The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Abnormal spermatozoa in the ejaculate: abortive apoptosis and faulty nuclear remodelling during spermatogenesis
Open accessAbstract
The mechanisms responsible for producing abnormal spermatozoa in the ejaculate are relatively unknown. Numerous studies have now shown the presence of nuclear DNA strand breaks in human ejaculated spermatozoa and the abnormal persistence of apoptotic marker proteins. The reason why human spermatozoa, in particular from men with abnormal semen parameters, possess these abnormalities is still not clear. Two processes that have been linked to the presence of nuclear DNA strand breaks in spermatozoa are anomalies in apoptosis during spermatogenesis or problems in the replacement of histones with protamines during spermiogenesis. Understanding the mechanisms responsible for producing abnormal spermatozoa in the human will improve knowledge about certain causes of male infertility.
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Citations
Cites
Relation of Mammalian Sperm Chromatin Heterogeneity to Fertility
Evenson, D. P., Darzynkiewicz, Z., & Melamed, M. R. (1980) · Science · doi:10.1126/science.7444440 · Cited by 812
Sun, J.-G., Jurisicova, A., & Casper, R. F. (1997) · Biology of Reproduction · doi:10.1095/biolreprod56.3.602 · Cited by 753
Oxidative stress, DNA damage and the Y chromosome
Aitken, R. J., & Krausz, C. (2001) · Reproduction · doi:10.1530/rep.0.1220497 · Cited by 730
Rodriguez, I., Ody, C., Araki, K., Garcia, I., & Vassalli, P. (1997) · The EMBO Journal · doi:10.1093/emboj/16.9.2262 · Cited by 602
Origin of DNA damage in ejaculated human spermatozoa
Sakkas, D. (1999) · Reviews of Reproduction · doi:10.1530/revreprod/4.1.31 · Cited by 526
Self-citationThe Fas System Is a Key Regulator of Germ Cell Apoptosis in the Testis*
Lee, J., Richburg, J. H., Younkin, S. C., & Boekelheide, K. (1997) · Endocrinology · doi:10.1210/endo.138.5.5110 · Cited by 519
Lopes, S., Sun, J.-G., Jurisicova, A., Meriano, J., & Casper, R. F. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00536-0 · Cited by 505
Gorczyca, W., Traganos, F., Jesionowska, H., & Darzynkiewicz, Z. (1993) · Experimental Cell Research · doi:10.1006/excr.1993.1182 · Cited by 478
Barroso, G., Morshedi, M., & Oehninger, S. (2000) · Human Reproduction · doi:10.1093/humrep/15.6.1338 · Cited by 475
Nature of DNA Damage in Ejaculated Human Spermatozoa and the Possible Involvement of Apoptosis1
Sakkas, D., Moffatt, O., Manicardi, G. C., Mariethoz, E., Tarozzi, N., & Bizzaro, D. (2002) · Biology of Reproduction · doi:10.1095/biolreprod66.4.1061 · Cited by 447
Self-citation
Cited by
Protamines and male infertility
Oliva, R. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml009 · Cited by 802
Gharagozloo, P., & Aitken, R. J. (2011) · Human Reproduction · doi:10.1093/humrep/der132 · Cited by 522
Sharma, R., Agarwal, A., Rohra, V. K., Assidi, M., Abu-Elmagd, M., & Turki, R. F. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0028-x · Cited by 451
Sperm chromatin structure and male fertility: biological and clinical aspects
Erenpreiss, J., Spano, M., Erenpreisa, J., Bungum, M., & Giwercman, A. (2006) · Asian Journal of Andrology · doi:10.1111/j.1745-7262.2006.00112.x · Cited by 304
Antioxidants and sperm DNA damage: a clinical perspective
Zini, A., San Gabriel, M., & Baazeem, A. (2009) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-009-9343-5 · Cited by 203
Metadata
- Authors
- Sakkas, D., Seli, E., Bizzaro, D., Tarozzi, N., & Manicardi, G. C.
- Venue
- Reproductive BioMedicine Online
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 7
- Issue
- 4
- Pages
- 428-432
- ISSN
- 1472-6483 (ISSN-L)
- OpenAlex
- W1986612378
- Cited by
- 275
- References
- 38
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Sakkas, D., Seli, E., Bizzaro, D., Tarozzi, N., & Manicardi, G. C. (2003). Abnormal spermatozoa in the ejaculate: abortive apoptosis and faulty nuclear remodelling during spermatogenesis. Reproductive BioMedicine Online. https://doi.org/10.1016/s1472-6483(10)61886-x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
