Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer’s disease

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

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Alzheimer's Disease: Genes, Proteins, and Therapy

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

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Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

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Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

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Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis

Qiu, W. Q., & Folstein, M. F. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.01.004 · Cited by 557

Copper in the brain and Alzheimer’s disease

Hung, Y. H., Bush, A. I., & Cherny, R. A. (2009) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-009-0600-y · Cited by 503

Protein misfolding and aggregation: new examples in medicine and biology of the dark side of the protein world

Stefani, M. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.08.004 · Cited by 433

Zinc homeostasis and neurodegenerative disorders

Szewczyk, B. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00033 · Cited by 288

Biological metals and Alzheimer's disease: Implications for therapeutics and diagnostics

Duce, J. A., & Bush, A. I. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.04.003 · Cited by 288

Delivery of peptide and protein drugs over the blood–brain barrier

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The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer’s disease

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Green Tea (-)-Epigallocatechin-3-Gallate Inhibits β-Amyloid-Induced Cognitive Dysfunction through Modification of Secretase Activity via Inhibition of ERK and NF-κB Pathways in Mice ,

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Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?

Biessels, G. J., & Kappelle, L. J. (2005) · Biochemical Society Transactions · doi:10.1042/bst0331041 · Cited by 293

Genetics of β-Amyloid Precursor Protein in Alzheimer's Disease

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The Polyphenol Oleuropein Aglycone Protects TgCRND8 Mice against Aß Plaque Pathology

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In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases

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S100 Proteins in Alzheimer’s Disease

Cristóvão, J. S., & Gomes, C. M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00463 · Cited by 188

Amyloid precursor protein and neural development

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Subcellular and metabolic examination of amyloid-β peptides in Alzheimer disease pathogenesis: Evidence for Aβ25–35

Kaminsky, Y. G., Marlatt, M. W., Smith, M. A., & Kosenko, E. A. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.09.005 · Cited by 171

The roles of amyloid precursor protein (APP) in neurogenesis

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Characterization of Amyloid β Peptides in Cerebrospinal Fluid by an Automated Immunoprecipitation Procedure Followed by Mass Spectrometry

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Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease

Cristóvão, J. S., Santos, R., & Gomes, C. M. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/9812178 · Cited by 146

Oleuropein Aglycone Protects Transgenic C. elegans Strains Expressing Aβ42 by Reducing Plaque Load and Motor Deficit

Diomede, L., Rigacci, S., Romeo, M., Stefani, M., & Salmona, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058893 · Cited by 151

Presenilin/γ-Secretase-mediated Cleavage of the Voltage-gated Sodium Channel β2-Subunit Regulates Cell Adhesion and Migration

Kim, D. Y., Ingano, L. A. M., Carey, B. W., Pettingell, W. H., & Kovacs, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412938200 · Cited by 151

Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade

Jacobsen, J. S., Comery, T. A., Martone, R. L., Elokdah, H. M., Crandall, D. L., Oganesian, A., Aschmies, S., Kirksey, Y. M., Gonzales, C., Xu, J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710823105 · Cited by 146

Loss of LR11/SORLA Enhances Early Pathology in a Mouse Model of Amyloidosis: Evidence for a Proximal Role in Alzheimer's Disease

Dodson, S. E., Andersen, O. M., Karmali, V., Fritz, J. J., Cheng, D., Peng, J., Levey, A. I., Willnow, T. E., & Lah, J. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4582-08.2008 · Cited by 141

The Central Vasopressinergic System: Examining the Opportunities for Psychiatric Drug Development

Ring, R. H. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053382241 · Cited by 142

Chloride intracellular channel 1 (CLIC1): Sensor and effector during oxidative stress

Averaimo, S., Milton, R. H., Duchen, M. R., & Mazzanti, M. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.02.073 · Cited by 134

How and When Environmental Agents and Dietary Factors Affect the Course of Alzheimers Disease: The “LEARn” Model (Latent Early-Life Associated Regulation) May Explain the Triggering of AD

Lahiri, D. K., Maloney, B., Basha, R. M., Ge, Y. W., & Zawia, N. (2007) · Current Alzheimer Research · doi:10.2174/156720507780362164 · Cited by 134

Proteolytic mechanisms in amyloid-β metabolism: therapeutic implications for Alzheimer's disease

Vardy, E. R. L. C., Catto, A. J., & Hooper, N. M. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.08.004 · Cited by 135

Soluble Arctic amyloid β protein inhibits hippocampal long‐term potentiation in vivo

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Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin α IIb β 3 –induced outside-in signaling and clusterin release

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S100-mediated signal transduction in the nervous system and neurological diseases.

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Curcumin Ameliorates Memory Decline via Inhibiting BACE1 Expression and β-Amyloid Pathology in 5×FAD Transgenic Mice

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Intranasal therapeutic strategies for management of Alzheimer’s disease

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A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis

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Current concepts in therapeutic strategies targeting cognitive decline and disease modification in Alzheimer’s disease

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Putting humpty dumpty back together again: what does protein quantification mean in bottom-up proteomics?

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Icariin Decreases the Expression of APP and BACE-1 and Reduces the β-amyloid Burden in an APP Transgenic Mouse Model of Alzheimer's Disease

Zhang, L., Shen, C., Chu, J., Zhang, R., Li, Y., & Li, L. (2014) · International Journal of Biological Sciences · doi:10.7150/ijbs.6232 · Cited by 85

Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality

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SIRT3 activator Honokiol attenuates β-Amyloid by modulating amyloidogenic pathway

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Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice

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Protein Phosphorylation is a Key Mechanism in Alzheimer’s Disease

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Proposed pathogenetic cascade of inclusion-body myositis: importance of amyloid-β, misfolded proteins, predisposing genes, and aging

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Estrogen Activates Classical and Alternative Mechanisms to Orchestrate Neuroprotection

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Increased processing of APLP2 and APP with concomitant formation of APP intracellular domains in BDNF and retinoic acid‐differentiated human neuroblastoma cells

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Modulation of Aβ generation by small ubiquitin-like modifiers does not require conjugation to target proteins

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The Role of P2X7 Receptor in Alzheimer’s Disease

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Ageing and dementia

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Pathogenesis of Alzheimer’s Disease

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ADME profiling, molecular docking, DFT, and MEP analysis reveal cissamaline, cissamanine, and cissamdine from Cissampelos capensis L.f. as potential anti-Alzheimer's agents

Alhawarri, M. B., Al-Thiabat, M. G., Dubey, A., Tufail, A., Fouad, D., Alrimawi, B. H., & Dayoob, M. (2024) · RSC Advances · doi:10.1039/d4ra01070a · Cited by 67

The Role of Butyrylcholinesterase and Iron in the Regulation of Cholinergic Network and Cognitive Dysfunction in Alzheimer’s Disease Pathogenesis

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Inhibitory effect of ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on memory impairment and neuronal toxicity induced by beta-amyloid

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Effects of Neprilysin Chimeric Proteins Targeted to Subcellular Compartments on Amyloid β Peptide Clearance in Primary Neurons

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Presenilin/γ‐secretase activity regulates protein clearance from the endocytic recycling compartment

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Resveratrol and Alzheimer's disease. From molecular pathophysiology to clinical trials

Drygalski, K., Fereniec, E., Koryciński, K., Chomentowski, A., Kiełczewska, A., Odrzygóźdź, C., & Modzelewska, B. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.09.019 · Cited by 57

Mechanical manipulation of Alzheimer’s amyloid β1–42 fibrils

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Molecular Insights into Destabilization of Alzheimer’s Aβ Protofibril by Arginine Containing Short Peptides: A Molecular Modeling Approach

Barale, S. S., Parulekar, R. S., Fandilolu, P. M., Dhanavade, M. J., & Sonawane, K. D. (2019) · ACS Omega · doi:10.1021/acsomega.8b02672 · Cited by 55

Molecular Pathogenesis of Alzheimer’s Disease: Reductionist versus Expansionist Approaches

Castellani, R. J., Zhu, X., Lee, H., Smith, M. A., & Perry, G. L. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10031386 · Cited by 57

The extracellular domain of Bri2 (ITM2B) binds the ABri peptide (1–23) and amyloid β-peptide (Aβ1–40): Implications for Bri2 effects on processing of amyloid precursor protein and Aβ aggregation

Peng, S., Landreh, M., Jörnvall, H., & Johansson, J. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.12.122 · Cited by 53

Genetic aspects of Alzheimer's disease

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Role of Dietary and Endogenous Antioxidants in Diabetes

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Mechanisms linking brain insulin resistance to Alzheimer's disease

Matioli, M. N. P. D. S., & Nitríni, R. (2015) · Dementia & Neuropsychologia · doi:10.1590/1980-57642015dn92000003 · Cited by 50

The Amyloid Precursor Protein (APP) of Alzheimer Disease and Its Paralog, APLP2, Modulate the Cu/Zn-Nitric Oxide-catalyzed Degradation of Glypican-1 Heparan Sulfate in Vivo

Cappai, R., Cheng, F., Ciccotosto, G. D., Needham, B. E., Masters, C. L., Multhaup, G., Fransson, L., & Mani, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409179200 · Cited by 49

Catechol Oxidase-like Oxidation Chemistry of the 1–20 and 1–16 Fragments of Alzheimer's Disease-related β-Amyloid Peptide

da Silva, G. F. Z., Tay, W. M., & Ming, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411533200 · Cited by 51

Effects and Mechanisms of Tea on Parkinson’s Disease, Alzheimer’s Disease and Depression

Luo, M., Gan, R., Li, B., Mao, Q., Shang, A., Xu, X., Li, H., & Li, H.-B. (2021) · Food Reviews International · doi:10.1080/87559129.2021.1904413 · Cited by 52

Therapeutic Efficacies of Berberine against Neurological Disorders: An Update of Pharmacological Effects and Mechanisms

Shou, J., & Shaw, P. (2022) · Cells · doi:10.3390/cells11050796 · Cited by 48

Functional competition within a membrane: Lipid recognition vs. transmembrane helix oligomerization

Stangl, M., & Schneider, D. (2015) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.03.011 · Cited by 45

Genetic Ablation of Luteinizing Hormone Receptor Improves the Amyloid Pathology in a Mouse Model of Alzheimer Disease

Lin, J., Li, X., Yuan, F., Lin, L., Cook, C. L., Rao, C. V., & Lei, Z. M. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181d072cf · Cited by 43

Effect of pioglitazone on altered expression of Aβ metabolism-associated molecules in the brain of fructose-drinking rats, a rodent model of insulin resistance

Luo, D., Hou, X., Hou, L., Wang, M., Xu, S., Dong, C., & Liu, X. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.04.045 · Cited by 42

Alzheimer’s Disease and Protein Kinases

Engin, A. B., & Engin, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-49844-3_11 · Cited by 43

Imaging β-amyloid fibrils in Alzheimer's disease: a critical analysis through simulation of amyloid fibril polymerization

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Posttranslational modification of proteins

Larsen, M. R., & Jensen, O. N. (2005) · Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics · doi:10.1002/047001153x.g305104 · Cited by 40

Metals and cholesterol: two sides of the same coin in Alzheimer’s disease pathology

Wong, B. X. W., Hung, Y. H., Bush, A. I., & Duce, J. A. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00091 · Cited by 41

Does the Genetic Feature of the Chinese Tree Shrew ( Tupaia belangeri chinensis ) Support Its Potential as a Viable Model for Alzheimer’s Disease Research?

Fan, Y., Luo, R., Su, L., Xiang, Q., Yu, D., Xu, L., Chen, J., Bi, R., Wu, D., Zheng, P., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170594 · Cited by 37

Can platelet activation result in increased plasma Aβ levels and contribute to the pathogenesis of Alzheimer’s disease?

Carbone, M. G., Pagni, G., Tagliarini, C., Imbimbo, B. P., & Pomara, N. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101420 · Cited by 39

Good gene, bad gene: New APP variant may be both

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Metabolic Dysfunction of Astrocyte: An Initiating Factor in Beta-amyloid Pathology?

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O-GlcNAcylation and neuronal energy status: Implications for Alzheimer’s disease

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Effect of duration of ischemia on myocardial proteome in ischemia/reperfusion injury

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The Role of Gonadotropins in Alzheimer's Disease: Potential Neurodegenerative Mechanisms

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Tailoring of Membrane Proteins by Alternative Splicing of Pre-mRNA

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NGP 555, a γ‐secretase modulator, lowers the amyloid biomarker, Aβ 42, in cerebrospinal fluid while preventing Alzheimer's disease cognitive decline in rodents

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