The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Scavenger Receptors that Recognize Advanced Glycation End Products
Abstract
Scavenger receptors recognize modified low-density lipoproteins (LDLs) such as acetylated LDL and oxidized LDL. Advanced glycation end products (AGE), which are generated through long-term exposure of proteins to glucose, also behave as active ligands for some scavenger receptors, including class A scavenger receptor (SR-A) and class B scavenger receptors such as CD36 and scavenger receptor, class B, type I (SR-BI). SR-BI, the first identified high-density lipoprotein (HDL) receptor, plays key roles in reverse cholesterol transport by promoting selective uptake of cholesteryl esters (CE) in HDL by hepatocytes, and cholesterol efflux of unesterified cholesterol from peripheral cells to HDL. Using Chinese hamster ovary cells overexpressing SR-BI (CHO-SR-BI cells), it was demonstrated that AGE-bovine serum albumin binds to SR-BI and inhibits selective uptake of HDL-CE by CHO-SR-BI cells as well as cholesterol efflux from CHO-SR-BI cells to HDL, suggesting potential roles of AGE in diabetic dyslipidemia and accelerated atherosclerosis in diabetes.
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“These AGE cell surface receptors include AGE-R1, AGE-R2, AGE-R3, and scavenger receptors such as macrophage scavenger receptors, scavenger receptor class B type I and II (SR-BI, SR-BII), and cluster of differentiation 36 (CD36).”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [45]
In the citing paper
“The interaction of AGEs with these receptors can enhance their catabolism and clearance by modulating endocytosis and degradation45,46, suggesting a potentially adaptive defensive mechanism in the body to reduce the detrimental effects of increased glycation products.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [45]
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Diabetes and advanced glycation endproducts
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Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies
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Metadata
- Authors
- Miyazaki, A.
- Affiliations
- Kumamoto University (JP)
- Corresponding author
- Miyazaki, A
- ORCID
- Miyazaki, A
- Venue
- Trends in Cardiovascular Medicine
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 12
- Issue
- 6
- Pages
- 258-262
- ISSN
- 1050-1738 (ISSN-L)
- OpenAlex
- W2130961250
- Cited by
- 113
- References
- 37
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 8 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 4
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cardiovascular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- advanced glycation end products, scavenger receptors, scavenger receptor class B type I, scavenger receptor A, CD36, modified low-density lipoprotein, high-density lipoprotein, reverse cholesterol transport, cholesteryl ester uptake, cholesterol efflux, diabetic dyslipidemia, atherosclerosis
- MeSH terms
- Animals, Disease Models, Animal, Cricetinae, Humans, Hyperlipidemias, Membrane Proteins, Receptors, Immunologic, Glycation End Products, Advanced, Receptors, Lipoprotein, CD36 Antigens, Receptors, Scavenger, Scavenger Receptors, Class A, Scavenger Receptors, Class B, In Vitro Techniques
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