The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Ablation of CD8 and CD4 T Cell Responses by High Viral Loads
Open accessAbstract
To evaluate the impact of sustained viral loads on anti-viral T cell responses we compared responses that cleared acute lymphocytic choriomeningitis virus infection with those that were elicited but could not resolve chronic infection. During acute infection, as replicating virus was cleared, CD8 T cell responses were down-regulated, and a pool of resting memory cells developed. In chronically infected hosts, the failure to control the infection was associated with pronounced and prolonged activation of virus-specific CD8 T cells. Nevertheless, there was a progressive diminution of their effector activities as their capacity to produce first IL-2, then TNF-α, and finally IFN-γ was lost. Chronic lymphocytic choriomeningitis virus infection was also associated with differential contraction of certain CD8 T cell responses, resulting in altered immunodominance. However, this altered immunodominance was not due to selective expansion of T cells expressing particular TCR Vβ segments during chronic infection. High viral loads were not only associated with the ablation of CD8 T cell responses, but also with impaired production of IL-2 by virus-specific CD4 T cells. Taken together, our data show that sustained exposure to high viral loads results in the progressive functional inactivation of virus-specific T cell responses, which may further promote virus persistence.
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Cited by
Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
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Human Effector and Memory CD8+ T Cell Responses to Smallpox and Yellow Fever Vaccines
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Shaping and reshaping CD8+ T-cell memory
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Baessler, A., & Vignali, D. A. A. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-090222-110914 · Cited by 420
Metadata
- Authors
- Fuller, M. J., & Zajac, A. J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-01-01
- Volume
- 170
- Issue
- 1
- Pages
- 477-486
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1602273859
- Cited by
- 276
- References
- 73
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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