CoChat
Sign Up
Cited by 199Peripheral Artery Disease ManagementCardiovascular and exercise physiologyExercise and Physiological Responses

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Exercise training for intermittent claudication: Does it adversely affect biochemical markers of the exercise-induced inflammatory response?

Open access
Tisi, P.V., Hulse, M., Chulakadabba, A., Gosling, P., Shearman, C.P.·1997·European Journal of Vascular and Endovascular Surgery
DOI 10.1016/s1078-5884(97)80283-3
Open this paper in CoChat — free account

Abstract

Objectives To identify a stable biochemical marker of disease severity in patients with intermittent claudication and to use these findings to assess the effect of therapeutic exercise training.Design Case-control study: prospective randomised-controlled trial of exercise training.Materials and methods Plasma fibrinogen, serum amyloid A protein (SAA), C-reactive protein (CRP) and urinary albumin-creatinine ratio (ACR) were measured in 67 claudicants and 15 controls. Twenty-two patients were randomised to supervised exercise training and 17 randomised to observation. Subjects were reviewed at 3, 6 and 12 months.Results The median (interquartile range) baseline fibrinogen was 3.7 g/l (3.3-4.25) in claudicants and 3.5 g/l (2.9-3.95) in controls (p = 0.045); CRP was 4.7 mg/l (2.2-9.0) and 2.1 mg/l (1.0-2.8), respectively (p < 0.0001); SAA was 72 mg/l (35-132) and 30 mg/l (20-89) (p = 0.0009). Claudicants showed an increased urinary ACR following treadmill exercise (Wilcoxon, p < 0.0001) with no change in controls. Exercise training reduced SAA at 6 months, CRP at 3 months and progressively attenuated the post-exercise increase in ACR. No similar changes were found in controls.Conclusions Repetitive low-grade inflammatory events in claudicants lead to elevation of serum acute-phase proteins. Exercise training is associated with symptomatic improvement and reduction inflammatory markers. The concern that exercise has adverse systemic effects therefore seems to be unjustified.

Overview

Integrity signals

Registry

Crossref · 10.1016/s1078-5884(97)80283-3

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 2

  1. Dormandy, 1989, Fate of the patient with chronic leg ischaemia, J Cardiovasc Surg, 30, 50
  2. Shearman, 1988, Glomerular permeability to large molecules: a marker of vascular permeability?, Br J Surg, 75, 1273

Cited by

Sorted by citations

See all 199

Related

See all

Metadata

Authors
Tisi, P. V., Hulse, M., Chulakadabba, A., Gosling, P., & Shearman, C. P.
Affiliations
  • Royal South Hants Hospital (GB)
  • Selly Oak Hospital (GB)
Venue
European Journal of Vascular and Endovascular Surgery
Publisher
Elsevier BV
Published
1997-11
Volume
14
Issue
5
Pages
344-350
ISSN
1078-5884 (ISSN-L)
DOI
10.1016/s1078-5884(97)80283-3
OpenAlex
W2165389773
Cited by
199
References
31
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 14 · 2014: 9 · 2013: 4 · 2012: 16
FWCI
4.22
Type
journal article
Language
en
Open access
Licence
Locations
  • European Journal of Vascular and Endovascular Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Peripheral Artery Disease Management
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords
intermittent claudication, exercise training, inflammatory markers, C-reactive protein, serum amyloid A, fibrinogen, urinary albumin-creatinine ratio, acute phase proteins, peripheral arterial disease, treadmill exercise, disease severity markers
MeSH terms
Aged, Albuminuria, Serum Amyloid A Protein, C-Reactive Protein, Creatinine, Exercise Therapy, Female, Fibrinogen, Humans, Inflammation, Intermittent Claudication, Male, Prospective Studies, Biomarkers, Case-Control Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review