The DOI matches its Crossref record; 312 of the 315 references it cites were found in a registry or an index.
Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer’s disease
Abstract
The processing of amyloid precursor protein (APP) generates amyloid-beta (Abeta) peptides 1-40 and 1-42. The latter is neurotoxic and its accumulation results in amyloid fibril formation and the generation of senile plaques, the hallmark of Alzheimer's disease (AD). Whilst there has been considerable progress made in understanding the generation of Abeta by alpha-, beta- and gamma-secretase activity on APP, recently enzymes involved in the degradation of Abeta have been identified including neprilysin and insulin-degrading enzyme (IDE). We review the pathways involved in proteolytic processing of APP and discuss the potential implications of aberrant proteolysis on neurodegeneration. It is conceivable that single nucleotide polymorphisms (SNPs) in the regulatory regions of genes in these proteolytic cascades, which alter their expression, could contribute to some of the age-related changes seen in AD.
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“The amyloid-beta peptides can be variable lengths depending on specific cleavage site, but commonly occur as a peptide of either 40 or 42 amino acids.(11)”
From Putting humpty dumpty back together again: what does protein quantification mean in bottom-up proteomics? (2022) · cites this paper as [11]
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Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619
Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., & Selkoe, D. J. (2002) · Nature · doi:10.1038/416535a · Cited by 4,291
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051
Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., et al. (1997) · Nature · doi:10.1038/385729a0 · Cited by 3,149
Research works printed but not linked: 5
- Blanquet, 1987, In situ hybridization of the beta amyloid protein (APP) cDNA to the vicinity of the interface of 21q21 and q22 in normal and Alzheimer’s disease individuals, Cytogenetics and Cell Genetics, 46, 582
- Corder, 1996, Alzheimer’s risk in relation to α1-antichymotrypsinand apolipoprotein E polymorphism in very old adults age 75+, Alzheimer Research, 2, 51
- Marynen, 1989, Alpha-2-macroglobulin, pregnancy zone protein and an alpha-2-macroglobulin pseudogene map to chromosome 12p12.2–p13, Cytogenetics and Cell Genetics, 51, 1040
- Rabin, 1985, Human alpha-1-antichymotrypsin and alpha-1-antitrypsin (PI) genes map to the same region on chromosome 14, Cytogenetics and Cell Genetics, 40, 728
- Van Uden, 2000, LDL receptor-related protein (LRP) in Alzheimer’s disease: Towards a unified theory of pathogenesis, Microscopy Research and Technique, 50, 268, 10.1002/1097-0029(20000815)50:4<268::AID-JEMT3>3.0.CO;2-1 · DOI
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Domert, J. (2017) · Linköping University medical dissertations · doi:10.3384/diss.diva-134667
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Peddapalli, V., & van Oosten‐Hawle, P. (2023) · Journal of Student Research · doi:10.47611/jsrhs.v12i4.5752
Osman, N., Awang, K., Hazni, H., Khaw, K. Y., Mak, W. Q., Tiamas, S. G., Maulana, S., Zubair, M., Pudjiastuti, P., Liew, S. Y., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4767405
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Ahmed, S., Barale, S. S., Kamble, R. S., Fatema, K., Sonawane, K. D., Hefferon, K. L., Paek, K., & Shohael, A. M. (2026) · Network Modeling Analysis in Health Informatics and Bioinformatics · doi:10.1007/s13721-025-00729-5
Tau nucléaire : un acteur clé dans le stress neuronal
Sultan, A. (2010) · theses.fr (ABES) · doi:10.70675/98c582c8z1d31z4edazbbfaz92750b338b46
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Zhang, P. (2017) · theses.fr (ABES) · doi:10.70675/74cb83e0z6db8z4bb5z838dz6e1bb1c6275f
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Luckett, P. H., Petersen, M. E., O’Bryant, S. E., Mapstone, M. E., Christian, B. T., Handen, B. L., Head, E., & Ances, B. M. (2026) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.70325
Metadata
- Authors
- Ling, Y., Morgan, K., & Kalsheker, N.
- Affiliations
- University of Nottingham (GB)
- Corresponding author
- Morgan, Kevin
- Venue
- The International Journal of Biochemistry & Cell Biology
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 35
- Issue
- 11
- Pages
- 1505-1535
- ISSN
- 1357-2725 (ISSN-L)
- OpenAlex
- W2050373702
- Cited by
- 224
- References
- 315
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 6 · 2023: 11 · 2022: 5 · 2021: 12 · 2020: 3 · 2019: 6 · 2018: 13 · 2017: 8 · 2016: 9 · 2015: 5 · 2014: 14 · 2013: 14 · 2012: 8
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The International Journal of Biochemistry & Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid precursor protein, Alzheimer's disease, amyloid-beta, proteolytic processing, alpha-secretase, beta-secretase, gamma-secretase, neprilysin, insulin-degrading enzyme, amyloid fibril formation, amyloid plaques, neurodegeneration, single nucleotide polymorphisms, gene expression regulation
- MeSH terms
- Alzheimer Disease, Animals, Humans, Endopeptidases, Protein Processing, Post-Translational, Aspartic Acid Endopeptidases, Amyloid beta-Protein Precursor, Amyloid Precursor Protein Secretases
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