Cited by 822Genomic variations and chromosomal abnormalitiesCancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Chromosome aberrations in solid tumors

Albertson, Donna G, Collins, Colin, McCormick, Frank, Gray, Joe W·2003·Nature Genetics

Abstract

Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations.

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Crossref · 10.1038/ng1215

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165 of 165 references verified0 citation errors · 0 not checkable

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Authors
Albertson, D. G., Collins, C., McCormick, F., & Gray, J. W.
Affiliations
  • University of California, San Francisco (US)
  • Lawrence Berkeley National Laboratory (US)
Corresponding author
  • Albertson, Donna G
  • Gray, Joe W
Venue
Nature Genetics
Published
2003-07-30
Volume
34
Issue
4
Pages
369-376
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
OpenAlex
W2060084956
Cited by
812
References
167
Citations by year
2026: 8 · 2025: 11 · 2024: 15 · 2023: 22 · 2022: 26 · 2021: 26 · 2020: 29 · 2019: 27 · 2018: 19 · 2017: 18 · 2016: 19 · 2015: 32 · 2014: 41 · 2013: 68 · 2012: 54
FWCI
4.93
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Avon Foundation for Women
  • U.S. Public Health Service
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
chromosomal abnormalities, solid tumors, genomic instability, gene expression dysregulation, tumor progression, chromosomal instability
MeSH terms
Chromosome Aberrations, Biological Evolution, Humans, Models, Genetic, Neoplasms, Oncogenes, Prognosis, Signal Transduction, Gene Dosage, Receptor Protein-Tyrosine Kinases

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