and inflammation in adipocytes
Dou, H., Wang, T., Su, H., Gao, D., Xu, Y., Li, Y., & Wang, H. (2019) · Endocrine · doi:10.1007/s12020-019-02157-8 · Cited by 70 · see citing works
Extracellular matrix remodelling in obesity and metabolic disorders
Musale, V., Wasserman, D. H., & Kang, L. (2023) · Life Metabolism · doi:10.1093/lifemeta/load021 · Cited by 76 · see citing works
Hedjazifar, S., Shahidi, R. K., Hammarstedt, A., Bonnet, L., CHURCH, C. D., Boucher, J., Blüher, M., & Smith, U. (2019) · Diabetes · doi:10.2337/db19-0701 · Cited by 70 · see citing works
Self-citationPonce, A. J., Galván-Salas, T., Lerma-Alvarado, R. M., Ruíz‐Herrera, X., Hernández-Cortés, T., Valencia-Jiménez, R., Cárdenas-Rodríguez, L. E., de la Escalera, G. M., Clapp, C., & Macotela, Y. (2020) · Endocrine · doi:10.1007/s12020-019-02170-x · Cited by 66 · see citing works
Therapeutic Efficacy of Antioxidants in Ameliorating Obesity Phenotype and Associated Comorbidities
Tun, S., Spainhower, C. J., Cottrill, C. L., Lakhani, H. V., Pillai, S. S., Dilip, A., Chaudhry, H., Shapiro, J. I., & Sodhi, K. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01234 · Cited by 67 · see citing works
Wang, P., Zeng, G., Yan, Y., Zhang, S., Dong, Y., Zhang, Y., Zhang, X., Liu, H., Zhang, Z., Jiang, C., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.10.001 · Cited by 63 · see citing works
From obesity to Alzheimer's disease through insulin resistance
Terzo, S., Amato, A., & Mulè, F. (2021) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2021.108026 · Cited by 62 · see citing works
Porro, S., Genchi, V. A., Cignarelli, A., Natalicchio, A., Laviola, L., Giorgino, F., & Perrini, S. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01446-8 · Cited by 63 · see citing works
Wang, Y., Hung, A. C., Lo, S. J., & Yuan, S. F. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.10.045 · Cited by 61 · see citing works
Schaffert, A., Krieg, L., Weiner, J., Schlichting, R., Ueberham, E., Karkossa, I., Bauer, M., Landgraf, K., Junge, K. M., Wabitsch, M., et al. (2021) · Environment International · doi:10.1016/j.envint.2021.106730 · Cited by 55 · see citing works
Dpp4+ interstitial progenitor cells contribute to basal and high fat diet-induced adipogenesis
Stefkovich, M. L., Traynor, S., Cheng, L., Merrick, D., & Seale, P. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101357 · Cited by 56 · see citing works
Gut microbiota-derived short chain fatty acids act as mediators of the gut-liver-brain axis
Li, C., Yao, J., Yang, C., Yu, S., Yang, Z., Wang, L., Li, S., & He, N. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01554-5 · Cited by 56 · see citing works
Ketogenic Diet: A Nutritional Therapeutic Tool for Lipedema?
Verde, L., Camajani, E., Annunziata, G., Šojat, A. S., Marina, L., Colao, A., Caprio, M., Muscogiuri, G., & Barrea, L. (2023) · Current Obesity Reports · doi:10.1007/s13679-023-00536-x · Cited by 55 · see citing works
White Adipose Tissue Dysfunction: Pathophysiology and Emergent Measurements
Santillana, N., Astudillo-Guerrero, C., D’Espessailles, A., & Cruz, G. (2023) · Nutrients · doi:10.3390/nu15071722 · Cited by 56 · see citing works
The impact of cellular senescence in human adipose tissue
Nerstedt, A., & Smith, U. (2023) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-023-00769-4 · Cited by 55 · see citing works
Self-citationGogg, S., Nerstedt, A., Borén, J., & Smith, U. (2019) · JCI Insight · doi:10.1172/jci.insight.125914 · Cited by 54 · see citing works
Self-citationThe multifaceted roles of the adipose tissue vasculature
Ioannidou, A., Fisher, R. M., & Hagberg, C. E. (2021) · Obesity Reviews · doi:10.1111/obr.13403 · Cited by 51 · see citing works
Ioannidou, A., Alatar, S., Schipper, R., Baganha, F., Åhlander, M., Hornell, A., Fisher, R. M., & Hagberg, C. E. (2021) · The Journal of Physiology · doi:10.1113/jp281445 · Cited by 54 · see citing works
Adipose Tissue Aging and Metabolic Disorder, and the Impact of Nutritional Interventions
Wang, X., Xu, M., & Li, Y. (2022) · Nutrients · doi:10.3390/nu14153134 · Cited by 51 · see citing works
Zwartjes, M. S. Z., Gerdes, V. E. A., & Nieuwdorp, M. (2021) · Metabolites · doi:10.3390/metabo11080531 · Cited by 50 · see citing works
miR-144-3p Promotes Adipogenesis Through Releasing C/EBPα From Klf3 and CtBP2
Shen, L., Li, Q., Wang, J., Zhao, Y., Niu, L., Bai, L., Shuai, S., Li, X., Zhang, S., & Zhu, L. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00677 · Cited by 50 · see citing works
Acetyl-CoA and Metabolite Fluxes Regulate White Adipose Tissue Expansion
Felix, J. B., Cox, A. R., & Hartig, S. M. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.02.008 · Cited by 49 · see citing works
Li, W., Zhuang, T., Wang, Z., Wang, X., Liu, L., Luo, Y., Wang, R., Li, L., Huang, W., Wang, Z., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154982 · Cited by 49 · see citing works
Is Adipose Tissue Inflammation the Culprit of Obesity‐Associated Comorbidities?
Turner, L., Wanasinghe, A. I., Brunori, P., & Santosa, S. (2025) · Obesity Reviews · doi:10.1111/obr.13956 · Cited by 58 · see citing works
Ginsenoside Rb2 improves insulin resistance by inhibiting adipocyte pyroptosis
Lin, Y., Hu, Y., Hu, X., Yang, L., Chen, X., Li, Q., & Gu, X. (2020) · Adipocyte · doi:10.1080/21623945.2020.1778826 · Cited by 49 · see citing works
Jensen, M. D. (2020) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2020.02.002 · Cited by 47 · see citing works
Adipose tissue macrophage burden, systemic inflammation, and insulin resistance
Jia, Q., Morgan-Bathke, M. E., & Jensen, M. D. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00109.2020 · Cited by 47 · see citing works
Emerging Role of Bone Morphogenetic Protein 4 in Metabolic Disorders
Baboota, R. K., Blüher, M., & Smith, U. (2021) · Diabetes · doi:10.2337/db20-0884 · Cited by 47 · see citing works
Self-citationGilleron, J., Bouget, G., Ivanov, S., Méziat, C., Ceppo, F., Vergoni, B., Djedaini, M., Soprani, A., Dumas, K., Jacquel, A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.083 · Cited by 46 · see citing works
Senolytics: Potential for Alleviating Diabetes and Its Complications
Palmer, A. K., Tchkonia, T., & Kirkland, J. L. (2021) · Endocrinology · doi:10.1210/endocr/bqab058 · Cited by 49 · see citing works
MHO or MUO? White adipose tissue remodeling
Zhao, J. Y., Li, Z., Ma, K. L., Hao, R., & Li, M. (2024) · Obesity Reviews · doi:10.1111/obr.13691 · Cited by 44 · see citing works
Polycystic Ovary Syndrome: Impact of Lipotoxicity on Metabolic and Reproductive Health
Brennan, K. M., Kroener, L. L., Chazenbalk, G. D., & Dumesic, D. A. (2019) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000661 · Cited by 44 · see citing works
Schreiber, C., Saraswati, S., Harkins, S. K., Gruber, A., Cremers, N., Thiele, W., Rothley, M., Plaumann, D., Korn, C., Armant, O., et al. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008216 · Cited by 43 · see citing works
Johnston, E. K., & Abbott, R. D. (2023) · Cells · doi:10.3390/cells12030407 · Cited by 41 · see citing works
Roy, P. K., Islam, J., & Lalhlenmawia, H. (2023) · The Egyptian Heart Journal · doi:10.1186/s43044-023-00352-7 · Cited by 51 · see citing works
Adipose Stromal Cell Expansion and Exhaustion: Mechanisms and Consequences
Eckel‐Mahan, K. L., Ribas‐Latre, A., & Kolonin, M. G. (2020) · Cells · doi:10.3390/cells9040863 · Cited by 41 · see citing works
Nankam, P. A. N., Nguelefack, T. B., Goedecke, J. H., & Blüher, M. (2021) · Antioxidants · doi:10.3390/antiox10040622 · Cited by 41 · see citing works
Adipose Tissue Dynamics: Cellular and Lipid Turnover in Health and Disease
Palacios‐Marin, I., Serra, D., Jiménez‐Chillarón, J. C., Herrero, L., & Todorčević, M. (2023) · Nutrients · doi:10.3390/nu15183968 · Cited by 43 · see citing works
STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity
Cox, A. R., Chernis, N., Bader, D. A., Saha, P., Masschelin, P. M., Felix, J. B., Sharp, R., Lian, Z., Putluri, V., Rajapakshe, K., et al. (2020) · Diabetes · doi:10.2337/db20-0384 · Cited by 40 · see citing works
Fano, M. D., Bartolini, D., Tortoioli, C., Vermigli, C., Malara, M., Galli, F., & Murdolo, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105511 · Cited by 44 · see citing works
PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms
He, Y., Taub, A., Yu, L., Yao, Y., Zhang, R., Zahr, T., Aaron, N., LeSauter, J., Fan, L., Liu, L., et al. (2022) · Advanced Science · doi:10.1002/advs.202204190 · Cited by 39 · see citing works
Cellular Senescence in Obesity and Associated Complications: a New Therapeutic Target
Narasimhan, A., Flores, R. R., Camell, C. D., Bernlohr, D., Robbins, P. D., & Niedernhofer, L. J. (2022) · Current Diabetes Reports · doi:10.1007/s11892-022-01493-w · Cited by 38 · see citing works
Gustafson, B., Nerstedt, A., Spinelli, R., Bèguinot, F., & Smith, U. (2022) · Diabetes · doi:10.2337/db22-0003 · Cited by 38 · see citing works
Self-citationPotential Pathophysiological Pathways in the Complex Relationships between OSA and Cancer
Sánchez‐de‐la‐Torre, M., Cubillos‐Zapata, C., Veatch, O. J., Rio, F. G., Gozal, D., & Martínez‐García, M. Á. (2023) · Cancers · doi:10.3390/cancers15041061 · Cited by 35 · see citing works
Effect of Antarctic krill phospholipid (KOPL) on high fat diet-induced obesity in mice
Xiang, X., Zhou, X., Wang, W., Zhou, Y., Zhou, X., Deng, S., Zheng, B., & Wen, Z. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110456 · Cited by 36 · see citing works
Sarmiento-Ortega, V. E., Moroni-González, D., Díaz, A., Brambila, E., & Treviño, S. (2021) · Biological Trace Element Research · doi:10.1007/s12011-021-03027-z · Cited by 36 · see citing works
Review of Novel Potential Insulin Resistance Biomarkers in PCOS Patients—The Debate Is Still Open
Kruszewska, J., Laudy-Wiaderny, H., & Kunicki, M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19042099 · Cited by 36 · see citing works
Zheng, R., Shen, H., Li, J., Zhao, J., Lu, L., Hu, M., Lin, Z., Ma, H., Tan, H., Hu, M., et al. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115824 · Cited by 35 · see citing works
Iacobini, C., Vitale, M., Haxhi, J., Menini, S., & Pugliese, G. (2024) · Cells · doi:10.3390/cells13090763 · Cited by 38 · see citing works
Insulin resistance induced by obesity: Mechanisms, metabolic implications and therapeutic approaches
Choo, Y. N., Ravi, R. N., & Subramaniyan, V. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11509-3 · Cited by 35 · see citing works
Fate of Adipose Progenitor Cells in Obesity-Related Chronic Inflammation
Pyrina, I., Chung, K., Michailidou, Z., Koutsilieris, M., Chavakis, T., & Chatzigeorgiou, A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00644 · Cited by 35 · see citing works
The impact of adipokines on vascular networks in adipose tissue
Vliora, M., Ravelli, C., Grillo, E., Corsini, M., Flouris, A. D., & Mitola, S. M. F. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.07.008 · Cited by 35 · see citing works
Pancreas–Liver–Adipose Axis: Target of Environmental Cadmium Exposure Linked to Metabolic Diseases
Moroni-González, D., Sarmiento-Ortega, V. E., Díaz, A., Brambila, E., & Treviño, S. (2023) · Toxics · doi:10.3390/toxics11030223 · Cited by 34 · see citing works
Das, S., Chattopadhyay, D., Chatterjee, S. K., Mondal, S. A., Majumdar, S. S., Mukhopadhyay, S., Saha, N., Ravichandiran, V., Bhattacharya, S., & Mukherjee, S. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.166050 · Cited by 33 · see citing works
Glucose Metabolism in Burns—What Happens?
Bădoiu, S. C., Miricescu, D., Stănescu-Spînu, I.-I., Totan, A., Badoiu, S. E., Costagliola, M., & Greabu, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105159 · Cited by 33 · see citing works
Soták, M., Rajan, M. R., Clark, M., Biörserud, C., Wallenius, V., Hagberg, C. E., & Börgeson, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010520 · Cited by 32 · see citing works
Understanding the Role of Adipokines in Cardiometabolic Dysfunction: A Review of Current Knowledge
Datta, S., Koka, S., & Boini, K. M. (2025) · Biomolecules · doi:10.3390/biom15050612 · Cited by 32 · see citing works
- Authors
- Hammarstedt, A., Gogg, S., Hedjazifar, S., Nerstedt, A., & Smith, U.
- Affiliations
- University of Gothenburg (SE)
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2018-10-01
- Volume
- 98
- Issue
- 4
- Pages
- 1911-1941
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2886159477
- Semantic Scholar
- fd3888ffa8acc9c4566bcf1bca5e37179ff9b03e
- Cited by
- 462
- References
- 336
- Citations by year
- 2026: 48 · 2025: 54 · 2024: 73 · 2023: 68 · 2022: 79 · 2021: 54 · 2020: 61 · 2019: 22 · 2018: 2
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Physiological Reviews (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- The Swedish Research Council, Sweden (K2013-54X-03506-42-5)
- Torsten Söderberg Foundation (M58/16)
- Novo Nordisk Foundation (NNF16OC0021202)
- ALF (ALFGBG-621581)
- Swedish Diabetes Foundation (DIA2016-108)
- Edgar Sjölund Foundation
- WM Lundgren Foundation (2016-0935)
- Gbg Diabetesförening (390/16)
- EFSD/Lilly
- Lisa och Johan Grönberg Foundation (2016-00087)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- subcutaneous adipose tissue, adipogenesis, adipose precursor cells, BMP4, GREM1, angiogenesis, lipolysis, free fatty acids, ectopic fat, insulin resistance, type 2 diabetes, epigenetic regulation
- MeSH terms
- Adipose Tissue, Animals, Cell Differentiation, Diabetes Mellitus, Type 2, Humans, Inflammation, Insulin Resistance, Obesity, Adipocytes, Adipogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review