Cited by 58Growth Hormone and Insulin-like Growth FactorsHormonal and reproductive studiesAdipokines, Inflammation, and Metabolic Diseases

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Impact of the GH-cortisol ratio on the age-dependent changes in body composition

Nass, R, Thorner, M.O·2002·Growth Hormone & IGF Research

DOI 10.1016/s1096-6374(02)00022-9

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Abstract

Aging is associated with a decrease in GH levels and this is paralleled by changes in body composition, i.e., increased visceral fat, and decreased lean body mass and bone mineral density. Similar changes in body composition are seen in the state of hypercortisolism. Increasing age has been shown to be associated with elevated evening cortisol levels in men. An increased exposure of several tissues to glucocorticoids with aging, i.e., visceral fat cells, in combination with the reduction of the lipolytic effects of declining GH levels, may contribute to the age-dependent increase of visceral fat accumulation. We hypothesize that the age-dependent changes in body fat are the result of an age-dependent decrease of the GH/cortisol ratio at the level of the adipocyte. This is caused by the decline in GH concentrations and the increase in cortisol levels and/or metabolism at the adipocyte.

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Authors: Nass, R., & Thorner, M. O.
Affiliations: University of Virginia Health System (US)
Corresponding author: Thorner, M.O
ORCID: Thorner, M.O
Venue: Growth Hormone & IGF Research
Publisher: Elsevier BV
Published: 2002-06
Volume: 12
Issue: 3
Pages: 147-161
ISSN: 1096-6374 (ISSN-L)
DOI: 10.1016/s1096-6374(02)00022-9
OpenAlex: W1974921448
Cited by: 58
References: 279
Citations by year: 2024: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 3
FWCI: 0.33
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Growth Hormone & IGF Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: growth hormone, cortisol, aging, body composition, visceral fat, adipocytes, hypercortisolism, lean body mass, bone mineral density, lipolysis, glucocorticoids
MeSH terms: Aging, Animals, Body Composition, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Insulin-Like Growth Factor I, Male, Models, Biological, Obesity, Pituitary-Adrenal System, Growth Hormone, Adipocytes, Human Growth Hormone

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Impact of the GH-cortisol ratio on the age-dependent changes in body composition

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