The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter

DNA sequencing with chain-terminating inhibitors

Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572 · see citing works

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

Maxam, A. M., & Gilbert, W. (1980) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(80)65059-9 · Cited by 14,678 · see citing works

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262 · see citing works

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

Sen, R., & Baltimore, D. (1986) · Cell · doi:10.1016/0092-8674(86)90346-6 · Cited by 2,754 · see citing works

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

Kakizuka, A., Miller, W. H., Umesono, K., Warrell, R. P., Frankel, S., Murty, V. V. V. S., Dmitrovsky, E., & Evans, R. M. (1991) · Cell · doi:10.1016/0092-8674(91)90112-c · Cited by 1,423 · see citing works

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus

de Thé, H., Chomienne, C., Lanotte, M., Degos, L., & Dejean, A. (1990) · Nature · doi:10.1038/347558a0 · Cited by 1,353 · see citing works

Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

Pevny, L., Simon, M. C., Robertson, E., Klein, W. H., Tsai, S.-F., D'Agati, V., Orkin, S. H., & Costantini, F. (1991) · Nature · doi:10.1038/349257a0 · Cited by 1,308 · see citing works

The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells

Metcalf, D. (1989) · Nature · doi:10.1038/339027a0 · Cited by 1,023 · see citing works

The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene

Klemsz, M. J., McKercher, S. R., Celada, A., Van Beveren, C., & Maki, R. A. (1990) · Cell · doi:10.1016/0092-8674(90)90219-5 · Cited by 954 · see citing works

Antigens on human monocytes identified by monoclonal antibodies.

Todd, R. F., Nadler, L. M., & Schlossman, S. F. (1981) · The Journal of Immunology · doi:10.4049/jimmunol.126.4.1435 · Cited by 564 · see citing works

The ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequence.

Karim, F. D., Urness, L. D., Thummel, C. S., Klemsz, M. J., McKercher, S. R., Celada, A., Van Beveren, C., Maki, R. A., Gunther, C. V., & Nye, J. A. (1990) · Genes & Development · doi:10.1101/gad.4.9.1451 · Cited by 499 · see citing works

Spi-1 is a putative oncogene in virally induced murine erythroleukaemias

Moreau-Gachelin, F., Tavitian, A., & Tambourin, P. (1988) · Nature · doi:10.1038/331277a0 · Cited by 447 · see citing works

Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins.

Kastner, P., Perez, A., Lutz, Y., Rochette‐Egly, C., Gaub, M. P., Durand, B., Lanotte, M., Berger, R., & Chambon, P. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05095.x · Cited by 415 · see citing works

PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activity.

Pongubala, J. M., Nagulapalli, S., Klemsz, M. J., McKercher, S. R., Maki, R. A., & Atchison, M. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.1.368 · Cited by 354 · see citing works

A c-erb-A binding site in rat growth hormone gene mediates trans-activation by thyroid hormone

Glass, C. K., Franco, R., Weinberger, C., Albert, V. R., Evans, R. M., & Rosenfeld, M. G. (1987) · Nature · doi:10.1038/329738a0 · Cited by 346 · see citing works

Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha).

Collins, S. J., Robertson, K. A., & Mueller, L. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.5.2154 · Cited by 317 · see citing works

Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells.Preprint

Xin, J.-H., Cowie, A., Lachance, P., & Hassell, J. A. (1992) · Genes & Development · doi:10.1101/gad.6.3.481 · Cited by 316 · see citing works

Characterization of a human macrophage-like cell line stimulated in vitro: a model of macrophage functions.

Larrick, J. W., Fischer, D. G., Anderson, S., & Koren, H. S. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.125.1.6 · Cited by 212 · see citing works

A novel modulator domain of Ets transcription factors.

Wasylyk, C., Kerckaert, J. P., & Wasylyk, B. (1992) · Genes & Development · doi:10.1101/gad.6.6.965 · Cited by 140 · see citing works

Separate promoters control transcription of the human aminopeptidase N gene in myeloid and intestinal epithelial cells

Shapiro, L. H., Ashmun, R., Roberts, W. M., & Look, A. T. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99056-3 · Cited by 120 · see citing works

The PU.1 transcription factor is the product of the putative oncogene Spi-1

Goebl, M. G. (1990) · Cell · doi:10.1016/0092-8674(90)90676-6 · Cited by 120 · see citing works

Differential expression of CD11b/CD18 (Mo1) and myeloperoxidase genes during myeloid differentiation

Rosmarin, A., Weil, S., Rosner, G., Griffin, J. D., Arnaout, M., & Tenen, D. G. (1989) · Blood · doi:10.1182/blood.v73.1.131.131 · Cited by 118 · see citing works

Characterization of the myeloid-specific CD11b promoter

Pahl, H., Rosmarin, A., & Tenen, D. (1992) · Blood · doi:10.1182/blood.v79.4.865.bloodjournal794865 · Cited by 95 · see citing works

Optimization of transient transfection into human myeloid cell lines using a luciferase reporter gene.

Pahl, H. L., Burn, T. C., & Tenen, D. G. (1991) · PubMed · Cited by 93 · see citing works

Site-directed mutagenesis reveals a liver transcription factor essential for the albumin transcriptional enhancer.

Zaret, K. S., Liu, J. K., & DiPersio, C. M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5469 · Cited by 91 · see citing works

Transcription of the human colony-stimulating factor-1 receptor gene is regulated by separate tissue-specific promoters

Roberts, W., Shapiro, L., Ashmun, R., & Look, A. T. (1992) · Blood · doi:10.1182/blood.v79.3.586.586 · Cited by 70 · see citing works

Detection of Two Tissue-Specific DNA-Binding Proteins with Affinity for Sites in the Mouse β-Globin Intervening Sequence 2

Galson, D. L., & Housman, D. E. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.1.381-392.1988 · Cited by 66 · see citing works

The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors.

Ray-Gallet, D., Culine, S., Tavitain, A., & Moreau-Gachelin, F. (1990) · PubMed · Cited by 62 · see citing works

Cloning and analysis of the CD18 promoter

Rosmarin, A., Levy, R., & Tenen, D. (1992) · Blood · doi:10.1182/blood.v79.10.2598.bloodjournal79102598 · Cited by 60 · see citing works

Cloning and analysis of the CD18 promoter

Rosmarin, A., Levy, R., & Tenen, D. G. (1992) · Blood · doi:10.1182/blood.v79.10.2598.2598 · Cited by 56 · see citing works

Transcription of the human colony-stimulating factor-1 receptor gene is regulated by separate tissue-specific promoters

Roberts, W., Shapiro, L., Ashmun, R., et al. (1992) · Blood · doi:10.1182/blood.v79.3.586.bloodjournal793586 · Cited by 55 · see citing works

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages

Scott, E. W., Simon, M. C., Anastasi, J., & Singh, H. (1994) · Science · doi:10.1126/science.8079170 · Cited by 1,532 · see citing works

Granules of the Human Neutrophilic Polymorphonuclear Leukocyte

Borregaard, N., & Cowland, J. B. (1997) · Blood · doi:10.1182/blood.v89.10.3503 · Cited by 1,514 · see citing works

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities

McKercher, S. R., Torbett, B. E., Anderson, K. L., Henkel, G. W., Vestal, D. J., Baribault, H., Klemsz, M., Feeney, A. J., Wu, G. E., Paige, C. J., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00949.x · Cited by 1,130 · see citing works

Stepwise reprogramming of B cells into macrophages.

Xie, H.-F., Ye, M., Feng, R., & Graf, T. (2004) · Cell · doi:10.1016/s0092-8674(04)00419-2 · Cited by 1,030 · see citing works

Genetic, Biochemical, and Clinical Features of Chronic Granulomatous Disease

Segal, B. H., Leto, T. L., Gallin, J. I., Malech, H. L., & Holland, S. M. (2000) · Medicine · doi:10.1097/00005792-200005000-00004 · Cited by 877 · see citing works

Transcription Factors, Normal Myeloid Development, and Leukemia

Tenen, D. G., Hromas, R., Licht, J. D., & Zhang, D.-E. (1997) · Blood · doi:10.1182/blood.v90.2.489 · Cited by 735 · see citing works

The kit Ligand, Stem Cell Factor

Galli, S. J., Zsebo, K. M., & Geissler, E. N. (1993) · Advances in immunology · doi:10.1016/s0065-2776(08)60508-8 · Cited by 631 · see citing works

An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis

Tokuhiro, S., Yamada, R., Chang, X., Suzuki, A., Kochi, Y., Sawada, T., Suzuki, M., Nagasaki, M., Ohtsuki, M., Ono, M., et al. (2003) · Nature Genetics · doi:10.1038/ng1267 · Cited by 624 · see citing works

Molecular Characterization and Pattern of Tissue Expression of the Gene for Neutrophil Gelatinase-Associated Lipocalin from Humans

Cowland, J. B., & Borregaard, N. (1997) · Genomics · doi:10.1006/geno.1997.4896 · Cited by 619 · see citing works

GM-CSF Regulates Alveolar Macrophage Differentiation and Innate Immunity in the Lung through PU.1

Shibata, Y., Berclaz, P., Chroneos, Z. C., Yoshida, M., Whitsett, J. A., & Trapnell, B. C. (2001) · Immunity · doi:10.1016/s1074-7613(01)00218-7 · Cited by 613 · see citing works

Osteopetrosis in mice lacking haematopoietic transcription factor PU.1

Tondravi, M. M., McKercher, S. R., Anderson, K., Erdmann, J. M., Quiroz, M. E., Maki, R. A., & Teitelbaum, S. L. (1997) · Nature · doi:10.1038/386081a0 · Cited by 537 · see citing works

Regulation of Interleukin 12 p40 Expression through an NF-κB Half-Site

Murphy, T. L., Cleveland, M., Kulesza, P., Magram, J., & MURPHY, K. M. M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.10.5258 · Cited by 482 · see citing works

Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1

Zhang, P., Behre, G., Pan, J., Iwama, A., Wara-aswapati, N., Radomska, H. S., Auron, P. E., Tenen, D. G., & Sun, Z. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.15.8705 · Cited by 459 · see citing works

The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor

Zhang, D.-E., Hetherington, C. J., Chen, H.-M., & Tenen, D. G. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.1.373-381.1994 · Cited by 411 · see citing works

The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor.

Zhang, D. E., Hetherington, C. J., Chen, H. M., & Tenen, D. G. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.1.373 · Cited by 411 · see citing works

Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPα ratio and granulocyte colony-stimulating factor

Dahl, R., Walsh, J. C., Lancki, D., Laslo, P., Iyer, S. R., Singh, H., & Simon, M. C. (2003) · Nature Immunology · doi:10.1038/ni973 · Cited by 380 · see citing works

Ets target genes: past, present and future

Sementchenko, V. I., & Watson, D. K. (2000) · Oncogene · doi:10.1038/sj.onc.1204034 · Cited by 371 · see citing works

PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding

Zhang, P., Zhang, X., Iwama, A., Yu, C., Smith, K. A., Mueller, B. U., Narravula, S., Torbett, B. E., Orkin, S. H., & Tenen, D. G. (2000) · Blood · doi:10.1182/blood.v96.8.2641 · Cited by 368 · see citing works

Transcriptional regulation of granulocyte and monocyte development

Friedman, A. D. (2002) · Oncogene · doi:10.1038/sj.onc.1205324 · Cited by 325 · see citing works

PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis

Dakic, A., Metcalf, D., Di Rago, L., Mifsud, S., Wu, L., & Nutt, S. L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050075 · Cited by 297 · see citing works

PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells.

Nuchprayoon, I., Meyers, S., Scott, L. M., Suzow, J., Hiebert, S., & Friedman, A. D. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.8.5558 · Cited by 296 · see citing works

PU.1 regulates both cytokine‐dependent proliferation and differentiation of granulocyte/macrophage progenitors

DeKoter, R. P., Walsh, J. C., & Singh, H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.15.4456 · Cited by 296 · see citing works

PU.1 (Spi-1) and C/EBPα Regulate Expression of the Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Gene

Hohaus, S., Petrovick, M. S., Voso, M. T., Sun, Z., Zhang, D.-E., & Tenen, D. G. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.10.5830 · Cited by 284 · see citing works

PDEF, a Novel Prostate Epithelium-specific Ets Transcription Factor, Interacts with the Androgen Receptor and Activates Prostate-specific Antigen Gene Expression

Oettgen, P., Finger, E., Sun, Z., Akbarali, Y., Thamrongsak, U., Boltax, J., Grall, F., Dube, A., Weiss, A., Brown, L., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1216 · Cited by 268 · see citing works

Transcriptional Regulation of CHI3L1, a Marker Gene for Late Stages of Macrophage Differentiation

Rehli, M., Niller, H. H., Ammon, C., Langmann, S., Schwarzfischer, L., Andreesen, R., & Krause, S. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306792200 · Cited by 249 · see citing works

The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia

Vangala, R. K., Heiss-Neumann, M. S., Rangatia, J. S., Singh, S. M., Schoch, C., Tenen, D. G., Hiddemann, W., & Behre, G. (2003) · Blood · doi:10.1182/blood-2002-04-1288 · Cited by 245 · see citing works

Heterozygous PU.1 mutations are associated with acute myeloid leukemia

Mueller, B. U., Pabst, T., Osato, M., Asou, N., Johansen, L. M., Minden, M. D., Behre, G., Hiddemann, W., Ito, Y., & Tenen, D. G. (2002) · Blood · doi:10.1182/blood.v100.3.998 · Cited by 243 · see citing works

Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of β ₂ integrin gene expression

Kong, T., Eltzschig, H. K., Karhausen, J., Colgan, S. P., & Shelley, C. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401339101 · Cited by 242 · see citing works

PU.1 and Interferon Consensus Sequence-binding Protein Regulate the Myeloid Expression of the Human Toll-like Receptor 4 Gene

Rehli, M., Poltorak, A., Schwarzfischer, L., Krause, S. W., Andreesen, R., & Beutler, B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9773 · Cited by 233 · see citing works

Advances in osteoclast biology: old findings and new insights from mouse models

Edwards, J., & Mundy, G. R. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.23 · Cited by 232 · see citing works

C/EBP, c-Myb, and PU.1 Cooperate To Regulate the Neutrophil Elastase Promoter

Oelgeschläger, M., Nuchprayoon, I., Lüscher, B., & Friedman, A. D. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4717 · Cited by 229 · see citing works

Isolation and Characterization of a Novel Epithelium-Specific Transcription Factor, ESE-1, a Member of the ets Family

Oettgen, P., Alani, R. M., Barcinski, M. A., Brown, L. F., Akbarali, Y., Boltax, J., KUNSCH, C. A., Münger, K., & Libermann, T. A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.8.4419 · Cited by 215 · see citing works

Thyroid-specific gene expression

Damante, G., & Lauro, R. D. (1994) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(94)90176-7 · Cited by 214 · see citing works

Transcription factors that regulate monocyte/macrophage differentiation

Valledor, A. F., Borràs, F. E., Cullell-Young, M., & Celada, A. (1998) · Journal of Leukocyte Biology · doi:10.1002/jlb.63.4.405 · Cited by 211 · see citing works

Identification of a Region Which Directs the Monocytic Activity of the Colony-Stimulating Factor 1 (Macrophage Colony-Stimulating Factor) Receptor Promoter and Binds PEBP2/CBF (AML1)

Zhang, D., Fujioka, K., Hetherington, C. J., Shapiro, L., Chen, H. M., Look, A. T., & Tenen, D. G. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8085 · Cited by 199 · see citing works

Sp1 is a critical factor for the monocytic specific expression of human CD14

Zhang, D., Hetherington, C. J., Tan, S., Dziennis, S. E., Gonzalez, D. A., Chen, H. M., & Tenen, D. G. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)78141-1 · Cited by 193 · see citing works

PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation

Olson, M. C., Scott, E. W., Hack, A. A., Su, G. H., Tenen, D. G., Singh, H., & Simon, M. C. (1995) · Immunity · doi:10.1016/1074-7613(95)90060-8 · Cited by 191 · see citing works

PU. 1 is required for myeloid-derived but not lymphoid-derived dendritic cells

Guerriero, A., Langmuir, P. B., Spain, L. M., & Scott, E. W. (2000) · Blood · doi:10.1182/blood.v95.3.879.003k13_879_885 · Cited by 190 · see citing works

Spi-1/PU.1 Transgenic Mice Develop Multistep Erythroleukemias

Moreau-Gachelin, F., Wendling, F., Molina, T., Denis, N., Titeux, M., Grimber, G., Briand, P., Vainchenker, W., & Tavitian, A. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2453 · Cited by 189 · see citing works

Differentiation of the Mononuclear Phagocyte System During Mouse Embryogenesis: The Role of Transcription Factor PU.1

Lichanska, A. M., Browne, C. M., Henkel, G. W., Murphy, K. M., Ostrowski, M. C., McKercher, S. R., Maki, R. A., & Hume, D. A. (1999) · Blood · doi:10.1182/blood.v94.1.127.413k07_127_138 · Cited by 185 · see citing works

Defective B cell receptor‐mediated responses in mice lacking the Ets protein, Spi‐B

Su, G. H., Chen, H., Muthusamy, N., Garrett‐Sinha, L. A., Baunoch, D., Tenen, D. G., & Simon, M. C. (1997) · The EMBO Journal · doi:10.1093/emboj/16.23.7118 · Cited by 182 · see citing works

c-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor

Behre, G., Whitmarsh, A. J., Coghlan, M. P., Hoang, T., Carpenter, C. L., Zhang, D.-E., Davis, R. J., & Tenen, D. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.8.4939 · Cited by 183 · see citing works

PU.1, Interferon Regulatory Factor 1, and Interferon Consensus Sequence-binding Protein Cooperate to Increase gp91 Expression

Eklund, E. A., Jalava, A., & Kakar, R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13957 · Cited by 176 · see citing works

Heat Shock Factor 1 Represses Transcription of the IL-1β Gene through Physical Interaction with the Nuclear Factor of Interleukin 6

Xie, Y., Chen, C., Stevenson, M. A., Auron, P. E., & Calderwood, S. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109296200 · Cited by 176 · see citing works

Potential Autoregulation of Transcription Factor PU.1 by an Upstream Regulatory Element

Okuno, Y., Huang, G., Rosenbauer, F., Evans, E. K., Radomska, H. S., Iwasaki, H., Akashi, K., Moreau-Gachelin, F., Li, Y., Zhang, P., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.7.2832-2845.2005 · Cited by 174 · see citing works

Temporal mapping of gene expression levels during the differentiation of individual primary hematopoietic cells

Cheng, T., Shen, H., Giokas, D., Gere, J., Tenen, D. G., & Scadden, D. T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13158 · Cited by 163 · see citing works

ETS transcription factors and regulation of immunity

Gallant, S., & Gilkeson, G. S. (2006) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-006-0017-z · Cited by 163 · see citing works

The transcription factor PU.1 is involved in macrophage proliferation.

Celada, A., Borràs, F. E., Soler, C., Lloberas, J., Klemsz, M., van Beveren, C., McKercher, S., & Maki, R. A. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.1.61 · Cited by 161 · see citing works

Mechanisms Establishing TLR4-Responsive Activation States of Inflammatory Response Genes

Escoubet‐Lozach, L., Benner, C. W., Kaikkonen, M. U., Lozach, J., Heinz, S., Spann, N. J., Crotti, A., Stender, J. D., Ghisletti, S., Reichart, D. R., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002401 · Cited by 161 · see citing works

Multistable and multistep dynamics in neutrophil differentiation

Chang, H. H., Oh, P., Ingber, D. E., & Huang, S. (2006) · BMC Cell Biology · doi:10.1186/1471-2121-7-11 · Cited by 161 · see citing works

Sequence Variants in Toll-Like Receptor Gene Cluster (TLR6-TLR1-TLR10) and Prostate Cancer Risk

Sun, J., Wiklund, F., Zheng, S. L., Chang, B., Bälter, K. A., Li, L., Johansson, J.-E., Li, G., Adami, H., Liu, W., et al. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji070 · Cited by 161 · see citing works

Granulocyte inducer C/EBPα inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions

Reddy, V. A., Iwama, A., Iotzova, G., Schulz, M., Elsasser, A., Vangala, R. K., Tenen, D. G., Hiddemann, W., & Behre, G. (2002) · Blood · doi:10.1182/blood.v100.2.483 · Cited by 152 · see citing works

Origins and functions of phagocytes in the embryo

Lichanska, A. M., & Hume, D. A. (2000) · Experimental Hematology · doi:10.1016/s0301-472x(00)00157-0 · Cited by 150 · see citing works

Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1

Anderson, G., Gries, M., Kurihara, N., Honjo, T., Anderson, J., Donnenberg, V. S., Donnenberg, A. D., Ghobrial, I. M., Mapara, M. Y., Stirling, D., et al. (2005) · Blood · doi:10.1182/blood-2005-08-3450 · Cited by 148 · see citing works

Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis.

Galson, D. L., Hensold, J. O., Bishop, T. R., Schalling, M., D'Andrea, A. D., Jones, C., Auron, P. E., & Housman, D. E. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.5.2929 · Cited by 147 · see citing works

Monocyte Expression of the Human Prointerleukin 1β Gene (IL1B) Is Dependent on Promoter Sequences Which Bind the Hematopoietic Transcription Factor Spi-1/PU.1

Kominato, Y., Galson, D. L., Waterman, W. R., Webb, A. C., & Auron, P. E. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.1.59 · Cited by 146 · see citing works

The transcription factor PU.1 is critical for viability and function of human brain microglia

Smith, A. M., Gibbons, H. M., Oldfield, R. L., Bergin, P. M., Mee, E. W., Faull, R. L. M., & Dragunow, M. (2013) · Glia · doi:10.1002/glia.22486 · Cited by 141 · see citing works

The key role of PU.1/SPI-1 in B cells, myeloid cells and macrophages

Lloberas, J., Soler, C., & Celada, A. (1999) · Immunology Today · doi:10.1016/s0167-5699(99)01442-5 · Cited by 142 · see citing works

Transcriptional regulation in myelopoiesis: Hematopoietic fate choice, myeloid differentiation, and leukemogenesis

Rosmarin, A. G., Yang, Z., & Resendes, K. K. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2004.08.015 · Cited by 142 · see citing works

Neutrophils Deficient in PU.1 Do Not Terminally Differentiate or Become Functionally Competent

Anderson, K. L., Smith, K. A., Pio, F., Torbett, B. E., & Maki, R. A. (1998) · Blood · doi:10.1182/blood.v92.5.1576 · Cited by 142 · see citing works

Inhibition of hematopoiesis by competitive binding of transcription factor PU.1

Voso, M. T., Burn, T. C., Wulf, G., Lim, B., Leone, G., & Tenen, D. G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.7932 · Cited by 141 · see citing works

Analysis of the thrombopoietin receptor (MPL) promoter implicates GATA and Ets proteins in the coregulation of megakaryocyte-specific genes

DeVeaux, S., Filipe, A., Lemarchandel, V., Ghysdael, J., Roméo, P., & Mignotte, V. (1996) · Blood · doi:10.1182/blood.v87.11.4678.bloodjournal87114678 · Cited by 138 · see citing works

The Spi‐1/PU.1 and Spi‐B ets family transcription factors and the recombination signal binding protein RBP‐J kappa interact with an Epstein‐Barr virus nuclear antigen 2 responsive cis‐element.

Laux, G., Adam, B.-L., Strobl, L. J., & Moreau-Gachelin, F. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06900.x · Cited by 137 · see citing works

Regulation of the myeloperoxidase enhancer binding proteins Pu1, C-EBP alpha, -beta, and -delta during granulocyte-lineage specification.

Ford, A. M., Bennett, C. L., Healy, L. E., Towatari, M., Greaves, M. F., & Enver, T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.10838 · Cited by 133 · see citing works

Function of PU.1 (Spi-1), C/EBP, and AML1 in Early Myelopoiesis: Regulation of Multiple Myeloid CSF Receptor Promoters

Zhang, D., Hohaus, S., Voso, M. T., Chen, H.-M., Smith, L. T., Hetherington, C. J., & Tenen, D. G. (1996) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-85232-9_14 · Cited by 131 · see citing works

Hoxa9 Immortalizes a Granulocyte-Macrophage Colony-Stimulating Factor-Dependent Promyelocyte Capable of Biphenotypic Differentiation to Neutrophils or Macrophages, Independent of Enforced Meis Expression

Calvo, K. R., Sykes, D. B., Pasillas, M. P., & Kamps, M. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.9.3274-3285.2000 · Cited by 126 · see citing works

Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes.

Reddy, M. A., Yang, B. S., Yue, X., Barnett, C. J., Ross, I. L., Sweet, M. J., Hume, D. A., & Ostrowski, M. C. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.6.2309 · Cited by 123 · see citing works

Novel Combinatorial Interactions of GATA-1, PU.1, and C/EBPε Isoforms Regulate Transcription of the Gene Encoding Eosinophil Granule Major Basic Protein

Du, J., Stankiewicz, M. J., Liu, Y., Xi, Q., Schmitz, J. E., Lekstrom-Himes, J. A., & Ackerman, S. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204777200 · Cited by 120 · see citing works

PU.1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancer.

Henkel, G., & Brown, M. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7737 · Cited by 118 · see citing works

PU.1 and Multiple IFN Regulatory Factor Proteins Synergize to Mediate Transcriptional Activation of the Human IL-1β Gene

Marecki, S., Riendeau, C. J., Liang, M. D., & Fenton, M. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.11.6829 · Cited by 111 · see citing works

The role of Ets family transcription factor PU.1 in hematopoietic cell differentiation, proliferation and apoptosis

Oikawa, T., Yamada, T., Kihara-Negishi, F., Yamamoto, H., Kondoh, N., Hitomi, Y., & Hashimoto, Y. (1999) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4400534 · Cited by 109 · see citing works

Regulation of the PU.1 gene by distal elements

Li, Y., Okuno, Y., Zhang, P., Radomska, H. S., Chen, H.-M., Iwasaki, H., Akashi, K., Klemsz, M. J., McKercher, S. R., Maki, R. A., et al. (2001) · Blood · doi:10.1182/blood.v98.10.2958 · Cited by 110 · see citing works

Spi-1/PU.1: an oncogene of the Ets family

Moreau-Gachelin, F. (1994) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(94)90011-6 · Cited by 110 · see citing works

TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors

Rehli, M., Lichanska, A., Cassady, A. I., Ostrowski, M. C., & Hume, D. A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1559 · Cited by 116 · see citing works

CCAAT Displacement Protein Competes with Multiple Transcriptional Activators for Binding to Four Sites in the Proximal gp91 Promoter

Luo, W., & Skalnik, D. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.18203 · Cited by 101 · see citing works

Characterization of ESE-2, a Novel ESE-1-related Ets Transcription Factor That Is Restricted to Glandular Epithelium and Differentiated Keratinocytes

Oettgen, P., Kas, K., Dube, A., Gu, X., Grall, F., Thamrongsak, U., Akbarali, Y., Finger, E., Boltax, J., Endress, G., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.29439 · Cited by 100 · see citing works

Role of the Ets Transcription Factors in the Regulation of the Vascular-Specific Tie2 Gene

Dube, A., Akbarali, Y., Sato, T. N., Libermann, T. A., & Oettgen, P. (1999) · Circulation Research · doi:10.1161/01.res.84.10.1177 · Cited by 97 · see citing works

The Transcription Factor PU.1 is a Critical Regulator of Cellular Communication in the Immune System

Turkistany, S. A., & DeKoter, R. P. (2011) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-011-0147-9 · Cited by 96 · see citing works

Role of Ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter

Iljin, K., Dube, A., Kontusaari, S., KORHONEN, J., Lahtinen, I., Oettgen, P., & Alitalo, K. K. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.2.377 · Cited by 96 · see citing works

CD18 (beta 2 leukocyte integrin) promoter requires PU.1 transcription factor for myeloid activity.

Rosmarin, A. G., Caprio, D. G., Levy, R., & Simkevich, C. P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.801 · Cited by 94 · see citing works

Sp1 Binds Two Sites in the CD11c Promoter In Vivo Specifically in Myeloid Cells and Cooperates with AP1 to Activate Transcription

Noti, J. D., Reinemann, B. C., & Petrus, M. N. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.6.2940 · Cited by 94 · see citing works

Transcription factors that regulate growth and differentiation of myeloid cells.

Nagamura-Inoue, T., Tamura, T., & Ozato, K. (2001) · International Reviews of Immunology · doi:10.3109/08830180109056724 · Cited by 94 · see citing works

Activation of Transcription by PU.1 Requires both Acidic and Glutamine Domains

Klemsz, M. J., & Maki, R. A. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.1.390 · Cited by 93 · see citing works

Surprising new roles for PU.1 in the adaptive immune response

Carotta, S., Wu, L., & Nutt, S. L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00955.x · Cited by 93 · see citing works

The Transcriptional Repressor GFI-1 Antagonizes PU.1 Activity through Protein-Protein Interaction

Dahl, R. E., Iyer, S. R., Owens, K., Cuylear, D. D., & Simon, M. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607613200 · Cited by 93 · see citing works

Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBP

Iwama, A., Zhang, P., Darlington, G. J., McKercher, S. R., Maki, R., & Tenen, D. G. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.12.3034 · Cited by 91 · see citing works

Overexpression of PU.1 Induces Growth and Differentiation Inhibition and Apoptotic Cell Death in Murine Erythroleukemia Cells

Yamada, T., Kondoh, N., Matsumoto, M., Yoshida, M., Maekawa, A., & Oikawa, T. (1997) · Blood · doi:10.1182/blood.v89.4.1383 · Cited by 91 · see citing works

The Human β2 Integrin CD18 promoter consists of Two Inverted Ets cis Elements

Böttinger, E. P., Shelley, C. S., Farokhzad, O. C., & Arnaout, M. A. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.4.2604 · Cited by 89 · see citing works

PU.1 and an HLH family member contribute to the myeloid‐specific transcription of the Fc gamma RIIIA promoter.

Feinman, R., Qiu, W. Q., Pearse, R. N., Nikolajczyk, B. S., Sen, R., Sheffery, M., & Ravetch, J. V. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06696.x · Cited by 88 · see citing works

GABP and PU.1 Compete for Binding, yet Cooperate to Increase CD18 (β2 Leukocyte Integrin) Transcription

Rosmarin, A. G., Caprio, D. G., Kirsch, D. G., Handa, H., & Simkevich, C. P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.40.23627 · Cited by 87 · see citing works

Cell-specific expression of the macrophage scavenger receptor gene is dependent on PU.1 and a composite AP-1/ets motif.

Moulton, K. S., Semple, K., Wu, H., & Glass, C. K. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4408 · Cited by 86 · see citing works

The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation

Kawaji, H., Severin, J., Lizio, M., Waterhouse, A. M., Katayama, S., Irvine, K. M., Hume, D. A., Forrest, A. R. R., Suzuki, H., Carninci, P., et al. (2009) · Genome biology · doi:10.1186/gb-2009-10-4-r40 · Cited by 85 · see citing works

Characterization of NERF, a Novel Transcription Factor Related to the Ets Factor ELF-1

Oettgen, P., Akbarali, Y., Boltax, J., Best, J. L., KUNSCH, C. A., & Libermann, T. A. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.5091 · Cited by 85 · see citing works

Involvement of the transcription factor PU.1/Spi-1 in myeloid cell-restricted expression of an interferon-inducible gene encoding the human high-affinity Fc gamma receptor.

Perez, C., Coeffier, E., Moreau-Gachelin, F., Wietzerbin, J., & Benech, P. D. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.8.5023 · Cited by 84 · see citing works

PU.1/Pip and Basic Helix Loop Helix Zipper Transcription Factors Interact With Binding Sites in the CD20 Promoter to Help Confer Lineage- and Stage-Specific Expression of CD20 in B Lymphocytes

Himmelmann, A. W., Riva, A., Wilson, G. L., Lucas, B. P., Thévenin, C., & Kehrl, J. H. (1997) · Blood · doi:10.1182/blood.v90.10.3984 · Cited by 84 · see citing works

CCAAT/Enhancer-binding Protein Activates the CD14 Promoter and Mediates Transforming Growth Factor β Signaling in Monocyte Development

Pan, Z., Hetherington, C. J., & Zhang, D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23242 · Cited by 80 · see citing works

Interaction between PU.1 and Another Ets Family Transcription Factor Promotes Macrophage-specific Basal Transcription Initiation

Ross, I. L., Xie, Y., Ostrowski, M. C., & Hume, D. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.12.6662 · Cited by 78 · see citing works

PU.1 but not ets-2 is essential for macrophage development from embryonic stem cells

Henkel, G., McKercher, Sr., Yamamoto, H., Anderson, K., Oshima, R., & Maki, R. (1996) · Blood · doi:10.1182/blood.v88.8.2917.bloodjournal8882917 · Cited by 76 · see citing works

A transcriptional regulatory element is associated with a nuclease-hypersensitive site in the pol gene of human immunodeficiency virus type 1

Lint, C. M. V., Ghysdael, J., Paras, P., Burny, A., & Verdin, E. M. (1994) · Journal of Virology · doi:10.1128/jvi.68.4.2632-2648.1994 · Cited by 76 · see citing works

Forced GATA-1 Expression in the Murine Myeloid Cell Line M1: Induction of c-Mpl Expression and Megakaryocytic/Erythroid Differentiation

Yamaguchi, Y., Zon, L. I., Ackerman, S. J., Yamamoto, M. P., & Suda, T. (1998) · Blood · doi:10.1182/blood.v91.2.450.450_450_457 · Cited by 75 · see citing works

The Sp1 transcription factor binds the CD11b promoter specifically in myeloid cells in vivo and is essential for myeloid-specific promoter activity.

Chen, H. M., Pahl, H. L., Scheibe, R. J., Zhang, D. E., & Tenen, D. G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53086-6 · Cited by 199 · see citing works

Identification of the promoter of the myelomonocytic leukocyte integrin CD11b.

Hickstein, D. D., Baker, D. M., Gollahon, K. A., & Back, A. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.6.2105 · Cited by 79 · see citing works

PU.1 negatively regulates the CD11c integrin gene promoter through recognition of the major transcriptional start site

López‐Rodríguez, C., & Corbí, A. L. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270804 · Cited by 36 · see citing works

Characterization of the myeloid-specific CD11b promoter

Pahl, H., Rosmarin, A., & Tenen, D. (1992) · Blood · doi:10.1182/blood.v79.4.865.bloodjournal794865 · Cited by 95 · see citing works

The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression.

Shelley, C., & Arnaout, M. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10525 · Cited by 61 · see citing works