Cited by 352Chemokine receptors and signalingAngiogenesis and VEGF in CancerImmune cells in cancer

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Chemokines in cancer

Vicari, Alain P, Caux, Christophe·2002·Cytokine & Growth Factor Reviews

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Abstract

Chemokines participate, by regulating cell trafficking and controlling angiogenesis, in the host response during infection and inflammation. Most of these mechanisms are also operating in cancer. The stimulation of angiogenesis and tumor growth--directly or indirectly through the recruitment of tumor-associated macrophages--are typical situations where chemokines promote tumor development. On the other hand, chemokines could be used to the benefit of cancer patients as they act in the recruitment of dendritic cells (DC) or/and effector cells or for their angiostatic properties. However, chemokine-mediated recruitment of immature DC within tumors, due to factors produced by the tumor milieu, could lead to the induction of immune tolerance and, therefore, novel strategies to eradicate tumors based on chemokines should attempt to avoid this risk.

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Authors: Vicari, A. P., & Caux, C.
Corresponding author: Vicari, Alain P
ORCID: Caux, Christophe
Venue: Cytokine & Growth Factor Reviews
Publisher: Elsevier BV
Published: 2002-04
Volume: 13
Issue: 2
Pages: 143-154
ISSN: 1359-6101 (ISSN-L)
DOI: 10.1016/s1359-6101(01)00033-8
OpenAlex: W2092021793
Cited by: 351
References: 173
Citations by year: 2025: 2 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 14 · 2019: 11 · 2018: 9 · 2017: 13 · 2016: 12 · 2015: 16 · 2014: 20 · 2013: 18 · 2012: 21
FWCI: 2.30
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cytokine & Growth Factor Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: chemokines, cancer, angiogenesis, tumor growth, tumor-associated macrophages, dendritic cell recruitment, immune tolerance, tumor microenvironment, cell trafficking
MeSH terms: Animals, Dendritic Cells, Humans, Killer Cells, Natural, Leukocytes, Models, Biological, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic, T-Lymphocytes, Chemokines

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