Tuned near infrared fluorescent hyaluronic acid conjugates for delivery to pancreatic cancer for intraoperative imaging
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: These studies demonstrate that by tuning HA molecular weight and the physicochemical properties of the conjugated moiety, in this case a NIRF probe, peritoneal biodistribution can be substantially altered to achieve optimized delivery to tumors intraoperative abdominal imaging.
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HA-conjugated fluorescent dyes were used to image pancreatic tumors.
“HA-conjugated fluorescent dyes were used to image pancreatic tumors.”
From Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis (2023) · cites this paper as [128]
Molecular weight of HA and properties of conjugated dyes influence imaging outcome.
“The results exhibited that the molecular weight of HA and the properties of conjugated dyes influence the imaging outcome [128].”
From Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis (2023) · cites this paper as [128]
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“The results exhibited that the molecular weight of HA and the properties of conjugated dyes influence the imaging outcome [128].”
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Wu, N., Wu, C., Du, Y., Chan, Z., & Zeng, R. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18060725
Renal-clearable fluorescent probe for early detection of pancreatic cancer in living murine models
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- Authors
- Qi, B., Crawford, A. J., Wojtynek, N. E., Talmon, G. A., Hollingsworth, M. A., Ly, Q. P., & Mohs, A. M.
- Affiliations
- University of Nebraska Medical Center (US)
- Fred and Pamela Buffett Cancer Center (US)
- Corresponding author
- Mohs, Aaron M.
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2020
- Volume
- 10
- Issue
- 8
- Pages
- 3413-3429
- ISSN
- 1838-7640 (ISSN-L)
- PMC
- PMC7069077
- OpenAlex
- W3006238295
- Cited by
- 18
- References
- 78
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 4 · 2021: 3 · 2020: 2
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Theranostics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R00CA153916, P50CA127297, U01CA210240, P30CA036727)
- National Institute of General Medical Sciences (P20GM103480)
- National Institute of Biomedical Imaging and Bioengineering (R01EB019449)
- National Center for Research Resources (S10RR017846, S10RR027940)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Keywords
- hyaluronic acid conjugates, near-infrared fluorescent probe, pancreatic cancer, intraoperative imaging, tumor targeting, abdominal imaging
- MeSH terms
- Adenocarcinoma, Animals, Contrast Media, Female, Fluorescent Dyes, Hyaluronic Acid, Intraoperative Care, Mice, Inbred C57BL, Pancreatic Neoplasms, Serum Albumin, Bovine, Molecular Structure, Drug Delivery Systems
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