Lipoatrophy Revisited

Leptin and the regulation of body weight in mammals

Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093

A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors

Carr, A., Samaras, K., Burton, S., Law, M. G., Freund, J., Chisholm, D. J., & Cooper, D. A. (1998) · AIDS · doi:10.1097/00002030-199807000-00003 · Cited by 2,364

Environmental Contributions to the Obesity Epidemic

Hill, J. O., & Peters, J. C. (1998) · Science · doi:10.1126/science.280.5368.1371 · Cited by 2,258

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164

Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy

Bonne, G., di Barletta, M. R., Varnous, S., Bécane, H. M., Hammouda, E.-H., Merlini, L., Muntoni, F., Greenberg, C. R., Gary, F., Urtizberea, J. A., et al. (1999) · Nature Genetics · doi:10.1038/6799 · Cited by 1,384

Missense Mutations in the Rod Domain of the Lamin A/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease

Fatkin, D., MacRae, C. A., Sasaki, T., Wolff, M. R., Porcu, M., Frenneaux, M. P., Atherton, J. J., Vidaillet, H. J., Jr., Spudich, S., Girolami, U. D., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199912023412302 · Cited by 1,366

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., & Goldstein, J. L. (1999) · Nature · doi:10.1038/43448 · Cited by 1,038

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice.

Halaas, J. L., Boozer, C., Blair-West, J., Fidahusein, N., Denton, D. A., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8878 · Cited by 1,033

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

Shimomura, I., Hammer, R. E., Richardson, J. A., Ikemoto, S., Bashmakov, Y., Goldstein, J. L., & Brown, M. S. (1998) · Genes & Development · doi:10.1101/gad.12.20.3182 · Cited by 790

Life without white fat: a transgenic mousePreprint

Moitra, J., Mason, M. M., Olive, M., Krylov, D. Y., Gavrilova, O., Marcus‐Samuels, B., Feigenbaum, L., Lee, E., Aoyama, T., Eckhaus, M., et al. (1998) · Genes & Development · doi:10.1101/gad.12.20.3168 · Cited by 776

LMNA, encoding lamin A/C, is mutated in partial lipodystrophy

Shackleton, S., Lloyd, D. J., Jackson, S. N. J., Evans, R. S., Niermeijer, M. F., Singh, B. M., Schmidt, H., Brabant, G. E., Kumar, S., Durrington, P. N., et al. (2000) · Nature Genetics · doi:10.1038/72807 · Cited by 701

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

Gavrilova, O., Marcus-Samuels, B., Graham, D., Kim, J. K., Shulman, G. I., Castle, A. L., Vinson, C., Eckhaus, M., & Reitman, M. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7901 · Cited by 676

Nuclear lamin A/C R482Q mutation in Canadian kindreds with Dunnigan-type familial partial lipodystrophy

Cao, H. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.1.109 · Cited by 668

What if Minkowski Had Been Ageusic? An Alternative Angle on Diabetes

McGarry, J. D. (1992) · Science · doi:10.1126/science.1439783 · Cited by 657

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

Shimabukuro, M., Koyama, K., Chen, G., Wang, M.-Y., Trieu, F., Lee, Y., Newgard, C. B., & Unger, R. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4637 · Cited by 646

Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.

Kopecky, J., Clarke, G., Enerbäck, S., Spiegelman, B., & Kozak, L. P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118363 · Cited by 553

The Search for Human Obesity Genes

Comuzzie, A. G., & Allison, D. B. (1998) · Science · doi:10.1126/science.280.5368.1374 · Cited by 543

Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4

Katz, E. B., Stenbit, A. E., Hatton, K. S., DePinho, R. A., & Charron, M. J. (1995) · Nature · doi:10.1038/377151a0 · Cited by 467

Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice

Kim, J. K., Gavrilova, O., Chen, Y., Reitman, M. L., & Shulman, G. I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8456 · Cited by 443

Different Mutations in the LMNA Gene Cause Autosomal Dominant and Autosomal Recessive Emery-Dreifuss Muscular Dystrophy

di Barletta, M. R., Ricci, E., Galluzzi, G., Tonali, P. A., Mora, M., Morandi, L. O., Romorini, A., Voït, T., Ørstavik, K. H., Merlini, L., et al. (2000) · The American Journal of Human Genetics · doi:10.1086/302869 · Cited by 422

Regulating Adipogenesis

Mandrup, S., & Lane, M. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.9.5367 · Cited by 404

Troglitazone action is independent of adipose tissue.

Burant, C., Sreenan, S., Hirano, K., Tai, T. A., Lohmiller, J. J., Lukens, J. N., Davidson, N. O., Ross, S. R., & Graves, R. A. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119839 · Cited by 331

Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy

Chen, G., Koyama, K., Yuan, X., Lee, Y., Zhou, Y.-T., O'Doherty, R. M., Newgard, C. B., & Unger, R. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14795 · Cited by 315

Efficacy and Safety of Troglitazone in the Treatment of Lipodystrophy Syndromes

Arioglu, E., Duncan-Morin, J., Sebring, N., Rother, K. I., Gottlieb, N., Lieberman, J., Herion, D., Kleiner, D. E., Reynolds, J., Premkumar, A., et al. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-4-200008150-00009 · Cited by 303

Generalized lipodystrophy, congenital and acquired (lipoatrophy)

Seip, M., & Trygstad, O. (1996) · Acta Paediatrica · doi:10.1111/j.1651-2227.1996.tb14262.x · Cited by 293

LIPODYSTROPHY AND HEPATOMEGALY WITH DIABETES, LIPÆMIA, AND OTHER METABOLIC DISTURBANCES

Lawrence, R. D. (1946) · The Lancet · doi:10.1016/s0140-6736(46)90528-4 · Cited by 287

Mutational and Haplotype Analyses of Families with Familial Partial Lipodystrophy (Dunnigan Variety) Reveal Recurrent Missense Mutations in the Globular C-Terminal Domain of Lamin A/C

Speckman, R. A., Garg, A., Du, F., Bennett, L. B., Veile, R. A., Oral, E. A., Taylor, S. I., Lovett, M., & Bowcock, A. M. (2000) · The American Journal of Human Genetics · doi:10.1086/302836 · Cited by 273

The Complement Abnormalities of Lipodystrophy

Sissons, J. G. P., West, R. J., Fallows, J., Williams, D. G., Boucher, B. J., Amos, N., & Peters, D. K. (1976) · New England Journal of Medicine · doi:10.1056/nejm197602262940902 · Cited by 269

Torpor in mice is induced by both leptin-dependent and -independent mechanisms

Gavrilova, O., Leon, L. R., Marcus‐Samuels, B., Mason, M. M., Castle, A. L., Refetoff, S., Vinson, C., & Reitman, M. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14623 · Cited by 213

Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin.

Ogawa, Y., Masuzaki, H., Hosoda, K., Aizawa‐Abe, M., Suga, J., Suda, M., Ebihara, K., Iwai, H., Matsuoka, N., Satoh, N., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.9.1822 · Cited by 203

A Gene for Congenital Generalized Lipodystrophy Maps to Human Chromosome 9q34

Garg, A., Wilson, R., Barnes, R., Arioǧlu, E., Zaidi, Z., Gürakan, F., Koçak, N., O’Rahilly, S., Taylor, S. I., Patel, S. B., et al. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.9.6103 · Cited by 192

Lipodystrophy in patients naive to HIV protease inhibitors

Madge, S., Loes, S. K., Mercey, D., Johnson, M. A., & Weller, I. V. D. (1999) · AIDS · doi:10.1097/00002030-199904160-00020 · Cited by 184

Mesenteric Lipodystrophy

KIPFER, R. E., MOERTEL, C. G., & DAHLIN, D. C. (1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-80-5-582 · Cited by 170

Inhibition of Adipocyte Differentiation by HIV Protease Inhibitors

Zhang, B., MacNaul, K. L., Szalkowski, D., Li, Z., Berger, J. P., & Moller, D. E. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.11.4274 · Cited by 165

Endocrine and Metabolic Evaluation of Human Immunodeficiency Virus-Infected Patients with Evidence of Protease Inhibitor-Associated Lipodystrophy

Yanovski, J. A., Miller, K. D., Kino, T., Friedman, T. C., Chrousos, G. P., Tsigos, C., & Falloon, J. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5740 · Cited by 153

Familial partial lipodystrophy: two types of an X linked dominant syndrome, lethal in the hemizygous state.

Köbberling, J., & Dunnigan, M. G. (1986) · Journal of Medical Genetics · doi:10.1136/jmg.23.2.120 · Cited by 152

Transcriptional activation of adipogenesis

Wu, Z., Puigserver, P., & Spiegelman, B. M. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00037-x · Cited by 138

Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity

Ross, S. R., Graves, R. A., & Spiegelman, B. M. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90035-g · Cited by 136

Leukodystrophy incidence in Germany

Heim, P., Claussen, M., Hoffmann, B., Conzelmann, E., Gärtner, J., HARZER, K., HUNNEMAN, D. H., Köhler, W., Kurlemann, G., & Kohlschütter, A. (1997) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19970905)71:4 · Cited by 134

Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity.Preprint

Ross, S. R., Graves, R. A., & Spiegelman, B. M. (1993) · Genes & Development · doi:10.1101/gad.7.7b.1318 · Cited by 134

Adverse metabolic disorders during highly active antiretroviral treatments (HAART) of HIV disease.

Vigouroux, C., Gharakhanian, S., Salhi, Y., Nguyen, T. H., Adda, N., Rozenbaum, W., & Capeau, J. (1999) · PubMed · Cited by 104

Leptin and diabetes in lipoatrophic mice

Gavrilova, O., Marcus-Samuels, B., Leon, L. R., Vinson, C., & Reitman, M. L. (2000) · Nature · doi:10.1038/35002663 · Cited by 88

HIV protease inhibitors block human preadipocyte differentiation, but not via the PPARgamma/RXR heterodimer

Wentworth, J. M., Burris, T. P., & Chatterjee, K. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.164r007 · Cited by 80

Early manifestations of the carbohydrate-deficient glycoprotein syndrome

Petersen, M. B., Brostrøm, K., Stibler, H., & Skovby, F. (1993) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)83488-2 · Cited by 69

Autosomal dominant partial lipodystrophy associated with Rieger anomaly, short stature, and insulinopenic diabetes

Aarskog, D., Ose, L., Pande, H., Eide, N. A., & Opitz, J. M. (1983) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320150104 · Cited by 58

Annular and semicircular lipoatrophies

Rongioletti, F., & Rebora, A. (1989) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(89)70053-0 · Cited by 49

Juvenile dermatomyositis associated with partial lipoatrophy

Kavanagh, G. M., Colaço, C. B., & Kennedy, C. (1993) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(93)70052-u · Cited by 46

Partial Lipodystrophy and Dermatomyositis

Torrelo, A. (1991) · Archives of Dermatology · doi:10.1001/archderm.127.12.1846 · Cited by 41

Dysregulation of insulin-like growth factors in a case of generalized acquired lipoatrophic diabetes mellitus (Lawrence Syndrome) connected with autoantibodies against adipocyte membranes

Hübler, A., Abendroth, K., Keiner, T., STÖCKER, W., Kauf, E., Hein, G. P., & Stein, G. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1211955 · Cited by 40

Partial Lipodystrophy and Familial C3 Deficiency

McLean, R. H., & HOEFNAGEL, D. (1980) · Human Heredity · doi:10.1159/000153119 · Cited by 40

Transgenic Mice Overexpressing the 1-Adrenergic Receptor in Adipose Tissue Are Resistant to Obesity

Soloveva, V. (1997) · Molecular Endocrinology · doi:10.1210/me.11.1.27 · Cited by 36

Partial Lipodystrophy Associated with Juvenile Dermatomyositis: Report of Two Cases

Quecedo, E., Febrer, I., Serrano, G., Martinez‐Aparicio, A., & Aliaga, A. (1996) · Pediatric Dermatology · doi:10.1111/j.1525-1470.1996.tb00728.x · Cited by 35

Insulin-Resistant Diabetes Mellitus and Hypermetabolism in Mandibuloacral Dysplasia: A Newly Recognized Form of Partial Lipodystrophy*

Cutler, D. L., KAUFMANN, S., & Freidenberg, G. R. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-5-1056 · Cited by 34

SHORT syndrome and insulin resistance

Schwingshandl, J., Mache, C. J., Rath, K., & Borkenstein, M. H. (1993) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320470619 · Cited by 33

ABNORMAL BLOOD GLUCOSE REGULATION IN COCKAYNE'S SYNDROME

Cotton, R. B., Keats, T. E., & McCoy, E. E. (1970) · PEDIATRICS · doi:10.1542/peds.46.1.54 · Cited by 25

Late-onset lipoatrophic diabetes. Phenotypic and genotypic familial studies and effect of treatment with metformin and lispro insulin analog.

Vantyghem, M., Vigouroux, C., Magré, J., Desbois‐Mouthon, C., Pattou, F. N., Fontaine, P., Lefebvre, J., & Capeau, J. (1999) · Diabetes Care · doi:10.2337/diacare.22.8.1374 · Cited by 22

Localized skin reactions to insulin: insulin lipodystrophies and skin reactions to pumped subcutaneous insulin therapy.

Levandoski, L. A., White, N. H., & Santiago, J. V. (1982) · PubMed · Cited by 18

Genetic Exclusion of 14 Candidate Genes in Lipoatropic Diabetes Using Linkage Analysis in 10 Consanguineous Families

Vigouroux, C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.10.3438 · Cited by 16

Localized Lipoatrophy due to Recombinant Growth Hormone Therapy in a Child with 6.7 Kilobase Gene Deletion Isolated Growth Hormone Deficiency

Büyükgebiz, A., Aydın, A., Dündar, B. N., & Yörükoğlu, K. (1999) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.1999.12.1.95 · Cited by 9

A case of acquired partial lipodystrophy associated with localized scleroderma and undifferentiated connective tissue disease

Biasi, D., Caramaschi, P., Carletto, A., & Bambara, L. M. (1999) · Rheumatology International · doi:10.1007/s002960050106 · Cited by 9

Thiazolidinediones

Yki-Järvinen, H. (2004) · New England Journal of Medicine · doi:10.1056/nejmra041001 · Cited by 1,830

Leptin-Replacement Therapy for Lipodystrophy

Oral, E. A., Simha, V., Ruiz, E., Andewelt, A., Premkumar, A., Snell, P., Wagner, A. J., DePaoli, A. M., Reitman, M. L., Taylor, S. I., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012437 · Cited by 1,247

Fat Accumulation in the Liver Is Associated with Defects in Insulin Suppression of Glucose Production and Serum Free Fatty Acids Independent of Obesity in Normal Men

Seppala-Lindroos, A. (2002) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.7.3023 · Cited by 168

Endogenous glucose production is inhibited by the adipose-derived protein Acrp30

Combs, T. P., Berg, A. H., Obici, S., Scherer, P. E., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14120 · Cited by 955

Type 2 diabetes across generations: from pathophysiology to prevention and management

Nolan, C. J., Damm, P., & Prentki, M. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60614-4 · Cited by 923

Lipoatrophic Diabetes: A Case Report with a Brief Review of the Literature

Lawson, M. A. (2008) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2008.06.007 · Cited by 7

What the Genetics of Lipodystrophy Can Teach Us About Insulin Resistance and Diabetes

Vatier, C., Bidault, G., Briand, N., Guénantin, A.-C., Salle-Teyssières, L., Lascols, O., Capeau, J., & Vigouroux, C. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0431-7 · Cited by 37

Lipoatrophy, Lipodystrophy, and Insulin Resistance

Ganda, O. P. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-4-200008150-00017 · Cited by 37

Lipoatrophic Diabetes in an Elderly Woman: Clinical Course and Serum Adipocytokine Concentrations

Iglesias, P., Fidalgo, P. A., Codoceo, R., & Díez, J. J. (2004) · Endocrine Journal · doi:10.1507/endocrj.51.279 · Cited by 13

Lipodystrophy: The experiment of nature to study leptin

Ahima, R. S., & Jackson, M. B. (2006) · Springer eBooks · doi:10.1007/978-0-387-31416-7_12