Cited by 627Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersMemory and Neural Mechanisms

Group 1 mGluR-Dependent Synaptic Long-Term Depression: Mechanisms and Implications for Circuitry and Disease

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Lüscher, Christian, Huber, Kimberly M.·2010·Neuron

Abstract

Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 mGluRs typically occurs in response to strong activity and triggers long-term plasticity of synaptic transmission in many brain regions, including the neocortex, hippocampus, midbrain, striatum, and cerebellum. Here we focus on mGluR-induced long-term synaptic depression (LTD) and review the literature that implicates Gp1 mGluRs in the plasticity of behavior, learning, and memory. Moreover, recent studies investigating the molecular mechanisms of mGluR-LTD have discovered links to mental retardation, autism, Alzheimer's disease, Parkinson's disease, and drug addiction. We discuss how mGluRs lead to plasticity of neural circuits and how the understanding of the molecular mechanisms of mGluR plasticity provides insight into brain disease.

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Crossref · 10.1016/j.neuron.2010.01.016

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  • LTD mediated through metabotropic glutamate receptors (mGluRs) has emerged as a major alternative to NMDAR-mediated LTD in widespread areas of the brain.

    “Notably, LTD mediated through metabotropic glutamate receptors (mGluRs) has emerged as a major alterative to NMDAR-mediated LTD in widespread areas of the brain124, 125, 126”

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  1. Bear MF Linden DJ Synapses WM Cowan WM Sudhof TC Stevens CF The mechanisms and meaning of long-term synaptic depression in the mammalian brain 2001 Baltimore Johns Hopkins University Press 455 517

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Authors
Lüscher, C., & Huber, K. M.
Affiliations
  • University of Geneva (CH)
  • The University of Texas Southwestern Medical Center (US)
Corresponding author
  • Lüscher, Christian
  • Huber, Kimberly M.
Venue
Neuron
Publisher
Elsevier BV
Published
2010-02
Volume
65
Issue
4
Pages
445-459
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2017197221
Cited by
627
References
156
Citations by year
2026: 18 · 2025: 24 · 2024: 24 · 2023: 26 · 2022: 30 · 2021: 60 · 2020: 32 · 2019: 32 · 2018: 54 · 2017: 31 · 2016: 55 · 2015: 30 · 2014: 56 · 2013: 47 · 2012: 49
FWCI
4.52
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion)
Funders
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
  • National Institutes of Health (HD052731, NS045711)
  • Autism Speaks
  • Simons Foundation
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
group I metabotropic glutamate receptors, synaptic plasticity, Gq-coupled receptors, excitatory synapses, learning and memory, autism spectrum disorder, intellectual disability, Alzheimer's disease, Parkinson's disease, drug addiction
MeSH terms
Animals, Brain, Brain Diseases, Humans, Nerve Net, Neural Pathways, Synaptic Transmission, Synapses, Receptors, Metabotropic Glutamate, Long-Term Synaptic Depression

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