Calmodulin Is a Limiting Factor in the Cell

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

Bredt, D. S., & Snyder, S. H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.2.682 · Cited by 3,308

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

Rao, A., Luo, C. H., & Hogan, P. G. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.707 · Cited by 2,592

Range of Messenger Action of Calcium Ion and Inositol 1,4,5-Trisphosphate

Allbritton, N. L., Meyer, T., & Stryer, L. (1992) · Science · doi:10.1126/science.1465619 · Cited by 1,146

Calmodulin supports both inactivation and facilitation of L-type calcium channels

Zühlke, R. D., Pitt, G. S., Deisseroth, K. A., Tsien, R. W., & REUTER, H. (1999) · Nature · doi:10.1038/20200 · Cited by 899

Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons

Deisseroth, K. A., Heist, E. K., & Tsien, R. W. (1998) · Nature · doi:10.1038/32448 · Cited by 656

Calmodulin is a subunit of nitric oxide synthase from macrophages.

Cho, H. J., Xie, Q. W., Calaycay, J. R., Mumford, R. A., Swiderek, K. M., Lee, T. D., & Nathan, C. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.2.599 · Cited by 635

Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin

Schumacher, M. A., Rivard, A. F., Bächinger, H. P., & Adelman, J. P. (2001) · Nature · doi:10.1038/35074145 · Cited by 604

Ca2+/calmodulin binds to and modulates P/Q-type calcium channels

Lee, A., Wong, S. T., Gallagher, D., Li, B., Storm, D. R., Scheuer, T., & Catterall, W. A. (1999) · Nature · doi:10.1038/20194 · Cited by 480

Calcium and Cell Function

(1982) · Elsevier eBooks · doi:10.1016/c2013-0-07290-8 · Cited by 418

Detection in Living Cells of Ca2+-dependent Changes in the Fluorescence Emission of an Indicator Composed of Two Green Fluorescent Protein Variants Linked by a Calmodulin-binding Sequence

Romoser, V. A., Hinkle, P. M., & Persechini, A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.20.13270 · Cited by 398

Photocontrol of Calmodulin Interaction with Target Peptides using Azobenzene Derivative

Shishido, H., Yamada, M. D., Kondo, K., & Maruta, S. (2009) · The Journal of Biochemistry · doi:10.1093/jb/mvp107 · Cited by 16

Myosin light chain kinase regulates intestinal permeability of mucosal homeostasis in Crohn’s disease

Yao, Y., Feng, Q., & Shen, J. (2020) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2021.1850269 · Cited by 15

Downregulated calmodulin expression contributes to endothelial cell impairment in diabetes

Liu, T., Xu, H.-H., Liu, Z., Zhang, H.-P., Zhou, H., Zhu, Z., Wang, Z.-Q., Xue, J., Li, Q., Ma, Y., et al. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01127-1 · Cited by 15

Role of calcium in membrane interactions by PI(4,5)P2-binding proteins

Monteiro, M. E., Sarmento, M. J., & Fernandes, F. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140149 · Cited by 15

Calmodulin: a highly conserved and ubiquitous Ca2+ sensor

Sobue, K. (2024) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.100.025 · Cited by 16

Calmodulin mutations affecting Gly114 impair binding to the NaV1.5 IQ-domain

Brohus, M., Busuioc, A.-O., Wimmer, R., Nyegaard, M., & Overgaard, M. T. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1210140 · Cited by 14

Computational analysis of interactions of oxidative stress and tetrahydrobiopterin reveals instability in eNOS coupling

Panday, S., Kar, S., & Kavdia, M. (2017) · Microvascular Research · doi:10.1016/j.mvr.2017.07.001 · Cited by 14

Evaluating Calmodulin–Protein Interactions by Rapid Photoactivated Cross-Linking in Live Cells Metabolically Labeled with Photo-Methionine

Black, D. J., Tran, Q., Keightley, A., Chinawalkar, A., McMullin, C., & Persechini, A. (2019) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00510 · Cited by 14

PKA and phosphatases attached to the CaV1.2 channel regulate channel activity in cell-free patches

Xu, J., Yu, L., Minobe, E., Lu, L., Lei, M., & Kameyama, M. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00157.2015 · Cited by 13

Activation State-Dependent Substrate Gating in Ca2+/Calmodulin-Dependent Protein Kinase II

Johnson, D. E., & Hudmon, A. (2017) · Neural Plasticity · doi:10.1155/2017/9601046 · Cited by 13

Fluorescence probe study of Ca2+-dependent interactions of calmodulin with calmodulin-binding peptides of the ryanodine receptor

Gangopadhyay, J. P., Grabarek, Z., & Ikemoto, N. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.154 · Cited by 13

Calmodulin-like protein enhances myosin-10 translation

Bennett, R. D., & Strehler, E. E. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.02.056 · Cited by 12

Impact of arrhythmogenic calmodulin variants on small conductance Ca 2+ ‐activated K + (SK3) channels

Saljic, A., Muthukumarasamy, K. M., la Cour, J. M., Boddum, K., Grunnet, M., Berchtold, M. W., & Jespersen, T. (2019) · Physiological Reports · doi:10.14814/phy2.14210 · Cited by 11

Aberrant interaction of calmodulin with the ryanodine receptor develops hypertrophy in the neonatal cardiomyocyte

Gangopadhyay, J. P., & Ikemoto, N. (2011) · Biochemical Journal · doi:10.1042/bj20110203 · Cited by 11

Calmodulin potentiates Gβγ activation of phospholipase C-β3

McCullar, J. S., Malencik, D. A., Vogel, W., Crofoot, K., Anderson, S. R., & Filtz, T. M. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.10.004 · Cited by 11

Regulation of basal autophagy by calmodulin availability

Giles, J. R., Lopez, V., McConnaha, E., Hayden, M. R., Kragenbring, C., Carli, D., Wauson, E., & Tran, Q. (2022) · FEBS Journal · doi:10.1111/febs.16432 · Cited by 9

ADAM10 isoforms: Optimizing usage of antibodies based on protein regulation, structural features, biological activity and clinical relevance to Alzheimer’s disease

Dorta, S., Alexandre-Silva, V., Popolin, C. P., de Sousa, D. B., Grigoli, M. M., Pelegrini, L. N. D. C., Manzine, P. R., Camins, A., Marcello, E. E., Endres, K., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102464 · Cited by 9

A CACNA1C variant associated with cardiac arrhythmias provides mechanistic insights in the calmodulation of L-type Ca2+ channels

Zhao, J., Segura, É., Marsolais, M., & Parent, L. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102632 · Cited by 9

Tat peptide‐calmodulin binding studies and bioinformatics of HIV‐1 protein–calmodulin interactions

McQueen, P., Donald, L. J., Vo, T. N., Nguyen, D. H., Griffiths, H., Shojania, S., Standing, K. G., & O’Neil, J. D. (2011) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.23048 · Cited by 11

Translational switch for long term maintenance of synaptic plasticity

Aslam, N., Kubota, Y., & Shouval, H. Z. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-s1-p102 · Cited by 9

The IQ Domains in Neuromodulin and PEP19 Represent Two Major Functional Classes

Black, D. J., LaMartina, D., & Persechini, A. (2009) · Biochemistry · doi:10.1021/bi9014874 · Cited by 9

Rate-dependent Ca2+ signalling underlying the force-frequency response in rat ventricular myocytes: a coupled electromechanical modeling study

Krishna, A., Valderrábano, M., Palade, P., & Clark, J. W. (2013) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-10-54 · Cited by 9

Characterization of filarial phosphoglycerate kinase

Kumar, R., Ahmad, F., & Rathaur, S. (2019) · Biochimie · doi:10.1016/j.biochi.2019.08.012 · Cited by 8

Biophysical attributes that affect CaMKII activation deduced with a novel spatial stochastic simulation approach

Li, X., & Holmes, W. R. (2018) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005946 · Cited by 8

Variations at the Semiconserved Glycine in the IQ Domain Consensus Sequence Have a Major Impact on Ca2+-Dependent Switching in Calmodulin−IQ Domain Complexes

Black, D. J., & Persechini, A. (2009) · Biochemistry · doi:10.1021/bi901695p · Cited by 8

Abelson tyrosine kinase and Calmodulin interact synergistically to transduce midline guidance cues in the Drosophila embryonic CNS

Hsouna, A., & VanBerkum, M. F. A. (2007) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2007.12.005 · Cited by 7

Kinetic Analysis Reveals Differences in the Binding Mechanism of Calmodulin and Calmodulin-like Protein to the IQ Motifs of Myosin-10

Caride, A. J., Bennett, R. D., & Strehler, E. E. (2010) · Biochemistry · doi:10.1021/bi100644q · Cited by 7

The role of calcium in the interaction between calmodulin and a minimal functional construct of eukaryotic elongation factor 2 kinase

Lee, K., Kumar, E. A., Dalby, K. N., & Ghose, R. (2019) · Protein Science · doi:10.1002/pro.3753 · Cited by 5

Theoretical-experimental studies of calmodulin-peptide interactions at different calcium equivalents

Sosa‐Peinado, A., León-Cruz, E., Velázquez‐López, I., Matuz‐Mares, D., Cano‐Sánchez, P., & González‐Andrade, M. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1841679 · Cited by 5

Engineering of a novel Ca2+-regulated kinesin molecular motor using a calmodulin dimer linker

Shishido, H., & Maruta, S. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.05.135 · Cited by 4

The Impact of Calcium Depletion on Proliferation of Chlorella sorokiniana Strain DSCG150

Kang, S., Cho, S., Jeong, D., Kim, U., Kim, J., Lee, S., & Jung, Y. (2024) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2403.03018 · Cited by 3

A novel assay to assess the effects of estrogen on the cardiac calmodulin binding equilibrium

Kaster, K., Patton, J., Clayton, S., Wauson, E., Giles, J. R., & Tran, Q. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120247 · Cited by 2

Kinesin-Calmodulin fusion protein as a molecular shuttle

Shishido, H., Nakazato, K., Katayama, E., Chaen, S., & Maruta, S. (2009) · The Journal of Biochemistry · doi:10.1093/jb/mvp173 · Cited by 2

A Modeling and Analysis Study Reveals That CaMKII in Synaptic Plasticity Is a Dominant Affecter in CaM Systems in a T286 Phosphorylation-Dependent Manner

Stevens-Bullmore, H., Kulasiri, D., & Samarasinghe, S. (2022) · Molecules · doi:10.3390/molecules27185974 · Cited by 2

Investigating the Impact of Electrostatic Interactions on Calmodulin Binding and Ca2+-Dependent Activation of the Calcium-Gated Potassium SK4 Channel

Segura, É., Zhao, J., Broszczak, M., Audet, F., Sauvé, R., & Parent, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084255 · Cited by 1

Neurogranin modulates the rate of association between calmodulin and target peptides

Putkey, J. A., Hoffman, L., Berka, V., & Wang, X. (2024) · Biophysical Journal · doi:10.1016/j.bpj.2024.05.010 · Cited by 1

Interaction between SK channel calmodulin binding domain and calmodulin

Lee, C. W. (2006) · doi:10.6083/m4qn651p · Cited by 1

A basic model of calcium homeostasis in non-excitable cellsPreprint

Selstø, C. H., & Ruoff, P. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.28.522077 · Cited by 1

Sensory pathways of muscle phenotypic plasticity: calcium signalling through CaMKII

Eilers, W. (2026) · e-space (Manchester Metropolitan University) · doi:10.83056/mmu.32434605

Microstructure-Based Monte Carlo Simulation of Ca2+ Dynamics Evoking Cardiac Calcium Channel Inactivation

Kawazu, T., Murakami, S., Adachi‐Akahane, S., Findlay, I., Ait‐Haddou, R., Kurachi, Y., & Nomura, T. (2008) · The Journal of Physiological Sciences · doi:10.2170/physiolsci.rp013208

Calmodulin as a universal regulator of voltage gated calcium channels

Taiakina, V. (2014) · UWSpace (University of Waterloo) · doi:10.13140/rg.2.1.3945.7685

Investigation of the effect mutations of CaM have upon in vitro and ex vivo function

Israel, O. (2010) · UWSpace (University of Waterloo)

Original Contribution Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells

Chen, K., & Popel, A. S. (2006)

Calmodulin

Yap, K. L., & Ikura, M. (2004) · Handbook of Metalloproteins · doi:10.1002/0470028637.met039

Calmodulin

Yap, K. L., & Ikura, M. (2004) · Encyclopedia of Inorganic and Bioinorganic Chemistry · doi:10.1002/9781119951438.eibc0504

A perilysosomal feedforward mechanism regulates starvation‐induced calcium signaling

Giles, J. R., Sesker, A., González, M., Ferow, A., McConnaha, E., & Tran, Q. (2026) · FEBS Journal · doi:10.1111/febs.70406

Inhibition du canal SK3 et du développement de métastases par un ether-lipide synthétique

Girault, A. (2011) · doi:10.70675/d72b49c7z791az4444z86c7zdb6556c6d9cd

Modulating Calcium Signaling by Protein Design and Analysis of Calcium Binding Proteins

Zhuo, Y. (2022) · Digital Archive @ GSU · doi:10.57709/4865017

Calmodulin, A Limiting Component

(2003) · Science Signaling · doi:10.1126/scisignal.1902003tw263

Calmodulin in the regulation of intracellular calcium.

Vincenzi, F. F. (1979) · PubMed · Cited by 11

Calmodulin: its role in calcium-mediated cellular regulation.

Oldham, S. B. (1982) · PubMed · Cited by 13

Pharmacological regulation of calmodulin's activity

Gietzen, K. (1984) · Cell Calcium · doi:10.1016/0143-4160(84)90071-x

Calmodulin

(2008) · Springer eBooks · doi:10.1007/978-3-540-38918-7_5329