Mammalian Microsomal Cytochrome P450 Monooxygenase

Williams, Pamela A., Cosme, Jose, Sridhar, Vandana, Johnson, Eric F., McRee, Duncan E.·2000·Molecular Cell

Cited by (707)

Items 201–300 of 707

  1. P450 structures and oxidative metabolismof xenobiotics
    David FV Lewis · 2003 · Pharmacogenomics
  2. The biodiversity of microbial cytochromes P450
    Steven L. Kelly, David C. Lamb, Colin J. Jackson, Andrew G. S. Warrilow, Diane E Kelly · 2003 · Advances in microbial physiology/Advances in Microbial Physiology
  3. Possible Involvement of Singlet Oxygen Species as Multiple Oxidants in P450 Catalytic Reactions
    Hiroyuki Yasui, Seiko Hayashi, Hiromu Sakurai · 2005 · Drug Metabolism and Pharmacokinetics
  4. Synthesis of 11-Hydroxyl O-Methylsterigmatocystin and the Role of a Cytochrome P-450 in the Final Step of Aflatoxin Biosynthesis
    Daniel Udwary, Linda Casillas, Craig A. Townsend · 2002 · Journal of the American Chemical Society
  5. Structure–function analysis of CYP27B1 and CYP27A1
    Natsumi Sawada, Toshiyuki Sakaki, Sachiko Kitanaka, Shigeaki Kato, Kuniyo Inouye · 2001 · European Journal of Biochemistry
  6. Combined Three-Dimensional Quantitative Structure-Activity Relationship Analysis of Cytochrome P450 2B6 Substrates and Protein Homology Modeling
    Qinmi Wang, James R. Halpert · 2002 · Drug Metabolism and Disposition
  7. Structure–function analysis of cytochromes P450 2B
    Yonghong Zhao, James R. Halpert · 2006 · Biochimica et Biophysica Acta (BBA) - General Subjects
  8. Metabolism of Sirolimus and Its Derivative Everolimus by Cytochrome P450 3A4: Insights from Docking, Molecular Dynamics, and Quantum Chemical Calculations
    Bernd Kuhn, Wolfgang Jacobsen, Uwe Christians, Leslie Z. Benet, Peter A. Kollman · 2001 · Journal of Medicinal Chemistry
  9. Theoretical study of the ligand–CYP2B4 complexes: Effect of structure on binding free energies and heme spin state
    Danni L. Harris, Jinyoung Park, Larry D. Gruenke, Lucy A. Waskell · 2004 · Proteins Structure Function and Bioinformatics
  10. History of Estrogen: Its Purification, Structure, Synthesis, Biologic Actions, and Clinical Implications
    Richard J. Santen, Evan R. Simpson · 2018 · Endocrinology
  11. Defective Activity of Recombinant Cytochromes P450 3A4.2 and 3A4.16 in Oxidation of Midazolam, Nifedipine, and Testosterone
    Mitsue Miyazaki, Katsunori Nakamura, Yukiyoshi Fujita, Frederick Peter Guengerich, Ryuya Horiuchi, Koujirou Yamamoto · 2008 · Drug Metabolism and Disposition
  12. Over-expression of CYP78A98, a cytochrome P450 gene from Jatropha curcas L., increases seed size of transgenic tobacco
    Yinshuai Tian, Min Zhang, Xiaole Hu, Linghui Wang, Jiao Dai, Ying Xu, Fang Chen · 2015 · Electronic Journal of Biotechnology
  13. Hydroxylation of Limonene Enantiomers and Analogs by Recombinant (−)-Limonene 3- and 6-Hydroxylases from Mint (Mentha) Species: Evidence for Catalysis within Sterically Constrained Active Sites
    Matthias Wüst, Dawn B Little, Michel Schalk, Rodney Croteau · 2001 · Archives of Biochemistry and Biophysics
  14. Molecular analysis of two cytochrome P450 monooxygenase genes required for paxilline biosynthesis in Penicillium paxilli, and effects of paxilline intermediates on mammalian maxi-K ion channels
    Lisa McMillan, R. L. Carr, Carolyn A. Young, Jonathan W. Astin, Rohan G. T. Lowe, Emily J. Parker, Geoffrey B. Jameson, Sarah C. Finch, Christopher O. Miles, Owen B. McManus et al. · 2003 · Molecular Genetics and Genomics
  15. A tissue specific cytochrome P450 required for the structure and function of Drosophila sensory organs
    Aarron T. Willingham, Thomas A. Keil · 2004 · Mechanisms of Development
  16. Structure-Based Drug Design for Cytochrome P450 Family 1 Inhibitors
    Zbigniew Dutkiewicz, Renata Mikstacka · 2018 · Bioinorganic Chemistry and Applications
  17. Modulation of UDP-glucuronosyltransferase activity by protein-protein association
    Yuji Ishii, Shuso Takeda, Hideyuki Yamada · 2009 · Drug Metabolism Reviews
  18. Advanced Understanding of the Electron Transfer Pathway of Cytochrome P450s
    Chun‐Chi Chen, Jian Min, Lilan Zhang, Yu Yang, Xuejing Yu, Rey‐Ting Guo · 2020 · ChemBioChem
  19. CYP3A4 Gene Polymorphisms Influence Testosterone 6β-hydroxylation
    Norie Murayama, Takahiro Nakamura, Mayumi Saeki, Akiko Soyama, Yoshiro Saito, Kimie Sai, Seiichi Ishida, Osamu Nakajima, Masaya Itoda, Yasuo Ohno et al. · 2002 · Drug Metabolism and Pharmacokinetics
  20. Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6‐drug interactions
    Jean‐Didier Maréchal, Carol A. Kemp, Gordon C. K. Roberts, Mark J. I. Paine, C. Roland Wolf, Michael J. Sutcliffe · 2007 · British Journal of Pharmacology
  21. Identification of the Amino Acid Residue of CYP27B1 Responsible for Binding of 25-Hydroxyvitamin D3 Whose Mutation Causes Vitamin D-dependent Rickets Type 1
    Keiko Yamamoto, Eriko Uchida, Naoko Urushino, Toshiyuki Sakaki, Norio Kagawa, Natsumi Sawada, Masaki Kamakura, Shigeaki Kato, Kuniyo Inouye, Sachiko Yamada · 2005 · Journal of Biological Chemistry
  22. Metabolic Regio- and Stereoselectivity of Cytochrome P450 2D6 towards 3,4-Methylenedioxy-N-alkylamphetamines: in Silico Predictions and Experimental Validation
    Peter H. J. Keizers, Chris de Graaf, Frans J. J. de Kanter, Chris Oostenbrink, K. Anton Feenstra, Jan N. M. Commandeur, Nico P.E. Vermeulen · 2005 · Journal of Medicinal Chemistry
  23. C17,20-lyase inhibitors. Part 2: Design, synthesis and structure–activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C17,20-lyase inhibitors
    Nobuyuki Matsunaga, Tomohiro Kaku, Akio Ojida, Toshimasa Tanaka, Takahito Hara, Masuo Yamaoka, Masami Kusaka, Akihiro Tasaka · 2004 · Bioorganic & Medicinal Chemistry
  24. Design, Synthesis, and Microbiological Evaluation of New Candida albicans CYP51 Inhibitors
    Fausto Schiaffella, Antonio Macchiarulo, Lara Milanese, Anna Vecchiarelli, Gabriele Costantino, Donatella Pietrella, Renata Fringuelli · 2005 · Journal of Medicinal Chemistry
  25. Unusual Regioselectivity and Active Site Topology of Human Cytochrome P450 2J2
    Pierre Lafite, François André, Darryl C. Zeldin, Patrick M. Dansette, Daniel Mansuy · 2007 · Biochemistry
  26. New methods in predictive metabolism
    Scott K. Boyer, Ismael Zamora · 2002 · Journal of Computer-Aided Molecular Design
  27. Genetic clues to the molecular basis of tobacco addiction and progress towards personalized therapy
    Robert T. Walton, Elaine C Johnstone, Marcus Robert Munafo, Matt J. Neville, Sian Griffiths · 2001 · Trends in Molecular Medicine
  28. Computational Identification and Systematic Classification of Novel Cytochrome P450 Genes in Salvia miltiorrhiza
    Haimei Chen, Bin Wu, David R. Nelson, Kai Wu, Chang Liu · 2014 · PLoS ONE
  29. Human Enzymes for Organic Synthesis
    Margit Winkler, Martina Geier, Steven Paul Hanlon, Bernd Nidetzky, Anton Glieder · 2018 · Angewandte Chemie International Edition
  30. Coumarins and P450s, Studies Reported to-Date
    Maryam K. Foroozesh, Jayalakshmi Sridhar, Navneet Goyal, Jiawang Liu · 2019 · Molecules
  31. Structures of Cytochrome P450 Enzymes
    T.L. Poulos, Eric F. Johnson · 2007 · Springer eBooks
  32. Effects of cytochrome b5 on drug oxidation activities of human cytochrome P450 (CYP) 3As: similarity of CYP3A5 with CYP3A4 but not CYP3A7
    Satoshi Yamaori, Hiroshi Yamazaki, Akihiro Suzuki, Ayako Yamada, Hirofumi Tani, Tamio Kamidate, Ken‐ichi Fujita, Tetsuya Kamataki · 2003 · Biochemical Pharmacology
  33. Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants
    Stefaan Sansen, Mei‐Hui Hsu, Charles David Stout, Eric F. Johnson · 2007 · Archives of Biochemistry and Biophysics
  34. Conformer- and Alignment-Independent Model for Predicting Structurally Diverse Competitive CYP2C9 Inhibitors
    Lovisa Afzelius, Ismael Zamora, Collen Mutowembwa Masimirembwa, Anders Karlén, Tommy B. Andersson, S. Mecucci, Massimo Baroni, Gabriele Cruciani · 2004 · Journal of Medicinal Chemistry
  35. Molecular Modeling of Cytochrome P450 1A1: Enzyme-Substrate Interactions and Substrate Binding Affinities
    Grażyna D. Szklarz, Mark D. Paulsen · 2002 · Journal of Biomolecular Structure and Dynamics
  36. Amino acids in SRS1 and SRS6 are critical for furanocoumarin metabolism by CYP6B1v1, a cytochrome P450 monooxygenase
    J.‐S. Chen, May R. Berenbaum, Mary A. Schuler · 2002 · Insect Molecular Biology
  37. Structure-Function Analysis of Vitamin D 24-Hydroxylase (CYP24A1) by Site-Directed Mutagenesis: Amino Acid Residues Responsible for Species-Based Difference of CYP24A1 between Humans and Rats
    Hiromi Hamamoto, Tatsuya Kusudo, Naoko Urushino, Hiroyuki Masuno, Keiko Yamamoto, Sachiko Yamada, Masaki Kamakura, Miho Ohta, Kuniyo Inouye, Toshiyuki Sakaki · 2006 · Molecular Pharmacology
  38. A Rational Approach to Re-engineer Cytochrome P450 2B1 Regioselectivity Based on the Crystal Structure of Cytochrome P450 2C5
    Santosh Kumar, Emily E. Scott, Hong Liu, James R. Halpert · 2003 · Journal of Biological Chemistry
  39. Plasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-ray Crystallography
    Paul Ross Wilderman, Manish B. Shah, Tong Liu, Sheng Li, Simon Hsu, Arthur G. Roberts, David R. Goodlett, Qinghai Zhang, Virgil L. Woods, Charles David Stout et al. · 2010 · Journal of Biological Chemistry
  40. The endocrine disruptor effect of the herbicides atrazine and glyphosate on Biomphalaria alexandrina snails
    Nahla E. Omran, Wesam Mohamed Salama · 2013 · Toxicology and Industrial Health
  41. Interaction of Cytochrome P450 3A4 and UDP-Glucuronosyltransferase 2B7: Evidence for Protein-Protein Association and Possible Involvement of CYP3A4 J-Helix in the Interaction
    Shuso Takeda, Yuji Ishii, Megumi Iwanaga, Arief Nurrochmad, Yuji Ito, Peter I. Mackenzie, Kiyoshi Nagata, Yasushi Yamazoe, Kazuta Oguri, Hideyuki Yamada · 2009 · Molecular Pharmacology
  42. Cholesterol-metabolizing cytochromes P450: implications for cholesterol lowering
    Irina A. Pikuleva · 2008 · Expert Opinion on Drug Metabolism & Toxicology
  43. Autoantibodies Against CYP2D6 and Other Drug-Metabolizing Enzymes in Autoimmune Hepatitis Type 2
    Takaharu Mizutani, Masakazu Shinoda, Yuta Tanaka, Takuya Kuno, Asuka Hattori, Toru Usui, Nayumi Kuno, Takashi Osaka · 2005 · Drug Metabolism Reviews
  44. Kinetic and Molecular Analysis of 5-Epiaristolochene 1,3-Dihydroxylase, a Cytochrome P450 Enzyme Catalyzing Successive Hydroxylations of Sesquiterpenes
    Shunji Takahashi, Yuxin Zhao, Paul E. O’Maille, Bryan T. Greenhagen, Joseph P. Noel, Robert M. Coates, Joe Chappell · 2004 · Journal of Biological Chemistry
  45. Novel Mutations in CYP21 Detected in Individuals with Hyperandrogenism
    Svetlana Lajić, Séverine Clauin, Tiina Robins, Patrick Vexiau, Hélène Blanché, Christine Bellanné‐Chantelot, Anna Wedell · 2002 · The Journal of Clinical Endocrinology & Metabolism
  46. Transcriptome Assembly and Systematic Identification of Novel Cytochrome P450s in Taxus chinensis
    Weifang Liao, Shengying Zhao, Meng Zhang, Kaige Dong, Ying Chen, Chunhua Fu, Longjiang Yu · 2017 · Frontiers in Plant Science
  47. Engineering Plant Cytochrome P450s for Enhanced Synthesis of Natural Products: Past Achievements and Future Perspectives
    Yi Shang, Sanwen Huang · 2019 · Plant Communications
  48. Metabolism of coumarin by human P450s: A molecular modelling study
    David F.V. Lewis, Yuko Ito, Brian G. Lake · 2005 · Toxicology in Vitro
  49. Functional characterisation of an engineered multidomain human P450 2E1 by molecular Lego
    M. Fairhead, Silva Giannini, Elizabeth M. J. Gillam, Gianfranco Gilardi · 2005 · JBIC Journal of Biological Inorganic Chemistry
  50. Thermodynamic and Biophysical Characterization of Cytochrome P450 BioI from Bacillus subtilis
    Rachel J. Lawson, David Leys, Michael J. Sutcliffe, Carol A. Kemp, Myles R. Cheesman, Susan J. Smith, John Clarkson, W. Ewen Smith, Ihtshamul Haq, John B. Perkins et al. · 2004 · Biochemistry
  51. The molecular and enzyme kinetic basis for the diminished activity of the cytochrome P450 2D6.17 (CYP2D6.17) variant
    Tashinga E. Bapiro, Julia A. Hasler, Marianne Ridderström, Collen Mutowembwa Masimirembwa · 2002 · Biochemical Pharmacology
  52. Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes
    David F.V Lewis · 2002 · Archives of Biochemistry and Biophysics
  53. Analysis of Human Cytochrome P450 2C8 Substrate Specificity Using a Substrate Pharmacophore and Site-Directed Mutants
    Armelle Melet, Cristina Marques‐Soares, G. Schoch, Anne‐Christine Macherey, Maryse Jaouen, Patrick M. Dansette, Marie‐Agnès Sari, Eric F. Johnson, Daniel Mansuy · 2004 · Biochemistry
  54. A Bioinformatics Approach for the Phenotype Prediction of Nonsynonymous Single Nucleotide Polymorphisms in Human Cytochromes P450
    Linlin Wang, Yong Li, Shufeng Zhou · 2009 · Drug Metabolism and Disposition
  55. POSSIBLE PATHWAY(S) OF TESTOSTERONE EGRESS FROM THE ACTIVE SITE OF CYTOCHROME P450 2B1: A STEERED MOLECULAR DYNAMICS SIMULATION
    Weihua Li, Hong Shu Liu, Emily E. Scott, Frauke Gräter, James R. Halpert, Xiaoming Luo, Jianhua Shen, Hualiang Jiang · 2005 · Drug Metabolism and Disposition
  56. Atomic-level description of protein–lipid interactions using an accelerated membrane model
    Javier L. Baylon, Josh V. Vermaas, Melanie P. Muller, Mark J. Arcario, Taras V. Pogorelov, Emad Tajkhorshid · 2016 · Biochimica et Biophysica Acta (BBA) - Biomembranes
  57. CYP2J2 Molecular Recognition: A New Axis for Therapeutic Design
    Aditi Das, Austin T. Weigle, William R. Arnold, Justin S. Kim, Lauren N. Carnevale, Hannah C. Huff · 2020 · Pharmacology & Therapeutics
  58. Direct electrochemistry of enzymes from the cytochrome P450 2C family
    Alka Shukla, Elizabeth M. J. Gillam, Deanne J. Mitchell, Paul V. Bernhardt · 2005 · Electrochemistry Communications
  59. Homology modeling of plant cytochrome P450s
    Sanjeewa G. Rupasinghe, Mary A. Schuler · 2006 · Phytochemistry Reviews
  60. Conformational States of Cytochrome P450cam Revealed by Trapping of Synthetic Molecular Wires
    Anna‐Maria A. Hays, Alexander R. Dunn, Richard Chiu, Harry B. Gray, Charles David Stout, David B. Goodin · 2004 · Journal of Molecular Biology
  61. Probing ligand binding modes of human cytochrome P450 2J2 by homology modeling, molecular dynamics simulation, and flexible molecular docking
    Weihua Li, Yun Tang, Hong Shu Liu, Jiagao Cheng, Weiliang Zhu, Hualiang Jiang · 2007 · Proteins Structure Function and Bioinformatics
  62. Recent advances in P450 research
    Judy L. Raucy, Scott W. Allen · 2001 · The Pharmacogenomics Journal
  63. Protein nucleation and crystallization by homologous protein thin film template
    Eugenia Pechkova, Claudio Ando Nicolini · 2002 · Journal of Cellular Biochemistry
  64. Cancer-relevant biochemical targets of cytotoxic Lonchocarpus flavonoids: A molecular docking analysis
    Caitlin E. Cassidy, William N. Setzer · 2009 · Journal of Molecular Modeling
  65. STRUCTURAL AND FUNCTIONAL DIVERSITY IN HEME MONOOXYGENASES
    T.L. Poulos · 2004 · Drug Metabolism and Disposition
  66. Disease-Causing Mutations in Proteins: Structural Analysis of the CYP1b1 Mutations Causing Primary Congenital Glaucoma in Humans
    Malkaram S. Achary, Aramati B. M. Reddy, Subhabrata Chakrabarti, Shirly George Panicker, Anil Kumar Mandal, Niyaz Ahmed, Dorairajan Balasubramanian, Seyed E. Hasnain, Hampapathalu Adimurthy Nagarajaram · 2006 · Biophysical Journal
  67. Crystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1H-imidazole: Ligand-Induced Structural Response through α-Helical Repositioning,
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  68. Engineering and assaying of cytochrome P450 biocatalysts
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  69. The roles of cytochrome P450 enzymes in prostate cancer development and treatment.
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  70. Membrane-Protein Interactions Contribute to Efficient 27-Hydroxylation of Cholesterol by Mitochondrial Cytochrome P450 27A1
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  71. Structural basis for the role in protein folding of conserved proline-rich regions in cytochromes P450
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  72. IDENTIFICATION OF CRITICAL AMINO ACID RESIDUES OF HUMAN CYP2A13 FOR THE METABOLIC ACTIVATION OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE, A TOBACCO-SPECIFIC CARCINOGEN
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  73. In Silico Approaches to Mechanistic and Predictive Toxicology: An Introduction to Bioinformatics for Toxicologists
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  74. Cytochrome P450 enzymes but not NADPH oxidases are the source of the NADPH-dependent lucigenin chemiluminescence in membrane assays
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  75. Structures of Cytochrome P450 2B6 Bound to 4-Benzylpyridine and 4-(4-Nitrobenzyl)pyridine: Insight into Inhibitor Binding and Rearrangement of Active Site Side Chains
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  76. Identification of New CYP2C19 Variants Exhibiting Decreased Enzyme Activity in the Metabolism of S-Mephenytoin and Omeprazole
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  77. Structural commonalities among integral membrane enzymes
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  78. Mutation of Tyrosine 190 to Alanine Eliminates the Inactivation of Cytochrome P450 2B1 by Peroxynitrite
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  79. Use of Noble Gases Xenon and Krypton as Heavy Atoms in Protein Structure Determination
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  80. Prediction of sites of metabolism in a substrate molecule, instanced by carbamazepine oxidation by CYP3A4
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  81. Key substrate recognition residues in the active site of a plant cytochrome P450, CYP73A1
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  82. Structural insights into the function of steroidogenic cytochrome P450 17A1
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  84. Influence of Transmembrane Helix Mutations on Cytochrome P450-Membrane Interactions and Function
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  85. Heterologous expression and strategies for encapsulation of membrane-localized plant P450s
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  86. Metabolism of A-ring diastereomers of 1α,25-dihydroxyvitamin D3 by CYP24A1
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  87. CYP2C8 Exists as a Dimer in Natural Membranes
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  88. CYP1A1 genotype-selective inhibition of benzo[a]pyrene activation by quercetin
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  89. A virtual high throughput screen for high affinity cytochrome P450cam substrates. Implications for in silico prediction of drug metabolism
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  90. Roles of cytochrome P450 enzymes in pharmacology and toxicology: Past, present, and future
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  91. Engineering of a Water-Soluble Plant Cytochrome P450, CYP73A1, and NMR-Based Orientation of Natural and Alternate Substrates in the Active Site
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  92. A Conservative Amino Acid Substitution Alters the Regiospecificity of CYP94A2, a Fatty Acid Hydroxylase from the Plant Vicia sativa
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  93. Substrate Routes to the Buried Active Site May Vary among Cytochromes P450: Mutagenesis of the F−G Region in P450 2B1
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  94. Computer-Assisted Design of Selective Imidazole Inhibitors for Cytochrome P450 Enzymes
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  95. Identifying Cytochrome P450 Functional Networks and Their Allosteric Regulatory Elements
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  96. Cytochromes P450 (P450s): A review of the class system with a focus on prokaryotic P450s
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  97. Tight-binding inhibition by α-naphthoflavone of human cytochrome P450 1A2
    Uhn‐Soo Cho, Eun Young Park, Mi Sook Dong, Bum Seok Park, Keehyuk Kim, Kyung Hyun Kim · 2003 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  98. Influence of P450 3A4 SRS-2 Residues on Cooperativity and/or Regioselectivity of Aflatoxin B1 Oxidation
    Linlong Xue, Huifen Faye Wang, Qinmi Wang, Grażyna D. Szklarz, Tammy L. Domanski, James R. Halpert, Maria Almira Correia · 2001 · Chemical Research in Toxicology
  99. Gene engineering, purification, crystallization and preliminary X-ray diffraction of cytochrome P450 p-coumarate-3-hydroxylase (C3H), the Arabidopsis membrane protein
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  100. The role of the length and sequence of the linker domain of cytochrome b5 in stimulating cytochrome P450 2B4 catalysis.
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