The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Activation Domain–Mediated Targeting of the SWI/SNF Complex to Promoters Stimulates Transcription from Nucleosome Arrays
Open accessAbstract
The yeast SWI/SNF complex is required for the transcription of several yeast genes and has been shown to alter nucleosome structure in an ATP-dependent reaction. In this study, we show that the complex stimulated in vitro transcription from nucleosome templates in an activation domain-dependent manner. Transcription stimulation by SWI/SNF required an activation domain with which it directly interacts. The acidic activation domains of VP16, Gcn4, Swi5, and Hap4 interacted directly with the purified SWI/SNF complex and with the SWI/SNF complex in whole-cell extracts. The similarity of activation domain interactions and transcriptional stimulation between SWI/SNF and the SAGA histone acetyltransferase complex may account for their apparent overlapping functions in vivo.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Because VP48 is known to directly interact with chromatin-remodeling cofactors21–23”
From Single-molecule states link transcription factor binding to gene expression (2024) · cites this paper as [23]
Citations
Cites
ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION
Workman, J. L., & Kingston, R. E. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.545 · Cited by 1,159
Self-citationStimulation of GAL4 Derivative Binding to Nucleosomal DNA by the Yeast SWI/SNF Complex
Côté, J., Quinn, J., Workman, J. L., & Peterson, C. L. (1994) · Science · doi:10.1126/science.8016655 · Cited by 861
Self-citationTriezenberg, S., Kingsbury, R., & McKnight, S. (1988) · Genes & Development · doi:10.1101/gad.2.6.718 · Cited by 785
Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex
Kwon, H., Imbalzano, A. N., Khavari, P. A., Kingston, R. E., & Green, M. R. (1994) · Nature · doi:10.1038/370477a0 · Cited by 780
Cosma, M. P., Tanaka, T. U., & Nasmyth, K. (1999) · Cell · doi:10.1016/s0092-8674(00)80740-0 · Cited by 693
RSC, an Essential, Abundant Chromatin-Remodeling Complex
Cairns, B. R., Lorch, Y., Li, Y., Zhang, M., Lacomis, L., Erdjument‐Bromage, H., Tempst, P., Du, J., Laurent, B. C., & Kornberg, R. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81820-6 · Cited by 667
Self-citationPeterson, C. L., & Herskowitz, I. (1992) · Cell · doi:10.1016/0092-8674(92)90192-f · Cited by 597
Neigeborn, L., & Carlson, M. (1984) · Genetics · doi:10.1093/genetics/108.4.845 · Cited by 587
Ikaros DNA-Binding Proteins Direct Formation of Chromatin Remodeling Complexes in Lymphocytes
Kim, J., Sif, S., Jones, B., Jackson, A., Koipally, J., Heller, E., Winandy, S., Viel, A., Sawyer, A., Ikeda, T., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80034-5 · Cited by 587
Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex
Fryer, C. J., & Archer, T. K. (1998) · Nature · doi:10.1038/30032 · Cited by 511
Cited by
Sorted by citations
Items 201–245 of 245
Ehrensberger, A. H., & Svejstrup, J. Q. (2012) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2012.697125 · Cited by 14
Molecular Biology of Fungal Amino Acid Biosynthesis Regulation
Braus, G. H., Pries, R., Düvel, K., & Valerius, O. (2004) · Springer eBooks · doi:10.1007/978-3-662-07426-8_13 · Cited by 13
Chromatin-remodeling complexes involved in gene activation by the glucocorticoid receptor
Wallberg, A. E., Wright, A. P. H., & Gustafsson, J.-Α. (2000) · Vitamins and hormones · doi:10.1016/s0083-6729(00)60017-1 · Cited by 12
Self-citationRawal, Y., Qiu, H., & Hinnebusch, A. G. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010277 · Cited by 11
Hannum, C. H., Kulaeva, O. I., Sun, H. H., Urbanowski, J. L., Wendus, A., Stillman, D. J., & Rolfes, R. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206168200 · Cited by 11
Valerius, O., Brendel, C., Wagner, C., Krappmann, S., Thoma, F., & Braus, G. H. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.5.876-885.2003 · Cited by 9
Fazlollahi, M., Muroff, I., Lee, E., Causton, H. C., & Bussemaker, H. J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1517140113 · Cited by 8
Proteomic characterization of the arsenic response locus in S. cerevisiae
West, K. L., Byrum, S. D., Mackintosh, S. G., Edmondson, R. D., Taverna, S. D., & Tackett, A. J. (2019) · Epigenetics · doi:10.1080/15592294.2019.1580110 · Cited by 8
Cliffe, A., Chang, L., Colgrove, R. C., & Knipe, D. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.00080-5 · Cited by 8
Judelson, H. S., Narayan, R. D., Fong, A. M. V. A., Tani, S., & Kim, K. S. (2007) · Current Genetics · doi:10.1007/s00294-007-0125-2 · Cited by 8
King, I. F. G., & Kingston, R. E. (2001) · Nature · doi:10.1038/414858a · Cited by 8
Jalal, D., Chalissery, J., Iqbal, M., & Hassan, A. H. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.103019 · Cited by 7
Self-citationFusions with histone H3 result in highly specific alteration of gene expression
Ha, N. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.4.1026 · Cited by 7
Peterson, C. L. (2001) · Biochemistry and Cell Biology · doi:10.1139/bcb-79-3-219 · Cited by 7
The Enigma of Transcriptional Activation Domains
Erkine, A. M., Oliveira, M., & Class, C. A. (2024) · Journal of Molecular Biology · doi:10.1016/j.jmb.2024.168766 · Cited by 6
Activation domains of gene-specific transcription factors: are histones among their targets?
Erkine, A. M. (2004) · Biochemistry and Cell Biology · doi:10.1139/o04-036 · Cited by 6
Zhu, L., Liu, Q., Zhao, C., Zhu, M., Yang, X., & Yang, J. (2025) · Mycology: An International Journal on Fungal Biology · doi:10.1080/21501203.2024.2425170 · Cited by 4
Genetics and Genomics of Malignant Rhabdoid Tumours
Wei, D., & Weissman, B. E. (2014) · Wiley eBooks · doi:10.1002/9780470015902.a0025012 · Cited by 4
Wendegatz, E.-C., Engelhardt, M., & Schüller, H.-J. (2024) · Current Genetics · doi:10.1007/s00294-024-01300-x · Cited by 3
Liu, J., Li, B., Yang, L., Ren, N., Xu, M., & Huang, Q. (2022) · The CRISPR Journal · doi:10.1089/crispr.2022.0001 · Cited by 3
Grammar rules and exceptions for the language of transcriptional activation domains
Cooper, D. G., Erkina, T. Y., Broyles, B. K., Class, C. A., & Erkine, A. M. (2024) · iScience · doi:10.1016/j.isci.2024.111057 · Cited by 3
Regulation of Bovine Herpesvirus 1 (BHV-1) Productive Infection by Cellular Transcription Factors
Workman, A. M. (2011) · Lincoln (University of Nebraska) · Cited by 2
Vinod, P. K. U., & Venkatesh, K. V. (2008) · In Silico Biology · doi:10.3233/isb-00358 · Cited by 2
TRAVERS, A. A., & Owen‐Hughes, T. (2004) · New comprehensive biochemistry · doi:10.1016/s0167-7306(03)39016-7 · Cited by 2
Broyles, B. K., Erkina, T. Y., Maris, T. P., Gutierrez, A. T., Coil, D. A., Wagner, T. M., Class, C. A., & Erkine, A. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.18.545482 · Cited by 2
Awad, S. M., Bonne, I., Sim, A. Y., & Abuelenain, G. L. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.16.608297 · Cited by 2
Soshnikova, N. V., Bayramova, D. O., & Georgieva, S. G. (2025) · Russian Journal of Genetics · doi:10.1134/s102279542570108x · Cited by 1
In Vitro Histone Demethylase Assays
Tu, S. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2481-4_3 · Cited by 1
Brg1 controls neurosensory cell fate commitment and differentiation in the mammalian inner earPreprint
Xu, J., Li, J., Loh, Y. E., Zhang, T., Jiang, H., Fritzsch, B., Ramakrishnan, A., Shen, L., & Xu, P. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/434159 · Cited by 1
O papel dos receptores nucleares na especificação atrial.
da Silva, B. S. P. (2014) · doi:10.11606/d.42.2014.tde-13082014-143607
Schwan, A. (2010) · DuEPublico (University of Duisburg-Essen)
Studies of transcription factor domains and their interactions with other transcription factors
Ferreira, M. E. (2009) · Figshare
A novel mechanism for target gene-specific SWI/SNF recruitment via the Snf2p N-terminus
Weider, M., Schröder, A., Klebl, F., & Sauer, N. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr004
Whole-genome expression analysis of snfyswi mutants of Saccharomyces cerevisiae
Sudarsanam, P., Iyer, V. R., Brown, P. O., & Winston, F. (2000)
Transcription: The Never Ending Story
Goodrich, J. A., & Tjian, R. (2007) · Springer eBooks · doi:10.1007/978-0-387-40049-5_1 · Cited by 1
Interrogating genome function using CRISPR tools: a narrative review
Ren, X., Takagi, M. A., & Shen, Y. (2020) · Journal of Bio-X Research · doi:10.1097/jbr.0000000000000066
Transcription regulation dynamics
de Jonge, W. J. (2020) · doi:10.33540/73
Tiwari, V. K., & Mariappan, A. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737244626.793573181
Morse, R. H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-814809-9.00006-8
Cohesin facilitates nucleosome invasion by transcription factors
Stoeber, S. D., Chen, H., Chen, R.-W., Smith, C., Becker, S., Vinson, S., Poirier, M. G., & Bai, L. (2026) · Science Advances · doi:10.1126/sciadv.aef1603
Ma, K., Li, M., Yuan, H., Zhao, J., & Qin, Y. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag543
Structural basis of a SWI/SNF-associated transcription pre-initiation complex
Nagai, S., Yang, C., Chen, D.-H., Trnka, M. J., Bushnell, D., Burlingame, A. L., Murakami, K., & Kornberg, R. D. (2026) · Cell · doi:10.1016/j.cell.2026.08.020
Metadata
- Authors
- Neely, K. E., Hassan, A. H., Wallberg, A. E., Steger, D. J., Cairns, B. R., Wright, A. P. H., & Workman, J. L.
- Affiliations
- Pennsylvania State University (US)
- Södertörn University (SE)
- University of Utah (US)
- Corresponding author
- Workman, Jerry L
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 1999-10
- Volume
- 4
- Issue
- 4
- Pages
- 649-655
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2119383396
- Cited by
- 245
- References
- 53
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 8 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 2 · 2018: 5 · 2017: 1 · 2016: 4 · 2015: 1 · 2014: 8 · 2013: 2 · 2012: 5
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- SWI/SNF complex, chromatin remodeling, transactivation domain, nucleosome arrays, transcription initiation, nucleosome structure, SAGA complex, histone acetyltransferase, protein-protein interaction, Swi5, HAP4, GCN4, VP16
- MeSH terms
- Chromatin, DNA-Binding Proteins, Fungal Proteins, Nuclear Proteins, Nucleosomes, Promoter Regions, Genetic, Protein Kinases, Recombinant Proteins, Transcription Factors, Yeasts, Transcriptional Activation, Gene Expression Regulation, Fungal, Herpes Simplex Virus Protein Vmw65, Cell Cycle Proteins, CCAAT-Binding Factor, Saccharomyces cerevisiae Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review