Leptin receptor missense mutation in the fatty Zucker rat
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Zucker rats are obese because of a loss-of-function mutation in the leptin receptor.
“Zucker rats are obese because of a loss-of-function mutation in the leptin receptor (49”
From Mitofusin-2 Determines Mitochondrial Network Architecture and Mitochondrial Metabolism (2003) · cites this paper as [49]
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- Authors
- Phillips, M. S., Liu, Q., Hammond, H. A., Dugan, V., Hey, P. J., Caskey, C. T., & Hess, J. F.
- Affiliations
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- ORCID
- Liu, Qingyun
- Venue
- Nature Genetics
- Published
- 1996-05
- Volume
- 13
- Issue
- 1
- Pages
- 18-19
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2154935464
- Cited by
- 822
- References
- 1
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 10 · 2023: 15 · 2022: 19 · 2021: 14 · 2020: 17 · 2019: 24 · 2018: 17 · 2017: 20 · 2016: 26 · 2015: 17 · 2014: 22 · 2013: 24 · 2012: 27
- FWCI
- 17.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin receptor, missense mutations, obesity, leptin resistance
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Carrier Proteins, Humans, Molecular Sequence Data, Mutation, Obesity, Rats, Zucker, Receptors, Cell Surface, Genetic Variation, Polymerase Chain Reaction, Consensus Sequence, Conserved Sequence, Sequence Homology, Amino Acid, DNA Primers, Receptors, Cytokine, Mice, Rats, Receptors, Leptin
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