The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.
Myocardial hypertrophy and enhanced left ventricular contractility in Zucker diabetic fatty rats
Abstract
Heart failure is known to be a complication of insulin-dependent (IDDM) and noninsulin-dependent diabetes mellitus (NIDDM) even in the absence of coronary heart disease or hypertension. The mechanisms leading to diabetic cardiomyopathy are unknown. The aim of the study was to characterize structural and functional alterations in hyperinsulinemic Zucker diabetic fatty (ZDF) rats treated with or without insulin. Diabetic animals showed a twofold increase in cardiomyocyte volume with increased left ventricular ANP but not BNP mRNA levels in spite of a reduced plasma renin activity (PRA) 2 months after onset of diabetes compared to nondiabetic littermates. These changes were associated with an increase in left ventricular performance as assessed by echocardiography. Insulin treatment led to a significant increase in body weight (BW), total heart weight, myocardial protein content, and left ventricular mass (LVM). Perivascular fibrosis and laminin thickness were significantly augmented in diabetic rat myocardium irrespective of insulin treatment, whereas interstitial collagen I and fibronectin were similarly found in diabetic and control myocardium. Initial stages of diabetic cardiomyopathy in hyperinsulinemic rats are characterized by cardiomyocyte hypertrophy and enhanced cardiac contractility. It is suggested that hyperinsulinemia may be involved in cardiac hypertrophy.
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“In genetically obese Zucker fatty rats, LVH is present in young animals shortly after the development of diabetes. This is associated with increased LV function by echocardiography (104); however, they eventually develop significant LV dysfunction in vivo as evidenced by decreased fractional shortening. This can be reversed with TZD treatment (394).”
From Cardiac remodeling in obesity (2008) · cites this paper as [104]
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Cites
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Zucker Diabetic Fatty Rat as a Model for Non-insulin-dependent Diabetes Mellitus
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Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736
“echocardiography (104); however, they eventually de-”
Poornima, I. G., Parikh, P., & Shannon, R. P. (2006) · Circulation Research · doi:10.1161/01.res.0000207406.94146.c2 · Cited by 567
Russo, I., & Frangogiannis, N. G. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.12.011 · Cited by 487
Cavalera, M., Wang, J., & Frangogiannis, N. G. (2014) · Translational research · doi:10.1016/j.trsl.2014.05.001 · Cited by 269
“Obese hyperinsulinemic Zucker rats also develop perivascular cardiac fibrosis, associated with cardiac hypertrophy (23) and diastolic dysfunction (24).”
BackgroundTuleta, I., & Frangogiannis, N. G. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.166044 · Cited by 229
“• Zucker rats develop myocardial fibrosis [310], hepatic fibrosis accompanied by NASH [311], and renal fibrosis that may precede hyperglycemia [312].”
Background
Metadata
- Authors
- Fredersdorf, S., Thumann, C., Ulucan, C., Griese, D. P., Luchner, A., Riegger, G. A. J., Kromer, E. P., & Weil, J.
- Affiliations
- University Hospital Regensburg (DE)
- Corresponding author
- Weil, Joachim
- Venue
- Cardiovascular Pathology
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 13
- Issue
- 1
- Pages
- 11-19
- ISSN
- 1054-8807 (ISSN-L)
- OpenAlex
- W2165355897
- Cited by
- 115
- References
- 46
- Citations by year
- 2026: 5 · 2024: 2 · 2022: 9 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 8 · 2016: 2 · 2015: 8 · 2014: 5 · 2013: 5 · 2012: 7
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiovascular Pathology (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- Funders
- Universität Regensburg
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Keywords
- diabetic cardiomyopathy, cardiac hypertrophy, left ventricular contractility, hyperinsulinemia, insulin therapy, Zucker diabetic fatty rats, heart failure, atrial natriuretic peptide, brain natriuretic peptide, plasma renin activity, myocardial fibrosis, laminin, type I collagen, fibronectin, left ventricular mass, cardiomyocyte volume
- MeSH terms
- Animals, Diabetes Mellitus, Experimental, Echocardiography, Fibronectins, Fibrosis, Cardiomegaly, Heart Ventricles, Hyperinsulinism, Image Processing, Computer-Assisted, Immunohistochemistry, Insulin, Laminin, Male, Myocardial Contraction, Myocardium, Atrial Natriuretic Factor, Rats, Zucker, RNA, Messenger, Blotting, Northern, Ventricular Function, Collagen Type I, Rats
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