The Effects of Physical Activity on Serum C-Reactive Protein and Inflammatory Markers
Open accessAbstract
Physical activity is associated with a reduced incidence of coronary disease, but the mechanisms mediating this effect are not defined. There has been considerable recent interest in inflammation in the pathogenesis of cardiovascular disease. Some of the beneficial role of physical activity may result from its effects on the inflammatory process. We searched PubMed for articles published between 1975 through May 2004 using the terms exercise, physical activity, or physical fitness combined with C-reactive protein, inflammation, inflammatory markers, or cytokines. The review revealed 19 articles on the acute inflammatory response to exercise, 18 on cross-sectional comparisons of subjects by activity levels, and 5 examining prospectively the effects of exercise training on the inflammatory process. Exercise produces a short-term, inflammatory response, whereas both cross-sectional comparisons and longitudinal exercise training studies demonstrate a long-term "anti-inflammatory" effect. This anti-inflammatory response may contribute to the beneficial effects of habitual physical activity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Acute exercise transiently boosts production and release of IL-6 from skeletal muscles; the IL-6 released during physical activity inhibits TNF-alpha production and induces IL-10 production.
“acute exercise transiently boosts production and release of IL-6 from skeletal muscles; the IL-6 that is released during physical activity inhibits TNF-α production and induces IL-10 production, one of exercise's anti-inflammatory mechanisms”
From Close relationships, inflammation, and health (2010) · cites this paper as Kasapis and Thompson, 2005
People who describe themselves as physically active have lower levels of inflammation than their sedentary counterparts.
“People who describe themselves as physically active have lower levels of inflammation than their sedentary counterparts”
From Close relationships, inflammation, and health (2010) · cites this paper as Kasapis and Thompson, 2005
When physical or cardiorespiratory fitness is assessed rigorously and objectively by maximal exercise testing, fitness is inversely associated with inflammation, even after adjusting for confounds including age, smoking, medications, and visceral fat.
“When physical or cardiorespiratory fitness is assessed rigorously and objectively by maximal exercise testing, fitness is inversely associated with inflammation, even after adjusting for confounds including age, smoking, medications, and visceral fat”
From Close relationships, inflammation, and health (2010) · cites this paper as Kasapis and Thompson, 2005
Regular aerobic exercise can increase factors involved in immunomodulatory function and diminish pro-inflammatory signaling through downstream anti-inflammatory effects of acute production of IL-6.
“For example, regular aerobic exercise can increase factors involved in immunomodulatory function and diminish pro-inflammatory signaling, through downstream anti-inflammatory effects of acute production of IL-6”
From Exercise Intervention in PTSD: A Narrative Review and Rationale for Implementation (2019) · cites this paper as [126]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725 · see citing works
Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000052939.59093.45 · Cited by 6,401 · see citing works
Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465 · see citing works
Fletcher, G. F., Ades, P. A., Kligfield, P., Arena, R., Balady, G. J., Bittner, V. A., Coke, L. A., Fleg, J. L., Forman, D. E., Gerber, T. C., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829b5b44 · Cited by 2,235 · see citing works
Köenig, W., Sund, M., Fröhlich, M., Fischer, H.-G., Löwel, H., Döring, A., Hutchinson, W. L., & Pepys, M. B. (1999) · Circulation · doi:10.1161/01.cir.99.2.237 · Cited by 1,952 · see citing works
Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
Pasceri, V., Willerson, J. T., & Yeh, E. T. H. (2000) · Circulation · doi:10.1161/01.cir.102.18.2165 · Cited by 1,941 · see citing works
Fletcher, G. F., Balady, G. J., Amsterdam, E. A., Chaitman, B., Eckel, R., Fleg, J., Froelicher, V. F., Leon, A. S., Piña, I. L., Rodney, R., et al. (2001) · Circulation · doi:10.1161/hc3901.095960 · Cited by 1,923 · see citing works
Atherosclerosis: Basic Mechanisms
Berliner, J. A., Navab, M., Fogelman, A. M., Frank, J. S., Demer, L. L., Edwards, P. A., Watson, A. D., & Lusis, A. J. (1995) · Circulation · doi:10.1161/01.cir.91.9.2488 · Cited by 1,726 · see citing works
Exercise and the immune system: regulation, integration, and adaptation
Pedersen, B. K., & Hoffman-Goetz, L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.1055 · Cited by 1,710 · see citing works
Fried, S. K., Bunkin, D. A., & Greenberg, A. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4660 · Cited by 1,528 · see citing works
Esposito, K., Pontillo, A., Di Palo, C., Giugliano, G., Masella, M., Marfella, R., & Giugliano, D. (2003) · JAMA · doi:10.1001/jama.289.14.1799 · Cited by 1,511 · see citing works
Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment.
Romano, M., Sironi, M., Toniatti, C., Polentarutti, N., Fruscella, P., Ghezzi, P., Faggioni, R., Luini, W., van Hinsbergh, V., Sozzani, S., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80334-9 · Cited by 1,181 · see citing works
Verma, S., Wang, C., Li, S., Dumont, A. S., Fedak, P. W. M., Badiwala, M. V., Dhillon, B., Weisel, R. D., Li, R., Mickle, D. A. G., et al. (2002) · Circulation · doi:10.1161/01.cir.0000029802.88087.5e · Cited by 1,052 · see citing works
Pro‐ and anti‐inflammatory cytokine balance in strenuous exercise in humans
Ostrowski, K., Rohde, T., Asp, S., Schjerling, P., & Pedersen, B. K. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.287ad.x · Cited by 1,014 · see citing works
Muscle‐derived interleukin‐6: mechanisms for activation and possible biological roles
FEBBRAIO, M. A., & PEDERSEN, B. K. (2002) · The FASEB Journal · doi:10.1096/fj.01-0876rev · Cited by 875 · see citing works
C-Reactive Protein as a Cardiovascular Risk Factor
Lagrand, W. K., Visser, C. A., Hermens, W. T., Niessen, H. W. M., Verheugt, F. W. A., Wolbink, G., & Hack, C. E. (1999) · Circulation · doi:10.1161/01.cir.100.1.96 · Cited by 833 · see citing works
Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running
Ostrowski, K., Rohde, T., Zacho, M., Asp, S., & Pedersen, B. K. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.949bp.x · Cited by 673 · see citing works
Gielen, S., Adams, V., Möbius-Winkler, S., Linke, A., Erbs, S., Yu, J., Kempf, W., Schubert, A., Schuler, G., & Hambrecht, R. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00848-9 · Cited by 613 · see citing works
Association between Physical Activity and Markers of Inflammation in a Healthy Elderly Population
Geffken, D. F., Cushman, M., Burke, G. L., Polak, J. F., Sakkinen, P. A., & Tracy, R. P. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.3.242 · Cited by 599 · see citing works
Muscle‐derived interleukin‐6: possible biological effects
Pedersen, B. K., Steensberg, A., & Schjerling, P. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0329c.xd · Cited by 599 · see citing works
Intensity and Amount of Physical Activity in Relation to Insulin Sensitivity
Mayer-Davis, E. J. (1998) · JAMA · doi:10.1001/jama.279.9.669 · Cited by 598 · see citing works
Does Exercise Reduce Inflammation? Physical Activity and C-Reactive Protein Among U.S. Adults
Ford, E. S. (2002) · Epidemiology · doi:10.1097/00001648-200209000-00012 · Cited by 575 · see citing works
Abramson, J. L., & Vaccarino, V. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.11.1286 · Cited by 512 · see citing works
Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review
Powers, S. K., Ji, L. L., & Leeuwenburgh, C. (1999) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199907000-00011 · Cited by 501 · see citing works
Physical Activity and Hemostatic and Inflammatory Variables in Elderly Men
Wannamethee, S. G., Lowe, G. D. O., Whincup, P. H., Rumley, A., Walker, M., & Lennon, L. (2002) · Circulation · doi:10.1161/01.cir.0000016346.14762.71 · Cited by 487 · see citing works
Physical Activity Prevents Age-Related Impairment in Nitric Oxide Availability in Elderly Athletes
Taddei, S., Galetta, F., Virdis, A., Ghiadoni, L., Salvetti, G., Franzoni, F., Giusti, C., & Salvetti, A. (2000) · Circulation · doi:10.1161/01.cir.101.25.2896 · Cited by 460 · see citing works
Taaffe, D. R., Harris, T. B., Ferrucci, L., Rowe, J., & Seeman, T. E. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.12.m709 · Cited by 438 · see citing works
Smith, J. K. (1999) · JAMA · doi:10.1001/jama.281.18.1722 · Cited by 420 · see citing works
A trauma‐like elevation of plasma cytokines in humans in response to treadmill running
Ostrowski, K., Hermann, C., Bangash, A., Schjerling, P., Nielsen, J. N., & Pedersen, B. K. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.889ba.x · Cited by 398 · see citing works
Mattusch, Dufaux, Heine, Mertens, & Rost (2000) · International Journal of Sports Medicine · doi:10.1055/s-2000-8852 · Cited by 389 · see citing works
Associations Between Cardiorespiratory Fitness and C-Reactive Protein in Men
Church, T. S., Barlow, C. E., Earnest, C. P., Kampert, J. B., Priest, E. L., & Blair, S. N. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000036611.77940.f8 · Cited by 382 · see citing works
Differentiation Between Obesity and Insulin Resistance in the Association With C-Reactive Protein
McLaughlin, T., Abbasi, F., Lamendola, C. A., Liang, L., Reaven, G. M., Schaaf, P., & Reaven, P. D. (2002) · Circulation · doi:10.1161/01.cir.0000041046.32962.86 · Cited by 374 · see citing works
Physical training reduces peripheral markers of inflammation in patients with chronic heart failure
Adamopoulos, S. N. (2001) · European Heart Journal · doi:10.1053/euhj.2000.2285 · Cited by 373 · see citing works
Changes in indicators of inflammation after eccentric exercise of the elbow flexors
Nosaka, K., & Clarkson, P. M. (1996) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199608000-00003 · Cited by 365 · see citing works
Survey of C-reactive protein and cardiovascular risk factors in apparently healthy men
Rohde, L. E. P., Hennekens, C. H., & Ridker, P. M. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00491-9 · Cited by 349 · see citing works
Human CRP Gene Polymorphism Influences CRP Levels
Brull, D. J., Serrano, N. C., Zito, F., Jones, L., Montgomery, H., Rumley, A., Sharma, P. K., Lowe, G. D. O., WORLD, M. J., Humphries, S. E., et al. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000084640.21712.9c · Cited by 305 · see citing works
Physical Activity and Hemostatic and Inflammatory Variables in Elderly Men
Wannamethee, S. G. (2002) · Circulation · doi:10.1161/hc1502.107117 · Cited by 296 · see citing works
Adiponectin - Its Role in Metabolism and Beyond
Stefan, N., & Stümvoll, M. (2002) · Hormone and Metabolic Research · doi:10.1055/s-2002-34785 · Cited by 293 · see citing works
Exercise and the immune system
Fitzgerald, L. (1988) · Immunology Today · doi:10.1016/0167-5699(88)91332-1 · Cited by 279 · see citing works
Independent Association Between Plasma Leptin and C-Reactive Protein in Healthy Humans
Shamsuzzaman, A., Winnicki, M., Wolk, R. A., Svatikova, A., Phillips, B. G., Davison, D. E., Berger, P. B., & Somers, V. K. (2004) · Circulation · doi:10.1161/01.cir.0000127960.28627.75 · Cited by 262 · see citing works
Castell, L. M., POORTMANS, J. R., Leclercq, R., Brasseur, M., Duchateau, J., & Newsholme, E. A. (1996) · European Journal of Applied Physiology · doi:10.1007/s004210050125 · Cited by 240 · see citing works
Muscle-derived interleukin-6: lipolytic, anti-inflammatory and immune regulatory effects
Pedersen, B. K., Steensberg, A., Keller, P., Keller, C., Fischer, C., Hiscock, N., van Hall, G., Plomgaard, P., & Febbraio, M. A. (2003) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-002-0981-z · Cited by 228 · see citing works
Cardiorespiratory Fitness and C-Reactive Protein Among a Tri-Ethnic Sample of Women
LaMonte, M. J., Durstine, J. L., Yanowitz, F. G., Lim, T. H., DuBose, K. D., Davis, P. G., & Ainsworth, B. E. (2002) · Circulation · doi:10.1161/01.cir.0000025425.20606.69 · Cited by 207 · see citing works
Tisi, P. V., Hulse, M., Chulakadabba, A., Gosling, P., & Shearman, C. P. (1997) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/s1078-5884(97)80283-3 · Cited by 199 · see citing works
Inflammatory Markers and Exercise: Differences Related to Exercise Type
King, D. E., Carek, P. J., Mainous, A. G., & Pearson, W. S. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000058440.28108.cc · Cited by 194 · see citing works
Effect of physical activity on serum C-reactive protein
Albert, M. A., Glynn, R. J., & Ridker, P. M. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2003.09.046 · Cited by 178 · see citing works
Strenuous exercise: analogous to the acute-phase response?
Weight, L. M., Alexander, D., & Jacobs, P. (1991) · Clinical Science · doi:10.1042/cs0810677 · Cited by 147 · see citing works
Chemokines are elevated in plasma after strenuous exercise in humans
Ostrowski, K., Rohde, T., Asp, S., Schjerling, P., & Pedersen, B. K. (2001) · European Journal of Applied Physiology · doi:10.1007/s004210170012 · Cited by 146 · see citing works
Body Mass Index, but Not Physical Activity, Is Associated with C-Reactive Protein
RAWSON, E. S., FREEDSON, P. S., OSGANIAN, S. K., MATTHEWS, C. E., REED, G., & OCKENE, I. S. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000074565.79230.ab · Cited by 144 · see citing works
Effect of marathon running on inflammatory and hemostatic markers
Siegel, A. J., Stec, J. J., Lipinska, I., Cott, E. M. V., Lewandrowski, K. B., Ridker, P. M., & Tofler, G. H. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01909-9 · Cited by 139 · see citing works
The Acute Phase Response and Exercise: The Ultramarathon as Prototype Exercise
Fallon, K. E. (2001) · Clinical Journal of Sport Medicine · doi:10.1097/00042752-200101000-00007 · Cited by 131 · see citing works
Isasi, C. R., Deckelbaum, R. J., Tracy, R. P., Starc, T. J., Berglund, L., & Shea, S. (2003) · PEDIATRICS · doi:10.1542/peds.111.2.332 · Cited by 129 · see citing works
Hematologic, iron-related, and acute-phase protein responses to sustained strenuous exercise
Taylor, C. B., Rogers, G. G., Goodman, C. A., Baynes, R. D., Bothwell, T. H., Bezwoda, W. R., Kramer, F., & Hattingh, J. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.62.2.464 · Cited by 121 · see citing works
Exercise and Cardiovascular Disease
Shern-Brewer, R., Santanam, N., Wetzstein, C. J., White-Welkley, J. E., & Parthasarathy, S. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.7.1181 · Cited by 114 · see citing works
C-Reactive protein is inversely related to physical fitness in middle-aged subjects
Aronson, D., Sheikh‐Ahmad, M., Avizohar, O., Kerner, A., Sella, R., Bartha, P., Markiewicz, W., Levy, Y., & Brook, G. J. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.04.025 · Cited by 113 · see citing works
Verdaet, D., Dendale, P., de Bacquer, D., Delanghe, J., Block, P., & Backer, G. D. D. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.05.007 · Cited by 110 · see citing works
Pitsavos, C. E., Chrysohoou, C. A., Panagiotakos, D. B., Skoumas, J., Zeimbekis, A., Kokkinos, P. F., Stefanadis, C., & TOUTOUZAS, P. K. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)03175-2 · Cited by 100 · see citing works
Liesen, H., Dufaux, B., & Hollmann, W. (1977) · European Journal of Applied Physiology · doi:10.1007/bf00430954 · Cited by 99 · see citing works
Tomaszewski, M., Charchar, F. J., Przybycin, M., Crawford, L., Wallace, A. M., Gosek, K., Lowe, G. D. O., Zukowska-Szczechowska, E., Grzeszczak, W., Sattar, N. A., et al. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000087036.75849.0b · Cited by 80 · see citing works
C reactive protein concentrations during long distance running.
Strachan, A. F., Noakes, T. D., Kotzenberg, G., Nel, A. E., & de Beer, F. C. (1984) · BMJ · doi:10.1136/bmj.289.6454.1249 · Cited by 79 · see citing works
C-Reactive Protein Serum Concentrations in Well-Trained Athletes*
Dufaux, B., Order, U., Geyer, H., & Hollmann, W. (1984) · International Journal of Sports Medicine · doi:10.1055/s-2008-1025889 · Cited by 76 · see citing works
Drenth, J. P. H., Krebbers, Bijzet, & Meer, V. D. P. (1998) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1998.00366.x · Cited by 69 · see citing works
Immunological response to oxidized LDL
Witztum, J. L. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(97)06116-9 · Cited by 37 · see citing works
Moderate exercise leads to decreased expression of ?1 and ?2 integrins on leucocytes
Jordan, J., Beneke, R., tler, M. H., Veith, A., Haller, H. G., & Luft, F. C. (1997) · European Journal of Applied Physiology · doi:10.1007/s004210050234 · Cited by 27 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Gleeson, M., Bishop, N. C., Stensel, D. J., Lindley, M. R., Mastana, S. S., & Nimmo, M. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3041 · Cited by 2,470 · see citing works
Fletcher, G. F., Ades, P. A., Kligfield, P., Arena, R., Balady, G. J., Bittner, V. A., Coke, L. A., Fleg, J. L., Forman, D. E., Gerber, T. C., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829b5b44 · Cited by 2,235 · see citing works
Obesity and inflammation: the linking mechanism and the complications
Ellulu, M. S., Patimah, I., Khaza’ai, H., Rahmat, A., & Abed, Y. (2017) · Archives of Medical Science · doi:10.5114/aoms.2016.58928 · Cited by 1,982 · see citing works
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
Physical Activity and Reduced Risk of Cardiovascular Events: Potential Mediating Mechanisms
Mora, S., Cook, N., Buring, J. E., Ridker, P. M., & Lee, I.-M. (2007) · Circulation · doi:10.1161/circulationaha.107.729939 · Cited by 1,000 · see citing works
Inflammation: Depression Fans the Flames and Feasts on the Heat
Kiecolt-Glaser, J. K., Derry, H. M., & Fagundes, C. P. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15020152 · Cited by 844 · see citing works
Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters
Del Giudice, M., & Gangestad, S. W. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.02.013 · Cited by 779 · see citing works
Holtermann, A., Krause, N., van der Beek, A. J., & Straker, L. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2017-097965 · Cited by 667 · see citing works
Balducci, S., Zanuso, S., Nicolucci, A., Fernando, F., Cavallo, S., Cardelli, P., Fallucca, S., Alessi, E., Letizia, C., Jimenez, A., et al. (2010) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.04.015 · Cited by 566 · see citing works
Inflammatory cytokines in general and central obesity and modulating effects of physical activity
Schmidt, F. M., Weschenfelder, J., Sander, C., Minkwitz, J., Thormann, J., Chittka, T., Mergl, R., Kirkby, K. C., Faßhauer, M., Stumvoll, M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121971 · Cited by 483 · see citing works
Physical activity in prevention and treatment of the metabolic syndrome
Lakka, T. A., & Laaksonen, D. E. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h06-113 · Cited by 482 · see citing works
Close relationships, inflammation, and health
Kiecolt-Glaser, J. K., Gouin, J.-P., & Hantsoo, L. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.09.003 · Cited by 480 · see citing works
Time-course of changes in inflammatory and performance responses following a soccer game
Ispirlidis, I., Fatouros, I. G., Jamurtas, A. Z., Nikolaidis, M. G., Michailidis, I., Douroudos, I., Margonis, K., Chatzinikolaou, A., Kalistratos, E., Katrabasas, I., et al. (2008) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0b013e3181818e0b · Cited by 467 · see citing works
Exercise modulates oxidative stress and inflammation in aging and cardiovascular diseases
Sallam, N., & Laher, I. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7239639 · Cited by 334 · see citing works
Stress, Inflammation, and Yoga Practice
Kiecolt-Glaser, J. K., Christian, L., Preston, H., Houts, C. R., Malarkey, W. B., Emery, C. F., & Glaser, R. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181cb9377 · Cited by 327 · see citing works
Blood-brain barrier permeability and physical exercise
Małkiewicz, M. A., Szarmach, A., Sabisz, A., Cubała, W. J., Szurowska, E., & Winklewski, P. J. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1403-x · Cited by 276 · see citing works
Grosso, G., Laudisio, D., Frias-Toral, E., Barrea, L., Muscogiuri, G., Savastano, S., & Colao, A. (2022) · Nutrients · doi:10.3390/nu14061137 · Cited by 255 · see citing works
Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men
Lampert, R., Bremner, J. D., Su, S., Miller, A., Lee, F., Cheema, F., Goldberg, J., & Vaccarino, V. (2008) · American Heart Journal · doi:10.1016/j.ahj.2008.07.009 · Cited by 240 · see citing works
Neilson, H. K., Friedenreich, C. M., Brockton, N. T., & Millikan, R. C. (2009) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0756 · Cited by 232 · see citing works
Pitharouli, M. C., Hagenaars, S. P., Glanville, K. P., Coleman, J. R. I., Hotopf, M., Lewis, C. M., & Pariante, C. M. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20060947 · Cited by 218 · see citing works
Exercise, Vascular Wall and Cardiovascular Diseases: An Update (Part 1)
Leung, F. P., Yung, L. M., Laher, I., Yao, X., Chen, Z. Y., & Huang, Y. (2008) · Sports Medicine · doi:10.2165/00007256-200838120-00005 · Cited by 219 · see citing works
Recent advances in obesity-induced inflammation and insulin resistance
Tateya, S., Kim, F., & Tamori, Y. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00093 · Cited by 211 · see citing works
Avan, A., Tavakoly Sany, S. B., Ghayour‐Mobarhan, M., Rahimi, H. R., Tajfard, M., & Ferns, G. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26791 · Cited by 182 · see citing works
Physical Activity Decreases Diverticular Complications
Strate, L. L., Liu, Y. L., Aldoori, W. H., & Giovannucci, E. L. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.121 · Cited by 185 · see citing works
Ribeiro, F., Alves, A. J., Duarte, J. A., & Oliveira, J. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.09.548 · Cited by 169 · see citing works
Challenging homeostasis to define biomarkers for nutrition related health
van Ommen, B., Keijer, J., Heil, S. G., & Kaput, J. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800390 · Cited by 167 · see citing works
Exercise in the prevention and treatment of maternal–fetal disease: a review of the literature
Weissgerber, T. L., Wolfe, L. A., Davies, G. A. L., & Mottola, M. F. (2006) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h06-060 · Cited by 165 · see citing works
Marques, A. H., Bjørke-Monsen, A.-L., Teixeira, A. L., & Silverman, M. N. (2015) · Brain Research · doi:10.1016/j.brainres.2014.10.051 · Cited by 166 · see citing works
Self-Reported Sitting Time and Markers of Inflammation, Insulin Resistance, and Adiposity
Yates, T., Khunti, K., Wilmot, E. G., Brady, E., Webb, D., Srinivasan, B., Henson, J., Talbot, D., & Davies, M. J. (2012) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2011.09.022 · Cited by 147 · see citing works
Exercise Intervention in PTSD: A Narrative Review and Rationale for Implementation
Hegberg, N. J., Hayes, J. P., & Hayes, S. M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00133 · Cited by 154 · see citing works
Horn, S. R., Long, M. M., Nelson, B. W., Allen, N. B., Fisher, P. A., & Byrne, M. L. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.06.016 · Cited by 129 · see citing works
Is the anti-inflammatory effect of regular exercise responsible for reduced cardiovascular disease?
Wilund, K. R. (2007) · Clinical Science · doi:10.1042/cs20060368 · Cited by 138 · see citing works
Walther, C., Möbius-Winkler, S., Linke, A., Bruegel, M., Thiery, J., Schuler, G., & Halbrecht, R. (2008) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3282f29aa6 · Cited by 135 · see citing works
Tartibian, B., Hajizadeh Maleki, B., Kanaley, J., & Sadeghi, K. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-71 · Cited by 120 · see citing works
Exercise intervention and inflammatory markers in coronary artery disease: A meta-analysis
Swardfager, W., Herrmann, N., Cornish, S., Mazereeuw, G., Marzolini, S., Sham, L., & Lanctôt, K. L. (2012) · American Heart Journal · doi:10.1016/j.ahj.2011.12.017 · Cited by 91 · see citing works
Hostinar, C. E., Nusslock, R., & Miller, G. E. (2018) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2016.1266647 · Cited by 90 · see citing works
Adjibade, M., Andreeva, V. A., Lemogne, C., Touvier, M., Shivappa, N., Hébert, J. R., Wirth, M. D., Hercberg, S., Galan, P., Julia, C., et al. (2017) · The Journal of Nutrition · doi:10.3945/jn.116.245167 · Cited by 91 · see citing works
Role of diet and exercise in aging, Alzheimer’s disease, and other chronic diseases
Khemka, S., Reddy, A., Garcia, R. I., Jacobs, M., Reddy, R. P., Roghani, A. K., Pattoor, V., Basu, T., Sehar, U., & Reddy, P. H. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102091 · Cited by 88 · see citing works
Swanson, D. R. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.01.006 · Cited by 81 · see citing works
Hall, C., Heck, J. E., Sandler, D. P., Ritz, B., Chen, H., & Krause, N. (2019) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.3787 · Cited by 65 · see citing works
Vagal atrial fibrillation: What is it and should we treat it?
Carpenter, A., Frontera, A., Bond, R., Duncan, E., & Thomas, G. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.08.108 · Cited by 65 · see citing works
Exercise and Self-Reported Limitations in Patients with Inflammatory Bowel Disease
DeFilippis, E. M., Tabani, S., Warren, R. U., Christos, P. J., Bosworth, B. P., & Scherl, E. J. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3832-4 · Cited by 64 · see citing works
Exercise Training Modulates Adipokine Dysregulations in Metabolic Syndrome
Babaei, P., & Hoseini, R. (2022) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2022.01.001 · Cited by 52 · see citing works
Inflammatory phenotype of depression symptom structure: A network perspective
Moriarity, D. P., van Borkulo, C., & Alloy, L. B. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.12.005 · Cited by 45 · see citing works
Deverts, D. J., Cohen, S., Kalra, P., & Matthews, K. A. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.07.017 · Cited by 44 · see citing works
Biologic variability of C-reactive protein: Is the available information reliable?
Braga, F., & Panteghini, M. (2012) · Clinica Chimica Acta · doi:10.1016/j.cca.2012.04.010 · Cited by 36 · see citing works
Morgan, J. A., Olagunju, A. T., Corrigan, F., & Baune, B. T. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.02.058 · Cited by 34 · see citing works
Forte, C., O’Sullivan, D., McDowell, C. P., Hallgren, M., Woods, C. B., & Herring, M. P. (2023) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-022-02080-w · Cited by 30 · see citing works
Koch, A. K., Schöls, M., Langhorst, J., Dobos, G., & Cramer, H. (2020) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2019.109917 · Cited by 29 · see citing works
Luo, S., O’Connor, S. G., Belcher, B. R., & Page, K. A. (2018) · Obesity · doi:10.1002/oby.22107 · Cited by 28 · see citing works
Haider, S., Grabovac, I., Winzer, E., Kapan, A., Schindler, K. E., Lackinger, C., Titze, S., & Dorner, T. E. (2017) · PLOS ONE · doi:10.1371/journal.pone.0185879 · Cited by 24 · see citing works
Impact of Dietary Patterns on Metabolic Syndrome in Young Adults: A Cross-Sectional Study
Liu, J., Lu, W., Lv, Q., Wang, Y., Xu, X., He, Y., Chang, H., Zhao, Y., Zhang, X., Zang, X., et al. (2024) · Nutrients · doi:10.3390/nu16172890 · Cited by 18 · see citing works
Aghapour (2015) · PubMed · doi:10.14661/2013.623-630 · Cited by 14 · see citing works
Skogstad, M., Lunde, L.-K., Ulvestad, B., Aass, H., Clemm, T., Mamen, A., & Skare, Ø. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15020264 · Cited by 9 · see citing works
Jafarikhah, R., Damirchi, A., Rahmani Nia, F., Razavi-Toosi, S. M. T., Shafaghi, A., & Asadian, M. (2023) · Scientific Reports · doi:10.1038/s41598-023-42687-w · Cited by 7 · see citing works
The Effect of Weight Loss on C-Reactive Protein: A Systematic Review
Selvin, E. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.1.31 · Cited by 5 · see citing works
- Authors
- Kasapis, C., & Thompson, P. D.
- Affiliations
- University of Connecticut (US)
- Hartford Hospital (US)
- Corresponding author
- Thompson, Paul D.
- ORCID
- Thompson, Paul D.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 45
- Issue
- 10
- Pages
- 1563-1569
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W140387039
- Cited by
- 1,149
- References
- 64
- Citations by year
- 2026: 44 · 2025: 51 · 2024: 41 · 2023: 58 · 2022: 71 · 2021: 53 · 2020: 58 · 2019: 87 · 2018: 53 · 2017: 68 · 2016: 60 · 2015: 71 · 2014: 58 · 2013: 54 · 2012: 72
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- physical activity, C-reactive protein, inflammatory markers, cytokines, exercise training, anti-inflammatory activity, coronary disease, cardiovascular disease pathogenesis
- MeSH terms
- C-Reactive Protein, Coronary Disease, Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Male, Physical Fitness, Exercise, Cytokines, Systemic Inflammatory Response Syndrome, Inflammation Mediators
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
