The DOI matches its Crossref record; 272 of the 279 references it cites were found in a registry or an index.
Impact of the GH-cortisol ratio on the age-dependent changes in body composition
Abstract
Aging is associated with a decrease in GH levels and this is paralleled by changes in body composition, i.e., increased visceral fat, and decreased lean body mass and bone mineral density. Similar changes in body composition are seen in the state of hypercortisolism. Increasing age has been shown to be associated with elevated evening cortisol levels in men. An increased exposure of several tissues to glucocorticoids with aging, i.e., visceral fat cells, in combination with the reduction of the lipolytic effects of declining GH levels, may contribute to the age-dependent increase of visceral fat accumulation. We hypothesize that the age-dependent changes in body fat are the result of an age-dependent decrease of the GH/cortisol ratio at the level of the adipocyte. This is caused by the decline in GH concentrations and the increase in cortisol levels and/or metabolism at the adipocyte.
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“This decrease in IGF-1 is associated with decreased muscle size and strength, decreased protein synthesis, and increased cell death,93 which in turn leads to increased visceral fat and decreased lean body mass.94”
From Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases (2014) · cites this paper as [94]
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Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases
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Metadata
- Authors
- Nass, R., & Thorner, M. O.
- Affiliations
- University of Virginia Health System (US)
- Corresponding author
- Thorner, M.O
- ORCID
- Thorner, M.O
- Venue
- Growth Hormone & IGF Research
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 12
- Issue
- 3
- Pages
- 147-161
- ISSN
- 1096-6374 (ISSN-L)
- OpenAlex
- W1974921448
- Cited by
- 58
- References
- 279
- Citations by year
- 2024: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Growth Hormone & IGF Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- growth hormone, cortisol, aging, body composition, visceral fat, adipocytes, hypercortisolism, lean body mass, bone mineral density, lipolysis, glucocorticoids
- MeSH terms
- Aging, Animals, Body Composition, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Insulin-Like Growth Factor I, Male, Models, Biological, Obesity, Pituitary-Adrenal System, Growth Hormone, Adipocytes, Human Growth Hormone
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