Group 1 mGluR-Dependent Synaptic Long-Term Depression: Mechanisms and Implications for Circuitry and Disease
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Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 mGluRs typically occurs in response to strong activity and triggers long-term plasticity of synaptic transmission in many brain regions, including the neocortex, hippocampus, midbrain, striatum, and cerebellum. Here we focus on mGluR-induced long-term synaptic depression (LTD) and review the literature that implicates Gp1 mGluRs in the plasticity of behavior, learning, and memory. Moreover, recent studies investigating the molecular mechanisms of mGluR-LTD have discovered links to mental retardation, autism, Alzheimer's disease, Parkinson's disease, and drug addiction. We discuss how mGluRs lead to plasticity of neural circuits and how the understanding of the molecular mechanisms of mGluR plasticity provides insight into brain disease.
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LTD mediated through metabotropic glutamate receptors (mGluRs) has emerged as a major alternative to NMDAR-mediated LTD in widespread areas of the brain.
“Notably, LTD mediated through metabotropic glutamate receptors (mGluRs) has emerged as a major alterative to NMDAR-mediated LTD in widespread areas of the brain124, 125, 126”
From A role for synaptic plasticity in the adolescent development of executive function (2013) · cites this paper as [126]
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- Authors
- Lüscher, C., & Huber, K. M.
- Affiliations
- University of Geneva (CH)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Lüscher, Christian
- Huber, Kimberly M.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 65
- Issue
- 4
- Pages
- 445-459
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2841961
- OpenAlex
- W2017197221
- Cited by
- 627
- References
- 156
- Citations by year
- 2026: 18 · 2025: 24 · 2024: 24 · 2023: 26 · 2022: 30 · 2021: 60 · 2020: 32 · 2019: 32 · 2018: 54 · 2017: 31 · 2016: 55 · 2015: 30 · 2014: 56 · 2013: 47 · 2012: 49
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1262 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Institutes of Health (HD052731, NS045711)
- Autism Speaks
- Simons Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- group I metabotropic glutamate receptors, synaptic plasticity, Gq-coupled receptors, excitatory synapses, learning and memory, autism spectrum disorder, intellectual disability, Alzheimer's disease, Parkinson's disease, drug addiction
- MeSH terms
- Animals, Brain, Brain Diseases, Humans, Nerve Net, Neural Pathways, Synaptic Transmission, Synapses, Receptors, Metabotropic Glutamate, Long-Term Synaptic Depression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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