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Carcinogenicity of perfluorooctanoic acid and perfluorooctanesulfonic acid
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“Proposed carcinogenic mechanisms include activation of peroxisome proliferator-activated receptor alpha (PPAR-α), which influences lipid metabolism, cell proliferation, and inflammation—pathways that may contribute to tumor development, B genotoxic effects, endocrine disruption, and epigenetic alterations [101].”
From Exposure to Per- and Polyfluoroalkyl Substances (PFASs) in Healthcare: Environmental and Clinical Insights (2025) · cites this paper as [101]
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Citations
Cites
International Agency for Research on Cancer
National Cancer Institute (2020) · Definitions · doi:10.32388/pfg7jq · Cited by 9,394
Serum Vaccine Antibody Concentrations in Children Exposed to Perfluorinated Compounds
Grandjean, P., Andersen, E. W., Budtz-Jørgensen, E., Nielsen, F., Mølbak, K., Weihe, P., & Heilmann, C. (2012) · JAMA · doi:10.1001/jama.2011.2034 · Cited by 809
Serum Concentrations of Per- and Polyfluoroalkyl Substances and Risk of Renal Cell Carcinoma
Shearer, J. J., Callahan, C. L., Calafat, A. M., Huang, W., Jones, R. R., Sabbisetti, V. S., Freedman, N. D., Sampson, J. N., Silverman, D. T., Purdue, M. P., et al. (2020) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djaa143 · Cited by 244
Self-citationButenhoff, J. L., Chang, S., Olsen, G. W., & Thomford, P. J. (2012) · Toxicology · doi:10.1016/j.tox.2012.01.003 · Cited by 149
Wang, J., Zhang, Y., Zhang, W., Jin, Y., & Dai, J. (2012) · Environmental Science & Technology · doi:10.1021/es300906q · Cited by 127
Dalsager, L., Christensen, N., Halekoh, U., Timmermann, C. A. G., Nielsen, F., Kyhl, H. B., Husby, S., Grandjean, P., Jensen, T. K., & Andersen, H. R. (2021) · Environment International · doi:10.1016/j.envint.2021.106395 · Cited by 90
Liu, Y., Eliot, M. N., Papandonatos, G. D., Kelsey, K. T., Fore, R., Langevin, S., Buckley, J., Chen, A., Lanphear, B. P., Cecil, K. M., et al. (2022) · Environmental Health Perspectives · doi:10.1289/ehp10118 · Cited by 78
Purdue, M. P., Rhee, J., Denic‐Roberts, H., McGlynn, K. A., Byrne, C., Sampson, J. N., Botelho, J. C., Calafat, A. M., & Rusiecki, J. A. (2023) · Environmental Health Perspectives · doi:10.1289/ehp12603 · Cited by 78
Xu, Y., Mlakar, S. J., Li, Y., Wahlberg, K. E., Scott, K., Pineda, D., Lindh, C. H., Jakobsson, K., & Engström, K. (2020) · Environment International · doi:10.1016/j.envint.2019.105446 · Cited by 74
Research works printed but not linked: 1
- 2017, Volume 110: Some chemicals used as solvents and in polymer manufacture, IARC Monogr Identif Carcinog Hazards Hum, 110, 37
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Public Health Risks of PFAS-Related Immunotoxicity Are Real
Bline, A. P., DeWitt, J. C., Kwiatkowski, C. F., Pelch, K. E., Reade, A., & Varshavsky, J. (2024) · Current Environmental Health Reports · doi:10.1007/s40572-024-00441-y · Cited by 137
Gaillard, L., Barouki, R., Blanc, É., Coumoul, X., & Andréau, K. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.07.021 · Cited by 140
Per- and polyfluoroalkyl substances (PFAS) exposure in the U.S. population: NHANES 1999–March 2020
Botelho, J. C., Kato, K., Wong, L.-Y., & Calafat, A. M. (2025) · Environmental Research · doi:10.1016/j.envres.2025.120916 · Cited by 134
Zheng, J., Liu, S., Yang, J., Zheng, S., & Sun, B. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.176158 · Cited by 99
Li, S., Oliva, P., Zhang, L., Goodrich, J. A., McConnell, R., Conti, D. V., Chatzi, L., & Aung, M. (2025) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-024-00742-2 · Cited by 101
Metadata
- Authors
- Zahm, S., Bonde, J. P., Chiu, W. A., Hoppin, J., Kanno, J., Abdallah, M., Blystone, C. R., Calkins, M. M., Dong, G.-H., Dorman, D. C., Fry, R., Guo, H., Haug, L. S., Hofmann, J. N., Iwasaki, M., Machala, M., Mancini, F. R., Maria-Engler, S. S., Møller, P., Ng, J. C., Pallardy, M., Post, G. B., Salihovic, S., Schlezinger, J., Soshilov, A., Steenland, K., Steffensen, I.-L., Tryndyak, V., White, A., Woskie, S., Fletcher, T., Ahmadi, A., Ahmadi, N., Benbrahim-Tallaa, L., Bijoux, W., Chittiboyina, S., de Conti, A., Facchin, C., Madia, F., Mattock, H., Merdas, M., Pasqual, E., Suonio, E., Viegas, S., Zupunski, L., Wedekind, R., & Schubauer-Berigan, M. K.
- Affiliations
- Centre international de recherche sur le cancer (FR)
- ORCID
- Zahm, Shelia
- Bonde, Jens Peter
- Chiu, Weihsueh A
- Hoppin, Jane
- Kanno, Jun
- Abdallah, Mohamed
- Calkins, Miriam M
- Dong, Guang-Hui
- Dorman, David C
- Fry, Rebecca
- Guo, Huan
- Haug, Line S
- Hofmann, Jonathan N
- Iwasaki, Motoki
- Machala, Miroslav
- Mancini, Francesca R
- Ng, Jack C
- Pallardy, Marc
- Post, Gloria B
- Schlezinger, Jennifer
- Soshilov, Anatoly
- Steenland, Kyle
- Steffensen, Inger-Lise
- Tryndyak, Volodymyr
- Woskie, Susan
- Fletcher, Tony
- Ahmadi, Ayat
- Bijoux, Wendy
- Facchin, Caterina
- Madia, Federica
- Merdas, Mira
- Pasqual, Elisa
- Wedekind, Roland
- Venue
- The Lancet Oncology
- Publisher
- Elsevier BV
- Published
- 2024-01
- Volume
- 25
- Issue
- 1
- Pages
- 16-17
- ISSN
- 1470-2045 (ISSN-L)
- PMC
- PMC12183505
- OpenAlex
- W4389208799
- Cited by
- 387
- References
- 10
- Citations by year
- 2026: 136 · 2025: 149 · 2024: 100
- FWCI
- 32.23
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- The Lancet Oncology (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (publishedVersion, cc-by-nc-nd)
- PubMed Central (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- World Health Organization
- National Cancer Institute (U01CA033193, R01CA033193)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Physical Sciences › Environmental Science › Water Science and Technology › Fluoride Effects and Removal
- Keywords
- perfluorooctanoic acid, PFOS, carcinogenicity, perfluorinated compounds, isomers, salt, cancer risk assessment
- MeSH terms
- Caprylates, Fluorocarbons, Humans, Alkanesulfonic Acids
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