The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
ERM-Dependent Movement of CD43 Defines a Novel Protein Complex Distal to the Immunological Synapse
Open accessAbstract
The large mucin CD43 is actively excluded from T cell/APC interaction sites, concentrating in a membrane domain distal to the site of TCR engagement. The cytoplasmic region of CD43 was necessary and sufficient for this antipodal movement. ERM cytoskeletal adaptor proteins colocalized with CD43 in this domain. An ERM dominant-negative mutant blocked the distal accumulation of CD43 and another known ERM binding protein, Rho-GDI. Inhibition of ERM function decreased the production of IL-2 and IFNgamma, without affecting PKC(theta) focusing or CD69 upregulation. These results indicate that ERM proteins organize a complex distal to the T cell/APC interaction site and provide evidence that full T cell activation may involve removal of inhibitory proteins from the immunological synapse.
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Citations
Cites
Distinct signal transduction in mouse CD4+ and CD8+ splenic T cells after CD28 receptor ligation.
Abe, R., Vandenberghe, P., Craighead, N., Smoot, D. S., Lee, K. P., & June, C. H. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.3.985 · Cited by 120
Cited by
Smith-Garvin, J. E., Koretzky, G. A., & Jordan, M. S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132706 · Cited by 2,144
ERM proteins and merlin: integrators at the cell cortex
Bretscher, A., Edwards, K., & Fehon, R. G. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm882 · Cited by 1,306
Organizing the cell cortex: the role of ERM proteins
Fehon, R. G., McClatchey, A. I., & Bretscher, A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2866 · Cited by 1,044
Tuning immune responses: diversity and adaptation of the immunological synapse
Friedl, P., den Boer, A. T., & Gunzer, M. (2005) · Nature Reviews Immunology · doi:10.1038/nri1647 · Cited by 276
Hamada, K., Shimizu, T., Yonemura, S., Tsukita, S., Tsukita, S., & Hakoshima, T. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg039 · Cited by 155
Immunological synapse and microclusters: the site for recognition and activation of T cells
Saito, T., & Yokosuka, T. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.03.014 · Cited by 124
Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies
Dupré, L., Boztug, K., & Pfajfer, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.665519 · Cited by 64
Fischer, H. J., Schweingruber, N., Lühder, F., & Reichardt, H. M. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.04.001 · Cited by 34
Metadata
- Authors
- Allenspach, E. J., Cullinan, P., Tong, J., Tang, Q., Tesciuba, A. G., Cannon, J. L., Takahashi, S. M., Morgan, R., Burkhardt, J. K., & Sperling, A. I.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2001-11
- Volume
- 15
- Issue
- 5
- Pages
- 739-750
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1966938433
- Cited by
- 264
- References
- 1
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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