Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166 · cited 1× · see citing works

Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis

Jänicke, R. U., Sprengart, M. L., Wati, M. R., & Porter, A. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.9357 · Cited by 1,955 · see citing works

Natural adjuvants: Endogenous activators of dendritic cells

Gallucci, S., Lolkema, M. P., & Matzinger, P. (1999) · Nature Medicine · doi:10.1038/15200 · Cited by 1,601 · see citing works

Corpse clearance defines the meaning of cell death

Savill, J., & Fadok, V. A. (2000) · Nature · doi:10.1038/35037722 · Cited by 1,535 · see citing works

A receptor for phosphatidylserine-specific clearance of apoptotic cells

Fadok, V. A., Bratton, D. L., Rose, D. M., Pearson, A. M., Ezekowitz, R. A. B., & Henson, P. M. (2000) · Nature · doi:10.1038/35011084 · Cited by 1,491 · see citing works

Consequences of Cell Death

Sauter, B., Albert, M. L., Francisco, L. M., Larsson, M., Somersan, S., & Bhardwaj, N. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.423 · Cited by 1,357 · see citing works

Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

Sebbagh, M., Renvoizé, C., Hamelin, J., Riché, N., Bertoglio, J., & Bréard, J. (2001) · Nature Cell Biology · doi:10.1038/35070019 · Cited by 915 · see citing works

Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2

Rudel, T., & Bokoch, G. (1997) · Science · doi:10.1126/science.276.5318.1571 · Cited by 748 · see citing works

CED-12/ELMO, a Novel Member of the CrkII/Dock180/Rac Pathway, Is Required for Phagocytosis and Cell Migration

Gumienny, T. L., Brugnera, E., Tosello-Trampont, A.-C., Kinchen, J. M., Haney, L. B., Nishiwaki, K., Walk, S. F., Nemergut, M. E., Macara, I. G., Francis, R., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00520-7 · Cited by 568 · see citing works

Extracellular ATP or ADP Induce Chemotaxis of Cultured Microglia through G_i/o-Coupled P2Y Receptors

Honda, S., Sasaki, Y., Ohsawa, K., Imai, Y., Nakamura, Y., Inoue, K., & Kohsaka, S. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-06-01975.2001 · Cited by 561 · see citing works

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

Fourcade, O. A., Simon, M., Viodé, C., Rugani, N., Balle, F. L., Ragab, A., Fournié, B., Sarda, L., & Chap, H. (1995) · Cell · doi:10.1016/0092-8674(95)90295-3 · Cited by 536 · see citing works

[22] Electrospray ionization mass spectrometry

Edmonds, C. G., & Smith, R. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)93430-s · Cited by 510 · see citing works

Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2

Street, I. P., Lin, H. K., Laliberté, F., Ghomashchi, F., Wang, Z., Perrier, H., Tremblay, N. M., Huang, Z., WEECH, P. K., & Gelb, M. H. (1993) · Biochemistry · doi:10.1021/bi00074a003 · Cited by 419 · see citing works

CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans

Reddien, P. W., & Horvitz, H. R. (2000) · Nature Cell Biology · doi:10.1038/35004000 · Cited by 414 · see citing works

Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment

Brown, S., Heinisch, I., Ross, E., Shaw, K., Buckley, C. D., & Savill, J. (2002) · Nature · doi:10.1038/nature00811 · Cited by 390 · see citing works

Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease

Rosen, A., & Casciola-Rosen, L. A. (1999) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400460 · Cited by 353 · see citing works

Distinct Roles in Signal Transduction for Each of the Phospholipase A2 Enzymes Present in P388D1 Macrophages

Balsinde, J., & Dennis, E. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.12.6758 · Cited by 353 · see citing works

I-PLA2 Activation during Apoptosis Promotes the Exposure of Membrane Lysophosphatidylcholine Leading to Binding by Natural Immunoglobulin M Antibodies and Complement Activation

Kim, S. J., Gershov, D., Ma, X., Brot, N., & Elkon, K. B. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020542 · Cited by 282 · see citing works

Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis

Engels, I. H., Stepczynska, A., Stroh, C., Lauber, K., Berg, C. P., Schwenzer, R., Wajant, H., Jänicke, R. U., Porter, A. G., Belka, C., et al. (2000) · Oncogene · doi:10.1038/sj.onc.1203824 · Cited by 253 · see citing works

Fas-induced Arachidonic Acid Release Is Mediated by Ca2+-independent Phospholipase A2 but Not Cytosolic Phospholipase A2, Which Undergoes Proteolytic Inactivation

Atsumi, G., Tajima, M., Hadano, A., Nakatani, Y., Murakami, M., & Kudo, I. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13870 · Cited by 235 · see citing works

Electrospray Ionization Mass Spectrometry Analysis of Lysophospholipids in Human Ascitic Fluids: Comparison of the Lysophospholipid Contents in Malignant vs Nonmalignant Ascitic Fluids

Xiao, Y.-J., Schwartz, B., Washington, M., KENNEDY, A. W., Webster, K. D., Belinson, J. L., & Xu, Y. (2001) · Analytical Biochemistry · doi:10.1006/abio.2001.5000 · Cited by 232 · see citing works

Cutting Edge: Heat Shock Protein gp96 Induces Maturation and Migration of CD11c+ Cells In Vivo

Binder, R. J., Anderson, K. M., Basu, S., & Srivastava, P. K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6029 · Cited by 216 · see citing works

Multiple Splice Variants of the Human Calcium-independent Phospholipase A2 and Their Effect on Enzyme Activity

Larsson, P., Claesson, H., & Kennedy, B. P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.207 · Cited by 216 · see citing works

Mice Lacking the Orphan G Protein-Coupled Receptor G2A Develop a Late-Onset Autoimmune Syndrome

Le, L. Q., Kabarowski, J. H. S., Weng, Z., Satterthwaite, A. B., Harvill, E. T., Jensen, E. R., Miller, J. F., & Witte, O. N. (2001) · Immunity · doi:10.1016/s1074-7613(01)00145-5 · Cited by 215 · see citing works

Apoptosis

Hengartner, M. O. (2001) · Cell · doi:10.1016/s0092-8674(01)00219-7 · Cited by 185 · see citing works

Distinct Roles of Two Intracellular Phospholipase A2s in Fatty Acid Release in the Cell Death Pathway

Atsumi, G., Murakami, M., Kojima, K., Hadano, A., Tajima, M., & Kudo, I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000271200 · Cited by 173 · see citing works

Evaluation of Plasma Lysophospholipids for Diagnostic Significance Using Electrospray Ionization Mass Spectrometry (ESI‐MS) Analyses

Xiao, Y., Chen, Y., KENNEDY, A. W., Belinson, J. L., & Xu, Y. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06554.x · Cited by 159 · see citing works

Surface Molecule Loss and Bleb Formation by Human Germinal Center B Cells Undergoing Apoptosis: Role of Apoptotic Blebs in Monocyte Chemotaxis

Segundo, C., Medina, F., Rodriguez, C. S., Martı́nez-Palencia, R., Leyva‐Cobián, F., & Brieva, J. A. (1999) · Blood · doi:10.1182/blood.v94.3.1012.415k05_1012_1020 · Cited by 105 · see citing works

The perturbed membrane of cells undergoing apoptosis is susceptible to type II secretory phospholipase A2 to liberate arachidonic acid

Atsumi, G.-I., Murakami, M., Tajima, M., Shimbara, S., Hara, N., & Kudo, I. (1997) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/s0005-2760(97)00082-9 · Cited by 104 · see citing works

Cellular components that functionally interact with signaling phospholipase A2s

Murakami, M., Nakatani, Y., Kuwata, H., & Kudo, I. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00118-9 · Cited by 91 · see citing works

The Adapter Protein Apoptotic Protease-activating Factor-1 (Apaf-1) Is Proteolytically Processed during Apoptosis

Lauber, K., Appel, H. A. E., Schlosser, S. F., Gregor, M., Schulze‐Osthoff, K., & Wesselborg, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101524200 · Cited by 82 · see citing works

Stereospecific chemoattraction of lymphoblastic cells by gradients of lysophosphatidylcholine.

Hoffman, R. D., Kligerman, M., Sundt, T. M., Anderson, N. D., & Shin, H. S. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.10.3285 · Cited by 44 · see citing works

Apoptosis: controlled demolition at the cellular level

Taylor, R. C., Cullen, S. P., & Martin, S. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2312 · Cited by 2,617 · see citing works

Molecular mechanisms of necroptosis: an ordered cellular explosion

Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2970 · Cited by 2,382 · see citing works

Apoptosis, Pyroptosis, and Necrosis: Mechanistic Description of Dead and Dying Eukaryotic Cells

Fink, S. L., & Cookson, B. T. (2005) · Infection and Immunity · doi:10.1128/iai.73.4.1907-1916.2005 · Cited by 2,206 · see citing works

Programmed Cell Death in Animal Development and Disease

Fuchs, Y., & Steller, H. (2011) · Cell · doi:10.1016/j.cell.2011.10.033 · Cited by 1,915 · see citing works

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

Elliott, M. R., Chekeni, F. B., Trampont, P. C., Lazarowski, E. R., Kadl, A., Walk, S. F., Park, D., Woodson, R. I., Ostankovich, M., Sharma, P., et al. (2009) · Nature · doi:10.1038/nature08296 · Cited by 1,654 · see citing works

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

Kaczmarek, A., Vandenabeele, P., & Krysko, D. V. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.003 · Cited by 1,411 · see citing works

Immunogenic cell stress and death

Kroemer, G., Galassi, C., Zitvogel, L., & Galluzzi, L. (2022) · Nature Immunology · doi:10.1038/s41590-022-01132-2 · Cited by 1,353 · see citing works

Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

Zernecke, A., Bidzhekov, K., Noels, H., Shagdarsuren, E., Gan, L., Denecke, B., Hristov, M., Koeppel, T. A., Nazari-Jahantigh, M., Lutgens, E., et al. (2009) · Science Signaling · doi:10.1126/scisignal.2000610 · Cited by 1,335 · see citing works

Overview of cell death signaling pathways

Jin, Z., & El‐Deiry, W. S. (2005) · Cancer Biology & Therapy · doi:10.4161/cbt.4.2.1508 · Cited by 1,323 · see citing works

Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion

Angeli, J. P. F., Krysko, D. V., & Conrad, M. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0149-1 · Cited by 1,262 · see citing works

Apoptotic cell clearance: basic biology and therapeutic potential

Poon, I. K. H., Lucas, C. D., Rossi, A. G., & Ravichandran, K. S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3607 · Cited by 1,223 · see citing works

Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

Dennis, E. A., Cao, J., Hsu, Y., Magrioti, V., & Kokotos, G. (2011) · Chemical Reviews · doi:10.1021/cr200085w · Cited by 1,213 · see citing works

Immunogenic and tolerogenic cell death

Green, D. R., Ferguson, T., Zitvogel, L., & Kroemer, G. (2009) · Nature Reviews Immunology · doi:10.1038/nri2545 · Cited by 1,176 · see citing works

Phagocyte partnership during the onset and resolution of inflammation

Soehnlein, O., & Lindbom, L. (2010) · Nature Reviews Immunology · doi:10.1038/nri2779 · Cited by 1,054 · see citing works

Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy

Gao, W., Wang, Y., Zhou, Y., Wang, X., & Yu, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01046-3 · Cited by 1,069 · see citing works

Phagocytosis of apoptotic cells in homeostasis

Arandjelovic, S., & Ravichandran, K. S. (2015) · Nature Immunology · doi:10.1038/ni.3253 · Cited by 959 · see citing works

Resolution of inflammation: a new therapeutic frontier

Fullerton, J. N., & Gilroy, D. W. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.39 · Cited by 937 · see citing works

Necrotic death as a cell fatePreprint

Zong, W., & Thompson, C. B. (2006) · Genes & Development · doi:10.1101/gad.1376506 · Cited by 912 · see citing works

Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD

Na, Y. R., Stakenborg, M., Seok, S. H., & Matteoli, G. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0172-4 · Cited by 900 · see citing works

Autoimmunity and the Clearance of Dead Cells

Nagata, S., Hanayama, R., & Kawane, K. (2010) · Cell · doi:10.1016/j.cell.2010.02.014 · Cited by 877 · see citing works

The clearance of dead cells by efferocytosis

Boada-Romero, E., Martinez, J., Heckmann, B. L., & Green, D. R. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0232-1 · Cited by 893 · see citing works

Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy

Huang, Q., Li, F., Liu, X., Li, W., Shi, W., Liu, F.-F., O'Sullivan, B., He, Z., Peng, Y., Tan, A.-C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2385 · Cited by 886 · see citing works

UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis

Koizumi, S., Shigemoto-Mogami, Y., Nasu-Tada, K., Shinozaki, Y., Ohsawa, K., Tsuda, M., Joshi, B. V., Jacobson, K. A., Kohsaka, S., & Inoue, K. (2007) · Nature · doi:10.1038/nature05704 · Cited by 802 · see citing works

The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis.

Zheng, L.-L., Zhang, Z.-J., Sheng, P., & Mobasheri, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101249 · Cited by 717 · see citing works

Resolution of inflammation: an integrated view

Ortega‐Gómez, A., Perretti, M., & Soehnlein, O. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202382 · Cited by 736 · see citing works

Apoptosis: a basic biological phenomenon with wide‐ranging implications in human disease

Fadeel, B., & Orrenius, S. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01570.x · Cited by 699 · see citing works

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

A-González, N., Bensinger, S. J., Hong, C., Beceiro, S., Bradley, M. N., Zelcer, N., Deniz, J. M., Ramírez, C. M., Díaz, M., Gallardo, G., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.018 · Cited by 674 · see citing works

Autophagy Gene-Dependent Clearance of Apoptotic Cells during Embryonic Development

Qu, X., Zou, Z., Sun, Q., Luby‐Phelps, K., Cheng, P., Hogan, R. N., Gilpin, C. J., & Levine, B. (2007) · Cell · doi:10.1016/j.cell.2006.12.044 · Cited by 655 · see citing works

Engulfment of apoptotic cells: signals for a good meal

Ravichandran, K. S., & Lorenz, U. M. (2007) · Nature reviews. Immunology · doi:10.1038/nri2214 · Cited by 634 · see citing works

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins

Subra, C., Grand, D., Laulagnier, K., Stella, A., Lambeau, G. J., Paillasse, M. R., de Médina, P., Monsarrat, B., Perret, B., Silvente‐Poirot, S., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m003657 · Cited by 635 · see citing works

The hallmarks of cancer immune evasion

Galassi, C., Chan, T. A.-T., Vitale, I., & Galluzzi, L. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.09.010 · Cited by 597 · see citing works

Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease

Mota, M., Banini, B. A., Cazanave, S. C., & Sanyal, A. J. (2016) · Metabolism · doi:10.1016/j.metabol.2016.02.014 · Cited by 570 · see citing works

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

Ravichandran, K. S. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.004 · Cited by 559 · see citing works

Clearance of Apoptotic Cells

Lauber, K., Blumenthal, S. G., Waibel, M., & Wesselborg, S. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00237-0 · Cited by 552 · see citing works

Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris

Caruso, S., & Poon, I. K. H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01486 · Cited by 541 · see citing works

Clearance of apoptotic cells: implications in health and disease

Elliott, M. R., & Ravichandran, K. S. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201004096 · Cited by 547 · see citing works

Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums

Ravichandran, K. S. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101157 · Cited by 547 · see citing works

Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease

Chong, Z. Z., Li, F., & Maiese, K. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.02.004 · Cited by 536 · see citing works

Apoptosis: The nexus of liver injury and fibrosis

Canbay, A. E., Friedman, S. L., & Gores, G. J. (2004) · Hepatology · doi:10.1002/hep.20051 · Cited by 529 · see citing works

Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury

Chen, P., Piao, X., & Bonaldo, P. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1482-4 · Cited by 525 · see citing works

Apoptosis: a mechanism of acute and chronic liver injury

Guicciardi, M. E., & Gores, G. J. (2005) · Gut · doi:10.1136/gut.2004.053850 · Cited by 509 · see citing works

Recent progress in phospholipase A2 research: From cells to animals to humans

Murakami, M., Taketomi, Y., Miki, Y., Sato, H., Hirabayashi, T., & Yamamoto, K. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.12.001 · Cited by 509 · see citing works

Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion

Hochreiter-Hufford, A., & Ravichandran, K. S. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008748 · Cited by 503 · see citing works

Immunogenic cell death, DAMPs and anticancer therapeutics: An emerging amalgamation

Garg, A. D., Nowis, D., Gołąb, J., Vandenabeele, P., Krysko, D. V., & Agostinis, P. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.08.003 · Cited by 498 · see citing works

Apoptotic Cells Activate the “Phoenix Rising” Pathway to Promote Wound Healing and Tissue Regeneration

Li, F., Huang, Q., Jiang, C., Peng, Y., Roop, D. R., Bedford, J. S., & Li, C. (2010) · Science Signaling · doi:10.1126/scisignal.2000634 · Cited by 494 · see citing works

Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment

Myers, K. V., Amend, S. R., & Pienta, K. J. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1022-2 · Cited by 482 · see citing works

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

Truman, L. A., Ford, C. A., Pasikowska, M., Pound, J. D., Wilkinson, S. J., Dumitriu, I. E., Melville, L., Melrose, L. A., Ogden, C. A., Nibbs, R., et al. (2008) · Blood · doi:10.1182/blood-2008-06-162404 · Cited by 473 · see citing works

Drugging the efferocytosis process: concepts and opportunities

Mehrotra, P., & Ravichandran, K. S. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00470-y · Cited by 459 · see citing works

Review: Evidence That Systemic Sclerosis Is a Vascular Disease

Matucci‐Cerinic, M., Kahaleh, B., & Wigley, F. M. (2013) · Arthritis & Rheumatism · doi:10.1002/art.37988 · Cited by 455 · see citing works

Autophagy and cellular immune responses

Ma, Y., Galluzzi, L., Zitvogel, L., & Kroemer, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.017 · Cited by 447 · see citing works

Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses

Garg, A. D., & Agostinis, P. (2017) · Immunological Reviews · doi:10.1111/imr.12574 · Cited by 448 · see citing works

How macrophages deal with death

Lemke, G. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0167-y · Cited by 437 · see citing works

Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses

Elliott, M. R., Koster, K. M., & Murphy, P. S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601520 · Cited by 440 · see citing works

The CASBAH: a searchable database of caspase substrates

Lüthi, A. U., & Martin, S. J. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402103 · Cited by 434 · see citing works

The Apoptosis Paradox in Cancer

Morana, O., Wood, W., & Gregory, C. D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031328 · Cited by 431 · see citing works

Clearance of apoptotic cells by phagocytes

Erwig, L.-P., & Henson, P. M. (2008) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402184 · Cited by 422 · see citing works

Secondary necrosis: The natural outcome of the complete apoptotic program

Silva, M. T. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.10.046 · Cited by 412 · see citing works

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

Garg, A. D., Galluzzi, L., Apétoh, L., Baert, T., Birge, R. B., Pedro, J. M. B., Breckpot, K., Brough, D., Chaurio, R. A., Cirone, M., et al. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00588 · Cited by 409 · see citing works

Apoptotic cell removal in development and tissue homeostasis

Henson, P. M., & Hume, D. A. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.03.005 · Cited by 388 · see citing works

Adipocyte Apoptosis, a Link between Obesity, Insulin Resistance, and Hepatic Steatosis

Alkhouri, N., Górnicka, A., Berk, M. P., Thapaliya, S., Dixon, L. J., Kashyap, S. R., Schauer, P. R., & Feldstein, A. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.074252 · Cited by 368 · see citing works

Apoptosis induces expression of sphingosine kinase 1 to release sphingosine‐1‐phosphate as a “come‐and‐get‐me” signal

Gude, D., Alvarez, S. E., Paugh, S. W., Mitra, P., Yu, J., Griffiths, R., Barbour, S. E., Milstien, S., & Spiegel, S. (2008) · The FASEB Journal · doi:10.1096/fj.08-107169 · Cited by 364 · see citing works

Metabolism and atherogenic disease association of lysophosphatidylcholine

Schmitz, G., & Ruebsaamen, K. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.05.029 · Cited by 358 · see citing works

Molecular mechanisms of late apoptotic/necrotic cell clearance

Poon, I. K. H., Hulett, M. D., & Parish, C. R. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.195 · Cited by 353 · see citing works

Caspases Connect Cell-Death Signaling to Organismal Homeostasis

Galluzzi, L., López-Soto, A., Kumar, S., & Kroemer, G. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.020 · Cited by 350 · see citing works

Microglia in the Retina: Roles in Development, Maturity, and Disease

Silverman, S. M., & Wong, W. T. (2018) · Annual Review of Vision Science · doi:10.1146/annurev-vision-091517-034425 · Cited by 351 · see citing works

MCF-7 breast carcinoma cells do not express caspase-3

Jänicke, R. U. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-0217-9 · Cited by 340 · see citing works

The role of phosphatidylcholine and choline metabolites to cell proliferation and survival

Ridgway, N. D. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2012.735643 · Cited by 338 · see citing works

Monocytes and Macrophages Regulate Immunity through Dynamic Networks of Survival and Cell Death

Parihar, A., Eubank, T. D., & Doseff, A. I. (2010) · Journal of Innate Immunity · doi:10.1159/000296507 · Cited by 333 · see citing works

Medium perfusion enables engineering of compact and contractile cardiac tissue

Radisic, M., Yang, L., Boublik, J., Cohen, R. J., Langer, R., Freed, L. E., & Vunjak‐Novakovic, G. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00171.2003 · Cited by 334 · see citing works

Apoptotic Cells with Oxidation-specific Epitopes Are Immunogenic and Proinflammatory

Chang, M.-K., Binder, C. J., Miller, Y. I., Subbanagounder, G., Silverman, G. J., Berliner, J. A., & Witztum, J. L. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031763 · Cited by 334 · see citing works

The Dynamics of Apoptotic Cell Clearance

Elliott, M. R., & Ravichandran, K. S. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.06.029 · Cited by 314 · see citing works

Microglial Cells Contribute to Endogenous Brain Defenses after Acute Neonatal Focal Stroke

Faustino, J. V., Wang, X., Johnson, C. E., Klibanov, A. L., Derugin, N., Wendland, M. F., & Vexler, Z. S. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2102-11.2011 · Cited by 318 · see citing works

Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease

Martini, R., Fischer, S., López‐Vales, R., & David, S. (2008) · Glia · doi:10.1002/glia.20766 · Cited by 319 · see citing works

Clearance Deficiency and Cell Death Pathways: A Model for the Pathogenesis of SLE

Mahajan, A., i, M. H., & Munoz, L. E. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00035 · Cited by 309 · see citing works

Caspase‐3 regulates the migration, invasion and metastasis of colon cancer cells

Zhou, M., Liu, X., Li, Z., Huang, Q., Li, F., & Li, C. (2018) · International Journal of Cancer · doi:10.1002/ijc.31374 · Cited by 305 · see citing works

Phagocytosis of Apoptotic Cells in Resolution of Inflammation

Kourtzelis, I., Hajishengallis, G., & Chavakis, T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00553 · Cited by 301 · see citing works

Mechanisms underlying neutrophil-mediated monocyte recruitment

Soehnlein, O., Lindbom, L., & Weber, C. (2009) · Blood · doi:10.1182/blood-2009-06-221630 · Cited by 297 · see citing works

CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection

Tyner, J. W., Uchida, O., Kajiwara, N., Kim, E. Y., Patel, A. C., O’Sullivan, M. P., Walter, M. J., Schwendener, R. A., Cook, D. N., Danoff, T. M., et al. (2005) · Nature Medicine · doi:10.1038/nm1303 · Cited by 299 · see citing works

Evidence for Phagocytosis of Influenza Virus-Infected, Apoptotic Cells by Neutrophils and Macrophages in Mice

Hashimoto, Y., Moki, T., Takizawa, T., Shiratsuchi, A., & Nakanishi, Y. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2448 · Cited by 285 · see citing works

The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically?

Gregory, C. D., & Devitt, A. (2004) · Immunology · doi:10.1111/j.1365-2567.2004.01959.x · Cited by 285 · see citing works

Essential Role of the Apoptotic Cell Engulfment Genes draper and ced-6 in Programmed Axon Pruning during Drosophila Metamorphosis

Awasaki, T., Tatsumi, R., Takahashi, K., Arai, K., Nakanishi, Y., Ueda, R., & Ito, K. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.027 · Cited by 285 · see citing works

Annexin-1 and Peptide Derivatives Are Released by Apoptotic Cells and Stimulate Phagocytosis of Apoptotic Neutrophils by Macrophages

Scannell, M., Flanagan, M. B., deStefani, A., Wynne, K. J., Cagney, G., Godson, C., & MADERNA, P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4595 · Cited by 282 · see citing works

Clearance deficiency and systemic lupus erythematosus (SLE)

Gaipl, U. S., Munoz, L. E., Grossmayer, G., Lauber, K., Franz, S., Sarter, K., Voll, R. E., Winkler, T., Kuhn, A., Kalden, J., et al. (2007) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.02.005 · Cited by 277 · see citing works

Microglia in CNS development: Shaping the brain for the future

Mosser, C., Baptista, S., Arnoux, I., & Audinat, É. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.01.002 · Cited by 268 · see citing works

Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development

Wang, X., He, Q., Zhou, C., Xu, Y., Liu, D., Fujiwara, N., Kubota, N., Click, A., Henderson, P., Vancil, J., et al. (2023) · Immunity · doi:10.1016/j.immuni.2022.11.013 · Cited by 262 · see citing works

Key mechanisms governing resolution of lung inflammation

Robb, C. T., Regan, K., Dorward, D. A., & Rossi, A. G. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0560-6 · Cited by 263 · see citing works

Migration to Apoptotic “Find-me” Signals Is Mediated via the Phagocyte Receptor G2A

Peter, C., Waibel, M., Radu, C. G., Yang, L. V., Witte, O. N., Schulze-Osthoff, K., Wesselborg, S., & Lauber, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706586200 · Cited by 258 · see citing works

Matrix Metalloproteinase-3: A Novel Signaling Proteinase from Apoptotic Neuronal Cells That Activates Microglia

Kim, Y. S., Kim, S. S., Cho, J. J., Choi, D. H., Hwang, O., Shin, D. H., Chun, H. S., Beal, M. F., & Joh, T. H. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4346-04.2005 · Cited by 256 · see citing works

Death-defying immunity: do apoptotic cells influence antigen processing and presentation?

Albert, M. L. (2004) · Nature reviews. Immunology · doi:10.1038/nri11308 · Cited by 257 · see citing works

Lactadherin Deficiency Leads to Apoptotic Cell Accumulation and Accelerated Atherosclerosis in Mice

Ait-Oufella, H., Kinugawa, K., Zoll, J., Simon, T., Boddaert, J., Heeneman, S., Blanc-Brude, O., Barateau, V., Potteaux, S., Merval, R., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.662080 · Cited by 255 · see citing works

Cellular senescence and cancer treatment

Schmitt, C. A. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.08.005 · Cited by 254 · see citing works

Cues for apoptotic cell engulfment: eat-me, don't eat-me and come-get-me signals

Grimsley‐Myers, C. M. (2003) · Trends in Cell Biology · doi:10.1016/j.tcb.2003.10.004 · Cited by 248 · see citing works

Autotaxin Is Overexpressed in Glioblastoma Multiforme and Contributes to Cell Motility of Glioblastoma by Converting Lysophosphatidylcholine TO Lysophosphatidic Acid

Kishi, Y., Okudaira, S., Tanaka, M., Hama, K., Shida, D., Kitayama, J., Yamori, T., Aoki, J., Fujimaki, T., & Arai, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601803200 · Cited by 245 · see citing works

Programmed cell removal: a new obstacle in the road to developing cancer

Chao, M. P., Majeti, R., & Weissman, I. L. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3171 · Cited by 246 · see citing works

Lysoglycerophospholipids in chronic inflammatory disorders: The PLA2/LPC and ATX/LPA axes

Sevastou, I. G., Kaffe, E., Mouratis, M.-A., & Aidinis, V. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.07.019 · Cited by 242 · see citing works

THE ENGULFMENT PROCESS OF PROGRAMMED CELL DEATH INCAENORHABDITIS ELEGANS

Reddien, P. W., & Horvitz, H. R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.022003.114619 · Cited by 238 · see citing works

Cellular regulation and proposed biological functions of group VIA calcium-independent phospholipase A in activated cells

Balsinde, J., & Balboa, M. A. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2005.03.002 · Cited by 238 · see citing works

An Updated Review of Pro- and Anti-Inflammatory Properties of Plasma Lysophosphatidylcholines in the Vascular System

Knuplez, E., & Marsche, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124501 · Cited by 236 · see citing works

Killers creating new life: caspases drive apoptosis-induced proliferation in tissue repair and disease

Fogarty, C. E., & Bergmann, A. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.47 · Cited by 235 · see citing works

The cardiolipin–cytochrome c interaction and the mitochondrial regulation of apoptosis

Iverson, S. L., & Orrenius, S. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.12.002 · Cited by 235 · see citing works

Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal." Cell 113(6

Lauber, K., Bohn, E., Kröber, S. M., & Xiao, Y.-J. (2003)

Come and get it!

Bell, É. (2003) · Nature reviews. Immunology · doi:10.1038/nri1171

Attraction of phagocytes by apoptotic cells is mediated by lysophosphatidylcholine

Müeller, R. B., Sheriff, A., Gaipl, U. S., Wesselborg, S., & Lauber, K. (2007) · Autoimmunity · doi:10.1080/08916930701356911 · Cited by 62 · see citing works

Eliminierung apoptotischer Zellen durch professionelle Phagozyten: Generierung, Freisetzung und Erkennung des monozytären Attraktionssignals Lysophosphatidylcholin und Bedeutung von Annexin I als Brückenprotein in der phagozytotischen Synapse

Waibel, M. (2007) · University writing server of the University of Hohenheim (Universität Hohenheim)

Migration to Apoptotic “Find-me” Signals Is Mediated via the Phagocyte Receptor G2A

Peter, C., Waibel, M., Radu, C. G., Yang, L. V., Witte, O. N., Schulze-Osthoff, K., Wesselborg, S., & Lauber, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706586200 · Cited by 258 · see citing works