Chromosome aberrations in solid tumors
Abstract
Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations.
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Advanced human cancers are aneuploid, containing cells with abnormal chromosome numbers.
“Advanced human cancers are invariably aneuploid, in that they harbour cells with abnormal chromosome numbers 1,2 .”
From Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control (2004) · cites this paper as [2]
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- Authors
- Albertson, D. G., Collins, C., McCormick, F., & Gray, J. W.
- Affiliations
- University of California, San Francisco (US)
- Lawrence Berkeley National Laboratory (US)
- Corresponding author
- Albertson, Donna G
- Gray, Joe W
- Venue
- Nature Genetics
- Published
- 2003-07-30
- Volume
- 34
- Issue
- 4
- Pages
- 369-376
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2060084956
- Cited by
- 812
- References
- 167
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 15 · 2023: 22 · 2022: 26 · 2021: 26 · 2020: 29 · 2019: 27 · 2018: 19 · 2017: 18 · 2016: 19 · 2015: 32 · 2014: 41 · 2013: 68 · 2012: 54
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Avon Foundation for Women
- U.S. Public Health Service
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- chromosomal abnormalities, solid tumors, genomic instability, gene expression dysregulation, tumor progression, chromosomal instability
- MeSH terms
- Chromosome Aberrations, Biological Evolution, Humans, Models, Genetic, Neoplasms, Oncogenes, Prognosis, Signal Transduction, Gene Dosage, Receptor Protein-Tyrosine Kinases
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