The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Latest developments in molecular tracers for fluorescence image-guided cancer surgery
Abstract
Real-time intraoperative guidance is essential during oncological surgery for complete and safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown potential for guiding surgeons during complex interventions. Recently, there has been a shift towards the use of fluorescence contrast agents for molecular imaging. The first targeted fluorescent agents, of which most consist of approved therapeutic antibodies conjugated to a fluorescent dye, have been evaluated in several early-phase clinical trials. Moreover, advances in protein engineering and drug design have led to the development of a variety of tracers suitable for molecular fluorescence image-guided surgery. In this Review, we discuss preclinical and clinical evidence, ongoing clinical trials, and the latest developments in the field of molecular near-infrared tracers for fluorescence-guided cancer surgery.
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Stummer, W., Pichlmeier, U., Meinel, T., Wiestler, O. D., Zanella, F., & Reulen, H.-J. (2006) · The Lancet Oncology · doi:10.1016/s1470-2045(06)70665-9 · Cited by 3,423
A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer
Whitley, M. J., Cardona, D. M., Lazarides, A. L., Spasojevic, I., Ferrer, J. M., Cahill, J., Lee, C.-L., Snuderl, M., Blazer, D. G., Hwang, E. S., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad0293 · Cited by 296
Cited by
Zeng, S., Liu, X., Kafuti, Y. S., Kim, H., Wang, J., Peng, X., Li, H., & Yoon, J. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00799a · Cited by 341
NIR-II light in clinical oncology: opportunities and challenges
Zhang, Z., Du, Y., Shi, X., Wang, K., Qu, Q., Liang, Q., Ma, X., He, K., Chi, C., Tang, J., et al. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00892-0 · Cited by 341
Li, D., Schreiber, C. L., & Smith, B. D. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202004449 · Cited by 163
de Maar, J. S., Sofias, A. M., Porta Siegel, T., Vreeken, R. J., Moonen, C., Bos, C., & Deckers, R. (2020) · Theranostics · doi:10.7150/thno.38625 · Cited by 71
Qi, B., Crawford, A. J., Wojtynek, N. E., Talmon, G. A., Hollingsworth, M. A., Ly, Q. P., & Mohs, A. M. (2020) · Theranostics · doi:10.7150/thno.40688 · Cited by 18
Metadata
- Authors
- Hernot, S., van Manen, L., Debie, P., Mieog, J. S. D., & Vahrmeijer, A. L.
- Venue
- The Lancet Oncology
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 20
- Issue
- 7
- Pages
- e354-e367
- ISSN
- 1470-2045 (ISSN-L)
- OpenAlex
- W2955213391
- Cited by
- 471
- References
- 2
- FWCI
- 30.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hernot, S., van Manen, L., Debie, P., Mieog, J. S. D., & Vahrmeijer, A. L. (2019). Latest developments in molecular tracers for fluorescence image-guided cancer surgery. The Lancet Oncology. https://doi.org/10.1016/s1470-2045(19)30317-1
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