Why the P600 is not just a P300: The role of the basal ganglia
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One of the important issues in event-related brain potential research is whether the language-related P600 and the P300 oddball effect are distinct components or not. We addressed this question by testing 14 aphasic patients, half of them with lesions including the basal ganglia and half of them with temporo-parietal lesions, in both an auditory oddball task and an experiment with auditory presented verb inflection violations. Whereas both patient groups displayed a clear P300 effect in the oddball experiment, only the group with temporo-parietal lesions showed a P600 in the language experiment. These data indicate that the basal ganglia seem to play a crucial role in the modulation of the P600, but not of the P300 component.
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Frisch et al. (2003) argued that basal-ganglia integrity contributes to modulation of the P600, distinguishing it from a simple P300 response.
“Frisch et al. (2003), for example, argued that basal-ganglia integrity contributes to modulation of the P600, distinguishing it from a simple P300 response [184].”
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Chmiel, J., & Kładna, A. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15155994
- Authors
- Frisch, S., Kotz, S. A., von Cramon, D. Y., & Friederici, A. D.
- Affiliations
- University of Potsdam (DE)
- Max Planck Institute for Human Cognitive and Brain Sciences (DE)
- Corresponding author
- Frisch, Stefan
- Venue
- Clinical Neurophysiology
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 114
- Issue
- 2
- Pages
- 336-340
- ISSN
- 1388-2457 (ISSN-L)
- OpenAlex
- W2146472529
- Cited by
- 162
- References
- 22
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 17 · 2015: 28 · 2014: 16 · 2013: 12 · 2012: 5
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- P600, P300, event-related potentials, basal ganglia, aphasia, auditory oddball paradigm, language processing, neuropsychological patients
- MeSH terms
- Aphasia, Basal Ganglia, Evoked Potentials, Auditory, Humans, Parietal Lobe, Speech Perception, Temporal Lobe, Event-Related Potentials, P300
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