The DOI matches its Crossref record; 164 of the 173 references it cites were found in a registry or an index.
Chemokines in cancer
Abstract
Chemokines participate, by regulating cell trafficking and controlling angiogenesis, in the host response during infection and inflammation. Most of these mechanisms are also operating in cancer. The stimulation of angiogenesis and tumor growth--directly or indirectly through the recruitment of tumor-associated macrophages--are typical situations where chemokines promote tumor development. On the other hand, chemokines could be used to the benefit of cancer patients as they act in the recruitment of dendritic cells (DC) or/and effector cells or for their angiostatic properties. However, chemokine-mediated recruitment of immature DC within tumors, due to factors produced by the tumor milieu, could lead to the induction of immune tolerance and, therefore, novel strategies to eradicate tumors based on chemokines should attempt to avoid this risk.
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“Other CXCR2 ligands have been identified as having autocrine roles in the growth of pancreatic, head and neck, and non-small-cell lung carcinoma44,45”
From Inflammation and cancer (2002) · cites this paper as [44]
In the citing paper
“It is well established that CXC chemokines with the three amino acids (Glu-Leu-Arg/ELR) immediately amino-terminal to the CXC motif (ELR+) are pro-angiogenic and stimulate endothelial cell chemotaxis”
From Inflammation and cancer (2002) · cites this paper as [44]
In the citing paper
“whereas ELR− CXC chemokines (for example, PF-4/CXCL4, MIG/CXCL9 and IP-10/CXCL10) possess angiostatic activities44,49.”
From Inflammation and cancer (2002) · cites this paper as [44]
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Metadata
- Authors
- Vicari, A. P., & Caux, C.
- Corresponding author
- Vicari, Alain P
- ORCID
- Caux, Christophe
- Venue
- Cytokine & Growth Factor Reviews
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 13
- Issue
- 2
- Pages
- 143-154
- ISSN
- 1359-6101 (ISSN-L)
- OpenAlex
- W2092021793
- Cited by
- 351
- References
- 173
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 14 · 2019: 11 · 2018: 9 · 2017: 13 · 2016: 12 · 2015: 16 · 2014: 20 · 2013: 18 · 2012: 21
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine & Growth Factor Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- chemokines, cancer, angiogenesis, tumor growth, tumor-associated macrophages, dendritic cell recruitment, immune tolerance, tumor microenvironment, cell trafficking
- MeSH terms
- Animals, Dendritic Cells, Humans, Killer Cells, Natural, Leukocytes, Models, Biological, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic, T-Lymphocytes, Chemokines
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