Cited by 453Cellular transport and secretionFungal and yeast genetics researchProtein Kinase Regulation and GTPase Signaling

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Brefeldin A Acts to Stabilize an Abortive ARF–GDP–Sec7 Domain Protein Complex

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Peyroche, Anne, Antonny, Bruno, Robineau, Sylviane, Acker, Joel, Cherfils, Jacqueline, Jackson, Catherine L.·1999·Molecular Cell

DOI 10.1016/s1097-2765(00)80455-4

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Abstract

We demonstrate that the major in vivo targets of brefeldin A (BFA) in the secretory pathway of budding yeast are the three members of the Sec7 domain family of ARF exchange factors: Gea1p and Gea2p (functionally interchangeable) and Sec7p. Specific residues within the Sec7 domain are important for BFA inhibition of ARF exchange activity, since mutations in these residues of Gea1p (sensitive to BFA) and of ARNO (resistant to BFA) reverse the sensitivity of each to BFA in vivo and in vitro. We show that the target of BFA inhibition of ARF exchange activity is an ARF-GDP-Sec7 domain protein complex, and that BFA acts to stabilize this complex to a greater extent for a BFA-sensitive Sec7 domain than for a resistant one.

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Authors: Peyroche, A., Antonny, B., Robineau, S., Acker, J., Cherfils, J., & Jackson, C. L.
Affiliations: Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
Centre National de la Recherche Scientifique (FR)
Corresponding author: Jackson, Catherine L.
ORCID: Antonny, Bruno
Cherfils, Jacqueline
Jackson, Catherine L.
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 1999-03
Volume: 3
Issue: 3
Pages: 275-285
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/s1097-2765(00)80455-4
OpenAlex: W2078959581
Cited by: 453
References: 38
Citations by year: 2026: 9 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 7 · 2021: 6 · 2020: 13 · 2019: 14 · 2018: 17 · 2017: 17 · 2016: 8 · 2015: 10 · 2014: 18 · 2013: 29 · 2012: 23
FWCI: 8.94
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5252 d)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: brefeldin A, Sec7 domain, protein complex stabilization, secretory pathway, Saccharomyces cerevisiae, ARNO
MeSH terms: Amino Acid Sequence, Antifungal Agents, Drug Resistance, Microbial, Fungal Proteins, Guanosine Diphosphate, Guanosine Triphosphate, Kinetics, Molecular Sequence Data, Mutation, Recombinant Fusion Proteins, Saccharomyces cerevisiae, Gene Dosage, GTP-Binding Proteins, Amino Acid Substitution, Brefeldin A, Guanine Nucleotide Exchange Factors, GTPase-Activating Proteins, ADP-Ribosylation Factors, Saccharomyces cerevisiae Proteins

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Brefeldin A Acts to Stabilize an Abortive ARF–GDP–Sec7 Domain Protein Complex

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