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Cited by 141Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchMemory Processes and Influences

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Cholinergic modulation of the hippocampus during encoding and retrieval

Rogers, Jason L, Kesner, Raymond P·2003·Neurobiology of Learning and Memory
DOI 10.1016/s1074-7427(03)00063-7
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Abstract

The present experiments were aimed at determining whether acetylcholine (ACh) plays a role in encoding and retrieval of spatial information using a modified Hebb-Williams maze. In addition, the present experiments tested two computational models of hippocampal function during encoding and retrieval using a maze sensitive to hippocampal disruption. Thirty male, Long-Evans rats served as subjects. Chronic cannulae were implanted bilaterally into the CA3 (n=26) and CA1 (n=5) subregions of the hippocampus. Rats were tested using a modified Hebb-Williams maze. In the first experiment, rats were injected with either saline or scopolamine hydrobromide 10 min before testing for each day. The number of errors made per day per group was used as the measure of learning. Encoding was assessed by the average number of errors made on the first five trials of Day 1 compared to the last five trials of Day 1, whereas the average number of errors made on the first five trials of Day 2 compared to the last five trials of Day I was used to assess retrieval. No deficit was found for the saline group. The scopolamine group showed a deficit in encoding, but not retrieval. In the second experiment, rats were injected with either saline or physostigmine 10 min before testing each day. In contrast to the scopolamine groups, the physostigmine group showed a deficit in retrieval, but not encoding. To test whether the retrieval deficit was due to a disruption in storage or gaining access to the information two groups of rats received either saline on Day 1 and physostigmine on Day 2 or physostigmine on Day 1 and saline on Day 2. In addition, one group received physostigmine immediately after testing on Day 1. Data indicate that physostigmine causes a disruption of retrieval by means of a disruption in consolidation process. In conclusion, the cholinergic antagonist, scopolamine, disrupts encoding in both CA3 and CA1 subregions of the hippocampus. Furthermore, the cholinesterase inhibitor, physostigmine, boosts ACh action during a time when cholinergic levels need to decline for proper consolidation.

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Metadata

Authors
Rogers, J. L., & Kesner, R. P.
Affiliations
University of Utah (US)
Corresponding author
Kesner, Raymond P
Venue
Neurobiology of Learning and Memory
Publisher
Elsevier BV
Published
2003-11
Volume
80
Issue
3
Pages
332-342
ISSN
1074-7427 (ISSN-L)
DOI
10.1016/s1074-7427(03)00063-7
OpenAlex
W2077816975
Cited by
141
References
32
Citations by year
2026: 4 · 2025: 7 · 2024: 3 · 2023: 7 · 2022: 10 · 2021: 7 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 7 · 2012: 10
FWCI
2.61
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neurobiology of Learning and Memory (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • National Institutes of Health
  • National Institute of Mental Health (R1MH065314)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
acetylcholine, hippocampus, spatial learning, memory encoding, memory retrieval, scopolamine, physostigmine, cholinergic modulation, memory consolidation, CA3, CA1, Hebb-Williams maze, cholinesterase inhibitors, anticholinergic agents
MeSH terms
Animals, Cholinergic Fibers, Cholinesterase Inhibitors, Female, Hippocampus, Learning, Memory, Physostigmine, Scopolamine, Space Perception, Muscarinic Agonists, Rats, Long-Evans, Rats

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