The DOI matches its Crossref record; 34 of the 37 references it cites were found in a registry or an index.
Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study
Open accessAbstract
Background Metastatic DNA mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) colorectal cancer has a poor prognosis after treatment with conventional chemotherapy and exhibits high levels of tumour neoantigens, tumour-infiltrating lymphocytes, and checkpoint regulators. All of these features are associated with the response to PD-1 blockade in other tumour types. Therefore, we aimed to study nivolumab, a PD-1 immune checkpoint inhibitor, in patients with dMMR/MSI-H metastatic colorectal cancer.Methods In this ongoing, multicentre, open-label, phase 2 trial, we enrolled adults (aged ≥18 years) with histologically confirmed recurrent or metastatic colorectal cancer locally assessed as dMMR/MSI-H from 31 sites (academic centres and hospitals) in eight countries (Australia, Belgium, Canada, France, Ireland, Italy, Spain, and the USA). Eligible patients had progressed on or after, or been intolerant of, at least one previous line of treatment, including a fluoropyrimidine and oxaliplatin or irinotecan. Patients were given 3 mg/kg nivolumab every 2 weeks until disease progression, death, unacceptable toxic effects, or withdrawal from study. The primary endpoint was investigator-assessed objective response as per Response Evaluation Criteria in Solid Tumors (version 1.1). All patients who received at least one dose of study drug were included in all analyses. This trial is registered with ClinicalTrials.gov, number NCT02060188.Findings Of the 74 patients who were enrolled between March 12, 2014, and March 16, 2016, 40 (54%) had received three or more previous treatments. At a median follow-up of 12·0 months (IQR 8·6-18·0), 23 (31·1%, 95% CI 20·8-42·9) of 74 patients achieved an investigator-assessed objective response and 51 (69%, 57-79) patients had disease control for 12 weeks or longer. Median duration of response was not yet reached; all responders were alive, and eight had responses lasting 12 months or longer (Kaplan-Meier 12-month estimate 86%, 95% CI 62-95). The most common grade 3 or 4 drug-related adverse events were increased concentrations of lipase (six [8%]) and amylase (two [3%]). 23 (31%) patients died during the study; none of these deaths were deemed to be treatment related by the investigator.Interpretation Nivolumab provided durable responses and disease control in pre-treated patients with dMMR/MSI-H metastatic colorectal cancer, and could be a new treatment option for these patients.Funding Bristol-Myers Squibb.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“Response rates range from 15 to 30% (in most solid tumors) to 45–60% (in melanoma and MSI-H tumors).”
From Immune-related adverse events and anti-tumor efficacy of immune checkpoint inhibitors (2019) · cites this paper as [8]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredIn the citing paper
“Initial results demonstrated a 31% objective response rate and 69% demonstrated at least 12 weeks of stable disease [78].”
From Update on Targeted Therapy and Immunotherapy for Metastatic Colorectal Cancer (2024) · cites this paper as [78]
In the citing paper
“The Checkmate-142 phase II study demonstrated the effectiveness of nivolumab in previously treated MSI-H mCRC patients [84].”
From RAS Mutations in Advanced Colorectal Cancer: Mechanisms, Clinical Implications, and Novel Therapeutic Approaches (2025) · cites this paper as [84]
In the citing paper
“Upon examining the subgroup analysis of this study, it was observed that patients without RAS or BRAF mutations achieved a 41% objective response rate with nivolumab. In comparison, the rate was 27% in RAS mutant patients.”
From RAS Mutations in Advanced Colorectal Cancer: Mechanisms, Clinical Implications, and Novel Therapeutic Approaches (2025) · cites this paper as [84]
In the citing paper
“Additionally, the efficacy of ICIs in phase II studies with dMMR/MSI and BRAFV600E tumors versus dMMR/MSI and BRAF wild type was similar [53,54,55,56].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [54]
In the citing paper
“Recently, a combination of nivolumab and ipilimumab, a CTLA-4 inhibitor, gained approval from the FDA for the treatment of previously treated MSI-H/dMMR mCRC [54,131].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [54]
In the citing paper
“Nivolumab, an anti-PD1 monoclonal antibody (moAb), has been utilized since 1 August 2017, for MSI-H/dMMR mCRC, as evidenced by the CheckMate 142 study [54].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [54]
In the citing paper
“The CHECKMATE 142 study reported that Nivolumab could provide a durable response in patients with dMMR/MSI-H metastatic colorectal cancer, proposing Nivolumab as a new treatment option in these patients [117].”
From Immune Checkpoint Inhibitors in Cancer Therapy (2022) · cites this paper as [117]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)
Eisenhauer, E. A., Therasse, P., Bogaerts, J., Schwartz, L. H., Sargent, D., Ford, R., Dancey, J., Arbuck, S., Gwyther, S., Mooney, M., et al. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2008.10.026 · Cited by 29,534
Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., Filiberti, A., Flechtner, H., Fleishman, S. B., Haes, J. C. J. M. D., et al. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.5.365 · Cited by 16,005
EuroQol: a new facility for the measurement of health-related quality of life
(1990) · Health Policy · doi:10.1016/0168-8510(90)90421-9 · Cited by 15,736
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
Le, D. T., Uram, J. N., Wang, H., Bartlett, B. R., Kemberling, H., Eyring, A. D., Skora, A. D., Luber, B. S., Azad, N. S., Laheru, D., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500596 · Cited by 9,377
Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck
Ferris, R. L., Blumenschein, G., Fayette, J., Guigay, J., Colevas, A. D., Licitra, L., Harrington, K., Kasper, S., Vokes, E. E., Even, C., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1602252 · Cited by 5,101
Interpreting the significance of changes in health-related quality-of-life scores.
Osoba, D., Rodrigues, G., Myles, J., Zee, B. C.-Y., & Pater, J. L. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.1.139 · Cited by 3,016
Brahmer, J. R., Drake, C. G., WOLLNER, I. S., Powderly, J. D., Picus, J., Sharfman, W. H., Stankevich, E., Pons, A., Salay, T. M., McMiller, T. L., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.26.7609 · Cited by 2,967
Grothey, A., Cutsem, E. V., Sobrero, A., Siena, S., Falcone, A., Ychou, M., Humblet, Y., Bouché, O., Mineur, L., Barone, C., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(12)61900-x · Cited by 2,895
Self-citationDe Roock, W., Claes, B., Bernasconi, D., De Schutter, J., Biesmans, B., Fountzilas, G., Kalogeras, K. T., Kotoula, V., Papamichael, D., Laurent-Puig, P., et al. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70130-3 · Cited by 2,144
Wild-Type BRAF Is Required for Response to Panitumumab or Cetuximab in Metastatic Colorectal Cancer
Di Nicolantonio, F., Martini, M., Molinari, F., Sartore-Bianchi, A., Arena, S., Saletti, P., De Dosso, S., Mazzucchelli, L., Frattini, M., Siena, S., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.0786 · Cited by 1,591
Cited by
Sorted by citations
Items 301–400 of 1,005
Molecular targeted therapy of BRAF -mutant colorectal cancer
Ducreux, M. P., Chamseddine, A. N., Laurent‐Puig, P., Smolenschi, C., Hollebecque, A., Dartigues, P., Samalin, E., Boige, V., Malka, D., & Gelli, M. (2019) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835919856494 · Cited by 105
Newly Emerging Immune Checkpoints: Promises for Future Cancer Therapy
Torphy, R. J., Schulick, R. D., & Zhu, Y. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122642 · Cited by 98
Wang, C.-K., Chevalier, D., Saluja, J., Sandhu, J., Lau, C., & Fakih, M. (2020) · The Oncologist · doi:10.1634/theoncologist.2020-0161 · Cited by 84
Adam, J., Louvet, E., Sourisseau, T., Dorvault, N., Bernard, M., Maingot, E., Faivre, L., Kuo, M.-S., Boissier, É., Dessoliers, M.-C., et al. (2018) · ESMO Open · doi:10.1136/esmoopen-2017-000257 · Cited by 96
RNA N6-methyladenosine demethylase FTO regulates PD-L1 expression in colon cancer cells
Tsuruta, N., Tsuchihashi, K., Ohmura, H., Yamaguchi, T., Ito, M., Ariyama, H., Kusaba, H., Akashi, K., & Baba, E. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.06.153 · Cited by 96
The Role of the Tumor Microenvironment and Treatment Strategies in Colorectal Cancer
Chen, Y., Zheng, X., & Wu, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.792691 · Cited by 104
Cheung, Y.-M. M., Wang, W., McGregor, B. A., & Hamnvik, O. R. (2022) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-021-03128-7 · Cited by 101
The Cancer Immunotherapy Biomarker Testing Landscape
Walk, E. E., Yohe, S. L., Beckman, A., Schade, A. E., Zutter, M. M., Pfeifer, J. D., & Berry, A. B. (2019) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2018-0584-cp · Cited by 95
Revilla, S. A., Kranenburg, O., & Coffer, P. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.903564 · Cited by 104
Interfaces between cellular responses to DNA damage and cancer immunotherapyPreprint
Pilger, D., Seymour, L. W., & Jackson, S. P. (2021) · Genes & Development · doi:10.1101/gad.348314.121 · Cited by 96
DNA repair defects and implications for immunotherapy
Bever, K. M., & Le, D. T. (2018) · Journal of Clinical Investigation · doi:10.1172/jci122010 · Cited by 96
Mutational and Antigenic Landscape in Tumor Progression and Cancer Immunotherapy
Vitale, I., Sistigu, A., Manic, G., Rudqvist, N.-P., Trajanoski, Z., & Galluzzi, L. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.01.003 · Cited by 95
Intrinsic β-catenin signaling suppresses CD8+ T-cell infiltration in colorectal cancer
Xue, J., Yu, X., Xue, L., Ge, X., Zhao, W., & Peng, W. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108921 · Cited by 96
Progress and Challenges of Predictive Biomarkers for Immune Checkpoint Blockade
Lei, Y., Li, X., Huang, Q., Zheng, X., & Liu, M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.617335 · Cited by 94
Kawazoe, A., Kuboki, Y., Shinozaki, E., Hara, H., Nishina, T., Komatsu, Y., Yuki, S., Wakabayashi, M., Nomura, S., Sato, A., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-1803 · Cited by 93
Immune Checkpoint Inhibitors in Colorectal Cancer: Challenges and Future Prospects
Makaremi, S., Asadzadeh, Z., Hemmat, N., Baghbanzadeh, A., Sgambato, A., Ghorbaninezhad, F., Safarpour, H., Argentiero, A., Brunetti, O., Bernardini, R., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9091075 · Cited by 99
The Role of Immune Checkpoint Inhibitors in Cancer Therapy
Basudan, A. (2022) · Clinics and Practice · doi:10.3390/clinpract13010003 · Cited by 99
HER2: An emerging target in colorectal cancer
Greally, M., Kelly, C. M., & Cercek, A. (2018) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2018.07.001 · Cited by 94
Kather, J. N., & Halama, N. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0441-6 · Cited by 95
Zou, Y., Hu, X., Zheng, S., Yang, A., Li, X., Tang, H., Kong, Y., & Xie, X. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.103137 · Cited by 94
Svrcek, M., Lascols, O., Cohen, R., Collura, A., Jonchère, V., Fléjou, J.-F., Buhard, O., & Duval, A. (2019) · Bulletin du Cancer · doi:10.1016/j.bulcan.2018.12.008 · Cited by 90
Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop
Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Groups, Bedognetti, D., Ceccarelli, M., Galluzzi, L., Lu, R. O., Palucka, K., Samayoa, J. A., Spranger, S., Warren, S. E., Wong, K., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0602-4 · Cited by 90
Intrinsic Resistance to Immune Checkpoint Blockade in a Mismatch Repair–Deficient Colorectal Cancer
Gurjao, C., Liu, D., Hofree, M., AlDubayan, S. H., Wakiro, I., Su, M.-J., Felt, K. D., Gjini, E., Brais, L. K., Rotem, A., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0683 · Cited by 92
Cohen, R., Buhard, O., Cervera, P., Hain, É., Dumont, S., Bardier–Dupas, A., Bachet, J., Gornet, J., López‐Trabada, D., Dumont, S., et al. (2017) · European Journal of Cancer · doi:10.1016/j.ejca.2017.09.022 · Cited by 90
Self-citationCombination regimens with PD-1/PD-L1 immune checkpoint inhibitors for gastrointestinal malignancies
Wang, D., Lin, J., Yang, X., Long, J., Bai, Y., Yang, X., Mao, Y., Sang, X., Seery, S., & Zhao, H. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0730-9 · Cited by 89
Lawler, M., Alsina, D., Adams, R., Anderson, A. S., Brown, G. M., Fearnhead, N. S., Fenwick, S. W., Halloran, S. P., Hochhauser, D., Hull, M. A., et al. (2017) · Gut · doi:10.1136/gutjnl-2017-315333 · Cited by 91
Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome
Chang, K., Taggart, M. W., Reyes-Uribe, L., Borràs, E., Riquelme, E. M., Barnett, R. M., Leoni, G., Lucas, F. A. S., Catanese, M. T., Mori, F., et al. (2018) · JAMA Oncology · doi:10.1001/jamaoncol.2018.1482 · Cited by 90
Self-citationCD73's Potential as an Immunotherapy Target in Gastrointestinal Cancers
Harvey, J. B., Phan, L. H., Villarreal, O. E., & Bowser, J. L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00508 · Cited by 88
How we treat metastatic colorectal cancer
Falco, V. D., Napolitano, S., Roselló, S., Huerta, M., Cervantes, A. M. R., Ciardiello, F., & Troiani, T. (2019) · ESMO Open · doi:10.1136/esmoopen-2020-000813 · Cited by 94
Hildebrand, L. A., Pierce, C., Dennis, M. J., Paracha, M., & Maoz, A. (2021) · Cancers · doi:10.3390/cancers13030391 · Cited by 91
Systematic Review of PD-1/PD-L1 Inhibitors in Oncology: From Personalized Medicine to Public Health
Chang, E., Pelosof, L. C., Lemery, S. J., Gong, Y. U. T., Goldberg, K. B., Farrell, A. T., Keegan, P., Veeraraghavan, J., Wei, G., Blumenthal, G. M., et al. (2021) · The Oncologist · doi:10.1002/onco.13887 · Cited by 94
Kim, R. D., Kovari, B. P., Martinez, M., Xie, H., Şahin, İ. H., Mehta, R. J., Strosberg, J., Imanirad, I., Ghayouri, M., Kim, Y., et al. (2022) · European Journal of Cancer · doi:10.1016/j.ejca.2022.03.026 · Cited by 90
Berntsson, J., Eberhard, J., Nodin, B., Leandersson, K., Larsson, A. H., & Jirström, K. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1465165 · Cited by 62
Zaidi, S. H. E., Harrison, T. A., Phipps, A. I., Steinfelder, R. S., Trinh, Q. M., Qu, C., Banbury, B. L., Georgeson, P., Grasso, C. S., Giannakis, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17386-z · Cited by 91
Yoon, H. H., Shi, Q., Heying, E. N., Murányi, A., Bredno, J., Ough, F., Djalilvand, A., Clements, J., Bowermaster, R., Liu, W.-W., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1984 · Cited by 89
ALKBH5 Holds Prognostic Values and Inhibits the Metastasis of Colon Cancer
Yang, P., Wang, Q., Liu, A., Zhu, J., & Feng, J. (2019) · Pathology & Oncology Research · doi:10.1007/s12253-019-00737-7 · Cited by 86
Perillo, F., Amoroso, C., Strati, F., Giuffrè, M. R., Díaz‐Basabe, A., Lattanzi, G., & Facciotti, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155389 · Cited by 88
Li, Y., Ma, Y., Wu, Z., Zeng, F., Song, B., Zhang, Y., Li, J., Lui, S., & Wu, M. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.751407 · Cited by 88
Guo, L., Wang, Y., Yang, W., Wang, C., Guo, T., Yang, J., Shao, Z., Cai, G., Cai, S., Zhang, L., et al. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.04.029 · Cited by 85
The role of DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy
Shi, C., Qin, K., Lin, A., Jiang, A., Cheng, Q., Liu, Z., Zhang, J., & Luo, P. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02469-0 · Cited by 85
Impact of hypoxia on DNA repair and genome integrity
Kaplan, A. R., & Glazer, P. M. (2019) · Mutagenesis · doi:10.1093/mutage/gez019 · Cited by 92
Heme oxygenase-1 orchestrates the immunosuppressive program of tumor-associated macrophages
Alaluf, E., Vokaer, B., Detavernier, A., Azouz, A., Splittgerber, M., Carrette, A., Boon, L., Libert, F., Soares, M. P., Moine, A. L., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.133929 · Cited by 86
Zhu, J., Ji, L., Chen, Y., Li, H., Huang, M., Dai, Z., Wang, J., Xiang, D., Fu, G., Lei, Z., et al. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01354-9 · Cited by 92
Yoshino, T., Cervantes, A. M. R., Bando, H., Martinelli, E., Oki, E., Xu, R., Mulansari, N. A., Babu, K. G., Lee, M. A., Tan, C., et al. (2023) · ESMO Open · doi:10.1016/j.esmoop.2023.101558 · Cited by 91
Zhou, Y., Zhang, Y., Jin, S., Lv, J., Li, M., & Feng, N. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117031 · Cited by 94
Epidemiology, pathogenesis, biology and evolving management of MSI-H/dMMR cancers
Ambrosini, M., Manca, P., Nasca, V., Sciortino, C., Ghelardi, F., Seligmann, J. F., Taı̈eb, J., & Pietrantonio, F. (2025) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-025-01015-z · Cited by 94
Immune overdrive signature in colorectal tumor subset predicts poor clinical outcome
Fakih, M., Ouyang, C., Wang, C., Tu, T. Y., Gozo, M. C., Cho, M., Sy, M., Longmate, J. A., & Lee, P. P. (2019) · Journal of Clinical Investigation · doi:10.1172/jci127046 · Cited by 84
Stromal PD-1/PD-L1 Expression Predicts Outcome in Colon Cancer Patients
Wyss, J., Dislich, B., Koelzer, V. H., Galván, J. A., Dawson, H., Hädrich, M., Inderbitzin, D., Lugli, A., Zlobec, I., & Berger, M. D. (2018) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2018.09.007 · Cited by 82
Histology-agnostic drug development — considering issues beyond the tissue
Pestana, R. C., Sen, S., Hobbs, B. P., & Hong, D. S. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0384-0 · Cited by 82
Guo, L., Wei, R., Lin, Y., & Kwok, H. F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01508 · Cited by 85
Genetic Predisposition to Colorectal Cancer: How Many and Which Genes to Test?
Rebuzzi, F., Ulivi, P., & Tedaldi, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032137 · Cited by 84
Liu, C., Xie, J., Lin, B., Tian, W., Wu, Y., Shan, X., Hong, L., Li, X., Liu, L., Jin, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202401061 · Cited by 90
Wind, T. T., Gacesa, R., Vich Vila, A., de Haan, J. J., Jalving, M., Weersma, R. K., & Hospers, G. A. P. (2020) · Melanoma Research · doi:10.1097/cmr.0000000000000656 · Cited by 73
Metastatic Extramammary Paget’s Disease: Pathogenesis and Novel Therapeutic Approach
Fukuda, K., & Funakoshi, T. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00038 · Cited by 87
Third- or Later-line Therapy for Metastatic Colorectal Cancer: Reviewing Best Practice
Bekaii‐Saab, T., Kim, R. D., Kim, T. W., O’Connor, J. M., Strickler, J. H., Malka, D., Bianchi, A. S., Bi, F., Yamaguchi, K., Yoshino, T., et al. (2018) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2018.11.002 · Cited by 83
Immune-related adverse events: promising predictors for efficacy of immune checkpoint inhibitors
Zhong, L., Wu, Q., Chen, F., Liu, J., & Xie, X. (2021) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02803-5 · Cited by 87
The Tumor Microenvironment Factors That Promote Resistance to Immune Checkpoint Blockade Therapy
Russell, B. L., Sooklal, S. A., Malindisa, S. T., Daka, L. J., & Ntwasa, M. M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.641428 · Cited by 86
Immunotherapy and immunoevasion of colorectal cancer
Zein, M. A., Boukhdoud, M., Shammaa, H., Mouslem, H., Ayoubi, L. M. E., Iratni, R., Issa, K., Khachab, M. Y., Assi, H. I., Sahebkar, A., et al. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103669 · Cited by 88
Song, P., Zhang, D., Cui, X., & Zhang, L. (2020) · Thoracic Cancer · doi:10.1111/1759-7714.13541 · Cited by 84
Cohen, R., Bennouna, J., Meurisse, A., Tournigand, C., de la Fouchardière, C., Tougeron, D., Borg, C., Mazard, T., Chibaudel, B., Garcia‐Larnicol, M., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001499 · Cited by 82
Self-citationWu, W., Liu, Y., Zeng, S., Han, Y., & Shen, H. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01166-3 · Cited by 83
Ni, J., Zhang, Z., Ge, M.-J., Chen, J., & Zhuo, W. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00953-z · Cited by 85
Tarhini, A. A., & Kudchadkar, R. R. (2018) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2018.09.005 · Cited by 84
Systemic treatment for metastatic colorectal cancer in the era of precision medicine
Sandhu, J. S., Lavingia, V. K., & Fakih, M. (2019) · Journal of Surgical Oncology · doi:10.1002/jso.25421 · Cited by 80
Wu, X., Qu, D., Weygant, N., Peng, J., & Houchen, C. W. (2020) · Cancers · doi:10.3390/cancers12020274 · Cited by 80
Ludford, K. T., Cohen, R., Svrcek, M., Foo, W. C., Colle, R., Parc, Y. R., Thomas, J. V., Morris, V. K., Kopetz, S., Chang, G. J., et al. (2020) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djaa052 · Cited by 82
Self-citationAntoniotti, C., Borelli, B., Rossini, D., Pietrantonio, F., Morano, F., Salvatore, L., Lonardi, S., Marmorino, F., Tamberi, S., Corallo, S., et al. (2020) · BMC Cancer · doi:10.1186/s12885-020-07169-6 · Cited by 82
Self-citationBellone, S., Roque, D. M., Siegel, E. R., Buza, N., Hui, P., Bonazzoli, E., Guglielmi, A., Zammataro, L. A., Nagarkatti, N., Zaidi, S., et al. (2021) · Cancer · doi:10.1002/cncr.34025 · Cited by 80
Emerging predictors of the response to the blockade of immune checkpoints in cancer therapy
Li, X., Song, W., Shao, C., Shi, Y., & Han, W. (2018) · Cellular and Molecular Immunology · doi:10.1038/s41423-018-0086-z · Cited by 79
Current Status and Future Perspective of Immunotherapy in Gastrointestinal Cancers
Lü, Z., Peng, Z., Liu, C. X., Wang, Z., Wang, Y., Jiao, X., Li, J., & Shen, L. (2020) · The Innovation · doi:10.1016/j.xinn.2020.100041 · Cited by 81
The clinical utility of microsatellite instability in colorectal cancer
Diao, Z., Han, Y., Chen, Y., Zhang, R., & Li, J. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.103171 · Cited by 78
Immune landscape and prognostic immune-related genes in KRAS-mutant colorectal cancer patients
Liu, J., Huang, X., Liu, H., Wei, C., Ru, H., Qin, H., Lai, H., Meng, Y., Wu, G., Xie, W., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-020-02638-9 · Cited by 79
Li, X., Zhou, Q., Japir, A. A.-W. M. M., Dutta, D., Lu, N., & Ge, Z. (2022) · ACS Nano · doi:10.1021/acsnano.2c06026 · Cited by 79
Anti-PD-1/PD-L1 therapy for colorectal cancer: Clinical implications and future considerations
Chen, X., Chen, L., Peng, X., Deng, L., Wang, Y., Li, J.-J., Guo, D., & Niu, X. (2023) · Translational Oncology · doi:10.1016/j.tranon.2023.101851 · Cited by 80
PD-1/PD-L1 pathway blockade works as an effective and practical therapy for cancer immunotherapy
Long, J., Zhang, Q., & Rongxin, Z. (2018) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2017.0086 · Cited by 82
Immunotherapy in gastrointestinal cancer: The current scenario and future perspectives
Abdul-Latif, M., Townsend, K., Dearman, C., Shiu, K., & Khan, K. H. (2020) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2020.102030 · Cited by 81
The Mechanism of Stimulating and Mobilizing the Immune System Enhancing the Anti-Tumor Immunity
Wu, Z., Li, S., & Zhu, X. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.682435 · Cited by 82
Biomarkers of response to immune checkpoint blockade in cancer treatment
Fujii, T., Naing, A., Rolfo, C. D., & Hajjar, J. (2018) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2018.07.010 · Cited by 77
Yamamoto, H., & Imai, K. (2019) · Seminars in Oncology · doi:10.1053/j.seminoncol.2019.08.003 · Cited by 75
Xiao, J., Li, W., Huang, Y. Y., Huang, M., Li, S., Zhai, X., Zhao, J., Gao, C., Xie, W., Qin, H., et al. (2021) · BMC Cancer · doi:10.1186/s12885-021-07942-1 · Cited by 139
Jagieła, J., Bartnicki, P., & Rysz, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094618 · Cited by 76
Sullivan, R. J., Atkins, M. B., Kirkwood, J. M., Agarwala, S. S., Clark, J. I., Ernstoff, M. S., Fecher, L. A., Gajewski, T. F., Gastman, B., Lawson, D. H., et al. (2018) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-018-0362-6 · Cited by 80
Petrelli, F., Ghidini, M., Cabiddu, M., Pezzica, E., Corti, D. D., Turati, L., Costanzo, A., VARRICCHIO, A., Ghidini, A., Barni, S., et al. (2019) · Anticancer Research · doi:10.21873/anticanres.13857 · Cited by 77
PD-L1 expression in colorectal cancer defines three subsets of tumor immune microenvironments
Valentini, A. M., Pinto, F. D., Cariola, F., Guerra, V., Giannelli, G., Caruso, M. L., & Pirrelli, M. (2018) · Oncotarget · doi:10.18632/oncotarget.24196 · Cited by 78
Kim, J. E., Chun, S., Hong, Y. S., Kim, K., Kim, S. Y., Kim, J., Sung, C. O., Cho, E. J., Kim, T. W., & Jang, S. J. (2018) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2018.09.005 · Cited by 76
Rivero, J. D., Cordes, L. M., Kłubo-Gwieździńska, J., Madan, R. A., Nieman, L. K., & Gulley, J. L. (2019) · The Oncologist · doi:10.1634/theoncologist.2018-0470 · Cited by 79
High-Accuracy Determination of Microsatellite Instability Compatible with Liquid Biopsies
Silveira, A. B., Bidard, F., Kasperek, A., Melaabi, S., Tanguy, M., Rodrigues, M. J., Bataillon, G., Cabel, L., Buecher, B., Pierga, J., et al. (2020) · Clinical Chemistry · doi:10.1093/clinchem/hvaa013 · Cited by 76
BRAF Mutated Colorectal Cancer: New Treatment Approaches
Molina‐Cerrillo, J., Román, M. S., Pozas, J., Alonso‐Gordoa, T., Pozas, M., Conde, E., Cancio-Suárez, M. R., Grande, E., García‐Bermejo, L., & Carrato, A. (2020) · Cancers · doi:10.3390/cancers12061571 · Cited by 78
Lenz, H., Parikh, A. R., Spigel, D. R., Cohn, A. L., Yoshino, T., Kochenderfer, M. D., Élez, E., Shao, S. H., Deming, D. A., Holdridge, R. C., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-008409 · Cited by 83
Self-citationImmune checkpoint inhibitors in colorectal cancer: limitation and challenges
Yan, S., Wang, W., Feng, Z., Xue, J., Liang, W., Wu, X., Tan, Z., Zhang, X., Zhang, S., Li, X., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1403533 · Cited by 83
Immune-checkpoint inhibitors for combating T-cell dysfunction in cancer
Grywalska, E., Pasiarski, M., Góźdź, S. S., & Roliński, J. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s150817 · Cited by 82
Shimozaki, K., Sukawa, Y., Beppu, N., Kurihara, I., Suzuki, S., Mizuno, R., Funakoshi, T., Ikemura, S., Tsugaru, K., Togasaki, K., et al. (2020) · Cancer Management and Research · doi:10.2147/cmar.s247554 · Cited by 77
SHP2 deneddylation mediates tumor immunosuppression in colon cancer via the CD47/SIRPα axis
Li, Y., Zhou, H., Liu, P., Lv, D., Shi, Y., Tang, B., Xu, J., Zhong, T., Xu, W., Zhang, J., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci162870 · Cited by 79
Ciombor, K. K., & Bekaii‐Saab, T. (2017) · The Oncologist · doi:10.1634/theoncologist.2017-0203 · Cited by 74
Nivolumab for the treatment of colorectal cancer
Smith, K. M., & Desai, J. (2018) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2018.1480942 · Cited by 73
Self-citationMolecular Subtypes and the Evolution of Treatment Decisions in Metastatic Colorectal Cancer
Dienstmann, R., Salazar, R., & Tabernero, J. M. (2018) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_200929 · Cited by 78
Exploring the best treatment options for BRAF-mutant metastatic colon cancer
Taı̈eb, J., Lapeyre-Prost, A., Laurent‐Puig, P., & Zaanan, A. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0526-2 · Cited by 76
Lu, L., Dong, J., Liu, Y., Qian, Y., Zhang, G., Zhou, W., Zhao, A., Ji, G., & Xu, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.964793 · Cited by 73
The Evolutionary Landscape of Treatment for BRAFV600E Mutant Metastatic Colorectal Cancer
Mauri, G., Bonazzina, E., Amatu, A., Tosi, F., Bencardino, K., Gori, V., Massihnia, D., Cipani, T., Spina, F., Ghezzi, S., et al. (2021) · Cancers · doi:10.3390/cancers13010137 · Cited by 73
Silva, M. C., Fernandes, Â., Oliveira, M. J., Resende, C., Correia, A., de‐Freitas‐Junior, J. C. M., Lavelle, A., Andrade-da-Costa, J., Leander, M., Xavier‐Ferreira, H., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-0264 · Cited by 84
Metadata
- Authors
- Overman, M. J., McDermott, R., Leach, J. L., Lonardi, S., Lenz, H.-J., Morse, M. A., Desai, J., Hill, A., Axelson, M., Moss, R. A., Goldberg, M. V., Cao, Z. A., Ledeine, J.-M., Maglinte, G. A., Kopetz, S., & André, T.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Cancer Trials Ireland (IE)
- Allina Health (US)
- Istituto Oncologico Veneto (IT)
- USC Norris Comprehensive Cancer Center (US)
- Duke Medical Center (US)
- The Royal Melbourne Hospital (AU)
- Bristol-Myers Squibb (United States) (US)
- Bristol-Myers Squibb (Belgium) (BE)
- Sorbonne Université (FR)
- Corresponding author
- Overman, Michael J
- ORCID
- Venue
- The Lancet Oncology
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 18
- Issue
- 9
- Pages
- 1182-1191
- ISSN
- 1470-2045 (ISSN-L)
- PMC
- PMC6207072
- OpenAlex
- W2739132742
- Cited by
- 2,836
- References
- 37
- Citations by year
- 2026: 185 · 2025: 242 · 2024: 302 · 2023: 382 · 2022: 377 · 2021: 438 · 2020: 361 · 2019: 288 · 2018: 223 · 2017: 31
- FWCI
- 108.88
- Type
- journal article
- Language
- en
- Update notices
- erratum (2017-09-01)
- Open access
- green
- europepmc.org
- Locations
- The Lancet Oncology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Health Research Board (ICORG-2016-1)
- National Institutes of Health (UL1TR000371)
- National Cancer Institute (P30CA016672)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Keywords
- nivolumab, metastatic colorectal cancer, mismatch repair deficiency, microsatellite instability-high, PD-1 inhibitors, immune checkpoint blockade, objective response rate, disease control rate, progression-free survival, overall survival, treatment toxicity, first-line therapy, second-line therapy, third-line therapy, neoantigens, tumor-infiltrating lymphocytes
- MeSH terms
- Nivolumab, Adult, Antibodies, Monoclonal, Antineoplastic Agents, Carcinoma, Female, Humans, Male, Middle Aged, Colorectal Neoplasms, Treatment Outcome, Disease-Free Survival, Microsatellite Instability, DNA Mismatch Repair, Programmed Cell Death 1 Receptor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
