Telomere shortening and cell fates in mouse models of neoplasia
Abstract
Cell division in the absence of telomerase leads to telomere shortening that can activate checkpoint responses and impair chromosomal stability. The absence of telomerase in primary human cells and its near universal reactivation in human cancers has highlighted the importance of telomere shortening and telomerase reactivation during tumor development. Data from telomerase-deficient mouse models of cancer have indicated that telomere shortening can exert profoundly different influences on cell fates in developing cancers, limiting tumorigenesis by enhancing cell death or facilitating carcinogenesis by compromising chromosomal stability. These alternate fates depend on the integrity of the p53 pathway and on cell type.
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Chronic cellular damage leading to liver cirrhosis results in shortened telomeres, anaphase bridges and a dramatically increased risk of liver cancer.
“Similarly, the chronic cellular damage that leads to liver cirrhosis results in shortened telomeres, anaphase bridges and a dramatically increased risk of liver cancer (131-134).”
From Telomeres and telomerase in cancer (2010) · cites this paper as [134]
Cites
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Chromosome aberrations in solid tumors
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- Authors
- Artandi, S. E.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Artandi, Steven E
- ORCID
- Artandi, Steven E
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2002-01
- Volume
- 8
- Issue
- 1
- Pages
- 44-47
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2077247569
- Cited by
- 40
- References
- 13
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 5 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 2 · 2014: 2 · 2012: 3
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- telomere shortening, telomerase, cell fate, carcinogenesis, chromosome stability, p53 pathway, cell death, cell division
- MeSH terms
- Animals, Cell Division, Disease Models, Animal, Humans, Models, Biological, Neoplasms, Genes, p53, Telomere, Cell Death, Apoptosis, Cell Lineage, Mice
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