New developments in tetracycline antibiotics: glycylcyclines and tetracycline efflux pump inhibitors

Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance

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High Frequency of Hypermutable Pseudomonas aeruginosa in Cystic Fibrosis Lung Infection

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The Challenge of Antibiotic Resistance

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High Mutation Frequencies Among Escherichia coli and Salmonella Pathogens

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In Vitro and In Vivo Antibacterial Activities of a Novel Glycylcycline, the 9- t -Butylglycylamido Derivative of Minocycline (GAR-936)

Petersen, P. J., Jacobus, N. V., Weiss, W. J., Sum, P., & TESTA, R. T. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.4.738 · Cited by 413

Mutation frequency and biological cost of antibiotic resistance in Helicobacter pylori

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Multiple antibiotic resistance and efflux

Nikaido, H. (1998) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(98)80083-0 · Cited by 301

The Pharmaceutical Industry

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Antimicrobial activity and spectrum of the new glycylcycline, GAR-936 tested against 1,203 recent clinical bacterial isolates

Gales, A. C., & Jones, R. N. (2000) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(99)00092-9 · Cited by 189

Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936

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Mutator clones of Neisseria meningitidis in epidemic serogroup A disease

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Inhibition of efflux pumps as a novel approach to combat drug resistance in bacteria.

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Glycylcyclines bind to the high-affinity tetracycline ribosomal binding site and evade Tet(M)- and Tet(O)-mediated ribosomal protection

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In Vitro Activities of Tigecycline (GAR-936) against Recently Isolated Clinical Bacteria in Spain

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In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines

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Glycylcyclines: third-generation tetracycline antibiotics

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Glycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines

Sum, P., LEE, V. J., TESTA, R. T., Hlavka, J. J., Ellestad, G. A., Bloom, J. D., Gluzman, Y., & Tally, F. P. (1994) · Journal of Medicinal Chemistry · doi:10.1021/jm00027a023 · Cited by 118

In Vitro Activities of the Glycylcycline GAR-936 against Gram-Positive Bacteria

Boucher, H. W., Wennersten, C. B., & Eliopoulos, G. M. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.8.2225-2229.2000 · Cited by 98

Reversal of Tetracycline Resistance Mediated by Different Bacterial Tetracycline Resistance Determinants by an Inhibitor of the Tet(B) Antiport Protein

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Mutations in the Interdomain Loop Region of the tetA (A) Tetracycline Resistance Gene Increase Efflux of Minocycline and Glycylcyclines

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Response of Escherichia coli hypermutators to selection pressure with antimicrobial agents from different classes

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Inhibition of protein synthesis occurring on tetracycline-resistant, TetM-protected ribosomes by a novel class of tetracyclines, the glycylcyclines

Rasmussen, B. A., Gluzman, Y., & Tally, F. P. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.7.1658 · Cited by 62

Insertional inactivation of mutS in Staphylococcus aureus reveals potential for elevated mutation frequencies, although the prevalence of mutators in clinical isolates is low

O’Neill, A. J. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkf118 · Cited by 62

A novel glycylcycline, 9-(N,N-dimethylglycylamido)-6-demethyl-6-deoxytetracycline, is neither transported nor recognized by the transposon Tn10-encoded metal-tetracycline/H+ antiporter

Someya, Y., Yamaguchi, A., & Sawai, T. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.1.247 · Cited by 58

Research and development of antibacterial agents

Chopra, I. (1998) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(98)80080-5 · Cited by 48

In vitro activities of two glycylcyclines against gram-positive bacteria

Eliopoulos, G. M., Wennersten, C. B., Cole, G., & Moellering, R. C. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.3.534 · Cited by 48

Mutations in the tetA(B) gene that cause a change in substrate specificity of the tetracycline efflux pump

Guay, G. G., Tuckman, M., & Rothstein, D. M. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.4.857 · Cited by 44

Origin of tetracycline efflux proteins: conclusions from nucleotide sequence analysis

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"Glycylcyclines". 3. 9-Aminodoxycyclinecarboxamides

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Comparative in-vitro activities of RP59500 (quinupristin/dalfopristin), CL 329,998, CL 331,002, trovafloxacin, clinafloxacin, teicoplanin and vancomycin against Gram-positive bacteria

Shonekan, D., Handwerger, S., & Mildvan, D. (1997) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/39.3.405 · Cited by 34

Detection of tetracyclines and efflux pump inhibitors

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In vitro activities of two glycylcyclines

Wise, R. A., & Andrews, J. M. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.5.1096 · Cited by 30

N,N-dimethylglycyl-amido derivative of minocycline and 6-demethyl-6-desoxytetracycline, two new glycylcyclines highly effective against tetracycline-resistant gram-positive cocci

Goldstein, F. W., Kitzis, M.-D., & Acar, J. F. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.9.2218 · Cited by 30

Susceptibilities of Mycoplasma hominis, Mycoplasma pneumoniae, and Ureaplasma urealyticum to new glycylcyclines in comparison with those to older tetracyclines

Kenny, G. E., & Cartwright, F. D. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.11.2628 · Cited by 24

Susceptibility of enterococci, methicillin-resistant Staphylococcus aureus and Streptococcus pneumoniae to the glycylcyclines

Weiss, J., Jacobus, N. V., Petersen, P. J., & TESTA, R. T. (1995) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/36.1.225 · Cited by 21

Activities of the glycylcyclines N,N-dimethylglycylamido-minocycline and N,N-dimethylglycylamido-6-demethyl-6-deoxytetracycline against Nocardia spp. and tetracycline-resistant isolates of rapidly growing mycobacteria

Brown, B. A., Wallace, R. J., & Onyi, G. O. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.4.874 · Cited by 20

In-vitro activity of two glycylcyclines against enterococci resistant to other agents

Fraise, A. P., Brenwald, N. P., Andrews, J. M., & Wise, R. A. (1995) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/35.6.877 · Cited by 19

Susceptibilities of Neisseria gonorrhoeae to the glycylcyclines

Whittington, W. L. H., Roberts, M. C., Hale, J., & Holmes, K. K. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.8.1864 · Cited by 17

In vitro activity of DMG-mino and DMG-DM Dot, two new glycylcyclines, against anaerobic bacteria

Nord, C. E., Lindmark, A., & Persson, I. (1993) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf02098471 · Cited by 13

In vitro activities of two new glycylcyclines, N,N-dimethylglycylamido derivatives of minocycline and 6-demethyl-6-deoxytetracycline, against 339 strains of anaerobic bacteria

Wexler, H. M., Molitoris, E., & Finegold, S. M. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.10.2513 · Cited by 13

Activity of glycylcyclines CL 329998 and CL 331002 against minocycline-resistant and other strains of methicillin-resistant Staphylococcus aureus

Hamilton-Miller, J. M. T., & Shah, S. (1996) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/37.6.1171 · Cited by 11

ChemInform Abstract: Glycylcyclines. Part 1. A New Generation of Potent Antibacterial Agents Through Modification of 9‐Aminotetracyclines.

Sum, P., LEE, V. J., TESTA, R. T., Hlavka, J. J., Ellestad, G. A., Bloom, J. D., Gluzman, Y., & Tally, F. P. (1994) · ChemInform · doi:10.1002/chin.199417260 · Cited by 2

Coagulase-Negative Staphylococci

Becker, K., Heilmann, C., & Peters, G. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00109-13 · Cited by 1,742

Efflux-mediated antimicrobial resistance

Poole, K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki171 · Cited by 1,082

Natural products to drugs: natural product-derived compounds in clinical trials

Butler, M. S. (2008) · Natural Product Reports · doi:10.1039/b514294f · Cited by 1,086

Update on acquired tetracycline resistance genes

Roberts, M. C. (2005) · FEMS Microbiology Letters · doi:10.1016/j.femsle.2005.02.034 · Cited by 1,010

Efflux-Mediated Drug Resistance in Bacteria

Li, X.-Z., & Nikaido, H. (2004) · Drugs · doi:10.2165/00003495-200464020-00004 · Cited by 803

Glycylcyclines: third-generation tetracycline antibiotics

Chopra, I. (2001) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(01)00081-9 · Cited by 121

Tigecycline: a case study

Loh, E., Ellis‐Grosse, E. J., Petersen, P. J., Sum, P., & Projan, S. J. (2007) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2.3.403 · Cited by 2

Recent Developments in Tetracycline Antibiotics

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The Glycylcyclines

Zhanel, G. G., Homenuik, K., Nichol, K. A., Noreddin, A. M., Vercaigne, L. M., Embil, J. M., Gin, A. S., Karlowsky, J. A., & Hoban, D. J. (2004) · Drugs · doi:10.2165/00003495-200464010-00005 · Cited by 314

Genetic Determinants of Tetracycline Resistance and their Effect on Tetracycline and Glycylcycline Antibiotics

Jones, C. H., Murphy, E., & Bradford, P. A. (2008) · Anti-Infective Agents · doi:10.2174/187152108783954650 · Cited by 5