Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.

Baynes, J W; Thorpe, S R

doi:10.2337/diabetes.48.1.1

Cited by 2,441Advanced Glycation End Products researchAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.

Baynes, J W, Thorpe, S R·1999·Diabetes

DOI 10.2337/diabetes.48.1.1

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Abstract

Oxidative stress and oxidative damage to tissues are common end points of chronic diseases, such as atherosclerosis, diabetes, and rheumatoid arthritis. The question addressed in this review is whether increased oxidative stress has a primary role in the pathogenesis of diabetic complications or whether it is a secondary indicator of end-stage tissue damage in diabetes. The increase in glycoxidation and lipoxidation products in plasma and tissue proteins suggests that oxidative stress is increased in diabetes. However, some of these products, such as 3-deoxyglucosone adducts to lysine and arginine residues, are formed independent of oxidation chemistry. Elevated levels of oxidizable substrates may also explain the increase in glycoxidation and lipoxidation products in tissue proteins, without the necessity of invoking an increase in oxidative stress. Further, age-adjusted levels of oxidized amino acids, a more direct indicator of oxidative stress, are not increased in skin collagen in diabetes. We propose that the increased chemical modification of proteins by carbohydrates and lipids in diabetes is the result of overload on metabolic pathways involved in detoxification of reactive carbonyl species, leading to a general increase in steady-state levels of reactive carbonyl compounds formed by both oxidative and nonoxidative reactions. The increase in glycoxidation and lipoxidation of tissue proteins in diabetes may therefore be viewed as the result of increased carbonyl stress. The distinction between oxidative and carbonyl stress is discussed along with the therapeutic implications of this difference.

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Arachidonic acid in granulocytes is not associated with CRP concentration.
“There was no association between arachidonic acid in granulocytes and CRP concentration (374)”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [374]
EPA or DHA concentration in granulocyte membranes is inversely associated with CRP concentration; the effect of DHA is stronger than that of EPA.
“The concentration of either EPA or DHA in granulocyte membranes was inversely associated with CRP concentration in one study (374) ; the effect of DHA was stronger than that of EPA.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [374]
Alpha-linolenic acid concentration in blood lipids or granulocytes is not associated with CRP or IL-6 concentration.
“The concentration of a-linolenic acid in blood lipids (578,579,582) or granulocytes (374) was not associated with CRP or IL-6 concentration.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [374]

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Authors: Baynes, J. W., & Thorpe, S. R.
Affiliations: University of South Carolina (US)
Venue: Diabetes
Publisher: American Diabetes Association
Published: 1999-01-01
Volume: 48
Issue: 1
Pages: 1-9
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.48.1.1
OpenAlex: W2124098523
Cited by: 2,441
References: 48
Citations by year: 2026: 16 · 2025: 24 · 2024: 29 · 2023: 36 · 2022: 61 · 2021: 63 · 2020: 59 · 2019: 70 · 2018: 97 · 2017: 96 · 2016: 94 · 2015: 104 · 2014: 143 · 2013: 145 · 2012: 116
FWCI: 56.44
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG-25272)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-19971)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: oxidative stress, diabetes complications, glycoxidation, lipid oxidation, carbonyl stress, advanced glycation end products, skin collagen, reactive carbonyl compounds, protein oxidation, diabetes pathogenesis
MeSH terms: Animals, Humans, Models, Biological, Oxidative Stress, Diabetes Complications

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Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.

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