The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Amnestic sleep-related eating disorder associated with zolpidem
Abstract
Objective To describe the association of amnestic nocturnal eating behavior with use of zolpidem for insomnia.Background Sleep-related eating disorder is increasingly recognized in relationship to other diagnosable sleep disorders. Many of these disorders, like restless legs syndrome (RLS), give rise to complaints of insomnia. Zolpidem is the most commonly prescribed drug for insomnia complaints, and although it has sometimes been associated with side effects of transient amnesia and sleep walking, an association with sleep-related eating has not been previously emphasized.Methods Consecutive case series of five patients who were using zolpidem and evaluated with nocturnal eating behaviors.Results We evaluated five patients over 11 months with problematic amnestic nocturnal eating associated with zolpidem used for complaints of insomnia. All five patients had RLS, three had obstructive sleep apnea syndrome, two had sleep walking, and one had psychophysiologic insomnia. With discontinuation of zolpidem and effective treatment of their sleep disorders, nocturnal eating resolved.Conclusions Zolpidem, at least in patients with underlying sleep disorders that cause frequent arousals, may cause or augment sleep-related eating behavior. This report demonstrates the importance of arriving at a specific diagnosis for insomnia complaints, and alerts the sleep practitioner to this unusual side effect of zolpidem.
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“Withdrawal syndromes after decrease or discontinuation of antidepressants may be associated with additional clinical manifestations. They include modifications of the illness course, such as switching to mania or other forms of excessive behavioral activations [24], but also loss of clinical effects and refractoriness to treatment; they have been reported with SSRI and SNRI [5, 6, 27].”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [27]
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Central Nervous System Side Effects Associated with Zolpidem Treatment
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Clinical and Polysomnographic Features of Sleep-Related Eating Disorder
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Hypnotics' association with mortality or cancer: a matched cohort study
Kripke, D. F., Langer, R. D., & Kline, L. E. (2012) · BMJ Open · doi:10.1136/bmjopen-2012-000850 · Cited by 408
“23 e 25 Sleep apnoeas, in turn, may lead to motor vehicle 26 Hypnotics may cause somnambulistic night-eating syndromes resulting in poor diet and obesity 27 as well as other automaton-like behaviours, which can be dangerous.”
BackgroundAcute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications
Cosci, F., & Chouinard, G. (2020) · Psychotherapy and Psychosomatics · doi:10.1159/000506868 · Cited by 265
Treatment of restless legs syndrome: An evidence‐based review and implications for clinical practice
Trenkwalder, C., Hening, W. A., Montagna, P., Oertel, W. H., Allen, R. P., Walters, A. S., Costa, J. N., Stiasny‐Kolster, K., & Sampaio, C. (2008) · Movement Disorders · doi:10.1002/mds.22254 · Cited by 261
“However, there have been recent reports of parasomnias, including nocturnal eating syndrome and complex somnambulism which raise concerns about the introduction of abnormal sleep states in patients.(73,74) Implications for clinical research.”
BackgroundThe Management of Restless Legs Syndrome: An Updated Algorithm
Silber, M. H., Buchfuhrer, M. J., Earley, C. J., Koo, B. B., Manconi, M., Winkelman, J. W., Earley, C. J., Becker, P., Berkowski, J. A., Buchfuhrer, M. J., et al. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.12.026 · Cited by 208
“34,35 Long-acting agents, such as clonazepam, may result in more adverse effects, such as unsteadiness during the night and drowsiness or cognitive impairment in the morning, and should generally be avoided unless used for comorbid psychiatric conditions with careful monitoring for adverse effects.”
BackgroundSelf-citation"I did what?" Zolpidem and the courts.
Daley, C. J. A., McNiel, D. E., & Binder, R. L. (2011) · PubMed · Cited by 186
Metadata
- Authors
- Morgenthaler, T. I., & Silber, M. H.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Morgenthaler, Timothy I
- Venue
- Sleep Medicine
- Publisher
- Elsevier BV
- Published
- 2002-07
- Volume
- 3
- Issue
- 4
- Pages
- 323-327
- ISSN
- 1389-9457 (ISSN-L)
- OpenAlex
- W2162977548
- Cited by
- 185
- References
- 33
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 3 · 2016: 9 · 2015: 4 · 2014: 11 · 2013: 17 · 2012: 10
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sleep Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Clinical Neurology › Restless Legs Syndrome Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep-related eating disorder, zolpidem, drug-induced amnesia, insomnia, restless legs syndrome, obstructive sleep apnea, sleepwalking, hypnotic side effects
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