Cited by 927Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS

Dawson, M·2003·Molecular and Cellular Neuroscience

DOI 10.1016/s1044-7431(03)00210-0

Open this paper in CoChat — free account

Abstract

Glial progenitor cells of the developing CNS committed to the oligodendrocyte lineage (OPCs) express the chondroitin sulfate proteoglycan, NG2. A proportion of OPCs fail to differentiate past the stage at which they express NG2 and the lipid antigen O4 and persist in the adult CNS in a phenotypically immature form. However, the physiological function of NG2(+) cells in the adult CNS is unknown. Using antibodies against NG2 we show that NG2 is expressed by a distinct cell population in the mature CNS with the homogeneous antigenic phenotype of oligodendrocyte progenitors. The morphology of NG2(+) OPCs varies from region to region, reflecting the different structural environments, but they appear to represent a homogeneous population within any one gray or white matter region. A study of nine CNS regions showed that NG2(+) OPCs are numerous throughout the CNS and numbers in the white matter are only 1.5 times that in the gray. Whereas the ratio of OPCs to myelinating oligodendrocytes in the spinal cord gray and white matter approximates 1:4, gray matter regions of the forebrain have a 1:1 ratio, a phenomenon that will have consequences for oligodendrocyte replacement following demyelination. BrdU incorporation experiments showed that NG2(+) cells are the major dividing cell population of the adult rat CNS. Since very little apoptosis was detected and BrdU became increasingly present in oligodendrocytes after a 10-day pulse chase, with a concomitant decrease in NG2(+) BrdU incorporating cells, we suggest that the size of the oligodendrocyte population may actually increase during adult life.

Integrity signals

Registry

Crossref · 10.1016/s1044-7431(03)00210-0

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cell death and control of cell survival in the oligodendrocyte lineage
Barres, B. A., Hart, I. K., Coles, H. S. R., Burne, J. F., Voyvodic, J. T., Richardson, W. D., & Raff, M. C. (1992) · Cell · doi:10.1016/0092-8674(92)90531-g · Cited by 1,345
Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus
Bergles, D. E., Roberts, J. D. B., Somogyi, P., & Jahr, C. E. (2000) · Nature · doi:10.1038/35012083 · Cited by 1,062
Why does remyelination fail in multiple sclerosis?
Franklin, R. J. M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn917 · Cited by 862
Proliferation and Differentiation of Progenitor Cells Throughout the Intact Adult Rat Spinal Cord
Horner, P. J., Power, A. E., Kempermann, G., Kuhn, H. G., Palmer, T. D., Winkler, J., Thal, L. J., & Gage, F. H. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02218.2000 · Cited by 777
NG2-Positive Oligodendrocyte Progenitor Cells in Adult Human Brain and Multiple Sclerosis Lesions
Chang, A., Nishiyama, A., Peterson, J. W., Prineas, J. W., & Trapp, B. D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06404.2000 · Cited by 711
The oligodendrocyte precursor cell in health and disease
Levine, J. M., Reynolds, R., & Fawcett, J. W. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01691-x · Cited by 673
MYELINATION IN RAT BRAIN: CHANGES IN MYELIN COMPOSITION DURING BRAIN MATURATION1
Norton, W. T., & Poduslo, S. E. (1973) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1973.tb07520.x · Cited by 668
The Age-Related Decrease in CNS Remyelination Efficiency Is Attributable to an Impairment of Both Oligodendrocyte Progenitor Recruitment and Differentiation
Sim, F. J., Zhao, C., Penderis, J., & Franklin, R. J. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02451.2002 · Cited by 625
Oligodendrocyte Population Dynamics and the Role of PDGF In Vivo
Calver, A. R., Hall, A. C., Yu, W., Walsh, F. S., Heath, J. K., Betsholtz, C., & Richardson, W. D. (1998) · Neuron · doi:10.1016/s0896-6273(00)80469-9 · Cited by 516
A singularity of PDGF alpha-receptor expression in the dorsoventral axis of the neural tube may define the origin of the oligodendrocyte lineage
Pringle, N. P., & Richardson, W. D. (1993) · Development · doi:10.1242/dev.117.2.525 · Cited by 510

Show all 43 references

Sorted by citations

Items 301–400 of 924

Differentiation of Glial Cells From hiPSCs: Potential Applications in Neurological Diseases and Cell Replacement Therapy
Zheng, W., Li, Q., Zhao, C., Da, Y., Zhang, H., & Chen, Z. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00239 · Cited by 50
Stage-specific control of oligodendrocyte survival and morphogenesis by TDP-43
Heo, D., Ling, J. P., Molina-Castro, G. C., Langseth, A. J., Waisman, A., Nave, K., Möbius, W., Wong, P. C., & Bergles, D. E. (2022) · eLife · doi:10.7554/elife.75230 · Cited by 49
Prospects of Cell Therapy for Disorders of Myelin
Ben‐Hur, T., & Goldman, S. A. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1444.014 · Cited by 47
Acute brain injuries trigger microglia as an additional source of the proteoglycan NG2
Huang, W., Bai, X., Meyer, E., & Scheller, A. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01016-2 · Cited by 47
Glial Progenitors as Targets for Transformation in Glioma
Ilkhanizadeh, S., Lau, J., Huang, M., Foster, D. J., Wong, R. A., Frantz, A., Wang, S., Weiss, W. A., & Persson, A. I. (2014) · Advances in cancer research · doi:10.1016/b978-0-12-800249-0.00001-9 · Cited by 47
Quantitative analysis of mitotic Olig2 cells in adult human brain and gliomas: Implications for glioma histogenesis and biology
Rhee, W., Ray, S., Yokoo, H., Hoane, M. E., Lee, C. C., Mikheev, A. M., Horner, P. J., & Rostomily, R. (2008) · Glia · doi:10.1002/glia.20780 · Cited by 46
Oligodendroglia-lineage cells in brain plasticity, homeostasis and psychiatric disorders
Birey, F., Kokkosis, A. G., & Aguirre, A. A. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.09.016 · Cited by 47
Glial aging and its impact on central nervous system myelin regeneration
Rawji, K. S., Neumann, B., & Franklin, R. J. M. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14933 · Cited by 47
Fate of neuron-glia synapses during proliferation and differentiation of NG2 cells
Fröhlich, N. T., Nagy, B., Hovhannisyan, A., & Kukley, M. (2011) · Journal of Anatomy · doi:10.1111/j.1469-7580.2011.01392.x · Cited by 45
Brain pathways to recovery from alcohol dependence
Cui, C., Noronha, A., Warren, K. R., Koob, G. F., Sinha, R., Thakkar, M. M., Matochik, J. A., Crews, F. T., Chandler, L. J., Adolf Pfefferbaum, A., et al. (2015) · Alcohol · doi:10.1016/j.alcohol.2015.04.006 · Cited by 49
NG2-Glia from Pallial Progenitors Produce the Largest Clonal Clusters of the Brain: Time Frame of Clonal Generation in Cortex and Olfactory Bulb
García‐Marqués, J., Núñez‐Llaves, R., & López‐Mascaraque, L. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3060-13.2014 · Cited by 50
Adult Neurogenesis and Gliogenesis: Possible Mechanisms for Neurorestoration
Rusznák, Z., Henskens, W., Schofield, E. C., Kim, W. S., & Fu, Y. (2016) · Experimental Neurobiology · doi:10.5607/en.2016.25.3.103 · Cited by 52
The bone morphogenetic protein antagonist noggin protects white matter after perinatal hypoxia–ischemia
Dizon, M. L. V., Maa, T., & Kessler, J. A. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.023 · Cited by 44
Prostacyclin promotes oligodendrocyte precursor recruitment and remyelination after spinal cord demyelination
Takahashi, C., Muramatsu, R., Fujimura, H., Mochizuki, H., & Yamashita, T. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.335 · Cited by 46
Regeneration of myelin sheaths of normal length and thickness in the zebrafish CNS correlates with growth of axons in caliber
Karttunen, M. J., Czopka, T., Goedhart, M., Early, J. J., & Lyons, D. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178058 · Cited by 44
Repurposing HAMI3379 to Block GPR17 and Promote Rodent and Human Oligodendrocyte Differentiation
Merten, N., Fischer, J., Simon, K., Zhang, L., Schröder, R. J., Peters, L., Letombe, A.-G., Hennen, S., Schrage, R., Bödefeld, T., et al. (2018) · Cell chemical biology · doi:10.1016/j.chembiol.2018.03.012 · Cited by 44
Unraveling Myelin Plasticity
Bonetto, G., Kamen, Y., Evans, K. A., & Káradóttir, R. T. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00156 · Cited by 47
Importance of oligodendrocyte protection, BBB breakdown and inflammation for remyelination
Watzlawik, J. O., Warrington, A. E., & Rodriguez, M. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.13 · Cited by 46
Multimodal imaging of subventricular zone neural stem/progenitor cells in the cuprizone mouse model reveals increased neurogenic potential for the olfactory bulb pathway, but no contribution to remyelination of the corpus callosum
Guglielmetti, C., Praet, J., Rangarajan, J. R., Vreys, R., Vocht, N. D., Maes, F., Verhoye, M., Ponsaerts, P., & der Linden, A. V. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.07.080 · Cited by 44
Origin of oligodendrocytes in mammalian forebrains: a revised perspective
Naruse, M., Ishizaki, Y., Ikenaka, K., Tanaka, A., & Hitoshi, S. (2016) · The Journal of Physiological Sciences · doi:10.1007/s12576-016-0479-7 · Cited by 43
The chemotherapy agent, thioTEPA, yields long-term impairment of hippocampal cell proliferation and memory deficits but not depression-related behaviors in mice
Mondie, C. M., Vandergrift, K. A., Wilson, C. L., Gulinello, M. E., & Weber, E. T. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.01.016 · Cited by 43
Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors
Lopez, K. A., Tannenbaum, A. M., Assanah, M. C., Linskey, K. R., Yun, J. J., Kangarlu, A., Gil, O. D., Canoll, P., & Bruce, J. N. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-0906 · Cited by 43
Transcriptional profiles of mouse oligodendrocyte precursor cells across the lifespan
Heo, D., Kim, A. A., Neumann, B., Doze, V. N., Xu, Y. K. T., Mironova, Y. A., Slosberg, J., Goff, L. A., Franklin, R. J. M., & Bergles, D. E. (2025) · Nature Aging · doi:10.1038/s43587-025-00840-2 · Cited by 42
Matrix metalloproteinase-9 controls proliferation of NG2+ progenitor cells immediately after spinal cord injury
Liu, H., & Shubayev, V. I. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.06.015 · Cited by 44
Sequential specification of oligodendrocyte lineage cells by distinct levels of Hedgehog and Notch signaling
Ravanelli, A. M., Kearns, C. A., Powers, R. K., Wang, Y., Hines, J. H., Donaldson, M. J., & Appel, B. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.10.004 · Cited by 43
Neuronal activity-dependent myelin repair after stroke
Jia, W., Kamen, Y., Pivoňková, H., & Káradóttir, R. T. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.03.005 · Cited by 45
Mechanisms and repair strategies for white matter degeneration in CNS injury and diseases
Shahsavani, N., Kataria, H., & Karimi‐Abdolrezaee, S. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166117 · Cited by 43
Structural reorganization of the dentate gyrus following entorhinal denervation: species differences between rat and mouse
Deller, T., Turco, D. D., Rappert, A., & Bechmann, I. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)63027-1 · Cited by 42
Sema4D deficiency results in an increase in the number of oligodendrocytes in healthy and injured mouse brains
Taniguchi, Y., Amazaki, M., Furuyama, T., Yamaguchi, W., Takahara, M., Saino, O., Wada, T., Niwa, H., Tashiro, F., Miyazaki, J., et al. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22124 · Cited by 42
Haloperidol activates quiescent oligodendroglia precursor cells in the adult mouse brain
Wang, H., Xu, H., Niu, J., Mei, F., Li, X., Kong, J., Cai, W., & Xiao, L. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.02.1068 · Cited by 42
Preclinical biodistribution, tropism, and efficacy of oligotropic AAV/Olig001 in a mouse model of congenital white matter disease
Francis, J. S., Markov, V., Wojtas, I. D., Gray, S., McCown, T., Samulski, R. J., Figueroa, M., & Leone, P. (2021) · Molecular Therapy - Methods & Clinical Development · doi:10.1016/j.omtm.2021.01.009 · Cited by 41
Age-Dependent Decline in Fate Switch from NG2 Cells to Astrocytes After Olig2 Deletion
Zuo, H., Wood, W. M., Sherafat, A., Hill, R., Lu, Q. R., & Nishiyama, A. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0712-17.2018 · Cited by 42
Neuronal Activity-Dependent Control of Postnatal Neurogenesis and Gliogenesis
Káradóttir, R. T., & Kuo, C. T. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031054 · Cited by 42
The role of oligodendrocytes and their progenitors on neural interface technology: A novel perspective on tissue regeneration and repair
Wellman, S. M., Cambi, F., & Kozai, T. D. Y. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.08.046 · Cited by 43
Inhibition of CD147 improves oligodendrogenesis and promotes white matter integrity and functional recovery in mice after ischemic stroke
Liu, S., Jin, R., Xiao, A. Y., Zhong, W. H., & Li, G. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.07.027 · Cited by 41
Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis
Thornton, M. A., Futia, G. L., Stockton, M. E., Budoff, S. A., Ramirez, A. N., Ozbay, B. N., Tzang, O., Kilborn, K., Poleg-Polsky, A., Restrepo, D., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01613-7 · Cited by 44
Spatial organization of NG2 glial cells and astrocytes in rat hippocampal CA1 region
Xu, G., Wang, W., & Zhou, M. (2013) · Hippocampus · doi:10.1002/hipo.22232 · Cited by 41
Role of adenosine in oligodendrocyte precursor maturation
Coppi, E., Cellai, L., Maraula, G., Dettori, I., Melani, A., Pugliese, A. M., & Pedata, F. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00155 · Cited by 46
Transient Cnp expression by early progenitors causes Cre-Lox-based reporter lines to map profoundly different fates
Tognatta, R., Sun, W., Goebbels, S., Nave, K., Nishiyama, A., Schoch, S., Dimou, L., & Dietrich, D. (2016) · Glia · doi:10.1002/glia.23095 · Cited by 40
Architecting the myelin landscape
Osso, L. A., & Chan, J. R. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.06.005 · Cited by 40
Sphingosine-1-Phosphate Receptor Modulators and Oligodendroglial Cells: Beyond Immunomodulation
Roggeri, A., Schepers, M., Tiane, A., Rombaut, B., van Veggel, L., Hellings, N., Prickaerts, J., Pittaluga, A., & Vanmierlo, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207537 · Cited by 40
Glial Cells and Their Contribution to the Mechanisms of Action of Cannabidiol in Neuropsychiatric Disorders
Scarante, F. F., Ribeiro, M. A., Almeida-Santos, A. F., Guimarães, F. S., & Campos, A. C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.618065 · Cited by 44
GABA and Neuroactive Steroid Interactions in Glia: New Roles for Old Players?
Magnaghi, V. (2007) · Current Neuropharmacology · doi:10.2174/157015907780077132 · Cited by 41
Remyelination in the central nervous system
Franklin, R. J. M., Bodini, B., & Goldman, S. A. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041371 · Cited by 40
Shaping of Regional Differences in Oligodendrocyte Dynamics by Regional Heterogeneity of the Pericellular Microenvironment
Sherafat, A., Pfeiffer, F., & Nishiyama, A. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.721376 · Cited by 40
Understanding the Role of the Glial Scar through the Depletion of Glial Cells after Spinal Cord Injury
Perez‐Gianmarco, L., & Kukley, M. (2023) · Cells · doi:10.3390/cells12141842 · Cited by 39
Essential Function, Sophisticated Regulation and Pathological Impact of the Selective RNA-Binding Protein QKI in CNS Myelin Development
Bockbrader, K., & Feng, Y. (2008) · Future Neurology · doi:10.2217/14796708.3.6.655 · Cited by 39
GGF2 (Nrg1‐β3) treatment enhances NG2+ cell response and improves functional recovery after spinal cord injury
Whittaker, M. T., Zai, L. J., Lee, H. J., Pajoohesh‐Ganji, A., Wu, J., Sharp, A., Wyse, R. J., & Wrathall, J. R. (2011) · Glia · doi:10.1002/glia.21262 · Cited by 39
The GPR17 receptor-A promising goal for therapy and a potential marker of the neurodegenerative process in multiple sclerosis
Dziedzic, A., Miller, E., Saluk-Bijak, J., & Bijak, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051852 · Cited by 38
P2X7 receptors and Fyn kinase mediate ATP-induced oligodendrocyte progenitor cell migration
Feng, J., Gao, X.-F., Pu, Y., Burnstock, G., Xiang, Z., & He, C. (2015) · Purinergic Signalling · doi:10.1007/s11302-015-9458-3 · Cited by 39
Neuroglial interactions underpinning myelin plasticity
de Faria, O., Pama, E., Evans, K. A., Luzhynskaya, A., & Káradóttir, R. T. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22539 · Cited by 40
BNIP 3 mediates pre‐myelinating oligodendrocyte cell death in hypoxia and ischemia
Li, C., Guan, T., Chen, X., Li, W., Cai, Q., Niu, J., Xiao, L., & Kong, J. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12314 · Cited by 38
How to Use the Cuprizone Model to Study De- and Remyelination
Kipp, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031445 · Cited by 37
“…oligodendrocytes might principally originate from SVZ-derived NPCs or parenchymal OPCs (pOPCs), the latter being widely distributed in the white and grey matter parenchyma [96–99] and defined by the expression of platelet-derived growth factor receptor α (PDGFR α ) and NG2 proteoglycan.”
Background
Electrical signalling properties of oligodendrocyte precursor cells
Bakiri, Y., Attwell, D., & Káradóttir, R. T. (2009) · Neuron Glia Biology · doi:10.1017/s1740925x09990202 · Cited by 38
Stem cell therapy for glaucoma: Science or snake oil?
Sun, Y., Williams, A. L., Waisbourd, M., Iacovitti, L., & Katz, L. J. (2014) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2014.07.001 · Cited by 37
Differential roles of epigenetic regulators in the survival and differentiation of oligodendrocyte precursor cells
Egawa, N., Shindo, A., Hikawa, R., Kinoshita, H., Liang, A. C., Itoh, K., Lok, J. M., Maki, T., Takahashi, R., Lo, E. H., et al. (2018) · Glia · doi:10.1002/glia.23567 · Cited by 37
NG2 cells and their neurogenic potential
Kirdajová, D., & Anděrová, M. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.11.005 · Cited by 37
Phenotypic Changes in NG2 + Cells after Spinal Cord Injury
Lytle, J. M., Vicini, S., & Wrathall, J. R. (2006) · Journal of Neurotrauma · doi:10.1089/neu.2006.23.1726 · Cited by 37
Connexins-Mediated Glia Networking Impacts Myelination and Remyelination in the Central Nervous System
Li, T., Giaume, C., & Xiao, L. (2014) · Molecular Neurobiology · doi:10.1007/s12035-013-8625-1 · Cited by 38
Chd7 Collaborates with Sox2 to Regulate Activation of Oligodendrocyte Precursor Cells after Spinal Cord Injury
Doi, T., Ogata, T., Yamauchi, J., Sawada, Y., Tanaka, S., & Nagao, M. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1109-17.2017 · Cited by 36
Dissipation of transmembrane potassium gradient is the main cause of cerebral ischemia-induced depolarization in astrocytes and neurons
Du, Y., Wang, W., Lutton, A. D., Kiyoshi, C. M., Ma, B., Taylor, A. T., Olesik, J. W., McTigue, D. M., Askwith, C. C., & Zhou, M. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.01.019 · Cited by 36
Cannabinoid‐mediated neuroprotection following interferon‐gamma treatment in a three‐dimensional mouse brain aggregate cell culture
Jackson, S., Baker, D., Cuzner, M., & Diemel, L. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03711.x · Cited by 31
Revisiting the astrocyte–oligodendrocyte relationship in the adult CNS
Carmen, J., Magnus, T., Cassiani‐Ingoni, R., Sherman, L. S., Rao, M. S., & Mattson, M. P. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.03.001 · Cited by 38
Coxsackievirus Preferentially Replicates and Induces Cytopathic Effects in Undifferentiated Neural Progenitor Cells
Tsueng, G., Tabor-Godwin, J. M., Gopal, A., Ruller, C. M., Deline, S., An, N., Frausto, R. F., Milner, R., Crocker, S. J., Whitton, J. L., et al. (2011) · Journal of Virology · doi:10.1128/jvi.02261-10 · Cited by 36
Glial Cells as Key Regulators in Neuroinflammatory Mechanisms Associated with Multiple Sclerosis
Theophanous, S., Sargiannidou, I., & Kleopa, K. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179588 · Cited by 38
Glutamatergic signaling between neurons and oligodendrocyte lineage cells: Is it synaptic or non‐synaptic?
Kula, B., Chen, T., & Kukley, M. (2019) · Glia · doi:10.1002/glia.23617 · Cited by 36
Matrix metalloproteinases shape the oligodendrocyte (niche) during development and upon demyelination
Gorter, R. P., & Baron, W. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.134980 · Cited by 37
Cell Fate Potential of NG2 Progenitors
Sánchez‐González, R., Bribián, A., & López‐Mascaraque, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-66753-9 · Cited by 37
Reduced Oligodendrocyte Precursor Cell Impairs Astrocytic Development in Early Life Stress
Wang, Y., Su, Y., Yu, G., Wang, X., Chen, X., Yu, B., Cheng, Y., Li, R., Sáez, J. C., Yi, C., et al. (2021) · Advanced Science · doi:10.1002/advs.202101181 · Cited by 37
Early Proliferation Does Not Prevent the Loss of Oligodendrocyte Progenitor Cells during the Chronic Phase of Secondary Degeneration in a CNS White Matter Tract
Payne, S. C., Bartlett, C. A., Savigni, D. L., Harvey, A. R., Dunlop, S. A., & Fitzgerald, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065710 · Cited by 36
Pro-Inflammatory Cytokines Reduce the Proliferation of NG2 Cells and Increase Shedding of NG2 In Vivo and In Vitro
Wennström, M., Janelidze, S., Bay-Richter, C., Minthon, L., & Brundin, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109387 · Cited by 35
NG2 cells differentiate into astrocytes in cerebellar slices
Leoni, G., Rattray, M., & Butt, A. M. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.07.007 · Cited by 35
Directed glial differentiation and transdifferentiation for neural tissue regeneration
Janowska, J., Gargaś, J., Ziemka‐Nałęcz, M., Zalewska, T., Bużańska, L., & Sypecka, J. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.08.010 · Cited by 36
Paired Related Homeobox Protein 1 Regulates Quiescence in Human Oligodendrocyte Progenitors
Wang, J., Saraswat, D., Sinha, A. K., Polanco, J. J., Dietz, K., O’Bara, M. A., Pol, S. U., Shayya, H. J., & Sim, F. J. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.068 · Cited by 35
Neural stem cells in inflammatory CNS diseases: mechanisms and therapy
Magnus, T., & Rao, M. S. R. (2005) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2005.tb00357.x · Cited by 34
Calcium Signaling in Neurons and Glial Cells: Role of Cav1 channels
Alves, V. S., Alves-Silva, H. S., Orts, D. J. B., Ribeiro-Silva, L., Arcisio-Miranda, M., & Oliveira, F. A. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.09.041 · Cited by 34
In Vivo Clonal Analysis Reveals Development Heterogeneity of Oligodendrocyte Precursor Cells Derived from Distinct Germinal Zones
Liu, R., Jia, Y., Guo, P., Jiang, W., Bai, R., & Liu, C. (2021) · Advanced Science · doi:10.1002/advs.202102274 · Cited by 33
Oligodendrocyte progenitor cells are paired with GABA neurons in the mouse dorsal cortex: Unbiased stereological analysis
Boulanger, J. J., & Messier, C. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.018 · Cited by 35
Demyelination-remyelination in the Central Nervous System: Ligand-dependent Participation of the Notch Signaling Pathway
Mathieu, P., Gubiani, M. F. A., Rodríguez, D., Pinto, L. I. G., Calcagno, M. D. L., & Adamo, A. M. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz130 · Cited by 34
Intravitreal application of AAV-BDNF or mutant AAV-CRMP2 protects retinal ganglion cells and stabilizes axons and myelin after partial optic nerve injury
Chiha, W., Bartlett, C. A., Petratos, S., Fitzgerald, M., & Harvey, A. R. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113167 · Cited by 33
Fluoxetine Promotes Hippocampal Oligodendrocyte Maturation and Delays Learning and Memory Decline in APP/PS1 Mice
Chao, F., Zhang, Y., Zhang, L., Jiang, L. H., Zhou, C., Tang, J., Liang, X., Fan, J., Dou, X., & Tang, Y. C. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.627362 · Cited by 34
Distribution and fate of DCX/PSA-NCAM expressing cells in the adult mammalian cortex: A local reservoir for adult cortical neuroplasticity?
König, R., Benedetti, B., Rotheneichner, P., Sullivan, A. O., Kreutzer, C., Bellés, M., Nácher, J., Weiger, T. M., Aigner, L., & Couillard‐Després, S. (2016) · Frontiers in Biology · doi:10.1007/s11515-016-1403-5 · Cited by 34
Hyperperfusion of Frontal White and Subcortical Gray Matter in Autism Spectrum Disorder
Peterson, B. S., Zargarian, A., Peterson, J. B., Goh, S., Sawardekar, S., Williams, S., Lythgoe, D. J., Zelaya, F. O., & Bansal, R. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.11.026 · Cited by 34
Age and Alzheimer’s Disease-Related Oligodendrocyte Changes in Hippocampal Subregions
DeFlitch, L., González‐Fernández, E., Crawley, I., & Kang, S. H. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.847097 · Cited by 34
Insertional effect following electrode implantation: an underreported but important phenomenon
Hamani, C., Davidson, B., Lipsman, N., Abrahão, A., Nestor, S. M., Rabin, J. S., Giacobbe, P., Pagano, R. L., & Campos, A. C. P. (2024) · Brain Communications · doi:10.1093/braincomms/fcae093 · Cited by 32
Morphological characterization of NG2 glia and their association with neuroglial cells in the 3-nitropropionic acid–lesioned striatum of rat
Jin, X., Riew, T., Kim, H. L., Choi, J.-H., & Lee, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-24385-0 · Cited by 32
Macroglial diversity: white and grey areas and relevance to remyelination
Werkman, I. L., Lentferink, D. H., & Baron, W. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03586-9 · Cited by 33
Deciphering the Oligodendrogenic Program of Neural Progenitors: Cell Intrinsic and Extrinsic Regulators
Rivera, F. J., Steffenhagen, C., Kremer, D., Kandasamy, M., Sandner, B., Couillard‐Després, S., Weidner, N., Küry, P., & Aigner, L. (2009) · Stem Cells and Development · doi:10.1089/scd.2009.0293 · Cited by 33
Stimulation of Adult Oligodendrogenesis by Myelin-Specific T Cells
Nielsen, H. H., Toft‐Hansen, H., Lambertsen, K. L., Owens, T., & Finsen, B. R. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.06.006 · Cited by 35
Gene network underlying the glial regenerative response to central nervous system injury
Kato, K., Losada‐Pérez, M., & Hidalgo, A. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24565 · Cited by 34
Brain network mapping and glioma pathophysiology
Mandal, A. S., Brem, S. S., & Suckling, J. (2023) · Brain Communications · doi:10.1093/braincomms/fcad040 · Cited by 33
Three Growth Factors Induce Proliferation and Differentiation of Neural Precursor Cells In Vitro and Support Cell-Transplantation after Spinal Cord Injury In Vivo
Younsi, A., Zheng, G., Scherer, M., Riemann, L., Zhang, H., Tail, M., Hatami, M., Skutella, T., Unterberg, A. W., & Zweckberger, K. (2020) · Stem Cells International · doi:10.1155/2020/5674921 · Cited by 31
The Role of Glial Mitochondria in α-Synuclein Toxicity
Jeon, Y., Kwon, Y., Jo, M., Lee, S., Kim, S., & Kim, H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.548283 · Cited by 31
Oligodendrocyte precursor cell maturation: role of adenosine receptors
Cherchi, F., Pugliese, A. M., & Coppi, E. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.306058 · Cited by 32
A Matter of State: Diversity in Oligodendrocyte Lineage Cells
Kamen, Y., Pivoňková, H., Evans, K. A., & Káradóttir, R. T. (2021) · The Neuroscientist · doi:10.1177/1073858420987208 · Cited by 35
The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2
Maus, F., Sakry, D., Binamé, F., Karram, K., Rajalingam, K., Watts, C., Heywood, R. M., Krüger, R., Stegmüller, J., Werner, H. B., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137311 · Cited by 32
Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke
Yang, J. M., Wu, J., Xie, X., Xia, P., Lü, J., Liu, J., Bai, L., Li, X., Yu, Z., & Li, H. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01540 · Cited by 30
Navigating oligodendrocyte precursor cell aging in brain health
Leenders, F., Koole, L., Slaets, H., Tiane, A., van den Hove, D., & Vanmierlo, T. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111959 · Cited by 30
The chemotherapeutic agent paclitaxel selectively impairs reversal learning while sparing prior learning, new learning and episodic memory
Panoz‐Brown, D., Carey, L. M., Smith, A. E., Gentry, M., Sluka, C. M., Corbin, H. E., Wu, J.-E., Hohmann, A. G., & Crystal, J. D. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.08.001 · Cited by 31
Functional Heterogeneity of Mouse and Human Brain OPCs: Relevance for Preclinical Studies in Multiple Sclerosis
Bribián, A., Medina-Rodriguez, E. M., Josa‐Prado, F., García‐Álvarez, I., Machín-Díaz, I., Esteban, P. F., Murcia‐Belmonte, V., Vega-Zelaya, L., Pastor, J., Garrido, L., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061681 · Cited by 30

Authors: Dawson, M.
Affiliations: Charing Cross Hospital (GB)
Corresponding author: Dawson, M
Venue: Molecular and Cellular Neuroscience
Publisher: Elsevier BV
Published: 2003-10
Volume: 24
Issue: 2
Pages: 476-488
ISSN: 1044-7431 (ISSN-L)
DOI: 10.1016/s1044-7431(03)00210-0
OpenAlex: W1985286185
Cited by: 927
References: 43
Citations by year: 2026: 25 · 2025: 27 · 2024: 56 · 2023: 54 · 2022: 38 · 2021: 71 · 2020: 57 · 2019: 46 · 2018: 51 · 2017: 59 · 2016: 40 · 2015: 48 · 2014: 43 · 2013: 52 · 2012: 28
FWCI: 5.53
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: NG2, oligodendrocyte precursor cells, cell cycling, oligodendrocyte lineage, myelination, demyelination, white matter, gray matter, BrdU incorporation, apoptosis, O4, chondroitin sulfate proteoglycans
MeSH terms: Chondroitin Sulfate Proteoglycan 4, Animals, Antigens, Cell Cycle, Central Nervous System, Gene Expression Regulation, Male, Neuroglia, Proteoglycans, Stem Cells, Rats, Sprague-Dawley, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks