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Histological and Ultrastructural Features of Atherosclerosis in Progeria
Abstract
This histological and ultrastructural study of a limited amount of vascular tissue from a progeric woman of 20 years who died of traumatic subdural hemorrhage supports the belief that the vascular changes are atherosclerotic. The unusual features observed were collagen fibrils with a relatively small diameter in the atherosclerotic intima and media, extensive loss of mural smooth muscle cells particularly in the aorta, and widespread contraction bands in smooth muscle cells in vascular and nonvascular tissues. Smooth muscle cells appear to be unusually susceptible to hemodynamic and ischemic stress. Further autopsy studies are required to elucidate the etiology and pathogenesis of this unique disease.
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Cardiovascular alterations observed in HGPS and normal aging are manifested in LAKI mice and are thought to be a major contributor to their premature death.
“Cardiovascular alterations observed in patients with HGPS and during normal aging are also manifested in LAKI mice and are thought to be a major contributor to their premature death”
From In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. (2016) · cites this paper as Stehbens et al., 1999
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Metadata
- Authors
- Stehbens, W. E., Wakefield, S. J., Gilbert-Barness, E., Olson, R. E., & Ackerman, J.
- Venue
- Cardiovascular Pathology
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 8
- Issue
- 1
- Pages
- 29-39
- ISSN
- 1054-8807
- Cited by
- 117
- References
- 0
- Language
- en
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