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Cited by 115Cardiac Fibrosis and RemodelingCardiovascular Function and Risk FactorsCardiomyopathy and Myosin Studies

The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.

Myocardial hypertrophy and enhanced left ventricular contractility in Zucker diabetic fatty rats

Fredersdorf, Sabine, Thumann, Christian, Ulucan, Coskun, Griese, Daniel P., Luchner, Andreas, Riegger, Günter A.J., Kromer, Eckhard P., Weil, Joachim·2004·Cardiovascular Pathology
DOI 10.1016/s1054-8807(03)00109-1
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Abstract

Heart failure is known to be a complication of insulin-dependent (IDDM) and noninsulin-dependent diabetes mellitus (NIDDM) even in the absence of coronary heart disease or hypertension. The mechanisms leading to diabetic cardiomyopathy are unknown. The aim of the study was to characterize structural and functional alterations in hyperinsulinemic Zucker diabetic fatty (ZDF) rats treated with or without insulin. Diabetic animals showed a twofold increase in cardiomyocyte volume with increased left ventricular ANP but not BNP mRNA levels in spite of a reduced plasma renin activity (PRA) 2 months after onset of diabetes compared to nondiabetic littermates. These changes were associated with an increase in left ventricular performance as assessed by echocardiography. Insulin treatment led to a significant increase in body weight (BW), total heart weight, myocardial protein content, and left ventricular mass (LVM). Perivascular fibrosis and laminin thickness were significantly augmented in diabetic rat myocardium irrespective of insulin treatment, whereas interstitial collagen I and fibronectin were similarly found in diabetic and control myocardium. Initial stages of diabetic cardiomyopathy in hyperinsulinemic rats are characterized by cardiomyocyte hypertrophy and enhanced cardiac contractility. It is suggested that hyperinsulinemia may be involved in cardiac hypertrophy.

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Crossref · 10.1016/s1054-8807(03)00109-1

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Metadata

Authors
Fredersdorf, S., Thumann, C., Ulucan, C., Griese, D. P., Luchner, A., Riegger, G. A. J., Kromer, E. P., & Weil, J.
Affiliations
University Hospital Regensburg (DE)
Corresponding author
Weil, Joachim
ORCID
Venue
Cardiovascular Pathology
Publisher
Elsevier BV
Published
2004-01
Volume
13
Issue
1
Pages
11-19
ISSN
1054-8807 (ISSN-L)
DOI
10.1016/s1054-8807(03)00109-1
OpenAlex
W2165355897
Cited by
115
References
46
Citations by year
2026: 5 · 2024: 2 · 2022: 9 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 8 · 2016: 2 · 2015: 8 · 2014: 5 · 2013: 5 · 2012: 7
FWCI
3.92
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Cardiovascular Pathology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
Funders
  • Universität Regensburg
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Keywords
diabetic cardiomyopathy, cardiac hypertrophy, left ventricular contractility, hyperinsulinemia, insulin therapy, Zucker diabetic fatty rats, heart failure, atrial natriuretic peptide, brain natriuretic peptide, plasma renin activity, myocardial fibrosis, laminin, type I collagen, fibronectin, left ventricular mass, cardiomyocyte volume
MeSH terms
Animals, Diabetes Mellitus, Experimental, Echocardiography, Fibronectins, Fibrosis, Cardiomegaly, Heart Ventricles, Hyperinsulinism, Image Processing, Computer-Assisted, Immunohistochemistry, Insulin, Laminin, Male, Myocardial Contraction, Myocardium, Atrial Natriuretic Factor, Rats, Zucker, RNA, Messenger, Blotting, Northern, Ventricular Function, Collagen Type I, Rats

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