Cited by 927Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS

Dawson, M·2003·Molecular and Cellular Neuroscience

DOI 10.1016/s1044-7431(03)00210-0

Open this paper in CoChat — free account

Abstract

Glial progenitor cells of the developing CNS committed to the oligodendrocyte lineage (OPCs) express the chondroitin sulfate proteoglycan, NG2. A proportion of OPCs fail to differentiate past the stage at which they express NG2 and the lipid antigen O4 and persist in the adult CNS in a phenotypically immature form. However, the physiological function of NG2(+) cells in the adult CNS is unknown. Using antibodies against NG2 we show that NG2 is expressed by a distinct cell population in the mature CNS with the homogeneous antigenic phenotype of oligodendrocyte progenitors. The morphology of NG2(+) OPCs varies from region to region, reflecting the different structural environments, but they appear to represent a homogeneous population within any one gray or white matter region. A study of nine CNS regions showed that NG2(+) OPCs are numerous throughout the CNS and numbers in the white matter are only 1.5 times that in the gray. Whereas the ratio of OPCs to myelinating oligodendrocytes in the spinal cord gray and white matter approximates 1:4, gray matter regions of the forebrain have a 1:1 ratio, a phenomenon that will have consequences for oligodendrocyte replacement following demyelination. BrdU incorporation experiments showed that NG2(+) cells are the major dividing cell population of the adult rat CNS. Since very little apoptosis was detected and BrdU became increasingly present in oligodendrocytes after a 10-day pulse chase, with a concomitant decrease in NG2(+) BrdU incorporating cells, we suggest that the size of the oligodendrocyte population may actually increase during adult life.

Integrity signals

Registry

Crossref · 10.1016/s1044-7431(03)00210-0

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cell death and control of cell survival in the oligodendrocyte lineage
Barres, B. A., Hart, I. K., Coles, H. S. R., Burne, J. F., Voyvodic, J. T., Richardson, W. D., & Raff, M. C. (1992) · Cell · doi:10.1016/0092-8674(92)90531-g · Cited by 1,345
Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus
Bergles, D. E., Roberts, J. D. B., Somogyi, P., & Jahr, C. E. (2000) · Nature · doi:10.1038/35012083 · Cited by 1,062
Why does remyelination fail in multiple sclerosis?
Franklin, R. J. M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn917 · Cited by 862
Proliferation and Differentiation of Progenitor Cells Throughout the Intact Adult Rat Spinal Cord
Horner, P. J., Power, A. E., Kempermann, G., Kuhn, H. G., Palmer, T. D., Winkler, J., Thal, L. J., & Gage, F. H. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02218.2000 · Cited by 777
NG2-Positive Oligodendrocyte Progenitor Cells in Adult Human Brain and Multiple Sclerosis Lesions
Chang, A., Nishiyama, A., Peterson, J. W., Prineas, J. W., & Trapp, B. D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06404.2000 · Cited by 711
The oligodendrocyte precursor cell in health and disease
Levine, J. M., Reynolds, R., & Fawcett, J. W. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01691-x · Cited by 673
MYELINATION IN RAT BRAIN: CHANGES IN MYELIN COMPOSITION DURING BRAIN MATURATION1
Norton, W. T., & Poduslo, S. E. (1973) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1973.tb07520.x · Cited by 668
The Age-Related Decrease in CNS Remyelination Efficiency Is Attributable to an Impairment of Both Oligodendrocyte Progenitor Recruitment and Differentiation
Sim, F. J., Zhao, C., Penderis, J., & Franklin, R. J. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02451.2002 · Cited by 625
Oligodendrocyte Population Dynamics and the Role of PDGF In Vivo
Calver, A. R., Hall, A. C., Yu, W., Walsh, F. S., Heath, J. K., Betsholtz, C., & Richardson, W. D. (1998) · Neuron · doi:10.1016/s0896-6273(00)80469-9 · Cited by 516
A singularity of PDGF alpha-receptor expression in the dorsoventral axis of the neural tube may define the origin of the oligodendrocyte lineage
Pringle, N. P., & Richardson, W. D. (1993) · Development · doi:10.1242/dev.117.2.525 · Cited by 510

Show all 43 references

Sorted by citations

Items 601–700 of 924

Axonal activity-dependent myelination in development: Insights for myelin repair
Mitew, S., Xing, Y. L., & Merson, T. D. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2016.03.002 · Cited by 12
Cyclin-dependent kinase inhibitor flavopiridol promotes remyelination in a cuprizone induced demyelination model
Mi, G., Gao, Y., Liu, S., Ye, E., Li, Y., Jin, X., Yang, H., & Yang, Z. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1220458 · Cited by 12
Activation profile of the F3/Contactin gene in the developing mouse cerebellum
Benedictis, L. D., Bizzoca, A., Corsi, P., Albieri, I., Consalez, G. G., & Gennarini, G. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.06.007 · Cited by 12
Quantitative gene‐expression analysis of the ligand‐receptor system for classical neurotransmitters and neuropeptides in hippocampal CA1, CA3, and dentate gyrus
Nakamura, N. H., Akiyama, K., & Naito, T. (2010) · Hippocampus · doi:10.1002/hipo.20830 · Cited by 12
Engineered neurogenesis in naïve adult rat cortex by Ngn2-mediated neuronal reprogramming of resident oligodendrocyte progenitor cells
Bazarek, S. F., Thaqi, M., King, P., Mehta, A. R., Patel, R., Briggs, C. A., Reisenbigler, E. K., Yousey, J. E., Miller, E. A., Stutzmann, G. E., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1237176 · Cited by 11
Nerve-Glial antigen 2: unmasking the enigmatic cellular identity in the central nervous system
Bottero, M., Pessina, G., Bason, C., Vigo, T., Uccelli, A., & Ferrara, G. B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1393842 · Cited by 11
Proliferative cells in the rat developing neocortical grey matter: new insights into gliogenesis
Moroni, R. F., Deleo, F., Regondi, M. C., Madaschi, L., Amadeo, A., & Frassoni, C. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1736-8 · Cited by 11
Combining whole-cell patch clamp and dye loading in acute brain slices with bulk RNA sequencing in embryonic to aged mice
Kamen, Y., & Káradóttir, R. T. (2021) · STAR Protocols · doi:10.1016/j.xpro.2021.100439 · Cited by 11
The sphingosine‐1‐phosphate receptor 1 modulator ponesimod repairs cuprizone‐induced demyelination and induces oligodendrocyte differentiation
Willems, E., Schepers, M., Piccart, E., Wolfs, E., Hellings, N., Ait-Tihyaty, M., & Vanmierlo, T. (2024) · The FASEB Journal · doi:10.1096/fj.202301557rr · Cited by 11
Tackling myelin deficits in neurodevelopmental disorders using drug delivery systems
Rokach, M., Portioli, C., Brahmachari, S., Estevão, B. M., Decuzzi, P., & Barak, B. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115218 · Cited by 11
Glial-restricted progenitor cells: a cure for diseased brain?
Rogujski, P., Łukomska, B., Janowski, M., & Stanaszek, L. (2024) · Biological Research · doi:10.1186/s40659-024-00486-1 · Cited by 12
Cell cycle activity of neural precursors in the diseased mammalian brain
Alonso, S. B., Schulze-Steikow, M., & Calegari, F. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00039 · Cited by 11
Smoothened, Stem Cell Maintenance and Brain Diseases
Ruat, M., Faure, H., & Daynac, M. (2014) · Topics in medicinal chemistry · doi:10.1007/7355_2014_83 · Cited by 12
NG2-Glia, a New Player in Energy Balance
Robins, S. C., & Kokoeva, M. V. (2018) · Neuroendocrinology · doi:10.1159/000488111 · Cited by 12
Glioblastoma models driven by different mutations converge to the proneural subtype
Alessandrini, F., Ceresa, D., Appolloni, I., Pagani, F., Poliani, P. L., Marubbi, D., & Malatesta, P. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.11.010 · Cited by 11
Oligomer β-amyloid Induces Hyperactivation of Ras to Impede NMDA Receptor-Dependent Long-Term Potentiation in Hippocampal CA1 of Mice
Wang, Y., Shi, Z., Zhang, Y., Yan, J., Yu, W., & Chen, L. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.595360 · Cited by 11
Repopulation of oligodendrocyte progenitor cell depleted tissue in a model of chronic demyelination
Foote, A. K., & Blakemore, W. F. (2005) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2004.00634.x · Cited by 11
Oligomeric amyloid beta prevents myelination in a clusterin-dependent mannerPreprint
Beiter, R. M., Ennerfelt, H. E., Rivet-Noor, C. R., Merchak, A. R., Bai, R., Johanson, D. M., Slogar, E. R., Sol‐Church, K., Phillips, J. L., Bathe, T., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.06.981373 · Cited by 11
How does Nogo receptor influence demyelination and remyelination in the context of multiple sclerosis?
Rashidbenam, Z., Öztürk, E., Pagnin, M., Theotokis, P., Grigoriadis, N., & Petratos, S. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1197492 · Cited by 12
Ablation of oligodendrogenesis in adult mice alters brain microstructure and activity independently of behavioral deficits
Kaller, M. S., Lazari, A., Feng, Y., van der Toorn, A., Rühling, S., Thomas, C. W., Shimizu, T., Bannerman, D. M., Vyazovskiy, V. V., Richardson, W. D., et al. (2024) · Glia · doi:10.1002/glia.24576 · Cited by 10
Cell death in glioblastoma and the central nervous system
Malone, K., LaCasse, E. C., & Beug, S. T. (2024) · Cellular Oncology · doi:10.1007/s13402-024-01007-8 · Cited by 11
Genetic Downregulation of GABAB Receptors from Oligodendrocyte Precursor Cells Protects Against Demyelination in the Mouse Spinal Cord
Gobbo, D., Rieder, P., Fang, L., Buttigieg, E., Schablowski, M., Damo, E., Bosche, N., Dallorto, E., May, P., Bai, X., et al. (2024) · Cells · doi:10.3390/cells13232014 · Cited by 10
Interactions of Oligodendrocyte Precursor Cells and Dopaminergic Neurons in the Mouse Substantia Nigra
Fitzgerald, J. C., Sun, Y., Reinecke, F., Bauer, E., Garaschuk, O., Kahle, P. J., & Pfeiffer, F. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.16298 · Cited by 10
The Many Lives of an Oligodendrocyte Precursor Cell
Buchanan, J., & Cheadle, L. (2025) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-112723-025806 · Cited by 11
Synantocytes: the fifth type of glia? In comparison with astrocytes.
Krawczyk, A. E., & Jaworska-Adamu, J. (2010) · Folia Histochemica et Cytobiologica · doi:10.2478/v10042-010-0033-z · Cited by 11
White Matter Structure
Edgar, J. M., & Griffiths, I. R. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-396460-1.00007-x · Cited by 13
The induction of Neuron-Glial2 (NG2) expressing cells in methamphetamine toxicity-induced neuroinflammation in rat brain are averted by melatonin
Hein, Z. M., Kraiwattanapirom, N., Mukda, S., & Chetsawang, B. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577232 · Cited by 10
Circadian Control of Glial Cell Homeodynamics
Rojo, D., Badner, A., & Gibson, E. M. (2022) · Journal of Biological Rhythms · doi:10.1177/07487304221120966 · Cited by 11
Quantification of oligodendrocyte progenitor cells in human and cat optic nerve: Implications for endogenous repair in multiple sclerosis
Jennings, A. R., & Carroll, W. M. (2010) · Glia · doi:10.1002/glia.21018 · Cited by 10
Microarray Database Mining and Cell Differentiation Defects in Schizophrenia
Radu, A., Hristescu, G., Katsel, P., Haroutunian, V. H., & Davis, K. L. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-7046-6_7 · Cited by 10
Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning
Schott, J. T., Kirby, L. A., Calabresi, P. A., & Baxi, E. G. (2016) · Journal of Visualized Experiments · doi:10.3791/53764 · Cited by 10
Mechanisms of cellular plasticity in cerebral perivascular region
Egawa, N., Lok, J. M., & Arai, K. (2016) · Progress in brain research · doi:10.1016/bs.pbr.2016.03.005 · Cited by 10
Organotypic Slice Cultures to Study Oligodendrocyte Proliferation, Fate, and Myelination
Sherafat, A., Hill, R., & Nishiyama, A. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7862-5_11 · Cited by 12
Myelin changes in Alexander disease
Gómez‐Pinedo, U., Duran‐Moreno, M., Sirerol-Piquer, M. S., & Matías‐Guiu, J. (2018) · Neurología (English Edition) · doi:10.1016/j.nrleng.2017.01.006 · Cited by 10
Diminished Ventral Oligodendrocyte Precursor Generation Results in the Subsequent Over-production of Dorsal Oligodendrocyte Precursors of Aberrant Morphology and Function
Starikov, L., & Kottmann, A. H. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.05.027 · Cited by 10
Glial progenitor cells of the adult human white and grey matter are contextually distinct
Osório, M. J., Mariani, J. N., Zou, L., Schanz, S. J., Heffernan, K. S., Cornwell, A., & Goldman, S. A. (2022) · Glia · doi:10.1002/glia.24291 · Cited by 10
Unique microenvironmental responses to PDGF stimulation in brain and spinal cord gliomas determine tumor phenotype
Ellis, J. A., Castelli, M., Assanah, M. C., Bruce, J. N., Canoll, P., & Ogden, A. T. (2015) · Journal of Neuro-Oncology · doi:10.1007/s11060-015-1769-2 · Cited by 10
Seizures increase importin‐β1 expression in NG2+ cells in the rat hippocampus
Brilli, E., Scali, M., Casarosa, S., Köhler, M., & Bozzi, Y. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21879 · Cited by 10
Clinical application of oligodendrocyte precursor cells for cell-based therapy
Egawa, N., Takase, H., Lok, J. M., Takahashi, R., & Arai, K. (2016) · Brain Circulation · doi:10.4103/2394-8108.192515 · Cited by 10
Differential expression of p120 catenin in glial cells of the adult rat brain
Chauvet, N., Privat, A., & Prieto, M. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20301 · Cited by 10
Oligodendroglial Lineage
Miller, R. H., & Reynolds, R. (2004) · Elsevier eBooks · doi:10.1016/b978-012439510-7/50064-4 · Cited by 10
Role of growth factors and their interplay during oligodendroglial differentiation and maturation
Dwivedi, S., Ranjan, S., Das, S., Kumari, J., & Singh, S. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.07.002 · Cited by 11
The Role of Oligodendrocyte Lineage Cells in the Pathogenesis of Alzheimer’s Disease
Liu, X., Lv, Z., Huang, Q., Lei, Y., Liu, H., & Xu, P. (2025) · Neurochemical Research · doi:10.1007/s11064-024-04325-3 · Cited by 9
Detection of mouse endogenous type B astrocytes migrating towards brain lesions
Elvira, G., Garcı́a, I., Gallo, J., Benito, M., Montesinos, P., Holgado-Martin, E., Ayuso‐Sacido, Á., Penadés, S., Desco, M., Silva, A., et al. (2015) · Stem Cell Research · doi:10.1016/j.scr.2014.11.006 · Cited by 9
Glial-Restricted Precursors Protect Neonatal Brain Slices from Hypoxic-Ischemic Cell Death Without Direct Tissue Contact
Sweda, R., Phillips, A. W., Marx, J. S., Johnston, M. V., Wilson, M. A., & Fatemi, A. S. (2016) · Stem Cells and Development · doi:10.1089/scd.2015.0378 · Cited by 9
Unbiased stereological analysis of the fate of oligodendrocyte progenitor cells in the adult mouse brain and effect of reference memory training
Boulanger, J. J., & Messier, C. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.04.027 · Cited by 10
High-glucose medium induces cellular differentiation and changes in metabolic functionality of oligodendroglia
da Rosa, P. M., Meira-Martins, L. A., Souza, D. O., Bobermin, L. D., Quincozes‐Santos, A., & Leite, M. C. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-04930-4 · Cited by 9
Spatiotemporal Profile and Morphological Changes of NG2 Glia in the CA1 Region of the Rat Hippocampus after Transient Forebrain Ischemia
Jin, X., Riew, T., Kim, S., Kim, H. L., & Lee, M. (2020) · Experimental Neurobiology · doi:10.5607/en.2020.29.1.50 · Cited by 9
Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery
Wei, G. Z., Ohri, S. S., Khattar, N. K., Listerman, A. W., Doyle, C. H., Andres, K. R., Karuppagounder, S. S., Ratan, R. R., Whittemore, S. R., & Hetman, M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0249591 · Cited by 9
Expression of Oligodendrocyte and Oligoprogenitor Cell Proteins in Frontal Cortical White and Gray Matter: Impact of Adolescent Development and Ethanol Exposure
Liu, W., Rohlman, A., Vetreno, R. P., & Crews, F. T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.651418 · Cited by 9
Oligodendrocytes, BK channels and remyelination
Rupnik, M., Baker, D., & Selwood, D. L. (2021) · F1000Research · doi:10.12688/f1000research.53422.1 · Cited by 9
Intranasal Administration of Undifferentiated Oligodendrocyte Lineage Cells as a Potential Approach to Deliver Oligodendrocyte Precursor Cells into Brain
Gómez‐Pinedo, U., Matías‐Guiu, J. A., Benito‐Martín, M. S., Moreno‐Jiménez, L., Sanclemente-Alamán, I., Selma-Calvo, B., Pérez-Suarez, S., Sancho-Bielsa, F. J., Canales-Aguirre, A. A., Mateos‐Díaz, J. C., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910738 · Cited by 9
Cytogenesis in the adult monkey motor cortex: Perivascular NG2 cells are the major adult born cell type
Stanton, G. B., Kohler, S. J., Boklweski, J., Cameron, J. L., & Greenough, W. T. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23693 · Cited by 9
MS CD49d+CD154+ Lymphocytes Reprogram Oligodendrocytes into Immune Reactive Cells Affecting CNS Regeneration
Piątek, P., Namiecińska, M., Domowicz, M., Przygodzka, P., Wieczorek, M., Michlewska, S., Lewkowicz, N., Tarkowski, M., & Lewkowicz, P. (2019) · Cells · doi:10.3390/cells8121508 · Cited by 9
Small molecule screening as an approach to encounter inefficient myelin repair
Manousi, A., & Küry, P. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.09.008 · Cited by 9
Ackr3-Venus knock-in mouse lights up brain vasculature
Ehrlich, A. T., Semache, M., Couvineau, P., Wojcik, S., Kobayashi, H., Thelen, M., Gross, F., Hogue, M., Gouill, C. L., Darcq, E., et al. (2021) · Molecular Brain · doi:10.1186/s13041-021-00862-y · Cited by 9
Glial Cells in Alzheimer’s Disease: Pathogenic Mechanisms and Therapeutic Frontiers
Sil, M., Mukherjee, N., Chatterjee, I., Ghosh, A., & Goswami, A. (2025) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02379-8 · Cited by 9
Targeting glial-orchestrated neuroinflammation in migraine pathophysiology
Lu, W., Zhang, Y., Shi, C., Tao, Y., Li, S., Sun, Y., Ji, F., Chen, G., Snutch, T., & Tao, J. (2026) · The Journal of Headache and Pain · doi:10.1186/s10194-026-02272-8 · Cited by 8
Characterization of a new mouse line triggering transient oligodendrocyte progenitor depletion
Brousse, B., Mercier, O., Magalon, K., Gubellini, P., Malapert, P., Cayre, M., & Durbec, P. L. (2023) · Scientific Reports · doi:10.1038/s41598-023-48926-4 · Cited by 8
EZH2 Inhibition Sensitizes IDH1R132H-Mutant Gliomas to Histone Deacetylase Inhibitor
Sprinzen, L., Garcia, F., Mela, A., Lei, L., Upadhyayula, P. S., Mahajan, A., Humala, N., Manier, L., Caprioli, R. M., Quiñones‐Hinojosa, A., et al. (2024) · Cells · doi:10.3390/cells13030219 · Cited by 8
A molecularly defined subpopulation of oligodendrocyte precursor cells controls the generation of myelinating oligodendrocytes during postnatal development
Moghimyfiroozabad, S., Paul, M. A., Bellenger, L., & Selimi, F. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002655 · Cited by 9
Neuronal differentiation of human iPS-cells in a rat cortical primary culture
Braun, H., Günther-Kern, A., Reymann, K. G., & Onteniente, B. (2012) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2012-1895 · Cited by 8
Promoting return of function in multiple sclerosis: An integrated approach
Gacias, M., & Casaccia, P. (2013) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2013.04.002 · Cited by 9
N-Phenylquinazolin-2-amine Yhhu4952 as a novel promotor for oligodendrocyte differentiation and myelination
Yu, X., Cheng, G., Zhang, L., Zhang, Y., Wang, Q., Zhao, M., Zeng, L., Hu, Y., & Feng, L. (2018) · Scientific Reports · doi:10.1038/s41598-018-32326-0 · Cited by 8
Chondroitin Sulphate Proteoglycan 4 (NG2/CSPG4) Localization in Low- and High-Grade Gliomas
Mellai, M., Annovazzi, L., Bisogno, I., Corona, C., Crociara, P., Iulini, B., Cassoni, P., Casalone, C., Boldorini, R. L., & Schiffer, D. (2020) · Cells · doi:10.3390/cells9061538 · Cited by 8
Purinergic Receptors on Oligodendrocyte Progenitors: Promising Targets for Myelin Repair in Multiple Sclerosis?
Lecca, D., Abbracchio, M. P., & Fumagalli, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.629618 · Cited by 8
G protein‐coupled receptor GPR37‐like 1 regulates adult oligodendrocyte generation
An, J., Zhang, Y., Fudge, A. D., Lü, H., Richardson, W. D., & Li, H. (2021) · Developmental Neurobiology · doi:10.1002/dneu.22854 · Cited by 8
Neural Stem Cells: Exogenous and Endogenous Promising Therapies for Stroke
Guerra‐Crespo, M., la Herrán-Arita, A. K. D., Boronat-Garca, A., Maya-Espinosa, G., Garca-Montes, J. R., Fallon, J. H., & Drucker-Col, R. (2012) · InTech eBooks · doi:10.5772/31400 · Cited by 8
La alteración de la mielina en la enfermedad de Alexander
Gómez‐Pinedo, U., Duran‐Moreno, M., Sirerol-Piquer, M. S., & Matías‐Guiu, J. (2017) · Neurología · doi:10.1016/j.nrl.2017.01.019 · Cited by 8
Age and Sex-Related Changes to Gene Expression in the Mouse Spinal Cord
McCallum-Loudeac, J. A., Anderson, G. M., & Wilson, M. J. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01371-3 · Cited by 8
Decreased Proliferation in the Neurogenic Niche, Disorganized Neuroblast Migration, and Increased Oligodendrogenesis in Adult Netrin-5-Deficient Mice
Ikegaya, S., Iga, Y., Mikawa, S., Zhou, L., Abe, M., Sakimura, K., Sato, K., & Yamagishi, S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.570974 · Cited by 8
Intrinsic regulation of adult subventricular zone neural progenitor cells and the effect of brain injury.
Jones, K. S., & Connor, B. J. (2012) · Europe PMC (PubMed Central) · Cited by 8
Expression of HMP/AN2, a melanoma associated antigen, in murine cerebral gliomas: potential for radioimmunotargeting
Paul, A. K. R., Ciesielski, M. J., Sajjad, M., Wang, X., Ferrone, S., Abdel-Nabi, H. H., & Fenstermaker, R. A. (2009) · Journal of Neuro-Oncology · doi:10.1007/s11060-009-9798-3 · Cited by 8
Impaired macroautophagy in oligodendrocyte precursor cells suppresses neuronal plasticity via a senescence-associated signaling
Chen, H., Sun, Y., Li, Q.-F., Du, Y.-T., Hu, N., Sui, A., Luo, X.-Q., Huang, X., Zhu, C., Yang, G., et al. (2025) · Science Advances · doi:10.1126/sciadv.adq7665 · Cited by 7
Accurate classification of major brain cell types using in vivo imaging and neural network processing
Gupta, A., John, J., John, J., Beretta, C. A., Kuner, T., & Knabbe, J. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002357 · Cited by 7
Effects of adolescent alcohol exposure on oligodendrocyte lineage cells and myelination in mice: Age and subregion differences
Huang, D., Li, M., Qiao, Z., Zhou, H., Cai, Y., Li, X., Zhang, Z., & Zhou, J. (2024) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2024.06.006 · Cited by 7
Promoting remyelination: A case study in regenerative medicine
Beyer, B. A., & Lairson, L. L. (2022) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2022.102201 · Cited by 8
Advanced in vivo fluorescence microscopy of neural electronic interface
Yang, Q., & Cui, X. T. (2023) · MRS Bulletin · doi:10.1557/s43577-023-00530-7 · Cited by 7
Absence of Sema4D improves oligodendrocyte recovery after cerebral ischemia/reperfusion injury in mice
Wada, T., Sawano, T., Tanaka, T., Furuyama, T., Fukumoto, M., Yamaguchi, W., Saino, O., Takeda, Y., Kogo, M., Matsuyama, T., et al. (2016) · Neuroscience Research · doi:10.1016/j.neures.2015.12.016 · Cited by 7
Lipopolysaccharide Upregulates the Expression of CINC-3 and LIX in Primary NG2 Cells
Li, Y., Du, X., & He, B. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1856-6 · Cited by 7
Effect of mesenchymal stem cells transplantation on the changes of oligodendrocyte lineage in rat brain with experimental autoimmune encephalomyelitis
Zhang, J., Wang, H., Fan, Y., & Yang, F. (2020) · Brain and Behavior · doi:10.1002/brb3.1999 · Cited by 7
Endogenous Remyelination in the CNS
Franklin, R. J. M., Zhao, C., Lubetzki, C., & ffrench‐Constant, C. (2012) · Springer eBooks · doi:10.1007/978-1-4614-2218-1_4 · Cited by 7
Distribution and phenotype of TrkB oligodendrocyte lineage cells in the adult rat spinal cord
Coulibaly, A. P., Deer, M. R., & Isaacson, L. G. (2014) · Brain Research · doi:10.1016/j.brainres.2014.07.032 · Cited by 7
OSLO: Automatic Cell Counting and Segmentation for Oligodendrocyte Progenitor Cells
Ma, H., Beiter, R. M., Gaultier, A., Acton, S. T., & Lin, Z. (2018) · Proceedings - International Conference on Image Processing · doi:10.1109/icip.2018.8451410 · Cited by 7
Stem Cells in Genetic Myelin Disorders
Kemp, K. C., Mallam, E., Scolding, N. J., & Wilkins, A. (2010) · Regenerative Medicine · doi:10.2217/rme.10.10 · Cited by 7
Long Noncoding RNAs in CNS Myelination and Disease
Zhang, J., Guan, M., Zhou, X., Berry, K., He, X., & Lu, Q. R. (2022) · The Neuroscientist · doi:10.1177/10738584221083919 · Cited by 6
Novel method of isolating nuclei of human oligodendrocyte precursor cells reveals substantial developmental changes in gene expression and H3K27ac histone modification
Kozlenkov, A., Vadukapuram, R., Zhou, P., Fam, P. S., Wegner, M., & Dracheva, S. M. (2023) · Glia · doi:10.1002/glia.24462 · Cited by 6
Pregnancy modulates precursor cell proliferation in a murine model of focal demyelination
Haddady, S., Low, H. P., Billings‐Gagliardi, S., Riskind, P. N., & Schwartz, W. J. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.02.061 · Cited by 6
The development of myelin repair agents for treatment of multiple sclerosis
Murphy, R., Murphy, K. J., & Pickering, M. (2013) · Bioengineered · doi:10.4161/bioe.22835 · Cited by 6
Plasticity in oligodendrocyte lineage progression: An OPC puzzle on our nerves
Craig, G. A., Yoo, S., D'Araujo, T. Y., & Xiao, J. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14845 · Cited by 6
High Mobility Group A1 Regulates Transcription Levels of Oligodendrocyte Marker Genes in Cultured Oligodendrocyte Precursor Cells
Egawa, N., Hamanaka, G., Chung, K. K., Ishikawa, H., Shindo, A., Maki, T., Takahashi, R., Inoue, H., Lo, E. H., & Arai, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042236 · Cited by 6
NG2 positive cells of rat spinal cord activated during experimental autoimmune encephalomyelitis are spatially associated with radially oriented astroglia and express p75 receptor: a role for nerve growth factor in oligodendrocyte progenitor migration?
Oderfeld-Nowak, B., Zaremba, M., Kwiatkowska-Patzer, B., Lipkowski, A. W., Kurkowska‐Jastrzębska, I., Triaca, V., & Aloe, L. (2009) · PubMed · Cited by 6
Brain cell proliferation in adult rats after irradiation with nonequilibrium atmospheric pressure plasma
Yamato, M., Tamura, Y., Tanaka, H., Ishikawa, K., Ikehara, Y., Hori, M., & Kataoka, Y. (2021) · Applied Physics Express · doi:10.35848/1882-0786/ac03c1 · Cited by 6
Minimally manipulated oligodendrocyte precursor cells retain exclusive commitment to the oligodendrocyte lineage following transplantation into intact and injured hippocampus
Webber, D. J., Compston, A., & Chandran, S. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05823.x · Cited by 6
Obesity blocks oligodendrocyte precursor cell differentiation and impedes repair after white matter strokePreprint
Xiao, G., Burguet, J., Kawaguchi, R., Havton, L. A., & Hinman, J. D. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/283184 · Cited by 6
Oligodendrocyte precursors gain Schwann cell‐like phenotype and remyelinate axons upon engraftment into peripheral nerves
Mi, R., Tammia, M., Shinn, D., Li, Y., Martin, R. A., Mao, H., & Höke, A. (2019) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2935 · Cited by 5
Convergent epigenetic regulation of glial plasticity in myelin repair and brain tumorigenesis: A focus on histone modifying enzymes
Wang, J., & Lu, Q. R. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105040 · Cited by 5
Dimethylarginine dimethylaminohydrolase 1 as a novel regulator of oligodendrocyte differentiation in the central nervous system remyelination
Uyeda, A., Quan, L., Kato, Y., Muramatsu, N., Tanabe, S., Sakai, K., Ichinohe, N., Kawahara, Y., Suzuki, T., & Muramatsu, R. (2021) · Glia · doi:10.1002/glia.24060 · Cited by 5
Neuronal deletion of phosphatase and tensin homolog in mice results in spatial dysregulation of adult hippocampal neurogenesis
Latchney, S. E., Lopez, B. R. R., Womble, P. D., Blandin, K. J., & Lugo, J. N. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1308066 · Cited by 5
Two outward potassium current types are expressed during the neural differentiation of neural stem cells.
Bai, R., Gao, G.-W., Xing, Y., & Xue, H. (2013) · PubMed Central · doi:10.3969/j.issn.1673-5374.2013.28.008 · Cited by 5

Authors: Dawson, M.
Affiliations: Charing Cross Hospital (GB)
Corresponding author: Dawson, M
Venue: Molecular and Cellular Neuroscience
Publisher: Elsevier BV
Published: 2003-10
Volume: 24
Issue: 2
Pages: 476-488
ISSN: 1044-7431 (ISSN-L)
DOI: 10.1016/s1044-7431(03)00210-0
OpenAlex: W1985286185
Cited by: 927
References: 43
Citations by year: 2026: 25 · 2025: 27 · 2024: 56 · 2023: 54 · 2022: 38 · 2021: 71 · 2020: 57 · 2019: 46 · 2018: 51 · 2017: 59 · 2016: 40 · 2015: 48 · 2014: 43 · 2013: 52 · 2012: 28
FWCI: 5.53
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: NG2, oligodendrocyte precursor cells, cell cycling, oligodendrocyte lineage, myelination, demyelination, white matter, gray matter, BrdU incorporation, apoptosis, O4, chondroitin sulfate proteoglycans
MeSH terms: Chondroitin Sulfate Proteoglycan 4, Animals, Antigens, Cell Cycle, Central Nervous System, Gene Expression Regulation, Male, Neuroglia, Proteoglycans, Stem Cells, Rats, Sprague-Dawley, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks