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Comparison of Activation versus Induction of Unresponsiveness of Virus-Specific CD4+ and CD8+ T Cells upon Acute versus Persistent Viral Infection
Open accessAbstract
The functional status of CD4+ T cells during establishment of persistent infection with the noncytopathic lymphocytic choriomeningitis virus was assessed and compared to that of cytotoxic CD8+ T cells. Functionality of virus-specific CD4+ T cells was measured by proliferative responses, cytokine secretion, cognate help, and IFNgamma-mediated protection against challenge infection with recombinant vaccinia virus. Functional CD4+ T cells were induced early after infection and remained measurable up to 6 weeks but then were rendered unresponsive. In contrast, CD8+ T cells were functionally inactivated within 10-15 days. Importantly, functional inactivation of virus-specific CD4+ T cells during persistent viral infection seemed to be critical for the survival of the host.
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Citations
Cited by
Molecular and cellular insights into T cell exhaustion
Wherry, E. J., & Kurachi, M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3862 · Cited by 4,652
Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062
Schwartz, R. H. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141110 · Cited by 1,487
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
Darrah, P. A., Patel, D. T., De Luca, P. M., Lindsay, R. W. B., Davey, D. F., Flynn, B. J., Hoff, S. T., Andersen, P., Reed, S. G., Morris, S. L., et al. (2007) · Nature Medicine · doi:10.1038/nm1592 · Cited by 1,378
Ablation of CD8 and CD4 T Cell Responses by High Viral Loads
Fuller, M. J., & Zajac, A. J. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.1.477 · Cited by 276
Metadata
- Authors
- Oxenius, A., Zinkernagel, R. M., & Hengartner, H.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 9
- Issue
- 4
- Pages
- 449-457
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1969309166
- Cited by
- 162
- References
- 0
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Comparison of Activation versus Induction of Unresponsiveness of Virus-Specific CD4+ and CD8+ T Cells upon Acute versus Persistent Viral Infection. https://app.cochat.ai/papers/10.1016/s1074-7613(00)80628-7
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- Oxenius, A., Zinkernagel, R. M., & Hengartner, H. (1998). Comparison of Activation versus Induction of Unresponsiveness of Virus-Specific CD4+ and CD8+ T Cells upon Acute versus Persistent Viral Infection. Immunity. https://doi.org/10.1016/s1074-7613(00)80628-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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