Mammalian Microsomal Cytochrome P450 Monooxygenase

Williams, Pamela A., Cosme, Jose, Sridhar, Vandana, Johnson, Eric F., McRee, Duncan E.·2000·Molecular Cell

DOI 10.1016/s1097-2765(00)80408-6

Cited by (707)

Items 401–500 of 707

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David F.V. Lewis · 2003 · Toxicology in Vitro
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Structural Determinants of Aromatase Cytochrome P450 Inhibition in Substrate Recognition Site-1
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Functional analysis of CYP2D6.31 variant: Homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution
Delphine Allorge, Didier Bréant, Jacky HARLOW, Joey Chowdry, Jean‐Marc Lo‐Guidice, Dany Chevalier, Christelle Cauffiez, Michel Lhermitte, Frank E. Blaney, Geoffrey T. Tucker et al. · 2005 · Proteins Structure Function and Bioinformatics
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CYP21 mutations in simple virilizing congenital adrenal hyperplasia
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Modelling human cytochromes P450 involved in drug metabolism from the CYP2C5 crystallographic template
David F.V. Lewis · 2002 · Journal of Inorganic Biochemistry
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Cytochrome P450 side-chain cleavage: Insights gained from homology modeling
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Christiane Jung · 2002 · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
The cytochrome P450BM-1 of Bacillus megaterium A14K is induced by 2,3,7,8-Tetrachlorinated dibenzo-p-dioxin: Biophysical, molecular and biochemical determinants
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Structure–function relationships of rat liver CYP3A9 to its human liver orthologs: site-directed active site mutagenesis to a progesterone dihydroxylase
Linlong Xue, Victor Gavrilovich Zgoda, Byron H. Arison, Maria Almira Correia · 2002 · Archives of Biochemistry and Biophysics
The Localization of Cytochrome P450s CYP1A1 and CYP1A2 into Different Lipid Microdomains Is Governed by Their N-terminal and Internal Protein Regions
Ji Won Park, James Robert Reed, Wayne L. Backes · 2015 · Journal of Biological Chemistry
Not All Amino Acid Substitutions of the Common Cluster E6 Mutation inCYP21Cause Congenital Adrenal Hyperplasia
Tiina Robins, Michela Barbaro, Svetlana Lajić, Anna Wedell · 2005 · The Journal of Clinical Endocrinology & Metabolism
JUD COON: 35 YEARS OF P450 RESEARCH, A SYNOPSIS OF P450 HISTORY
Todd D. Porter · 2004 · Drug Metabolism and Disposition
Do Drug Metabolism and Pharmacokinetic Departments Make Any Contribution to Drug Discovery?
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Association of Cytochrome P450 Enzymes is a Determining Factor in their Catalytic Activity
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Sequence alignments, variabilities, and vagaries
Sandra E. Graham, Julian A. Peterson · 2002 · Methods in enzymology on CD-ROM/Methods in enzymology
Discovery of the Biosynthetic Pathway of Beticolin 1 Reveals a Novel Non‐Heme Iron‐Dependent Oxygenase for Anthraquinone Ring Cleavage
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Effect of the 5α-reductase enzyme inhibitor dutasteride in the brain of intact and parkinsonian mice
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Langmuir–Blodgett nanotemplates for protein crystallography
Eugenia Pechkova, Claudio Ando Nicolini · 2017 · Nature Protocols
Quantitative structure-activity relationships within a homologous series of 7-alkoxyresorufins exhibiting activity towards CYP1A and CYP2B enzymes: molecular modelling studies on key members of the resorufin series with CYP2C5-derived models of human CYP1A1, CYP1A2, CYP2B6 and CYP3A4
David F. V. Lewis, Brian G. Lake, Maurice Dickins · 2004 · Xenobiotica
TOPOLOGICAL CHANGES IN THE CYP3A4 ACTIVE SITE PROBED WITH PHENYLDIAZENE: EFFECT OF INTERACTION WITH NADPH-CYTOCHROME P450 REDUCTASE AND CYTOCHROME B5 AND OF SITE-DIRECTED MUTAGENESIS
Yoshitaka Yamaguchi, Kishore Kumar Khan, You Ai He, You He, James R. Halpert · 2004 · Drug Metabolism and Disposition
In silico description of differential enantioselectivity in methoxychlor O-demethylation by CYP2C enzymes
Zsolt Bikádi, Eszter Hazai · 2008 · Biochimica et Biophysica Acta (BBA) - General Subjects
Characterization of Medicago truncatula (barrel medic) hydroperoxide lyase (CYP74C3), a water-soluble detergent-free cytochrome P450 monomer whose biological activity is defined by monomer–micelle association
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N-Terminal Deletions and His-Tag Fusions Dramatically Affect Expression of Cytochrome P450 2C2 in Bacteria
Balraj Doray, Ci-Di Chen, BYRON W. KEMPER · 2001 · Archives of Biochemistry and Biophysics
A 3D-QSAR model for CYP2D6 inhibition in the aryloxypropanolamine series
Roy J. Vaz, Akbar Nayeem, Kenneth S. Santone, Gamini Chandrasena, Ashvinikumar V. Gavai · 2005 · Bioorganic & Medicinal Chemistry Letters
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Masayuki Hata, Yoshikazu Tanaka, Naoko Kyoda, Taisuke Osakabe, Hitomi Yuki, Itsuko Ishii, Mitsukazu Kitada, Saburo Neya, Tyuji Hoshino · 2008 · Bioorganic & Medicinal Chemistry
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Javier Garrigós‐Martínez, Astrid Weninger, José Luis González Montesinos, Christian Schmid, Francisco Valero, Claudia Rinnofner, Anton Glieder, Xavier Garcia‐Ortega · 2021 · Microbial Cell Factories
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Free energies of binding of R- and S-propranolol to wild-type and F483A mutant cytochrome P450 2D6 from molecular dynamics simulations
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Biocatalysis and substrate chemodiversity: Adaptation of aerobic living organisms to their chemical environment
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Evolution of drug metabolism: Hitchhiking the technology bandwagon
John O. Miners · 2002 · Clinical and Experimental Pharmacology and Physiology
Modelling Human Cytochromes P450 for Evaluating Drug Metabolism: An Update
David F. V. Lewis · 2000 · Drug metabolism and drug interactions
Site-Directed Mutagenesis of Cytochrome P450eryF: Implications for Substrate Oxidation, Cooperativity, and Topology of the Active Site
Kishore Kumar Khan, You Ai He, You He, James R. Halpert · 2002 · Chemical Research in Toxicology
A comparative approach to structure–function studies of mammalian aromatases
Alan James Conley, Samantha M. Mapes, C. Jo Corbin, D.L. Greger, Karen M. Walters, John M. Trant, Sandra E. Graham · 2001 · The Journal of Steroid Biochemistry and Molecular Biology
Genetically-engineered bacteria expressing human enzymes and their use in the study of mutagens and mutagenesis
Philip David Josephy · 2002 · Toxicology
The genome sequence ofMycobacterium tuberculosis reveals cytochromes P450 as novel anti-TB drug targets
Alison Souter, Kirsty J. McLean, W. Ewen Smith, Andrew W. Munro · 2000 · Journal of Chemical Technology & Biotechnology
Homology modelling of CYP3A4 from the CYP2C5 crystallographic template: analysis of typical CYP3A4 substrate interactions
D. F. V. Lewis, Brian G. Lake, Maurice Dickins, Peter S. Goldfarb · 2004 · Xenobiotica
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Lovisa Afzelius, Florian Raubacher, Anders Karlén, Flemming Steen Jørgensen, Tommy B. Andersson, Collen Mutowembwa Masimirembwa, Ismael Zamora · 2004 · Drug Metabolism and Disposition
Phylogenomic Analysis of Cytochrome P450 Gene Superfamily and Their Association with Flavonoids Biosynthesis in Peanut (Arachis hypogaea L.)
Kun Zhang, Yong-Mei Qin, Wei Sun, Hourui Shi, Shuzhen Zhao, Liangqiong He, Changsheng Li, Jin Zhao, Jiaowen Pan, Guanghao Wang et al. · 2023 · Genes
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Yoh Wada, M. Mitsuda, Yasuhiro Ishihara, Masashi Watanabe, M. Iwasaki, S. Asahi · 2008 · The Journal of Biochemistry
Protein Engineering of the Cytochrome P450 Monooxygenase from Bacillus megaterium
Vlada B. Urlacher, Rolf Dieter Schmid · 2004 · Methods in enzymology on CD-ROM/Methods in enzymology
Directed Evolution Reveals Requisite Sequence Elements in the Functional Expression of P450 2F1 inEscherichia coli
James B. Y. H. Behrendorff, Chad D. Moore, Keon-Hee Kim, Dae‐Hwan Kim, Christopher A. Smith, Wayne A. Johnston, Chul‐Ho Yun, Garold S. Yost, Elizabeth M. J. Gillam · 2012 · Chemical Research in Toxicology
Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme
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Homology modelling of CYP2A6 based on the CYP2C5 crystallographic template: enzyme–substrate interactions and QSARs for binding affinity and inhibition
D.F.V. Lewis, Brian G. Lake, Maurice Dickins, Peter S. Goldfarb · 2003 · Toxicology in Vitro
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Structural Similarities and Differences of the Heme Pockets of Various P450 Isoforms as Revealed by Resonance Raman Spectroscopy
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Identification and Analysis of Conserved Sequence Motifs in Cytochrome P450 Family 2
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Cloning and expression of two novel pig liver and kidney fatty acid hydroxylases [cytochrome P450 (CYP)4A24 and CYP4A25]
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Bryan T. Greenhagen, Paul Griggs, Shunji Takahashi, Lyle Ralston, Joe Chappell · 2002 · Archives of Biochemistry and Biophysics
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Sirkku T. Saarikoski, Tuula Suitiala, Reetta J. Holmila, Olli Impivaara, Jorma O. Järvisalo, Ari Hirvonen, Kirsti Husgafvel‐Pursiainen · 2004 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
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Differing Membrane Interactions of Two Highly Similar Drug-Metabolizing Cytochrome P450 Isoforms: CYP 2C9 and CYP 2C19
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The ?-helical membrane spanning domain of cytochrome interacts with cytochrome P450 via nonspecific interactions
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ASSESSMENT OF ARGININE 97 AND LYSINE 72 AS DETERMINANTS OF SUBSTRATE SPECIFICITY IN CYTOCHROME P450 2C9 (CYP2C9)
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