Cited by 333Telomeres, Telomerase, and SenescenceDNA Repair MechanismsGenetics, Aging, and Longevity in Model Organisms

DNA damage and repair in telomeres: relation to aging

Open access
Kruk, P A, Rampino, N J, Bohr, V A·1995·Proceedings of the National Academy of Sciences

Abstract

We have established a method for the detection of DNA damage and its repair in human telomeres, the natural ends of chromosomes which are necessary for replication and critical for chromosomal stability. We find that ultraviolet light-induced pyrimidine dimers in telomeric DNA are repaired less efficiently than endogenous genes but more efficiently than inactive, noncoding regions. We have also measured telomeric length, telomeric DNA damage, and its repair in relation to the progression of aging. Telomeres are shorter in fibroblasts from an old donor compared to fibroblasts from a young donor, shortest in cells from a patient with the progeroid disorder Werner syndrome, and relatively long in fibroblasts from a patient with Alzheimer disease. Telomeric DNA repair efficiency is lower in cells from an old donor than in cells from a young donor, normal in Alzheimer cells, and slightly lower in Werner cells. It is possible that this decline in telomeric repair with aging is of functional significance to an age-related decline in genomic stability.

Integrity signals

Registry

Crossref · 10.1073/pnas.92.1.258

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kruk, P. A., Rampino, N. J., & Bohr, V. A.
Affiliations
National Institutes of Health (US)
Venue
Proceedings of the National Academy of Sciences
Published
1995-01-03
Volume
92
Issue
1
Pages
258-262
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2072908461
Cited by
333
References
35
Citations by year
2026: 4 · 2025: 5 · 2024: 9 · 2023: 9 · 2022: 17 · 2021: 11 · 2020: 5 · 2019: 10 · 2018: 3 · 2017: 13 · 2016: 8 · 2015: 8 · 2014: 10 · 2013: 3 · 2012: 12
FWCI
8.39
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
telomeres, DNA damage, DNA repair, aging, pyrimidine dimers, ultraviolet radiation, telomere length, Werner syndrome, progeroid disorder, Alzheimer's disease, fibroblasts, genome stability, chromosome stability
MeSH terms
Aged, Alzheimer Disease, Base Sequence, Cell Line, Child, DNA, DNA Damage, DNA Repair, Fibroblasts, Humans, Infant, Newborn, Kinetics, Molecular Sequence Data, Pyrimidine Dimers, Ultraviolet Rays, Werner Syndrome, Blotting, Southern, Restriction Mapping, Telomere

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review