The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Tuning immune responses: diversity and adaptation of the immunological synapse
Abstract
The onset and regulation of a specific immune response results from communication between T cells and antigen-presenting cells (APCs), which form molecular interactions at the site of cell-cell contact--and this is known as the immunological synapse. Initially, the immunological synapse was viewed as a stereotypical adhesion and signalling device with a defined molecular structure and signalling processes. However, as we discuss here, T-cell-APC interactions comprise a diverse range of contact modes and distinct molecular arrangements. These diverse interaction modes might define a molecular code, in which the differences in timing, spacing and molecular composition of the signalling platform determine the outcome of T-cell-APC interactions.
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“Lck and ZAP-70 have been shown to translocate to microclusters of receptors and signaling molecules in the peripheral regions of the T-APC interface within lipid rafts during initiation of the TCR activation signal. The clusters form a central supramolecular activation cluster (c-SMAC) of the IS [24], [25], [26].”
From RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling (2010) · cites this paper as [24]
Citations
Cites
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Grakoui, A., Bromley, S. K., Sumen, C., Davis, M. M., Shaw, A. S., Allen, P. M., & Dustin, M. L. (1999) · Science · doi:10.1126/science.285.5425.221 · Cited by 3,102
Three-dimensional segregation of supramolecular activation clusters in T cells
Monks, C. R. F., Freiberg, B. A., Kupfer, H., Sciaky, N., & Kupfer, A. (1998) · Nature · doi:10.1038/25764 · Cited by 1,968
T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
Mempel, T. R., Henrickson, S. E., & von Andrian, U. H. (2004) · Nature · doi:10.1038/nature02238 · Cited by 1,714
Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response
Hart, D. N. J. (1997) · Blood · doi:10.1182/blood.v90.9.3245 · Cited by 1,483
T-Cell Function and Migration — Two Sides of the Same Coin
von Andrian, U. H., & Mackay, C. R. (2000) · New England Journal of Medicine · doi:10.1056/nejm200010053431407 · Cited by 1,437
Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node
Miller, M. J., Wei, S. H., Parker, I., & Cahalan, M. D. (2002) · Science · doi:10.1126/science.1070051 · Cited by 1,207
Serial triggering of many T-cell receptors by a few peptide–MHC complexes
Valitutti, S., Müller, S., Cella, M., Padovan, E., & Lanzavecchia, A. (1995) · Nature · doi:10.1038/375148a0 · Cited by 1,128
Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
Cella, M., Engering, A., Pinet, V., Pieters, J., & Lanzavecchia, A. (1997) · Nature · doi:10.1038/42030 · Cited by 1,123
Bromley, S. K., Burack, W. R., Johnson, K. G., Somersalo, K., Sims, T. N., Sumen, C., Davis, M. M., Shaw, A. S., Allen, P. M., & Dustin, M. L. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.375 · Cited by 979
Cited by
Rodriguez-Plata, M. T., Puigdomènech, I., Izquierdo-Useros, N., Puertas, M. C., Carrillo, J., Erkizia, I., Clotet, B., Blanco, J., & Martinez-Picado, J. (2013) · Retrovirology · doi:10.1186/1742-4690-10-42 · Cited by 45
RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling
Chae, H.-D., Siefring, J. E., Hildeman, D. A., Gu, Y., & Williams, D. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013970 · Cited by 35
ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion
Jung, S. H., Yoo, E. H., Yu, M. J., Song, H. M., Kang, H. Y., Cho, J.-Y., & Lee, J. R. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501913 · Cited by 19
Metadata
- Authors
- Friedl, P., den Boer, A. T., & Gunzer, M.
- Venue
- Nature Reviews Immunology
- Published
- 2005-07-01
- Volume
- 5
- Issue
- 7
- Pages
- 532-545
- ISSN
- 1474-1733
- 1474-1741
- Cited by
- 276
- References
- 117
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
- www.springer.com/tdm (vor)
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- Friedl, P., den Boer, A. T., & Gunzer, M. (2005). Tuning immune responses: diversity and adaptation of the immunological synapse. Nature Reviews Immunology. https://doi.org/10.1038/nri1647
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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