Myocardial hypertrophy and enhanced left ventricular contractility in Zucker diabetic fatty rats
Abstract
Heart failure is known to be a complication of insulin-dependent (IDDM) and noninsulin-dependent diabetes mellitus (NIDDM) even in the absence of coronary heart disease or hypertension. The mechanisms leading to diabetic cardiomyopathy are unknown. The aim of the study was to characterize structural and functional alterations in hyperinsulinemic Zucker diabetic fatty (ZDF) rats treated with or without insulin. Diabetic animals showed a twofold increase in cardiomyocyte volume with increased left ventricular ANP but not BNP mRNA levels in spite of a reduced plasma renin activity (PRA) 2 months after onset of diabetes compared to nondiabetic littermates. These changes were associated with an increase in left ventricular performance as assessed by echocardiography. Insulin treatment led to a significant increase in body weight (BW), total heart weight, myocardial protein content, and left ventricular mass (LVM). Perivascular fibrosis and laminin thickness were significantly augmented in diabetic rat myocardium irrespective of insulin treatment, whereas interstitial collagen I and fibronectin were similarly found in diabetic and control myocardium. Initial stages of diabetic cardiomyopathy in hyperinsulinemic rats are characterized by cardiomyocyte hypertrophy and enhanced cardiac contractility. It is suggested that hyperinsulinemia may be involved in cardiac hypertrophy.
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In genetically obese Zucker fatty rats, LVH is present in young animals shortly after the development of diabetes, associated with increased LV function by echocardiography; they eventually develop significant LV dysfunction in vivo as evidenced by decreased fractional shortening, which can be reversed with TZD treatment.
“In genetically obese Zucker fatty rats, LVH is present in young animals shortly after the development of diabetes. This is associated with increased LV function by echocardiography (104); however, they eventually develop significant LV dysfunction in vivo as evidenced by decreased fractional shortening. This can be reversed with TZD treatment (394).”
From Cardiac remodeling in obesity (2008) · cites this paper as [104]
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“∼ [2 7] ↑ [1 0, 28 ] ↑ [1 2, 30 ] ↑ [1 3] ↑ [3 2]”
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ResultCardiovascular Consequences of Sleep Apnea
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“The inbred obese ZDF rats, that carry the Lepr mutation, develop non-insulin-dependent diabetes and progressive renal disease in association with cardiac abnormalities (4, 23), which renders ZDF rats a suitable model for studying renal and cardiovascular alterations in type 2 diabetes.”
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“One study even reported enhanced LV contractility in ZDF rats.(12) Collectively, these experimental data illustrate the lack of consensus about the nature and severity of the disturbances in cardiac performance in this animal model of type 2 DM.”
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Effects of exercise training on cardiac apoptosis in obese rats
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“Augmented perivascular fibrosis and laminin thickness have been observed in the myocardium by others too.(23,24) In the persistent severely diabetic Ob-ZSF1 rats we observed widespread necrosis similar to that reported in diabetic patients.”
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“Other studies with ZDF rats have reported both no differences in blood pressures as well as increased blood pressure compared to lean controls, seemingly depending on the age of the animals at the moment of study and the method employed [40-42].”
BackgroundMore Activated Cardiac Mitochondrial‐dependent Apoptotic Pathway in Obese Zucker Rats
Lu, M., Tzang, B., Kuo, W., Wu, F., Chen, Y.-S., Tsai, C., Huang, C., & Lee, S. (2007) · Obesity · doi:10.1038/oby.2007.315 · Cited by 47 · see citing works
“Introduction The obese Zucker rat, a genetic model of severe obesity, presents many of the same cardiopulmonary deficits as noted in obese humans, including respiratory control dysfunction (1–4), chest wall limitations (5), upper airway narrowing (6), hypertension (7), myocardial hypertrophy (8), and poor exercise cap…”
BackgroundPovlsen, J. A., Løfgren, B., Dalgas, C., Birkler, R. I. D., Johannsen, M., Støttrup, N. B., & Bøtker, H. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064093 · Cited by 45 · see citing works
“In addition to hyperlipidemia and hypercholesterolemia, ZDF rats develop several obesity- and hyperglycemia-related complications including arterial hypertension, cardiomyopathy, cardiac hypertrophy and nephropathy [29,30].”
BackgroundBaynes, J., & Murray, D. B. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.5.9831 · Cited by 45 · see citing works
“On the other hand, work by Fredersdorf et al.23 investigating insulin’s affect on myocardial morphology and function in non insulin dependent diabetes concluded that at 19 weeks of age the ZDF rat exhibited LV hypertrophy and enhanced contractility as assessed by echocardiography.”
MethodResultInfluentialRiojas-Hernández, A., Bernal‐Ramírez, J., Rodríguez-Mier, D., Morales, E., Domínguez-Barragán, E. M., Borja-Villa, C., Rivera-Álvarez, I., García‐Rivas, G., Altamirano, J., & Garcı́a, N. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.09.018 · Cited by 43 · see citing works
“ac damage have been described as a consequence of enhanced intracellular lipid accumulation, due to increased transport of long-chain fatty acids [30], accompanied by an increase in NADPH oxidase activity, and the parallel increase in pro-apoptotic proteins [20,22].”
BackgroundCardiac Fas Receptor‐dependent Apoptotic Pathway in Obese Zucker Rats
Lee, S., Tzang, B., Kuo, W., Lin, Y., Yang, A., Chen, S. H., Tsai, F., Wu, F., Lu, M., & Huang, C. (2007) · Obesity · doi:10.1038/oby.2007.286 · Cited by 42 · see citing works
“Introduction The obese Zucker rat, a genetic model of severe obesity, presents with many of the same cardiopulmonary deficits as noted in obese humans, including respiratory control dysfunction (1–3), chest wall limitations (4), upper airway narrowing (5), hypertension (6), myocardial hypertrophy (7), and poor exercis…”
BackgroundSchäfer, S., Huber, J., Wihler, C., Rütten, H., Busch, A. E., & Linz, W. (2005) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2005.04.011 · Cited by 43 · see citing works
“Earlier reports describing reduced myocardial systolic function in Zucker diabetic fatty [13] and Goto-Kakizaki rats [14] could not be reproduced by another group [15].”
BackgroundHuang, T. H.-W., He, L., Qin, Q., Yang, Q., Peng, G., Harada, M., Qi, Y., YAMAHARA, J., Roufogalis, B. D., & Li, Y. J. (2007) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2007.00750.x · Cited by 39 · see citing works
Engineered Heart Tissue Model of Diabetic Myocardium
Song, H., Zandstra, P. W., & Radisic, M. (2011) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0617 · Cited by 37 · see citing works
“These rats result from the breeding between SHHF rats and ZDF rats.”
InfluentialOkere, I. C., Chandler, M. P., McElfresh, T. A., Rennison, J. H., Kung, T. A., Hoit, B. D., Ernsberger, P. R., Young, M. E., & Stanley, W. C. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04545.x · Cited by 36 · see citing works
Hodrea, J., Saeed, A., Molnár, Á., Fintha, A., Bárczi, A., Wagner, L. J., Szabo, A. J., Fekete, A., & Balogh, D. B. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263285 · Cited by 35 · see citing works
Howarth, F. C., Qureshi, M. A., Hassan, Z. A., Isaev, D. S., Parekh, K., John, A., Öz, M., Raza, H., Adeghate, E. A., & Adrian, T. E. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-1112-y · Cited by 34 · see citing works
“Increased ejection fraction and fractional shortening and increased myocyte volume have been reported in 19-week ZDF rats [28].”
BackgroundRadovits, T., Korkmaz, S., Mátyás, C., Oláh, A., Németh, B. T., Páli, S., Hirschberg, K., Zubarevich, A., Gwanmesia, P., Li, S., et al. (2015) · Journal of Diabetes Research · doi:10.1155/2015/728741 · Cited by 31 · see citing works
“reported no myocardial collagen deposition in ZDF diabetic animals at 14 weeks of age [27]; other studies demonstrated only perivascular but not interstitial myocardial fibrosis [24] at the age of 19 weeks, while a robust fibrotic remodelling of the left ventricle has been described in 45-week-old ZDF rats [28].”
BackgroundResultGarcia, J. A. D., dos Santos, L., de Moura, A. L., Ricardo, K. F. S., Wanschel, A. C. B. A., Shishido, S. M., Spadari-Bratfisch, R. C., de Souza, H. P., & Krieger, M. H. (2008) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31815c39d4 · Cited by 30 · see citing works
Baldi, J. C., Wilson, G. A., Wilson, L. C., WILKINS, G. T., & Lamberts, R. R. (2016) · Sports Medicine · doi:10.1007/s40279-016-0542-9 · Cited by 29 · see citing works
Vasopeptidase inhibition has beneficial cardiac effects in spontaneously diabetic Goto–Kakizaki rats
Grönholm, T., Cheng, Z. J., Palojoki, E., Eriksson, A., Bäcklund, T., Vuolteenaho, O. J., Finckenberg, P., Laine, M., Mervaala, E. M. A., & Tikkanen, I. T. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.07.015 · Cited by 29 · see citing works
“Also in another diabetic rat model, the Zucker diabetic fatty rat, the expression of ANP mRNA was increased, probably due to hyperglycemia-induced volume expansion (Fredersdorf et al., 2004).”
BackgroundPulmonary arterial dysfunction in insulin resistant obese Zucker rats
Moral‐Sanz, J., Menéndez, C., Moreno, L., Moreno, E., Cogolludo, A. L., & Pérez‐Vizcaíno, F. (2011) · Respiratory Research · doi:10.1186/1465-9921-12-51 · Cited by 29 · see citing works
“For this purpose we have used a well established genetic model of obesity and insulin resistance, the obese Zucker rat, characterized by a missense mutation in the leptin receptor [28] and associated with several cardiovascular complications [22,29].”
MethodFernandes, T. M., Casaes, L., Soci, Ú. P. R., Silveira, A. C., Gomes, J. L. P., Barretti, D. L. M., Roque, F. R., & de Oliveira, E. M. (2018) · Obesity Facts · doi:10.1159/000454835 · Cited by 28 · see citing works
Sex, sex steroids, and diabetic cardiomyopathy: making the case for experimental focus
Reichelt, M. E., Mellor, K. M., Bell, J. R., Chandramouli, C., Headrick, J. P., & Delbridge, L. M. D. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00141.2013 · Cited by 24 · see citing works
Obesity and sudden cardiac death: Prevalence, pathogenesis, prevention and intervention
Yao, Y., Jia, X., & Li, B. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1044923 · Cited by 25 · see citing works
“Obese hyperinsulinemic Zucker rats also showed perivascular cardiac fibrosis, associated with increased left ventricular mass and cardiac hypertrophy (Fredersdorf et al., 2004).”
BackgroundInducible nitric oxide synthase depresses cardiac contractile function in Zucker diabetic fatty rats
Song, D., Kuo, K., Yao, R., Hutchings, S., & Pang, C. C. Y. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.09.043 · Cited by 21 · see citing works
“, 2000) or increased (Fredersdorf et al., 2004) baseline”
BackgroundContractile Smooth Muscle and Active Stress Generation in Porcine Common Carotids
Zhou, B., Prim, D. A., Romito, E. A., McNamara, L. P., Spinale, F. G., Shazly, T. M., & Eberth, J. F. (2017) · Journal of Biomechanical Engineering · doi:10.1115/1.4037949 · Cited by 20 · see citing works
The coexistence of nocturnal sustained hypoxia and obesity additively increases cardiac apoptosis
Lee, S., Kuo, W., Bau, D., Ko, F.-Y., Wu, F., Kuo, C., Tsai, F., Wang, P. S., Lu, M.-C., & Huang, C. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00152.2007 · Cited by 20 · see citing works
Cosson, E., Valensi, P. E., Laude, D., Mesangeau, D., & Dabiré, H. (2009) · Diabetes & Metabolism · doi:10.1016/j.diabet.2009.02.007 · Cited by 19 · see citing works
Yalçın, F., Shiota, M., Greenberg, N. L., Thomas, J. D., & Shiota, T. (2008) · Echocardiography · doi:10.1111/j.1540-8175.2007.00603.x · Cited by 19 · see citing works
Cardiac Hypertrophy-Related Pathways in Obesity
Chen, W.-K. (2014) · The Chinese Journal of Physiology · doi:10.4077/cjp.2014.bab146 · Cited by 18 · see citing works
“The obese Zucker rat, a genetic model of morbid obesity, presents many of the same cardiopulmonary deficits noted in obese humans including respiratory control dysfunction (24, 25, 27), chest wall limitations (12), upper airway narrowing (34), hypertension (2), myocardial hypertrophy (13), cardiac apoptosis (29, 30) a…”
BackgroundSeldin, M. M., Kim, E. D., Romay, M. C., Li, S., Rau, C. D., Wang, J., Krishnan, K. C., Wang, Y., Deb, A., & Lusis, A. J. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00068.2016 · Cited by 18 · see citing works
van Lunteren, E., & Moyer, M. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00191.2007 · Cited by 18 · see citing works
“Atrial natriuretic peptide levels are increased in the plasma as well as heart atrium and ventricle of streptozotocin-diabetic rats (25), and gene expression is increased in the heart left ventricle of Zucker diabetic fatty rats (17).”
BackgroundIn vivo creatine kinase reaction kinetics at rest and stress in type II diabetic rat heart
Bashir, A., Coggan, A. R., & Gropler, R. J. (2015) · Physiological Reports · doi:10.14814/phy2.12248 · Cited by 17 · see citing works
“Previous studies have reported enhanced, similar, and reduction in heart function in ZDF rats (Fredersdorf et al. 2004; van den Brom et al. 2010; Daniels et al. 2012).”
ResultFibronectin increases the force production of mouse papillary muscles via α5β1 integrin
Wu, X. Y., Chakraborty, S., Heaps, C. L., Davis, M. J., Meininger, G. A., & Muthuchamy, M. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.10.003 · Cited by 17 · see citing works
“An imbalance in the production and the degradation of ECM proteinsmay lead to structural alterations such as basement membrane thickening and ECM protein deposition in tissues during the development of cardiovascular diseases [22,26,42,47–59].”
BackgroundResch, M., Schmid, P., Amann, K., Fredersdorf, S., Weil, J., Schach, C., Birner, C. M., Griese, D. P., Kreuzer, P. M., Brunner, S., et al. (2011) · Cardiovascular Diabetology · doi:10.1186/1475-2840-10-94 · Cited by 16 · see citing works
“We previously reported a state of hyporeninemic hyperaldosteronism in a model of type II diabetes mellitus, the Zucker Diabetic Fatty ZDF-rat [17].”
BackgroundResultSelf-citationColton, H. M., Stokes, A. H., Yoon, L. W., Quaile, M. P., Novak, P. J., Falls, J. G., Kimbrough, C. L., Cariello, N. F., Jordan, H. L., & Berridge, B. R. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr003 · Cited by 16 · see citing works
“ANP and BNP are synthesized and stored as full-length prohormones and, on secretion, are cleaved to yield equimolar amounts of N-terminal proNP (NT-proNP) and the active NP hormone.”
BackgroundInfluentialSong, D., Yao, R., & Pang, C. C. Y. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.06.036 · Cited by 16 · see citing works
“TheZDFrats, at 18weeksof age, havebeenshown tohave unchanged systolic blood pressure and decreased heart rate (Fredersdorf et al., 2004).”
BackgroundmTORC1 inhibitors rapamycin and metformin affect cardiovascular markers differentially in ZDF rats
Nistala, R., Raja, A., & Pulakat, L. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2016-0567 · Cited by 15 · see citing works
Hubesch, G., Hanthazi, A., Acheampong, A., Chomette, L., Lasolle, H., Hupkens, E., Jespers, P., Vegh, G., Wembonyama, C. W. M., Verhoeven, C., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.809885 · Cited by 15 · see citing works
“Additionally, obesity was mostly experimentally induced with specific genetic manipulations targeting the leptin signaling (58, 59, 62, 63).”
BackgroundResch, M., Bergler, T., Fredersdorf, S., Griese, D. P., Weil, J., Kreuzer, P. M., Brunner, S., Riegger, G. A. J., Luchner, A., & Endemann, D. (2010) · Hypertension Research · doi:10.1038/hr.2010.132 · Cited by 15 · see citing works
Self-citationOtani, K., Funada, H., Teranishi, R., Okada, M., & Yamawaki, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084228 · Cited by 14 · see citing works
“Another report demonstrated in ZDF rats that fractional shortening and EF were rather increased with the existence of cardiomyocyte hypertrophy at 19 weeks old, indicating that the cardiac dysfunction was not obvious [28].”
BackgroundHaley, J. M., Thackeray, J. T., Thorn, S., & DaSilva, J. N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127581 · Cited by 13 · see citing works
“Similar contradictions exist in assessing systolic function in ZDF rats, with reports showing reduced %EF by 14 weeks [20,27], while others indicate normal systolic function in 44 week old ZDF [41] or even increased function in 19 week ZDF animals [42].”
BackgroundVasopeptidase inhibition attenuates proteinuria and podocyte injury in Zucker diabetic fatty rats
Fredersdorf, S., Weil, J., Ulucan, C., Birner, C. M., Büttner, R., Schubert, T. E. O., Böger, C. A., Debl, K., Muders, F., Riegger, G. A. J., et al. (2007) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-007-0147-9 · Cited by 11 · see citing works
“In addition, our group has observed additional cardiac adaptations with enhanced cardiac contractility, myocardial hypertrophy and perivascular fibrosis during early stages of diabetes mellitus (Fredersdorf et al. 2002, 2004).”
MethodSelf-citationShushakova, N., Park, J. K., Menne, J., & Fliser, D. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2009.02165.x · Cited by 9 · see citing works
Cook, R. F., Bussey, C. T., Mellor, K. M., Cragg, P. A., & Lamberts, R. R. (2017) · Experimental Physiology · doi:10.1113/ep086293 · Cited by 9 · see citing works
“β-Adrenergic receptor subtype regulation of resting HR in diabetes In this study, we derived a calculated conscious HR from the direct recording of ABP and showed that resting HR is reduced by 17% in diabetic rats compared with non-diabetic rats, as also described by others (Fredersdorf et al. 2004; Thaung et al. 2015…”
ResultRussell, J. C., & Proctor, S. D. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707226 · Cited by 9 · see citing works
“…and inflammatory British Journal of Pharmacology (2007) 151 216–225 processes (Fasshause et al., 2004) with lower plasma concentrations reported in both obese humans and some rodent models of obesity/insulin resistance (Altomonte et al., 2003; Alemzadeh and Tushaus, 2004; Fredersdorf et al., 2004).”
BackgroundDebin, R., Lauzier, B., Sicard, P., Delemasure, S., Amoureux, S., Duvillard, L., Vergely, C., Cottin, Y., & Rochette, L. (2009) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2008.00659.x · Cited by 8 · see citing works
Furumoto, T., Fujii, S., Onozuka, H., Zaman, A. K. M. T., Goto, D., Sugawara, T., Mikami, T., Watanabe, S., Abe, K., Terauchi, Y., et al. (2005) · Coronary Artery Disease · doi:10.1097/00019501-200503000-00007 · Cited by 6 · see citing works
Kamada, K., Saku, K., Tohyama, T., Kawada, T., Mannoji, H., Abe, K., Nishikawa, T., Sunagawa, G., Kishi, T., Sunagawa, K., et al. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00515.2018 · Cited by 6 · see citing works
Shmygol, A., Bru‐Mercier, G., Sultan, A. S., & Howarth, F. C. (2024) · Clinical Science · doi:10.1042/cs20242144 · Cited by 5 · see citing works
Chen, J., Wang, H., Chang, W., Jao, C.-C., Wu, B., Shyu, W., & Lee, S. (2010) · Hypertension Research · doi:10.1038/hr.2010.109 · Cited by 5 · see citing works
The effect of non-insulin dependent diabetes mellitus on uncontrolled hemorrhage in a rodent model
Sinert, R. H., Finkelstein, D., Pius, M., Baron, B. J., Adar, E., Rizzo, P., & Shahidi, H. (2005) · Resuscitation · doi:10.1016/j.resuscitation.2004.12.026 · Cited by 5 · see citing works
Sun, G., Zhang, G., Jackson, C. V., & Wang, Y. (2018) · Cardiology Research and Cardiovascular Medicine · doi:10.29011/2575-7083.000033 · Cited by 4 · see citing works
Howarth, F. C., Qureshi, M. A., Hassan, Z. A., Kury, L. A., Isaev, D. S., Parekh, K. A., Yammahi, S. R. R. K. D., John, A., Öz, M., Raza, H., et al. (2012) · Hamdan Medical Journal · doi:10.7707/hmj.v5i2.140 · Cited by 4 · see citing works
Zimering, M. B. (2021) · doi:10.31038/edmj.2021523 · Cited by 3 · see citing works
“Chronic hypertension is a significant risk factor for the later occurrence of adverse cerebrovascular, cardiovascular and renal outcomes in humans [20-22].”
BackgroundChronic Diabetic Complications: Endothelial Cells at the Frontline
Khan, Z. A., & Chakrabarti, S. (2010) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/978160805160111001010121 · Cited by 3 · see citing works
Wingard, M. C., Dalal, S., Shook, P. L., Ramirez, P. R., Raza, M. U., Johnson, P. M., Connelly, B. A., Thewke, D. P., Singh, M., & Singh, K. (2022) · Physiological Reports · doi:10.14814/phy2.15434 · Cited by 2 · see citing works
Biomarkers of Myocardial Fibrosis in Diabetes, Echocardiography, and Magnetic Resonance Imaging
Madsen, P. L. (2022) · Biomarkers in disease · doi:10.1007/978-3-030-81303-1_45-1 · Cited by 2 · see citing works
Clinical Applications in Extra-Cardiac Diseases
Clerico, A., Passino, C., & Emdin, M. (2007) · Springer eBooks · doi:10.1007/88-470-0498-5_6 · Cited by 2 · see citing works
Sager, H. B., Ergün, S., Hartmann, A., Hoffmann, U., Krämer, B. K., Mihatsch, M. J., & Weil, J. (2009) · Transplantation Proceedings · doi:10.1016/j.transproceed.2009.03.059 · Cited by 2 · see citing works
Self-citationZahradnı́ková, A., Ijaz, H., & Cagalinec, M. (2026) · Endocrine Regulations · doi:10.2478/enr-2026-0012 · Cited by 1 · see citing works
“In contrast, at the age of 19 weeks, Fredersdorf et al. (2004) have reported increased left ventricular myocyte volume from the immunohistological tissue morphology analysis.”
Kumar, C. U., Reddy, S. S., & Reddy, G. B. (2022) · Proceedings of the National Academy of Sciences India Section B Biological Sciences · doi:10.1007/s40011-021-01305-3 · Cited by 1 · see citing works
“Hyperinsulinemic obese Zucker rats also show cardiac hypertrophy along with fibrosis [28].”
BackgroundMorphological quantification of myocardial pathology in the Zucker diabetic fatty rat
Abuderman, A. (2016) · New Trends and Issues Proceedings on Advances Pure and Applied Sciences · doi:10.18844/gjpaas.v0i7.3181 · Cited by 1 · see citing works
“Quantitative immunohistochemistry of areas positive for fibronectin and collagen I showed no increase in interstitial collagen I or fibronectin [15].”
BackgroundArranjo estrutural das fibras de colágeno do coração de cães normais e diabéticos
Benedicto, H. G. (2005) · doi:10.11606/t.10.2005.tde-06062007-160152 · Cited by 1 · see citing works
Diabetic cardiomyopathy: phenotypes, mechanisms, and therapeutic targets
Johnson, E. J. (2015) · Research Exchange (Washington State University) · Cited by 1 · see citing works
Song, D. (2008) · cIRcle (University of British Columbia) · doi:10.14288/1.0066398
“In vivo echocardiographic measurements have shown depressed (Zhou et al., 2000) or increased (Fredersdorf et al., 2004) baseline cardiac contractile function of 19-20 week old Zucker diabetic fatty (ZDF) rats, an animal model of type 2 diabetes.”
Role of cardiac FoxO1 in conditions of insulin resistance, nutrient excess, and diabetes
Puthanveetil, P. (2012) · cIRcle (University of British Columbia) · doi:10.14288/1.0072615
- Authors
- Fredersdorf, S., Thumann, C., Ulucan, C., Griese, D. P., Luchner, A., Riegger, G. A. J., Kromer, E. P., & Weil, J.
- Affiliations
- University Hospital Regensburg (DE)
- Corresponding author
- Weil, Joachim
- Venue
- Cardiovascular Pathology
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 13
- Issue
- 1
- Pages
- 11-19
- ISSN
- 1054-8807 (ISSN-L)
- OpenAlex
- W2165355897
- Cited by
- 115
- References
- 46
- Citations by year
- 2026: 5 · 2024: 2 · 2022: 9 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 8 · 2016: 2 · 2015: 8 · 2014: 5 · 2013: 5 · 2012: 7
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiovascular Pathology (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- Funders
- Universität Regensburg
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Keywords
- diabetic cardiomyopathy, cardiac hypertrophy, left ventricular contractility, hyperinsulinemia, insulin therapy, Zucker diabetic fatty rats, heart failure, atrial natriuretic peptide, brain natriuretic peptide, plasma renin activity, myocardial fibrosis, laminin, type I collagen, fibronectin, left ventricular mass, cardiomyocyte volume
- MeSH terms
- Animals, Diabetes Mellitus, Experimental, Echocardiography, Fibronectins, Fibrosis, Cardiomegaly, Heart Ventricles, Hyperinsulinism, Image Processing, Computer-Assisted, Immunohistochemistry, Insulin, Laminin, Male, Myocardial Contraction, Myocardium, Atrial Natriuretic Factor, Rats, Zucker, RNA, Messenger, Blotting, Northern, Ventricular Function, Collagen Type I, Rats
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