Transferrin receptor 2: a new molecule in iron metabolism
Abstract
Transferrin receptor 1 (TfR1) which mediates uptake of transferrin-bound iron, is essential for life in mammals. Recently, a close homologue of human transferrin receptor 1 was cloned and called transferrin receptor 2 (TfR2). A similar molecule has been identified in the mouse. Human transferrin receptor 2 is 45% identical with transferrin receptor 1 in the extracellular domain, but contains no iron responsive element in its mRNA and is apparently not regulated by intracellular iron concentration nor by interaction with HFE. Transferrin receptor 2, like transferrin receptor 1, binds transferrin in a pH-dependent manner (but with 25 times lower affinity) and delivers iron to cells. However, transferrin receptor 2 distribution differs from transferrin receptor 1, increasing in differentiating hepatocytes and decreasing in differentiating erythroblasts. Expression of both receptors is cell cycle dependent. Mutations in the human transferrin receptor 2 gene cause iron overload disease, suggesting it has a role in iron homeostasis.
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Induction of ferritin mRNA was observed in mouse liver and erythroid cells treated with oxidative stress-inducing compounds.
“induction of ferritin mRNA was observed in mouse liver (303) and erythroid cells (78) treated with oxidative stress–inducing compounds.”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [303]
The 180-bp region contains the mouse ferritin H ARE sequence identified as the responsive enhancer to electrophilic chemical stress.
“It should be noted that the 180-bp region (20) actually contains the mouse ferritin H ARE sequence identified as the responsive enhancer to electrophilic chemical stress (302, 303).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [303]
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(Bubalus bubalis bubalis - Simpson, 1945)
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- Authors
- Trinder, D., & Baker, E.
- Affiliations
- The University of Western Australia (AU)
- Corresponding author
- Baker, Erica
- Venue
- The International Journal of Biochemistry & Cell Biology
- Publisher
- Elsevier BV
- Published
- 2003-03
- Volume
- 35
- Issue
- 3
- Pages
- 292-296
- ISSN
- 1357-2725 (ISSN-L)
- OpenAlex
- W2066822786
- Cited by
- 94
- References
- 17
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 2 · 2022: 4 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 6 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 2
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The International Journal of Biochemistry & Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- transferrin receptor 2, transferrin receptor 1, iron metabolism, iron homeostasis, transferrin uptake, HFE gene, cell cycle regulation, hepatocyte differentiation, erythroblast differentiation
- MeSH terms
- Animals, Cloning, Molecular, Cricetinae, Humans, Hydrogen-Ion Concentration, Iron, Liver, Mutation, Receptors, Transferrin, RNA, Messenger, CHO Cells, Mice
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