The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators
Open accessAbstract
Mounting evidence indicates that Smad proteins are required for TGF beta signaling, but the way(s) in which Smad proteins propagate this signal is unclear. We found that two human Smad proteins (Smad3 and Smad4) could specifically recognize an identical 8 bp palindromic sequences (GTCTAGAC). Tandem repeats of this palindrome conferred striking TGF beta responsiveness to a minimal promoter. This responsiveness was abrogated by targeted deletion of the cellular Smad4 gene. These results define a novel biochemical property of Smad proteins that is likely to play a direct role in the biologic responses to TGF beta and related ligands.
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Cites
TGF-β signalling from cell membrane to nucleus through SMAD proteins
Heldin, C.-H., Miyazono, K., & ten Dijke, P. (1997) · Nature · doi:10.1038/37284 · Cited by 3,696
DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
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Self-citationInactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability
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Self-citationTGFβ signals through a heteromeric protein kinase receptor complex
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Is a p53-Regulated Inhibitor of G2/M Progression
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Self-citationTGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
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Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
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Receptor-associated Mad homologues synergize as effectors of the TGF-β response
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Cited by
Identification of c- MYC as a Target of the APC Pathway
He, T.-C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · Science · doi:10.1126/science.281.5382.1509 · Cited by 4,566
Self-citationTGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
Massagué, J., Blain, S. W., & Lo, R. S. (2000) · Cell · doi:10.1016/s0092-8674(00)00121-5 · Cited by 2,385
TGF-β signaling and the fibrotic response
Leask, A., & Abraham, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1273rev · Cited by 2,319
TGF-β Signaling in Tumor Suppression and Cancer Progression
Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics · doi:10.1038/ng1001-117 · Cited by 2,275
SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS
Feng, X.-H., & Derynck, R. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.022404.142018 · Cited by 1,869
Metadata
- Authors
- Zawel, L., Le Dai, J., Buckhaults, P., Zhou, S., Kinzler, K. W., Vogelstein, B., & Kern, S. E.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 1998-03
- Volume
- 1
- Issue
- 4
- Pages
- 611-617
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W4235438234
- Cited by
- 939
- References
- 33
- FWCI
- 23.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zawel, L., Le Dai, J., Buckhaults, P., Zhou, S., Kinzler, K. W., Vogelstein, B., & Kern, S. E. (1998). Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators. Molecular Cell. https://doi.org/10.1016/s1097-2765(00)80061-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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