The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Brefeldin A Acts to Stabilize an Abortive ARF–GDP–Sec7 Domain Protein Complex
Open accessAbstract
We demonstrate that the major in vivo targets of brefeldin A (BFA) in the secretory pathway of budding yeast are the three members of the Sec7 domain family of ARF exchange factors: Gea1p and Gea2p (functionally interchangeable) and Sec7p. Specific residues within the Sec7 domain are important for BFA inhibition of ARF exchange activity, since mutations in these residues of Gea1p (sensitive to BFA) and of ARNO (resistant to BFA) reverse the sensitivity of each to BFA in vivo and in vitro. We show that the target of BFA inhibition of ARF exchange activity is an ARF-GDP-Sec7 domain protein complex, and that BFA acts to stabilize this complex to a greater extent for a BFA-sensitive Sec7 domain than for a resistant one.
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“The fungal metabolite brefeldin A (Fig. 4), a macrocyclic lactone used to study membrane trafficking, inhibits Golgi functions by stabilizing ARF(GDP) with its guanine exchange factor ARNO. 86,87”
From Chasing molecular glue degraders: screening approaches (2022) · cites this paper as [87]
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Cites
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Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein
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Metadata
- Authors
- Peyroche, A., Antonny, B., Robineau, S., Acker, J., Cherfils, J., & Jackson, C. L.
- Affiliations
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Jackson, Catherine L.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 1999-03
- Volume
- 3
- Issue
- 3
- Pages
- 275-285
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2078959581
- Cited by
- 453
- References
- 38
- Citations by year
- 2026: 9 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 7 · 2021: 6 · 2020: 13 · 2019: 14 · 2018: 17 · 2017: 17 · 2016: 8 · 2015: 10 · 2014: 18 · 2013: 29 · 2012: 23
- FWCI
- 8.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- brefeldin A, Sec7 domain, protein complex stabilization, secretory pathway, Saccharomyces cerevisiae, ARNO
- MeSH terms
- Amino Acid Sequence, Antifungal Agents, Drug Resistance, Microbial, Fungal Proteins, Guanosine Diphosphate, Guanosine Triphosphate, Kinetics, Molecular Sequence Data, Mutation, Recombinant Fusion Proteins, Saccharomyces cerevisiae, Gene Dosage, GTP-Binding Proteins, Amino Acid Substitution, Brefeldin A, Guanine Nucleotide Exchange Factors, GTPase-Activating Proteins, ADP-Ribosylation Factors, Saccharomyces cerevisiae Proteins
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