Gestational Perfluoroalkyl Substance Exposure and DNA Methylation at Birth and 12 Years of Age: A Longitudinal Epigenome-Wide Association Study
Open accessAbstract
Background: DNA methylation alterations may underlie associations between gestational perfluoroalkyl substances (PFAS) exposure and later-life health outcomes. To the best of our knowledge, no longitudinal studies have examined the associations between gestational PFAS and DNA methylation. Objectives: We examined associations of gestational PFAS exposure with longitudinal DNA methylation measures at birth and in adolescence using the Health Outcomes and Measures of the Environment (HOME) Study (2003–2006; Cincinnati, Ohio). Methods: We quantified serum concentrations of perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoate (PFNA), and perfluorohexane sulfonate (PFHxS) in mothers during pregnancy. We measured DNA methylation in cord blood (n=266) and peripheral leukocytes at 12 years of age (n=160) using the Illumina HumanMethylation EPIC BeadChip. We analyzed associations between log2-transformed PFAS concentrations and repeated DNA methylation measures using linear regression with generalized estimating equations. We included interaction terms between children’s age and gestational PFAS. We performed Gene Ontology enrichment analysis to identify molecular pathways. We used Project Viva (1999–2002; Boston, Massachusetts) to replicate significant associations. Results: After adjusting for covariates, 435 cytosine–guanine dinucleotide (CpG) sites were associated with PFAS (false discovery rate, q<0.05). Specifically, we identified 2 CpGs for PFOS, 12 for PFOA, 8 for PFHxS, and 413 for PFNA; none overlapped. Among these, 2 CpGs for PFOA and 4 for PFNA were replicated in Project Viva. Some of the PFAS-associated CpG sites annotated to gene regions related to cancers, cognitive health, cardiovascular disease, and kidney function. We found little evidence that the associations between PFAS and DNA methylation differed by children’s age. Discussion: In these longitudinal data, PFAS biomarkers were associated with differences in several CpGs at birth and at 12 years of age in or near genes linked to some PFAS-associated health outcomes. Future studies should examine whether DNA methylation mediates associations between gestational PFAS exposure and health. https://doi.org/10.1289/EHP10118
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Prenatal PFAS-associated DNA methylation changes identified in the Project Viva cohort-specifically, 435 CpG sites altered in cord blood and persisting into childhood-include loci associated with neural, metabolic, and cognitive health.
“Prenatal PFAS-associated DNA methylation changes identified in the Project Viva cohort—specifically, 435 CpG sites altered in cord blood and persisting into childhood—include loci associated with neural, metabolic, and cognitive health [67].”
From Exposure to Per- and Polyfluoroalkyl Substances (PFASs) in Healthcare: Environmental and Clinical Insights (2025) · cites this paper as [67]
The Results (page not provided) identify 435 PFAS-associated CpG sites in the HOME Study, with associations generally consistent at birth and age 12; only six of those sites were replicated in Project Viva. The Discussion (page not provided) links some identified gene regions to neural development, obesity, and cognitive health. The claim incorrectly places the 435-site finding in Project Viva. (LLM, conf=0.92)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Statistical significance for genomewide studies
Storey, J. D., & Tibshirani, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1530509100 · Cited by 9,692 · see citing works
Adjusting batch effects in microarray expression data using empirical Bayes methods
Johnson, W. E., Li, C., & Rabinovic, A. (2007) · Biostatistics · doi:10.1093/biostatistics/kxj037 · Cited by 8,658 · see citing works
Longitudinal Data Analysis for Discrete and Continuous Outcomes
Zeger, S. L., & Liang, K. (1986) · Biometrics · doi:10.2307/2531248 · Cited by 7,730 · see citing works
Leek, J. T., Johnson, W. E., Parker, H. S., Jaffe, A. E., & Storey, J. D. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts034 · Cited by 6,231 · see citing works
Controlling the false discovery rate in behavior genetics research
Benjamini, Y., Drai, D., Elmer, G., Kafkafi, N., & Golani, I. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00297-2 · Cited by 4,146 · see citing works
An overview of the uses of per- and polyfluoroalkyl substances (PFAS)
Glüge, J., Scheringer, M., Cousins, I. T., DeWitt, J. C., Goldenman, G., Herzke, D., Lohmann, R., Ng, C. A., Trier, X., & Wang, Z. (2020) · Environmental Science: Processes & Impacts · doi:10.1039/d0em00291g · Cited by 2,466 · see citing works
Du, P., Zhang, X., Huang, C.-C., Jafari, N., Kibbe, W. A., Hou, L., & Lin, S. M. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-587 · Cited by 2,136 · see citing works
Teschendorff, A. E., Marabita, F., Lechner, M., Bartlett, T. E., Tegner, J. N., Gómez-Cabrero, D., & Beck, S. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts680 · Cited by 1,652 · see citing works
Pidsley, R., Zotenko, E., Peters, T. J., Lawrence, M. G., Risbridger, G. P., Molloy, P., Van Djik, S., Muhlhausler, B., Stirzaker, C., & Clark, S. J. (2016) · Genome biology · doi:10.1186/s13059-016-1066-1 · Cited by 1,480 · see citing works
Epigenetics and environmental chemicals
Baccarelli, A., & Bollati, V. (2009) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e32832925cc · Cited by 935 · see citing works
Self-citationThe UCSC Genome Browser database: 2019 update
Haeussler, M., Zweig, A. S., Tyner, C., Speir, M. L., Rosenbloom, K. R., Raney, B. J., Lee, C. M., Lee, B. T., Hinrichs, A. S., Gonzalez, J. N., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1095 · Cited by 877 · see citing works
Early Life Exposure to Endocrine Disrupting Chemicals and Childhood Obesity and Neurodevelopment
Braun, J. M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.186 · Cited by 837 · see citing works
Self-citationZhou, W., Laird, P. W., & Shen, H. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw967 · Cited by 742 · see citing works
Intra-individual Change Over Time in DNA Methylation With Familial Clustering
Bjornsson, H. T. (2008) · JAMA · doi:10.1001/jama.299.24.2877 · Cited by 702 · see citing works
A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development
Tang, W. W. C., Dietmann, S., Irie, N., Leitch, H. G., Floros, V. I., Bradshaw, C. R., Hackett, J. A., Chinnery, P. F., & Surani, M. A. (2015) · Cell · doi:10.1016/j.cell.2015.04.053 · Cited by 670 · see citing works
Blake, B. E., & Fenton, S. E. (2020) · Toxicology · doi:10.1016/j.tox.2020.152565 · Cited by 499 · see citing works
Salas, L. A., Koestler, D. C., Butler, R. A., Hansen, H. M., Wiencke, J. K., Kelsey, K. T., & Christensen, B. C. (2018) · Genome biology · doi:10.1186/s13059-018-1448-7 · Cited by 418 · see citing works
Self-citationRappazzo, K., Coffman, E., & Hines, E. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14070691 · Cited by 405 · see citing works
Oken, E., Baccarelli, A., Gold, D. R., KLEINMAN, K. P., Litonjua, A. A., Meo, D. D., Rich-Edwards, J. W., Rifas‐Shiman, S. L., Sagiv, S. K., Taveras, E. M., et al. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu008 · Cited by 373 · see citing works
Self-citationVieira, V. M., Hoffman, K., Shin, H., Weinberg, J., Webster, T. F., & Fletcher, T. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1205829 · Cited by 355 · see citing works
Andrews, D. Q., & Naidenko, O. V. (2020) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.0c00713 · Cited by 270 · see citing works
Hoffman, K., Webster, T. F., Weisskopf, M. G., Weinberg, J., & Vieira, V. M. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.1001898 · Cited by 262 · see citing works
Breton, C. V., Marsit, C. J., Faustman, E. M., Nadeau, K. C., Goodrich, J. M., Dolinoy, D. C., Herbstman, J. B., Holland, N., LaSalle, J. M., Schmidt, R. J., et al. (2017) · Environmental Health Perspectives · doi:10.1289/ehp595 · Cited by 261 · see citing works
The role of the insulin-like growth factor system in prenatal growth
Randhawa, R. S., & Cohen, P. (2005) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2005.07.028 · Cited by 229 · see citing works
Prenatal Perfluoroalkyl Substance Exposure and Child Adiposity at 8 Years of Age: The HOME Study
Braun, J. M., Chen, A.-M., Romano, M., Calafat, A., Webster, G. M., Yolton, K., & Lanphear, B. (2015) · Obesity · doi:10.1002/oby.21258 · Cited by 223 · see citing works
Self-citationBonefeld‐Jørgensen, E. C., Long, M., Bossi, R., Ayotte, P., Asmund, G., Krüger, T., Ghisari, M., Mulvad, G., Kern, P., Nzulumiki, P., et al. (2011) · Environmental Health · doi:10.1186/1476-069x-10-88 · Cited by 216 · see citing works
Abraham, K., Mielke, H., Fromme, H., Völkel, W., Menzel, J., Peiser, M., Zepp, F., Willich, S. N., & Weikert, C. (2020) · Archives of Toxicology · doi:10.1007/s00204-020-02715-4 · Cited by 209 · see citing works
Review of processing and analysis methods for DNA methylation array data
Wilhelm-Benartzi, C. S., Koestler, D. C., Karagas, M. R., Flanagan, J. M., Christensen, B. C., Kelsey, K. T., Marsit, C. J., Houseman, E. A., & Brown, R. E. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.496 · Cited by 202 · see citing works
Self-citationGuerrero-Preston, R. E., Goldman, L. R., Brebi, P., Ili, C., LeBron, C., Witter, F. R., Apelberg, B. J., Hernández-Roystacher, M., Jaffe, A. E., Halden, R. U., et al. (2010) · Epigenetics · doi:10.4161/epi.5.6.12378 · Cited by 198 · see citing works
Gervin, K., Salas, L. A., Bakulski, K. M., van Zelm, M. C., Koestler, D. C., Wiencke, J. K., Duijts, L., Moll, H. A., Kelsey, K. T., Kobor, M. S., et al. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0717-y · Cited by 195 · see citing works
Self-citationImproved selectivity for the analysis of maternal serum and cord serum for polyfluoroalkyl chemicals
Kato, K., Basden, B. J., Needham, L. L., & Calafat, A. M. (2010) · Journal of Chromatography A · doi:10.1016/j.chroma.2010.10.051 · Cited by 189 · see citing works
Kato, K., Wong, L.-Y., Chen, A., Dunbar, C. A., Webster, G. M., Lanphear, B. P., & Calafat, A. M. (2014) · Environmental Science & Technology · doi:10.1021/es501811k · Cited by 182 · see citing works
Self-citationPark, S. K., Peng, Q., Ding, N., Mukherjee, B., & Harlow, S. D. (2019) · Environmental Research · doi:10.1016/j.envres.2019.05.028 · Cited by 179 · see citing works
Racial differences in gene‐specific DNA methylation levels are present at birth
Adkins, R. M., Krushkal, J., Tylavsky, F. A., & Thomas, F. (2011) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20770 · Cited by 172 · see citing works
Cohort Profile: The Health Outcomes and Measures of the Environment (HOME) study
Braun, J. M., Kalloo, G., Chen, A., Dietrich, K. N., Liddy-Hicks, S., Morgan, S., Xu, Y. Y., Yolton, K. A., & Lanphear, B. P. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw006 · Cited by 164 · see citing works
Self-citationEpigenetic changes by per- and polyfluoroalkyl substances (PFAS)
Kim, S., Thapar, I. K., & Brooks, B. W. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.116929 · Cited by 157 · see citing works
Ammonium Perfluorooctanoate Production and Occupational Mortality
Lundin, J. I., Alexander, B. H., Olsen, G. W., & Church, T. R. (2009) · Epidemiology · doi:10.1097/ede.0b013e3181b5f395 · Cited by 156 · see citing works
Wielsøe, M., Kern, P., & Bonefeld‐Jørgensen, E. C. (2017) · Environmental Health · doi:10.1186/s12940-017-0269-6 · Cited by 154 · see citing works
Kato, K., Kalathil, A. A., Patel, A. M., Ye, X., & Calafat, A. M. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.06.085 · Cited by 148 · see citing works
Boronow, K. E., Brody, J. G., Schaider, L. A., Peaslee, G. F., Havas, L., & Cohn, B. A. (2018) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-018-0109-y · Cited by 136 · see citing works
Severity of COVID-19 at elevated exposure to perfluorinated alkylates
Grandjean, P., Timmermann, C. A. G., Kruse, M., Nielsen, F., Vinholt, P. J., Boding, L., Heilmann, C., & Mølbak, K. (2020) · PLOS ONE · doi:10.1371/journal.pone.0244815 · Cited by 131 · see citing works
Transcriptional regulation of tenascin genes
Chiovaro, F., Chiquet‐Ehrismann, R., & Chiquet, M. (2015) · Cell Adhesion & Migration · doi:10.1080/19336918.2015.1008333 · Cited by 120 · see citing works
Prenatal and childhood exposure to per- and polyfluoroalkyl substances (PFASs) and child cognition
Harris, M. H., Oken, E., Rifas‐Shiman, S. L., Calafat, A. M., Ye, X., Bellinger, D. C., Webster, T. F., White, R. F., & Sagiv, S. K. (2018) · Environment International · doi:10.1016/j.envint.2018.03.025 · Cited by 115 · see citing works
Self-citation1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function
Gorski, M., van der Most, P. J., Teumer, A., Chu, A. Y., Li, M., Mijatovic, V., Nolte, I. M., Cocca, M., Taliun, D., Gomez, F., et al. (2017) · Scientific Reports · doi:10.1038/srep45040 · Cited by 113 · see citing works
Self-citationSagiv, S., Rifas-Shiman, S., Fleisch, A., Webster, T., Calafat, A., Ye, X.-Y., Gillman, M., & Oken, E. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx332 · Cited by 113 · see citing works
Self-citationKingsley, S. L., Eliot, M., Kelsey, K. T., Calafat, A. M., Ehrlich, S., Lanphear, B. P., Chen, A., & Braun, J. M. (2018) · Environmental Research · doi:10.1016/j.envres.2018.04.033 · Cited by 110 · see citing works
Self-citationSolomon, O., MacIsaac, J. L., Quach, H., Tindula, G. N., Kobor, M. S., Huen, K., Meaney, M. J., Eskenazi, B., Barcellos, L. F., & Holland, N. (2018) · Epigenetics · doi:10.1080/15592294.2018.1497386 · Cited by 106 · see citing works
A case-control study of perfluoroalkyl substances and the risk of breast cancer in Taiwanese women
Tsai, M., Chang, S.-H., Kuo, W., Kuo, C., Li, S.-Y., Wang, M.-Y., Chang, D., Lu, Y., Huang, C., Cheng, A., et al. (2020) · Environment International · doi:10.1016/j.envint.2020.105850 · Cited by 103 · see citing works
Mortality and cancer incidence in ammonium perfluorooctanoate production workers
Raleigh, K. K., Alexander, B. H., Olsen, G. W., Ramachandran, G., Morey, S. Z., Church, T. R., Logan, P. W., Scott, P., & Allen, E. M. (2014) · Occupational and Environmental Medicine · doi:10.1136/oemed-2014-102109 · Cited by 97 · see citing works
Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans
Mez, J. B., Chung, J., Jun, G., Kriegel, J., Bourlas, A. P., Sherva, R., Logue, M. W., Barnes, L. L., Bennett, D. A., Buxbaum, J. D., et al. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.09.002 · Cited by 96 · see citing works
DeWitt, J. C., Williams, W. C., Creech, N. J., & Luebke, R. W. (2015) · Journal of Immunotoxicology · doi:10.3109/1547691x.2014.996682 · Cited by 84 · see citing works
Ouidir, M., Mendola, P., Louis, G. M. B., Kannan, K., Zhang, C., & Ayele, F. T. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00894-6 · Cited by 84 · see citing works
Vuong, A. M., Webster, G. M., Yolton, K. A., Calafat, A. M., Muckle, G., Lanphear, B. P., & Chen, A. (2021) · Environmental Research · doi:10.1016/j.envres.2021.110825 · Cited by 84 · see citing works
Self-citationKobayashi, S., Azumi, K., Goudarzi, H., Araki, A., Miyashita, C., Kobayashi, S., Itoh, S., Sasaki, S., Ishizuka, M., Nakazawa, H., et al. (2016) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2016.50 · Cited by 83 · see citing works
Yao, X., Glessner, J., Li, J., Qi, X., Hou, X., Zhu, C., Li, X., March, M., Yang, L., Mentch, F. D., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01195-5 · Cited by 81 · see citing works
Davalieva, K., Kostovska, I. M., Kiprijanovska, S., Markoska, K., Sabit, K. K., Filipovski, V. A., Ставридис, С., Станков, О., Komina, S., Petruševska, G., et al. (2015) · The Prostate · doi:10.1002/pros.23034 · Cited by 77 · see citing works
miR-15b-5p Promotes Growth and Metastasis in Breast Cancer by Targeting HPSE2
Wu, B., Liu, G., Jin, Y., Yang, T., Zhang, D., Ding, L., Zhou, F., Pan, Y., & Wei, Y. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00108 · Cited by 75 · see citing works
Braun, J. M., Buckley, J. P., Cecil, K. M., Chen, A., Kalkwarf, H. J., Lanphear, B. P., Xu, Y. Y., Woeste, A., & Yolton, K. A. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-034838 · Cited by 73 · see citing works
Self-citationWakil, S. M., Ram, R., Muiya, N. P., Mehta, M., Andres, E., Mazhar, N., Baz, B., Hagos, S. T., Alshahid, M., Meyer, B. F., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.11.019 · Cited by 66 · see citing works
Starling, A., Liu, C.-N., Shen, G.-N., Yang, I. V., Kechris, K., Borengasser, S. J., Boyle, K., Zhang, W.-M., Smith, H., Calafat, A., et al. (2020) · Environmental Health Perspectives · doi:10.1289/ehp6888 · Cited by 66 · see citing works
Braun, J. M., Daniels, J. L., Poole, C., Olshan, A. F., Hornung, R., Bernert, J. T., Xia, Y., Bearer, C. F., Barr, D. B., & Lanphear, B. P. (2010) · Environmental Health · doi:10.1186/1476-069x-9-53 · Cited by 63 · see citing works
Self-citationMiura, R., Araki, A., Miyashita, C., Kobayashi, S., Kobayashi, S., Wang, S., Chen, C., Miyake, K., Ishizuka, M., Iwasaki, Y., et al. (2018) · Environment International · doi:10.1016/j.envint.2018.03.004 · Cited by 60 · see citing works
the FINNAKI study group, Vilander, L. M., Kaunisto, M. A., Vaara, S. T., & Pettilä, V. (2017) · Critical Care · doi:10.1186/s13054-017-1631-3 · Cited by 52 · see citing works
Chromosomal microarray analysis in the genetic evaluation of 279 patients with syndromic obesity
D’Angelo, C. S., Varela, M. C., de Castro, C. I. E., Otto, P. A., Pérez, A. B. A., Lourenço, C. M., Kim, C. A., Bertola, D. R., Kok, F., Garcia-Alonso, L., et al. (2018) · Molecular Cytogenetics · doi:10.1186/s13039-018-0363-7 · Cited by 51 · see citing works
Maternal Exposure to Synthetic Chemicals and Obesity in the Offspring: Recent Findings
Liu, Y., & Peterson, K. E. (2015) · Current Environmental Health Reports · doi:10.1007/s40572-015-0068-6 · Cited by 50 · see citing works
Self-citationMa, Q., Wu, X., Wu, J., Liang, Z., & Liu, T. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4111 · Cited by 50 · see citing works
Li, N., Liu, Y., Papandonatos, G., Calafat, A., Eaton, C., Kelsey, K., Cecil, K., Kalkwarf, H., Yolton, K., Lanphear, B., et al. (2021) · Environment International · doi:10.1016/j.envint.2020.106344 · Cited by 49 · see citing works
Self-citationLiu, Y., Li, N., Papandonatos, G., Calafat, A., Eaton, C., Kelsey, K., Chen, A.-M., Lanphear, B., Cecil, K., Kalkwarf, H., et al. (2020) · Environmental Science and Technology · doi:10.1021/acs.est.0c06088 · Cited by 44 · see citing works
Self-citationXu, Y., Mlakar, S. J., Lindh, C. H., Scott, K., Fletcher, T., Jakobsson, K., & Engström, K. (2020) · Environment International · doi:10.1016/j.envint.2020.106148 · Cited by 37 · see citing works
Robinson, S. L., Zeng, X., Guan, W., Sundaram, R., Mendola, P., Putnick, D. L., Waterland, R. A., Gunasekara, C., Kannan, K., Gao, C., et al. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110668 · Cited by 37 · see citing works
Rockwell, C. E., Turley, A. E., Cheng, X., Fields, P. E., & Klaassen, C. D. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.12.004 · Cited by 35 · see citing works
Prenatal Perfluorooctyl Sulfonate Exposure and Alu DNA Hypomethylation in Cord Blood
Liu, C.-Y., Chen, P., Lien, P.-C., & Liao, Y.-P. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15061066 · Cited by 33 · see citing works
van den Dungen, M. W., Murk, A. J., Kampman, E., Steegenga, W. T., & Kok, D. E. G. (2017) · Current Zoology · doi:10.1093/eep/dvx001 · Cited by 31 · see citing works
DNA Methylation Patterns in Cord Blood of Neonates Across Gestational Age
Braid, S., Okrah, K., Shetty, A. C., & Bravo, H. C. (2017) · Nursing Research · doi:10.1097/nnr.0000000000000210 · Cited by 24 · see citing works
MAGI1, a New Potential Tumor Suppressor Gene in Estrogen Receptor Positive Breast Cancer
Alday-Parejo, B., Richard, F., Wörthmüller, J., Rau, T. T., Galván, J. A., Desmedt, C., Santamaria‐Martínez, A., & Rüegg, C. (2020) · Cancers · doi:10.3390/cancers12010223 · Cited by 24 · see citing works
Yukawa, T., Oshitani, N., Yamagami, H., Watanabe, K., Higuchi, K., & Arakawa, T. (2007) · International Journal of Molecular Medicine · doi:10.3892/ijmm.20.2.161 · Cited by 22 · see citing works
Song, J., Song, D., Jhung, K., & Cheon, K.-A. A. (2010) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e32834152d1 · Cited by 21 · see citing works
Kelsey, K. T., Rytel, M., Dere, E., Butler, R. A., Eliot, M., Huse, S. M., Houseman, E. A., Koestler, D. C., & Boekelheide, K. (2019) · Environmental Health · doi:10.1186/s12940-019-0533-z · Cited by 21 · see citing works
Self-citationProgramming the Future: Epigenetics in the Context of DOHaD
Barrett, J. R. (2017) · Environmental Health Perspectives · doi:10.1289/ehp.125-a72 · Cited by 18 · see citing works
Vastrad, B. M., Vastrad, C. M., Tengli, A., & Iliger, S. (2017) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-017-4562-y · Cited by 13 · see citing works
Kim, S., Kim, H., Jeon, S. W., Lim, W., Kim, S. I., Lee, Y. J., Kim, S. Y., & Kim, Y. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110227 · Cited by 11 · see citing works
Common variants in SLC6A2, SLC6A3, DRD2, and major depressive disorder
Bi, Y., Huang, X., Niu, W., Chen, S., Wu, X., Cao, Y., Zhang, R., Yang, F., Wang, L., Li, W., et al. (2017) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000163 · Cited by 8 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- ATSDR (Agency for Toxic Substances and Disease Registry). 2018. Toxicological Profile for Perfluoroalkyls. https://wwwn.cdc.gov/TSP/ToxProfiles/ToxProfiles.aspx?id=1117&tid=237 [accessed 13 December 2021]. 37220203
- Belaya K, Finlayson S, Slater CR, Cossins J, Liu WW, Maxwell S, et al. 2012. Mutations in DPAGT1 cause a limb-girdle congenital myasthenic syndrome with tubular aggregates. Am J Hum Genet 91(1): 193– 201, PMID:, 10.1016/j.ajhg.201ok2.05.022. 22742743 PMC3397259 · DOI
Cited by
Sorted by citations
Carcinogenicity of Perfluorooctanoic Acid and Perfluorooctanesulfonic Acid
Zahm, S., Bonde, J. P., Chiu, W. A., Hoppin, J., Kanno, J., Abdallah, M., Blystone, C. R., Calkins, M. M., Dong, G.-H., Dorman, D. C., et al. (2024) · The Lancet Oncology · doi:10.1016/s1470-2045(23)00622-8 · Cited by 387 · see citing works
Mei, J., Jiang, J., Zhao, L., Pan, Y., Xu, K., Gao, X., Yuan, J., Li, L., Wang, Y., Wang, L., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2408575121 · Cited by 65 · see citing works
Self-citationPlasma PFOA and PFOS Levels, DNA Methylation, and Blood Lipid Levels: A Pilot Study
Cheng, X., Wei, Y., Zhang, Z., Wang, F., He, J., Wang, R., Xu, Y., Keerman, M., Zhang, S., Zhang, Y., et al. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c04107 · Cited by 60 · see citing works
Liu, Y., Wosu, A. C., Fleisch, A. F., Dunlop, A. L., Starling, A. P., Ferrara, A. M., Dabelea, D., Oken, E., Buckley, J. P., Chatzi, L., et al. (2023) · Environmental Health Perspectives · doi:10.1289/ehp11545 · Cited by 57 · see citing works
Self-citationZhang, Y., Mustieles, V., Sun, Q., Coull, B. A., McElrath, T. F., Rifas‐Shiman, S. L., Martin, L. J., Sun, Y., Wang, Y., Oken, E., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.14934 · Cited by 55 · see citing works
Self-citationHirke, A., Varghese, B., Varade, S., & Adela, R. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.120828 · Cited by 55 · see citing works
Effects of In Utero PFOS Exposure on Epigenetics and Metabolism in Mouse Fetal Livers
Ho, T. C., Wan, H. T., Lee, W. K., Lam, T. K. Y., Lin, X., Chan, T., Lai, K. P., & Wong, C. K. C. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c05207 · Cited by 47 · see citing works
Yi, W., Shi, J., Wang, L., Wang, D., Wang, Y., Song, J., Xin, L., & Jiang, F. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.134177 · Cited by 47 · see citing works
Perng, W., Nakiwala, D., & Goodrich, J. M. (2022) · Current Environmental Health Reports · doi:10.1007/s40572-022-00387-z · Cited by 40 · see citing works
Petroff, R., Cavalcante, R. G., Langen, E. S., Dolinoy, D. C., Padmanabhan, V., & Goodrich, J. M. (2023) · Clinical Epigenetics · doi:10.1186/s13148-023-01461-5 · Cited by 40 · see citing works
Bakulski, K. M., Blostein, F., & London, S. J. (2023) · Environmental Health Perspectives · doi:10.1289/ehp12956 · Cited by 38 · see citing works
Zhao, H., Xie, J., Wu, S., Sánchez, O. F., Zhang, X., Freeman, J. L., & Yuan, C. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119684 · Cited by 34 · see citing works
Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Childhood Autism-related Outcomes
Ames, J., Burjak, M., Avalos, L. A., Braun, J. M., Bulka, C. M., Croen, L., Dunlop, A. L., Ferrara, A. M., Fry, R. C., Hedderson, M. M., et al. (2023) · Epidemiology · doi:10.1097/ede.0000000000001587 · Cited by 35 · see citing works
Self-citationDutta, S., Goodrich, J. M., Dolinoy, D. C., & Ruden, D. M. (2023) · Genes · doi:10.3390/genes15010016 · Cited by 35 · see citing works
Liu, Y., Calafat, A. M., Chen, A., Lanphear, B. P., Jones, N. Y., Cecil, K. M., Rose, S. R., Yolton, K. A., Buckley, J. P., & Braun, J. M. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.164353 · Cited by 31 · see citing works
Self-citationBraun, J. M., Papandonatos, G. D., Li, N., Sears, C. G., Buckley, J. P., Cecil, K. M., Chen, A., Eaton, C. B., Kalkwarf, H. J., Kelsey, K. T., et al. (2022) · Environmental Research · doi:10.1016/j.envres.2022.114021 · Cited by 30 · see citing works
Self-citationXie, Z., Sun, S., Ji, H., Miao, M., He, W., Song, X., Cao, W., Wu, Q., Liang, H., & Yuan, W. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.132845 · Cited by 29 · see citing works
Epigenetic Consequences of In Utero PFAS Exposure: Implications for Development and Long-Term Health
Abdulkadir, A., Kandel, S., Lewis, N., D’Auvergne, O., Rosby, R., & Hossain, E. (2025) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22060917 · Cited by 27 · see citing works
Zhang, Y., Mustieles, V., Wang, Y., Sun, Q., Coull, B. A., Sun, Y., Slitt, A. L., & Messerlian, C. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.2c07152 · Cited by 25 · see citing works
Hall, A. M., Fleury, E. S., Papandonatos, G., Buckley, J. P., Cecil, K., Chen, A.-M., Lanphear, B., Yolton, K., Walker, D. I., Pennell, K., et al. (2023) · Environmental Science and Technology · doi:10.1021/acs.est.3c07515 · Cited by 22 · see citing works
Self-citationWang, H., Li, W., Yang, J., Wang, Y., Du, H., Han, M., Xu, L., Liu, S., Yi, J., Chen, Y., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.159747 · Cited by 22 · see citing works
Wang, L., Zong, L., Cao, D., & Guan, M. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000002461 · Cited by 21 · see citing works
Niemiec, S. S., Kechris, K., Pattee, J., Yang, I. V., Adgate, J., Calafat, A., Dabelea, D., & Starling, A. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116215 · Cited by 18 · see citing works
Merrill, A. K., Sobolewski, M., & Susiarjo, M. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.112031 · Cited by 22 · see citing works
Morales-Grahl, E., Hilz, E. N., & Gore, A. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136887 · Cited by 22 · see citing works
Pan, J., Ouyang, C., Zhou, S., Wang, X., Liu, H., Zhang, J., Wang, X., Shi, X., Yang, A., & Hu, X. (2024) · Toxics · doi:10.3390/toxics12050314 · Cited by 19 · see citing works
Immune impacts of fire smoke exposure
Johnson, M. M. D., Kaushik, A., Kline, O., Smith, E. M., Zhou, X., Pat, Y., Buergi, L., Aguilera, J., Alkotob, S., Simonin, E. M., et al. (2025) · Nature Medicine · doi:10.1038/s41591-025-03777-6 · Cited by 16 · see citing works
Considerations for Measurements of Aggregate PFAS Exposure in Precision Environmental Health
Manz, K. E. (2024) · ACS Measurement Science Au · doi:10.1021/acsmeasuresciau.4c00052 · Cited by 14 · see citing works
Tain, Y., & Hsu, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094599 · Cited by 14 · see citing works
Briassoulis, G., Ilia, S., & Briassouli, E. (2025) · Life · doi:10.3390/life15071057 · Cited by 15 · see citing works
Ghozal, M., Kadawathagedara, M., Delvert, R., Divaret‐Chauveau, A., Rahérison, C., Varraso, R., Bédard, A., Crépet, A., Sirot, V., Charles, M.-A. A., et al. (2024) · Environmental Health · doi:10.1186/s12940-023-01046-y · Cited by 13 · see citing works
Contemporary Concise Review 2023: Environmental and occupational lung diseases
Yatera, K., & Nishida, C. (2024) · Respirology · doi:10.1111/resp.14761 · Cited by 17 · see citing works
Li, H., Hu, Y., Wang, P., Zhang, L., Wang, H., Gui, Y., Xu, Y., Zhao, Y., Cao, W., Wang, M., et al. (2025) · Environmental Chemistry Letters · doi:10.1007/s10311-025-01820-z · Cited by 11 · see citing works
Schrott, R., Ladd‐Acosta, C., Padmanabhan, V., Barr, D. B., Breton, C. V., Cárdenas, A., Carignan, C. C., Dabelea, D., Dunlop, A. L., Fallin, D., et al. (2025) · Current Zoology · doi:10.1093/eep/dvaf010 · Cited by 11 · see citing works
Self-citationPuvvula, J., Braun, J. M., DeFranco, E., Ho, S., Leung, Y., Huang, S., Zhang, X., Vuong, A. M., Kim, S. S., Percy, Z., et al. (2024) · Epigenetics Communications · doi:10.1186/s43682-024-00027-7 · Cited by 9 · see citing works
Self-citationRethinking the Carcinogenic Classification of Perfluorooctanoic Acid (PFOA)
Sun, Y., Ruan, T., Yan, B., Zhou, Q., Wu, Y., & Jiang, G. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c04663 · Cited by 9 · see citing works
Key characteristics of carcinogens meet hallmarks for prevention-cutting the Gordian knot
Senga, S. S., Bisson, W. H., & Colacci, A. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1420687 · Cited by 8 · see citing works
Xie, Z., Jin, L., Wu, Q., Ji, H., Miao, M., Song, X., Zhu, H., Su, H., Yuan, W., & Liang, H. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.137545 · Cited by 8 · see citing works
Lyu, Y., Guo, R., Zhong, W., & Zhu, L. Y. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.4c14697 · Cited by 8 · see citing works
A Method for Determining PFAS in Bovine Meat and Tuna Fish by UHPLC‐HRMS Orbitrap
Roviaro, A., Scarduzio, A., Savini, S., & Sannino, A. (2025) · Journal of Mass Spectrometry · doi:10.1002/jms.5151 · Cited by 7 · see citing works
Guo, H., Wu, Z., Shen, G., Huang, Z., Zha, Z., Zheng, X., Luo, X., Mai, B., Ye, J., & Li, J. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.138189 · Cited by 7 · see citing works
Jia, Z., Qiu, F., He, Y., Chen, H., Yang, C., Liu, H., Zheng, T., Xu, S., Wang, S., & Li, Y. (2024) · BMC Medicine · doi:10.1186/s12916-024-03629-z · Cited by 6 · see citing works
Arzu, J. L., Kelsey, K. T., Papandonatos, G. D., Cecil, K. M., Chen, A., Langevin, S. M., Lanphear, B. P., Yolton, K. A., Buckley, J. P., & Braun, J. M. (2024) · Clinical Epigenetics · doi:10.1186/s13148-024-01779-8 · Cited by 6 · see citing works
Self-citationDrouard, G., Suhonen, S., Heikkinen, A., Wang, Z., Kaprio, J. A., & Ollikainen, M. (2025) · Aging Cell · doi:10.1111/acel.70088 · Cited by 6 · see citing works
Khodasevich, D., Bozack, A. K., Needham, B. L., Rehkopf, D. H., & Cárdenas, A. (2025) · Environmental Research · doi:10.1016/j.envres.2025.121827 · Cited by 6 · see citing works
Hu, Y., Chen, H., Sun, S., Zhang, L., Yang, D., Zhao, J., Zhang, Q., Pan, Y., Liu, X., & Liu, Z. (2025) · Environmental Health · doi:10.1186/s12940-025-01213-3 · Cited by 5 · see citing works
Epigenome‐wide association study on methamphetamine dependence
Shirai, T., Okazaki, S., Tanifuji, T., Otsuka, I., Horai, T., Mouri, K., Takemura, Y., Aso, K., Yamamoto, N., & Hishimoto, A. (2024) · Addiction Biology · doi:10.1111/adb.13383 · Cited by 5 · see citing works
Marks and Mechanisms: Unraveling Potential Health Impacts of PFAS via DNA Methylation
Schmidt, S. (2022) · Environmental Health Perspectives · doi:10.1289/ehp11287 · Cited by 5 · see citing works
Yamamoto, M., Eguchi, A., Sakurai, K., Nakayama, S. F., Konno, Y., & Kamijima, M. (2025) · Environmental Science and Technology · doi:10.1021/acs.est.5c09583 · Cited by 4 · see citing works
Liu, Y., Gairola, R., Kuiper, J. R., Papandonatos, G. D., Kelsey, K. T., Langevin, S. M., Buckley, J. P., Chen, A., Lanphear, B. P., Cecil, K. M., et al. (2023) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.3c00410 · Cited by 4 · see citing works
Self-citationMendy, A., Percy, Z., Braun, J. M., Lanphear, B. P., Guardia, M. J. L., Hale, R. C., Langevin, S. M., Kelsey, K. T., Chen, A., & Yolton, K. A. (2025) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.180079 · Cited by 3 · see citing works
Self-citationLiu, J., Lin, L., Zhang, H., Li, X., Ding, Y., & Yao, J. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.119712 · Cited by 3 · see citing works
Gorini, F., Tonacci, A., Palazzo, M., Bustaffa, E., Minichilli, F., & Borghini, A. (2026) · Antioxidants · doi:10.3390/antiox15060718 · Cited by 3 · see citing works
Prenatal PFAS exposures and cardiometabolic health in middle childhood in the MIREC cohort
Fossa, A. J., Hall, A. M., Papandonatos, G. D., Arbuckle, T. E., Ashley‐Martin, J., Borghese, M. M., Bruin, J., Chen, A., Fisher, M. M., Krzeczkowski, J. E., et al. (2025) · Environmental Research · doi:10.1016/j.envres.2025.121330 · Cited by 3 · see citing works
Self-citationArunsi, U. O., Ezirim, D. C., Arunsi, C. C., Altayyar, A., Eke, G., Jonathan, F. C., Opieh, A. K., Anadi, I. V., Ofoegbu, C. O., Nwankwo, V. C., et al. (2025) · Cancers · doi:10.3390/cancers17213507 · Cited by 2 · see citing works
Liu, S. J., Chen, Y., Feuerstahler, L. M., Koelmel, J. P., Pollitt, K. J. G., Xu, Y., Lanphear, B. P., Yolton, K. A., Chen, A., Pennell, K. D., et al. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.5c06490 · Cited by 2 · see citing works
Self-citationPeng, J., He, J., Ma, C., & Xue, J. (2025) · Toxics · doi:10.3390/toxics13040320 · Cited by 2 · see citing works
Genome-wide Association Study of Asthma Exacerbations in the Spanish Population
Martín-González, E., Pérez-García, J., Martin‐Almeida, M., Pérez, J. M. H., González‐Pérez, R., Sardón‐Prado, O., Pérez, J. A. P., Carracedo, M. A. G., Guedes, P. P., Sánchez‐Machín, I., et al. (2025) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2025.03.012 · Cited by 1 · see citing works
Metabolomics-based investigation of PFOS-induced molecular perturbations across multiple rat organs
Yen, T.-H., Lee, S.-H., Liang, H., Huang, Z.-X., Chen, C.-T., Li, C., & Lin, C.-Y. (2026) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2026.104957 · Cited by 1 · see citing works
Tang, G., Lan, Z., Huang, J., Dai, T., Meng, T., Xu, Z., Chen, M., Wen, L., Cheng, Y., & Ding, L. (2026) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2026.140474 · Cited by 1 · see citing works
Nikpay, M. (2024) · Epigenomes · doi:10.3390/epigenomes8030029 · Cited by 1 · see citing works
Chen, P., Wei, C., Chen, M., Lin, C., Lu, T., Chen, C., & Hsieh, W. (2025) · Research Square · doi:10.21203/rs.3.rs-6273014/v1 · Cited by 1 · see citing works
Ponsonby, A., Holland, L., Tanner, S., Gogos, A., England-Mason, G., Drummond, K. D., Marx, W., Thomson, S. M., Novakovic, B., Dewey, D., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-7747095/v1
Ghozal, M., Kadawathagedara, M., Delvert, R., Divaret‐Chauveau, A., Rahérison, C., Varraso, R., Bédard, A., Crépet, A., Sirot, V., Charles, M.-A. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24971327
Petroff, R., Cavalcante, R. G., Langen, E. S., Dolinoy, D. C., Padmanabhan, V., & Goodrich, J. M. (2023) · Figshare · doi:10.6084/m9.figshare.22622252
Shafiq, N., Gao, C., Tang, W., Li, R., & Huang, Y. (2026) · iScience · doi:10.1016/j.isci.2025.114606
Li, L., Xu, R., Wang, Y., Huang, L., Cao, X., Yuan, Z., Chen, B., Zhang, S., Qin, R., Cai, F., et al. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.5c13613
Wei, C., Chen, M.-H., Lin, C.-C., Lu, T., Chen, C., Hsieh, W., & Chen, P. (2026) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000472
Bivalency Erosion as a Unifying Mechanism of PFAS Inter‐ and Transgenerational Neurotoxicity
Fedulov, A. (2026) · Journal of Applied Toxicology · doi:10.1002/jat.70244
Hollister, J., Porter, C., Xiang, B., Beitel, S. C., Rivers, P. S., Lutrick, K., Burgess, J. L., & Ellingson, K. (2026) · BMJ Paediatrics Open · doi:10.1136/bmjpo-2026-004484
Imaging and Molecular Biomarkers of PFAS-Related Vascular Aging: A Narrative Review
Borghini, A., Faita, F., Simonini, L., Palazzo, M., Sagheddu, C., Cavigli, C., Donzelli, G., Bustaffa, E., Masi, S., Gorini, F., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27136064 · Cited by 1 · see citing works
Deng, B., Xia, X., & Sun, X. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1892134
Kidney Risks Linked to Per‐ and Polyfluoroalkyl Substance Exposure
Chávez‐Valencia, V., & Lagunas‐Rangel, F. A. (2026) · Environmental Toxicology · doi:10.1002/tox.70197
Mustafa, G., Afzal, A., Zaman, F., Alvi, A., Zahid, M. T., Kumar, R., Nimra, A., Ahn, H.-J., Tanpure, R. S., Chang, S., et al. (2026) · Journal of Hazardous Materials Advances · doi:10.1016/j.hazadv.2026.101575
Tan, Y., Dunlop, A. W., Everson, T. M., Smith, A. K., Eick, S. M., Tang, Z., Pan, S., Sehgal, N., Barr, D. B., Kannan, K., et al. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.6c03113
Smith, A. R., Hernandez‐Castro, I., Bozack, A. K., Rifas‐Shiman, S. L., Gold, D. R., Hivert, M., Oken, E., & Cárdenas, A. (2026) · Environmental Research · doi:10.1016/j.envres.2026.125759
Self-citationLiu, N., Zhu, H., Yan, G., Zhang, B., Lin, N., & Tan, B. (2026) · Journal of Environmental Sciences · doi:10.1016/j.jes.2026.105829
- Authors
- Liu, Y., Eliot, M. N., Papandonatos, G. D., Kelsey, K. T., Fore, R., Langevin, S., Buckley, J., Chen, A., Lanphear, B. P., Cecil, K. M., Yolton, K., Hivert, M.-F., Sagiv, S. K., Baccarelli, A. A., Oken, E., & Braun, J. M.
- Affiliations
- Brown University (US)
- Harvard University (US)
- University of Cincinnati (US)
- Johns Hopkins University (US)
- University of Pennsylvania (US)
- Simon Fraser University (CA)
- Cincinnati Children's Hospital Medical Center (US)
- University of California, Berkeley (US)
- Columbia University (US)
- Corresponding author
- Liu, Yun
- ORCID
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-03
- Volume
- 130
- Issue
- 3
- Pages
- 37005-37005
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- PMC
- PMC8911098
- OpenAlex
- W4220903784
- Cited by
- 78
- References
- 82
- Citations by year
- 2026: 17 · 2025: 23 · 2024: 15 · 2023: 16 · 2022: 7
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- Locations
- Environmental Health Perspectives (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, public-domain)
- Funders
- National Institutes of Health (UH3OD023286, UG3OD023286)
- National Institute of Environmental Health Sciences (R01ES030078, R01ES020349, R01ES027224, L40 ES032257, P01ES011261, R01ES032836, R01ES025214)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD034568)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- perfluorinated compounds, prenatal exposure, DNA methylation, epigenetics, perfluorooctanoic acid, PFOS, perfluorononanoate, PFHxS, umbilical cord blood, prenatal environmental exposure, cancer risk, cognitive health, cardiovascular disease, renal function, home study
- MeSH terms
- Epigenome, Adolescent, Child, Environmental Pollutants, Female, Fluorocarbons, Humans, Infant, Newborn, Longitudinal Studies, Pregnancy, Alkanesulfonic Acids, DNA Methylation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review