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Differentiation of Phagocytic Monocytes into Lymph Node Dendritic Cells In Vivo
Open accessAbstract
We investigated the differentiation and trafficking of inflammatory monocytes that phagocytosed subcutaneously injected fluorescent microspheres. As expected, most of the monocytes became microsphere+ macrophages, which remained in subcutaneous tissue. However, about 25% of latex+ cells migrated to the T cell area of draining lymph nodes, where they expressed dendritic cell (DC)-restricted markers and high levels of costimulatory molecules. Microsphere-transporting cells were distinct from resident skin DCs, and this transport was reduced by more than 85% in monocyte-deficient osteopetrotic mice. Thus, a substantial minority of inflammatory monocytes carry phagocytosed particles to lymph nodes and differentiate into DCs.
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Citations
Cited by
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
“These cells then rapidly exit the bloodstream and develop into tissue macrophages or DC”
BackgroundMonocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,391
Monocyte recruitment during infection and inflammation
Shi, C., & Pamer, E. G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3070 · Cited by 3,015
Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309
Metadata
- Authors
- Randolph, G. J., Inaba, K., Robbiani, D. F., Steinman, R. M., & Muller, W. A.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1999-12
- Volume
- 11
- Issue
- 6
- Pages
- 753-761
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2088024377
- Cited by
- 900
- References
- 0
- FWCI
- 13.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Randolph, G. J., Inaba, K., Robbiani, D. F., Steinman, R. M., & Muller, W. A. (1999). Differentiation of Phagocytic Monocytes into Lymph Node Dendritic Cells In Vivo. Immunity. https://doi.org/10.1016/s1074-7613(00)80149-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
