Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study
Abstract
Background Knowledge about the distribution of human papillomavirus (HPV) genotypes in invasive cervical cancer is crucial to guide the introduction of prophylactic vaccines. We aimed to provide novel and comprehensive data about the worldwide genotype distribution in patients with invasive cervical cancer. Methods Paraffin-embedded samples of histologically confirmed cases of invasive cervical cancer were collected from 38 countries in Europe, North America, central South America, Africa, Asia, and Oceania. Inclusion criteria were a pathological confirmation of a primary invasive cervical cancer of epithelial origin in the tissue sample selected for analysis of HPV DNA, and information about the year of diagnosis. HPV detection was done by use of PCR with SPF-10 broad-spectrum primers followed by DNA enzyme immunoassay and genotyping with a reverse hybridisation line probe assay. Sequence analysis was done to characterise HPV-positive samples with unknown HPV types. Data analyses included algorithms of multiple infections to estimate type-specific relative contributions. Findings 22,661 paraffin-embedded samples were obtained from 14,249 women. 10,575 cases of invasive cervical cancer were included in the study, and 8977 (85%) of these were positive for HPV DNA. The most common HPV types were 16, 18, 31, 33, 35, 45, 52, and 58 with a combined worldwide relative contribution of 8196 of 8977 (91%, 95% CI 90-92). HPV types 16 and 18 were detected in 6357 of 8977 of cases (71%,…
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Bivalent and quadrivalent HPV vaccines target HPV types 16 and 18, which cause about 70% of cervical cancers.
“These vaccines target high-risk HPV types that cause about 70% (bivalent and quadrivalent vaccines: HPV types 16 and 18) and 90% (9-valent vaccine: HPV types 16, 18, 31, 33, 45, 52, and 58) of cervical cancers.9, 10”
The 9-valent HPV vaccine targets HPV types 16, 18, 31, 33, 45, 52, and 58, which cause about 90% of cervical cancers.
“These vaccines target high-risk HPV types that cause about 70% (bivalent and quadrivalent vaccines: HPV types 16 and 18) and 90% (9-valent vaccine: HPV types 16, 18, 31, 33, 45, 52, and 58) of cervical cancers.9, 10”
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- Authors
- de Sanjose, S., Quint, W. G., Alemany, L., Geraets, D. T., Klaustermeier, J. E., Lloveras, B., Tous, S., Felix, A., Bravo, L. E., Shin, H.-R., Vallejos, C. S., de Ruiz, P. A., Lima, M. A., Guimera, N., Clavero, O., Alejo, M., Llombart-Bosch, A., Cheng-Yang, C., Tatti, S. A., Kasamatsu, E., Iljazovic, E., Odida, M., Prado, R., Seoud, M., Grce, M., Usubutun, A., Jain, A., Suarez, G. A. H., Lombardi, L. E., Banjo, A., Menéndez, C., Domingo, E. J., Velasco, J., Nessa, A., Chichareon, S. C. B., Qiao, Y. L., Lerma, E., Garland, S. M., Sasagawa, T., Ferrera, A., Hammouda, D., Mariani, L., Pelayo, A., Steiner, I., Oliva, E., Meijer, C. J., Al-Jassar, W. F., Cruz, E., Wright, T. C., Puras, A., Llave, C. L., Tzardi, M., Agorastos, T., Garcia-Barriola, V., Clavel, C., Ordi, J., Andújar, M., Castellsagué, X., Sánchez, G. I., Nowakowski, A. M., Bornstein, J., Muñoz, N., & Bosch, F. X.
- Affiliations
- DDL Diagnostic Laboratory (NL)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Hospital Universitario del Valle ESE (CO)
- National Cancer Center (KR)
- Instituto Nacional de Enfermedades Neoplásicas (PE)
- Taiwan Association of Gynecologic Oncologists (TW)
- Universidad Nacional de Asunción (PY)
- Makerere University (UG)
- University of Chile (CL)
- American University of Beirut Medical Center (LB)
- Ruđer Bošković Institute (HR)
- Hospital General San Juan de Dios (GT)
- Lagos University Teaching Hospital (NG)
- Hospital Clínic de Barcelona (ES)
- Philippine General Hospital (PH)
- Hospital Universitario San Agustín (ES)
- Bangladesh Medical University (BD)
- Prince of Songkla University (TH)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Hospital de Sant Pau (ES)
- Royal Women's Hospital (AU)
- Kanazawa University Hospital (JP)
- National Autonomous University of Honduras (HN)
- Instituto Nazionale Tumori Regina Elena (IT)
- Hospital Clínico San Carlos (ES)
- Massachusetts General Hospital (US)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Kuwait University (KW)
- NewYork–Presbyterian Hospital (US)
- Hospital Virgen del Camino (ES)
- University of Crete (GR)
- Centre Hospitalier Universitaire de Reims (FR)
- Hospital Universitario Insular de Gran Canaria (ES)
- Universidad de Antioquia (CO)
- Medical University of Lublin (PL)
- Western Galilee Hospital (IL)
- ORCID
- Quint, Wim GV
- Tous, Sara
- Bravo, Luis Eduardo
- Vallejos, Carlos S
- Clavero, Omar
- Kasamatsu, Elena
- Prado, Rodrigo
- Seoud, Muhieddine
- Grce, Magdalena
- Menéndez, Clara
- Domingo, Efrén Javier
- Nessa, Ashrafun
- Qiao, You Lin
- Garland, Suzanne M
- Sasagawa, Toshiyuki
- Ferrera, Annabelle
- Pelayo, Adela
- Oliva, Esther
- Meijer, Chris JLM
- Wright, Thomas C
- Llave, Cecilia Ladines
- Andújar, Miguel
- Castellsagué, Xavier
- Sánchez, Gloria I
- Nowakowski, Andrzej Marcin
- Bornstein, Jacob
- Bosch, F Xavier
- Venue
- The Lancet Oncology
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 11
- Issue
- 11
- Pages
- 1048-1056
- ISSN
- 1470-2045 (ISSN-L)
- OpenAlex
- W2139736159
- Cited by
- 2,728
- References
- 0
- Citations by year
- 2026: 129 · 2025: 162 · 2024: 209 · 2023: 183 · 2022: 213 · 2021: 199 · 2020: 182 · 2019: 176 · 2018: 170 · 2017: 179 · 2016: 160 · 2015: 201 · 2014: 172 · 2013: 163 · 2012: 137
- FWCI
- 91.00
- Type
- journal article
- Language
- en
- Update notices
- erratum (2015-10-01)
- Open access
- closed
- Locations
- The Lancet Oncology (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Acceda (Universidad de Las Palmas de Gran Canaria) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Institutional Repository of the Ruđer Bošković Institute (Ruđer Bošković Institute) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- GlaxoSmithKline
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- human papillomavirus, HPV genotypes, invasive cervical cancer, HPV genotype distribution, HPV16, HPV 18, HPV45, cervical adenocarcinoma, multiple HPV infection, cervical cancer prevention, age at diagnosis
- MeSH terms
- Adenocarcinoma, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms, Cross-Sectional Studies, DNA, Viral, Female, Genetic Testing, Genotype, Humans, International Cooperation, Mass Screening, Middle Aged, Neoplasm Invasiveness, Retrospective Studies, Linear Models, Logistic Models, Polymerase Chain Reaction, Paraffin Embedding, Carcinoma, Adenosquamous, Papillomaviridae, Papillomavirus Infections, Papillomavirus Vaccines, Young Adult
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