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Brefeldin A Acts to Stabilize an Abortive ARF–GDP–Sec7 Domain Protein Complex
Open accessAbstract
We demonstrate that the major in vivo targets of brefeldin A (BFA) in the secretory pathway of budding yeast are the three members of the Sec7 domain family of ARF exchange factors: Gea1p and Gea2p (functionally interchangeable) and Sec7p. Specific residues within the Sec7 domain are important for BFA inhibition of ARF exchange activity, since mutations in these residues of Gea1p (sensitive to BFA) and of ARNO (resistant to BFA) reverse the sensitivity of each to BFA in vivo and in vitro. We show that the target of BFA inhibition of ARF exchange activity is an ARF-GDP-Sec7 domain protein complex, and that BFA acts to stabilize this complex to a greater extent for a BFA-sensitive Sec7 domain than for a resistant one.
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“The fungal metabolite brefeldin A (Fig. 4), a macrocyclic lactone used to study membrane trafficking, inhibits Golgi functions by stabilizing ARF(GDP) with its guanine exchange factor ARNO. 86,87”
From Chasing molecular glue degraders: screening approaches (2022) · cites this paper as [87]
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Cites
Sherman, F., Fink, G. R., & Hicks, J. B. (1979) · Cold Spring Harbor Laboratory eBooks · Cited by 7,430
Brefeldin A: insights into the control of membrane traffic and organelle structure.
Klausner, R. D., Donaldson, J. G., & Lippincott‐Schwartz, J. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.116.5.1071 · Cited by 1,843
Methods in yeast genetics : a Cold Spring Harbor Laboratory course manual
Amberg, D. C., Burke, D. J., & Strathern, J. N. (2005) · Cited by 1,803
Lippincott‐Schwartz, J., Yuan, L. C., Bonifacino, J. S., & Klausner, R. D. (1989) · Cell · doi:10.1016/0092-8674(89)90685-5 · Cited by 1,688
Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein
Donaldson, J. G., Finazzi, D., & Klausner, R. D. (1992) · Nature · doi:10.1038/360350a0 · Cited by 754
Helms, J. B., & Rothman, J. E. (1992) · Nature · doi:10.1038/360352a0 · Cited by 746
Serafini, T. A., Orci, L., AMHERDT, M., Brunner, M., Kahn, R., & Rothmant, J. E. (1991) · Cell · doi:10.1016/0092-8674(91)90176-y · Cited by 609
Structural Basis for Activation of ARF GTPase
Goldberg, J. D. (1998) · Cell · doi:10.1016/s0092-8674(00)81754-7 · Cited by 549
A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains
Chardin, P., Paris, S., Antonny, B., Robineau, S., Béraud-Dufour, S., Jackson, C. L., & Chabre, M. (1996) · Nature · doi:10.1038/384481a0 · Cited by 482
Self-citationOrcl, L., Tagaya, M., AMHERDT, M., Perrelet, A., Donaldson, J. G., Lippincott‐Schwartz, J., Klausner, R. D., & Rothman, J. E. (1991) · Cell · doi:10.1016/0092-8674(91)90273-2 · Cited by 463
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Metadata
- Authors
- Peyroche, A., Antonny, B., Robineau, S., Acker, J., Cherfils, J., & Jackson, C. L.
- Affiliations
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Jackson, Catherine L.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 1999-03
- Volume
- 3
- Issue
- 3
- Pages
- 275-285
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2078959581
- Cited by
- 453
- References
- 38
- Citations by year
- 2026: 9 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 7 · 2021: 6 · 2020: 13 · 2019: 14 · 2018: 17 · 2017: 17 · 2016: 8 · 2015: 10 · 2014: 18 · 2013: 29 · 2012: 23
- FWCI
- 8.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- brefeldin A, Sec7 domain, protein complex stabilization, secretory pathway, Saccharomyces cerevisiae, ARNO
- MeSH terms
- Amino Acid Sequence, Antifungal Agents, Drug Resistance, Microbial, Fungal Proteins, Guanosine Diphosphate, Guanosine Triphosphate, Kinetics, Molecular Sequence Data, Mutation, Recombinant Fusion Proteins, Saccharomyces cerevisiae, Gene Dosage, GTP-Binding Proteins, Amino Acid Substitution, Brefeldin A, Guanine Nucleotide Exchange Factors, GTPase-Activating Proteins, ADP-Ribosylation Factors, Saccharomyces cerevisiae Proteins
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